{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:45:34Z","timestamp":1780393534915,"version":"3.54.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s00228-025-03975-8","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T06:04:15Z","timestamp":1768802655000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute coronary syndrome as a turning point for guideline adherence and outcomes in heart failure with coronary artery disease and diabetes mellitus"],"prefix":"10.1007","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6414-3743","authenticated-orcid":false,"given":"Fuat","family":"Polat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7633-4767","authenticated-orcid":false,"given":"Nur Kamer Kaya","family":"\u0130nalka\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4543-1758","authenticated-orcid":false,"given":"\u0130brahim","family":"Kele\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"issue":"42","key":"3975_CR1","doi-asserted-by":"publisher","first-page":"2929","DOI":"10.1093\/eurheartj\/ehu299","volume":"35","author":"M Nichols","year":"2014","unstructured":"Nichols M, Townsend N, Scarborough P et al (2014) Cardiovascular disease in Europe 2014: epidemiological update. Eur Heart J 35(42):2929","journal-title":"Eur Heart J"},{"issue":"22","key":"3975_CR2","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1161\/CIR.0b013e318235eb4d","volume":"124","author":"SC Smith","year":"2011","unstructured":"Smith SC, Benjamin EJ, Bonow RO et al (2011) AHA\/ACCF secondary prevention and risk reduction therapy for patients with coronary and other atherosclerotic vascular disease: 2011 update: a guideline from the American heart association and American College of Cardiology foundation. Circulation 124(22):2458\u201373","journal-title":"Circulation"},{"key":"3975_CR3","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.1038\/s41591-024-03123-2","volume":"30","author":"EW Gregg","year":"2024","unstructured":"Gregg EW, Pratt A, Owens A et al (2024) The burden of diabetes-associated multiple long-term conditions on years of life spent and lost. Nat Med 30:2830\u20137","journal-title":"Nat Med"},{"key":"3975_CR4","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1136\/hrt.2010.213710","volume":"97","author":"PP Cacoub","year":"2011","unstructured":"Cacoub PP, Zeymer U, Limbourg T et al (2011) Effects of adherence to guidelines for the control of major cardiovascular risk factors on outcomes in the REduction of Atherothrombosis for Continued Health (REACH) Registry Europe. Heart 97:660\u20137","journal-title":"Heart"},{"key":"3975_CR5","first-page":"e596","volume":"140","author":"DK Arnett","year":"2019","unstructured":"Arnett DK, Blumenthal RS, Albert MA et al (2019) 2019 ACC\/AHA guideline on the primary prevention of cardiovascular disease: a report of the American college of Cardiology\/American heart association task force on clinical practice guidelines. Circulation 140:e596\u2013e646","journal-title":"Circulation"},{"issue":"2","key":"3975_CR6","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.amjmed.2003.12.041","volume":"117","author":"KA Eagle","year":"2004","unstructured":"Eagle KA, Kline-Rogers E, Goodman SG et al (2004) Adherence to evidence-based therapies after discharge for acute coronary syndromes: an ongoing prospective, observational study. Am J Med 117(2):73\u201381","journal-title":"Am J Med"},{"key":"3975_CR7","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1002\/ejhf.887","volume":"19","author":"M Komajda","year":"2017","unstructured":"Komajda M, Cowie MR, Tavazzi L et al (2017) Physicians\u2019 guideline adherence is associated with better prognosis in outpatients with heart failure with reduced ejection fraction: the QUALIFY international registry. Eur J Heart Fail 19:1414\u201323","journal-title":"Eur J Heart Fail"},{"issue":"1","key":"3975_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53348-2","volume":"9","author":"JJ Hai","year":"2019","unstructured":"Hai JJ, Wong CK, Un KC et al (2019) Guideline-based critical care pathway improves long-term clinical outcomes in patients with acute coronary syndrome. Sci Rep 9(1):16814","journal-title":"Sci Rep"},{"key":"3975_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-018-0728-6","volume":"17","author":"TR Einarson","year":"2018","unstructured":"Einarson TR, Acs A, Ludwig C et al (2018) Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007\u20132017. Cardiovasc Diabetol 17:83","journal-title":"Cardiovasc Diabetol"},{"issue":"6","key":"3975_CR10","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.ihj.2022.11.011","volume":"74","author":"A Sigamani","year":"2022","unstructured":"Sigamani A, Gupta R (2022) Revisiting secondary prevention in coronary heart disease. Indian Heart J 74(6):431\u201340","journal-title":"Indian Heart J"},{"key":"3975_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-63598-4","volume":"14","author":"HP Wu","year":"2024","unstructured":"Wu HP, Yang FC, Lin HD et al (2024) Association between statin therapy and long-term clinical outcomes in patients with stable coronary disease undergoing percutaneous coronary intervention. Sci Rep 14:12674","journal-title":"Sci Rep"},{"key":"3975_CR12","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0140-6736(11)60679-X","volume":"378","author":"G Danaei","year":"2011","unstructured":"Danaei G, Finucane MM, Lu Y et al (2011) National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet 378:31\u201340","journal-title":"Lancet"},{"issue":"23","key":"3975_CR13","doi-asserted-by":"publisher","first-page":"3028","DOI":"10.1161\/CIRCULATIONAHA.108.768986","volume":"119","author":"PM Ho","year":"2009","unstructured":"Ho PM, Bryson CL, Rumsfeld JS (2009) Medication adherence: its importance in cardiovascular outcomes. Circulation 119(23):3028\u20133035","journal-title":"Circulation"},{"issue":"11","key":"3975_CR14","first-page":"CD000011","volume":"2014","author":"R Nieuwlaat","year":"2014","unstructured":"Nieuwlaat R, Wilczynski N, Navarro T et al (2014) Interventions for enhancing medication adherence. Cochrane Database Syst Rev 2014(11):CD000011","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"3975_CR15","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ahj.2015.03.019","volume":"170","author":"R Mathews","year":"2015","unstructured":"Mathews R, Wang TY, Honeycutt E et al (2015) Persistence with secondary prevention medications after acute myocardial infarction: insights from the TRANSLATE-ACS study. Am Heart J 170(1):62\u201369","journal-title":"Am Heart J"},{"issue":"12","key":"3975_CR16","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1161\/CIRCULATIONAHA.113.003589","volume":"129","author":"SV Arnold","year":"2014","unstructured":"Arnold SV, Kosiborod M, Tang F et al (2014) Patterns of statin initiation, intensification, and maximization among patients hospitalized with an acute myocardial infarction. Circulation 129(12):1303\u20131309","journal-title":"Circulation"},{"issue":"3","key":"3975_CR17","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1001\/jamacardio.2018.4936","volume":"4","author":"F Rodriguez","year":"2019","unstructured":"Rodriguez F, Maron DJ, Knowles JW, Virani SS, Lin S, Heidenreich PA (2019) Association of statin adherence with mortality in patients with atherosclerotic cardiovascular disease. JAMA Cardiol 4(3):206\u2013213","journal-title":"JAMA Cardiol"},{"issue":"11","key":"3975_CR18","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1056\/NEJMoa1409077","volume":"371","author":"JJ McMurray","year":"2014","unstructured":"McMurray JJ, Packer M, Desai AS et al (2014) Angiotensin\u2013neprilysin inhibition versus enalapril in heart failure. N Engl J Med 371(11):993\u20131004","journal-title":"N Engl J Med"},{"issue":"36","key":"3975_CR19","doi-asserted-by":"publisher","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","volume":"42","author":"TA McDonagh","year":"2021","unstructured":"McDonagh TA, Metra M, Adamo M et al (2021) 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 42(36):3599\u20133726","journal-title":"Eur Heart J"},{"issue":"22","key":"3975_CR20","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1056\/NEJMoa1504720","volume":"373","author":"B Zinman","year":"2015","unstructured":"Zinman B, Wanner C, Lachin JM et al (2015) Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 373(22):2117\u20132128","journal-title":"N Engl J Med"},{"issue":"15","key":"3975_CR21","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1001\/jama.2013.1063","volume":"309","author":"J Butler","year":"2013","unstructured":"Butler J, Fonarow GC, Gheorghiade M (2013) Strategies and opportunities for drug development in heart failure. JAMA 309(15):1593\u20131594","journal-title":"JAMA"},{"issue":"11","key":"3975_CR22","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1002\/ejhf.887","volume":"19","author":"M Komajda","year":"2017","unstructured":"Komajda M, Cowie MR, Tavazzi L et al (2017) Physicians\u2019 guideline adherence is associated with better prognosis in outpatients with heart failure with reduced ejection fraction: the QUALIFY international registry. Eur J Heart Fail 19(11):1414\u20131423","journal-title":"Eur J Heart Fail"},{"issue":"20","key":"3975_CR23","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1161\/CIRCULATIONAHA.105.583666","volume":"113","author":"YD Tang","year":"2006","unstructured":"Tang YD, Katz SD (2006) Anemia in chronic heart failure: prevalence, etiology, clinical correlates, and treatment options. Circulation 113(20):2454\u20132461","journal-title":"Circulation"},{"issue":"15","key":"3975_CR24","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1056\/NEJMoa1003795","volume":"363","author":"S Zoungas","year":"2010","unstructured":"Zoungas S, Patel A, Chalmers J et al (2010) Severe hypoglycemia and risks of vascular events and death. N Engl J Med 363(15):1410\u20131418","journal-title":"N Engl J Med"},{"issue":"7","key":"3975_CR25","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1093\/eurheartj\/eht386","volume":"35","author":"K Damman","year":"2014","unstructured":"Damman K, Valente MA, Voors AA, O\u2019Connor CM, van Veldhuisen DJ, Hillege HL (2014) Renal impairment, worsening renal function, and outcome in patients with heart failure: an updated meta-analysis. Eur Heart J 35(7):455\u2013469","journal-title":"Eur Heart J"},{"issue":"2","key":"3975_CR26","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ahj.2009.11.022","volume":"159","author":"LA Allen","year":"2010","unstructured":"-Allen LA, Fonarow GC, Liang L et al (2010) Medication initiation burden required to comply with heart failure quality measures: results from the OPTIMIZE-HF registry. Am Heart J 159(2):238\u2013246","journal-title":"Am Heart J"},{"issue":"6","key":"3975_CR27","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1161\/CIRCHEARTFAILURE.112.967406","volume":"5","author":"RD Kociol","year":"2012","unstructured":"Kociol RD, Peterson ED, Hammill BG et al (2012) National survey of hospital strategies to reduce heart failure readmissions: findings from the Get With The Guidelines-Heart Failure registry. Circ Heart Fail 5(6):680\u2013687","journal-title":"Circ Heart Fail"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-025-03975-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00228-025-03975-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-025-03975-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T15:04:28Z","timestamp":1771859068000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00228-025-03975-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,19]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["3975"],"URL":"https:\/\/doi.org\/10.1007\/s00228-025-03975-8","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,19]]},"assertion":[{"value":"28 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Cerrahpa\u015fa Medical Faculty Clinical Research Ethics Committee approved the study protocol with the decision dated 02\/08\/2019 and numbered 30330229-604.01.02-118994.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics committee approval"}},{"value":"All participants involved in this study provided informed consent before their inclusion. The consent process was conducted according to ethical standards, explaining the study\u2019s purpose, procedures, potential risks, and benefits. Participants were assured of confidentiality, voluntary participation, and the right to withdraw without consequences. This study was conducted in accordance with the principles of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Participants in this study were informed that the data collected may be used for publication purposes while ensuring anonymity and confidentiality. The consent for publication includes an understanding that no personally identifiable information will be disclosed.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Written informed consent was obtained from all participants who participated in this study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Clinical trial number"}},{"value":"The authors declare no competing interests.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"43"}}