{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T07:26:40Z","timestamp":1787038000242,"version":"build-2736575974"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00228-026-04159-8","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T23:24:27Z","timestamp":1785972267000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of oliceridine versus sufentanil in perioperative anesthesia and analgesia: a systematic review and meta-analysis with trial sequential analysis"],"prefix":"10.1007","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4082-1949","authenticated-orcid":false,"given":"Munder","family":"Lateiresh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0424-2037","authenticated-orcid":false,"given":"Ayham","family":"Qatza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9666-5623","authenticated-orcid":false,"given":"Engy","family":"Elkoury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7919-0682","authenticated-orcid":false,"given":"Tareq H. F.","family":"Elwafae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6406-4212","authenticated-orcid":false,"given":"Muhammed","family":"Elhadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"issue":"2","key":"4159_CR1","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1213\/01.ANE.0000068822.10113.9E","volume":"97","author":"JL Apfelbaum","year":"2003","unstructured":"Apfelbaum JL et al (2003) Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg 97(2):534\u2013540","journal-title":"Anesth Analg"},{"key":"4159_CR2","doi-asserted-by":"publisher","unstructured":"American Society of Anesthesiologists Task Force on Acute Pain Management (2012) Practice guidelines for acute pain management in the perioperative setting: an updated report by the American society of anesthesiologists task force on acute pain management. Anesth 116(2):248\u2013273. https:\/\/doi.org\/10.1097\/ALN.0b013e31823c1030","DOI":"10.1097\/ALN.0b013e31823c1030"},{"issue":"1","key":"4159_CR3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1177\/2049463712438493","volume":"6","author":"H Pathan","year":"2012","unstructured":"Pathan H, Williams J (2012) Basic opioid pharmacology: an update. Br J Pain 6(1):11\u201316","journal-title":"Br J Pain"},{"issue":"26","key":"4159_CR4","doi-asserted-by":"publisher","first-page":"e202200269","DOI":"10.1002\/anie.202200269","volume":"61","author":"H Wang","year":"2022","unstructured":"Wang H et al (2022) Structure-based evolution of g protein-biased \u00b5-opioid receptor agonists. Angew Chem Int Ed 61(26):e202200269","journal-title":"Angew Chem Int Ed"},{"key":"4159_CR5","doi-asserted-by":"publisher","first-page":"e19146","DOI":"10.7717\/peerj.19146","volume":"13","author":"M Fostier","year":"2025","unstructured":"Fostier M et al (2025) Propofol-based deep sedation for colonoscopy: does sufentanil, alfentanil or ketamine help? A propensity score weighted retrospective study. PeerJ 13:e19146","journal-title":"PeerJ"},{"key":"4159_CR6","doi-asserted-by":"publisher","first-page":"1412726","DOI":"10.3389\/fphar.2024.1412726","volume":"15","author":"D Huang","year":"2024","unstructured":"Huang D et al (2024) Global research on sufentanil use in anesthesiology from 2003 to 2023: a bibliometric analysis. Front Pharmacol 15:1412726","journal-title":"Front Pharmacol"},{"issue":"8","key":"4159_CR7","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1001\/jamasurg.2018.1039","volume":"153","author":"S Shafi","year":"2018","unstructured":"Shafi S et al (2018) Association of opioid-related adverse drug events with clinical and cost outcomes among surgical patients in a large integrated health care delivery system. JAMA Surg 153(8):757\u2013763","journal-title":"JAMA Surg"},{"issue":"3","key":"4159_CR8","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.ygyno.2022.06.020","volume":"166","author":"K Levytska","year":"2022","unstructured":"Levytska K et al (2022) Enhanced recovery after surgery (ERAS) protocol is associated with lower post-operative opioid use and a reduced office burden after minimally invasive surgery. Gynecol Oncol 166(3):471\u2013475","journal-title":"Gynecol Oncol"},{"issue":"8","key":"4159_CR9","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1007\/s00204-021-03068-2","volume":"95","author":"BA Baldo","year":"2021","unstructured":"Baldo BA (2021) Toxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity. Arch Toxicol 95(8):2627\u20132642","journal-title":"Arch Toxicol"},{"issue":"6","key":"4159_CR10","doi-asserted-by":"publisher","first-page":"e473","DOI":"10.1016\/j.bja.2020.09.021","volume":"125","author":"D Lambert","year":"2020","unstructured":"Lambert D, Calo G (2020) Approval of oliceridine (TRV130) for intravenous use in moderate to severe pain in adults. Br J Anaesth 125(6):e473\u2013e474","journal-title":"Br J Anaesth"},{"issue":"5","key":"4159_CR11","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1038\/s41386-022-01507-x","volume":"48","author":"E Ventriglia","year":"2023","unstructured":"Ventriglia E et al (2023) Essential role of P-glycoprotein in the mechanism of action of oliceridine. Neuropsychopharmacology 48(5):831\u2013842","journal-title":"Neuropsychopharmacology"},{"issue":"7","key":"4159_CR12","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1111\/papr.12801","volume":"19","author":"NK Singla","year":"2019","unstructured":"Singla NK et al (2019) APOLLO-2: a randomized, placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein\u2013biased ligand at the \u00b5-opioid receptor, for management of moderate to severe acute pain following abdominoplasty. Pain Pract 19(7):715\u2013731","journal-title":"Pain Pract"},{"key":"4159_CR13","doi-asserted-by":"publisher","first-page":"927","DOI":"10.2147\/JPR.S171013","volume":"12","author":"ER Viscusi","year":"2019","unstructured":"Viscusi ER et al (2019) APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the \u00b5-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy. J Pain Res 12:927\u2013943","journal-title":"J Pain Res"},{"key":"4159_CR14","doi-asserted-by":"publisher","first-page":"p7492865","DOI":"10.1155\/2020\/7492865","volume":"2020","author":"S Bergese","year":"2020","unstructured":"Bergese S et al (2020) Low incidence of postoperative respiratory depression with oliceridine compared to morphine: a retrospective chart analysis. Pain Res Manag 2020:p7492865","journal-title":"Pain Res Manag"},{"issue":"1","key":"4159_CR15","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s13643-021-01626-4","volume":"10","author":"MJ Page","year":"2021","unstructured":"Page MJ et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Syst Rev 10(1):89","journal-title":"Syst Rev"},{"key":"4159_CR16","doi-asserted-by":"publisher","first-page":"j4008","DOI":"10.1136\/bmj.j4008","volume":"358","author":"BJ Shea","year":"2017","unstructured":"Shea BJ et al (2017) AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ 358:j4008","journal-title":"BMJ"},{"key":"4159_CR17","volume-title":"Covidence systematic review software","author":"V Innovation","year":"2026","unstructured":"Innovation V (2026) Covidence systematic review software. Melbourne, Australia, Veritas Health Innovation"},{"key":"4159_CR18","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898","journal-title":"BMJ"},{"issue":"1","key":"4159_CR19","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1002\/jrsm.1411","volume":"12","author":"LA McGuinness","year":"2021","unstructured":"McGuinness LA, Higgins JPT (2021) Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments. Res Synth Methods 12(1):55\u201361","journal-title":"Res Synth Methods"},{"key":"4159_CR20","unstructured":"Prime E, University. M (2023) GRADEpro GDT: GRADEpro guideline development tool. In: McMaster University and Evidence Prime"},{"key":"4159_CR21","unstructured":"GRADEpro (2023) GDT: GRADEpro guideline development tool. In: McMaster University and Evidence Prime"},{"issue":"4","key":"4159_CR22","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1136\/ebmental-2019-300117","volume":"22","author":"S Balduzzi","year":"2019","unstructured":"Balduzzi S, R\u00fccker G, Schwarzer G (2019) How to perform a meta-analysis with R: a practical tutorial. Evid Based Ment Health 22(4):153\u2013160","journal-title":"Evid Based Ment Health"},{"key":"4159_CR23","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1471-2288-14-135","volume":"14","author":"X Wan","year":"2014","unstructured":"Wan X et al (2014) Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Med Res Methodol 14:135","journal-title":"BMC Med Res Methodol"},{"key":"4159_CR24","doi-asserted-by":"publisher","first-page":"582143","DOI":"10.2147\/DDDT.S582143","volume":"20","author":"J Duan","year":"2026","unstructured":"Duan J et al (2026) Comparison of postoperative analgesic efficacy of oliceridine and sufentanil in total laparoscopy hysterectomy, a clinical double-blind controlled trial. Drug Des Devel Ther 20:582143","journal-title":"Drug Des Devel Ther"},{"key":"4159_CR25","first-page":"1","volume":"20","author":"N Hu","year":"2026","unstructured":"Hu N, Zhang WC, Zhang QQ, Ding ZJ, Zhang X (2026) Oliceridine versus sufentanil for postoperative recovery and opioid-related adverse events in patients undergoing thoracoscopic lobectomy: a randomized double-blind controlled trial. Drug Des Devel Ther 20:1\u201312","journal-title":"Drug Des Devel Ther"},{"issue":"9","key":"4159_CR26","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1002\/sim.1761","volume":"23","author":"MJ Sweeting","year":"2004","unstructured":"Sweeting MJ, Sutton AJ, Lambert PC (2004) What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data. Stat Med 23(9):1351\u20131375","journal-title":"Stat Med"},{"issue":"4","key":"4159_CR27","doi-asserted-by":"publisher","first-page":"101014","DOI":"10.1016\/j.imr.2023.101014","volume":"12","author":"M Borenstein","year":"2023","unstructured":"Borenstein M (2023) How to understand and report heterogeneity in a meta-analysis: The difference between I-squared and prediction intervals. Integr Med Res 12(4):101014","journal-title":"Integr Med Res"},{"issue":"10","key":"4159_CR28","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.jclinepi.2007.11.010","volume":"61","author":"JL Peters","year":"2008","unstructured":"Peters JL et al (2008) Contour-enhanced meta-analysis funnel plots help distinguish publication bias from other causes of asymmetry. J Clin Epidemiol 61(10):991\u2013996","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"4159_CR29","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12874-017-0315-7","volume":"17","author":"J Wetterslev","year":"2017","unstructured":"Wetterslev J, Jakobsen JC, Gluud C (2017) Trial sequential analysis in systematic reviews with meta-analysis. BMC Med Res Methodol 17(1):39","journal-title":"BMC Med Res Methodol"},{"key":"4159_CR30","doi-asserted-by":"publisher","first-page":"9515","DOI":"10.2147\/DDDT.S547901","volume":"19","author":"L Chen","year":"2025","unstructured":"Chen L et al (2025) Effects of oliceridine versus sufentanil on hemodynamic stability in elderly hypertensive patients during laryngeal mask airway anesthesia: a randomized controlled trial. Drug Des Devel Ther 19:9515\u20139522","journal-title":"Drug Des Devel Ther"},{"key":"4159_CR31","doi-asserted-by":"publisher","unstructured":"Ke Z, He Y, Hu Q, Zheng D, Yao Z, Zhou WA (2026) Comparison of the effects of oliceridine and sufentanil on the quality of recovery after hysteroscopic surgery: a prospective double-blind randomized controlled trial. J Anesth 40(2):235\u2013244. https:\/\/doi.org\/10.1007\/s00540-025-03578-8","DOI":"10.1007\/s00540-025-03578-8"},{"key":"4159_CR32","doi-asserted-by":"publisher","first-page":"5111","DOI":"10.2147\/DDDT.S512529","volume":"19","author":"B Ma","year":"2025","unstructured":"Ma B et al (2025) A comparative evaluation of the safety and efficacy of oliceridine and sufentanil in gastrointestinal endoscopy: a single-center, randomized controlled trial. Drug Des Devel Ther 19:5111\u20135121","journal-title":"Drug Des Devel Ther"},{"key":"4159_CR33","doi-asserted-by":"publisher","first-page":"1576154","DOI":"10.3389\/fphar.2025.1576154","volume":"16","author":"Y Meng","year":"2025","unstructured":"Meng Y et al (2025) Comparison of oliceridine and sufentanil in patient - controlled intravenous analgesia for post - thoracoscopic nausea and vomiting: a prospective, double - blind, randomized controlled trial. Front Pharmacol 16:1576154","journal-title":"Front Pharmacol"},{"key":"4159_CR34","doi-asserted-by":"publisher","first-page":"10033","DOI":"10.2147\/DDDT.S553848","volume":"19","author":"Y Tian","year":"2025","unstructured":"Tian Y et al (2025) Effect of oliceridine combined with sufentanil on patient-controlled intravenous analgesia in elderly patients after laparoscopic radical resection of rectal cancer: a prospective randomized controlled study. Drug Des Devel Ther 19:10033\u201310043","journal-title":"Drug Des Devel Ther"},{"issue":"1","key":"4159_CR35","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12871-021-01307-8","volume":"21","author":"AK Khanna","year":"2021","unstructured":"Khanna AK et al (2021) Opioid-induced respiratory depression increases hospital costs and length of stay in patients recovering on the general care floor. BMC Anesthesiol 21(1):88","journal-title":"BMC Anesthesiol"},{"issue":"3","key":"4159_CR36","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1124\/jpet.112.201616","volume":"344","author":"SM DeWire","year":"2013","unstructured":"DeWire SM et al (2013) A G protein-biased ligand at the \u00b5-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. J Pharmacol Exp Ther 344(3):708\u2013717","journal-title":"J Pharmacol Exp Ther"},{"issue":"7619","key":"4159_CR37","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/nature19112","volume":"537","author":"A Manglik","year":"2016","unstructured":"Manglik A et al (2016) Structure-based discovery of opioid analgesics with reduced side effects. Nature 537(7619):185\u2013190","journal-title":"Nature"},{"key":"4159_CR38","doi-asserted-by":"publisher","unstructured":"Ju J, Li Z, Liu J, Peng X, Gao F (2025) Biased opioid receptor agonists: balancing analgesic efficacy and side-effect profiles. Int J Mol Sci 26(5):1862. https:\/\/doi.org\/10.3390\/ijms26051862","DOI":"10.3390\/ijms26051862"},{"issue":"3","key":"4159_CR39","doi-asserted-by":"publisher","first-page":"164","DOI":"10.4097\/kjae.2014.67.3.164","volume":"67","author":"YE Moon","year":"2014","unstructured":"Moon YE (2014) Postoperative nausea and vomiting. Korean J Anesthesiol 67(3):164\u2013170","journal-title":"Korean J Anesthesiol"},{"issue":"9","key":"4159_CR40","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1016\/j.cgh.2017.05.014","volume":"15","author":"M Camilleri","year":"2017","unstructured":"Camilleri M, Lembo A, Katzka DA (2017) Opioids in gastroenterology: treating adverse effects and creating therapeutic benefits. Clin Gastroenterol Hepatol 15(9):1338\u20131349","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"4159_CR41","doi-asserted-by":"publisher","first-page":"11470","DOI":"10.1038\/s41598-025-95978-9","volume":"15","author":"Y Liu","year":"2025","unstructured":"Liu Y, Zhu Y, Fu H (2025) Tolerability of different doses of oliceridine versus traditional opioids in acute pain management: a systematic review and meta-analysis. Sci Rep 15(1):11470","journal-title":"Sci Rep"},{"key":"4159_CR42","doi-asserted-by":"publisher","unstructured":"Dou X, Yang X, Liu Y, Liu J, Bi L, Zhao L, Hu F, Huang M, Zhang J, Zhou X, Jiang Y (2026) Risk factors for postoperative nausea and vomiting after general anesthesia: a systematic review and meta-analysis. Front Med (Lausanne) 13:1791765. https:\/\/doi.org\/10.3389\/fmed.2026.1791765","DOI":"10.3389\/fmed.2026.1791765"},{"issue":"3","key":"4159_CR43","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1007\/s00540-024-03327-3","volume":"38","author":"S Hirai","year":"2024","unstructured":"Hirai S, Ida M, Kawaguchi M (2024) Comparison of prophylaxis strategy for postoperative nausea and vomiting and its incidence before and after the implementation of 5-hydroxytryptamine 3 in surgical setting: a single-center, retrospective study. J Anesth 38(3):398\u2013404","journal-title":"J Anesth"},{"issue":"4","key":"4159_CR44","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.clnu.2010.01.004","volume":"29","author":"KK Varadhan","year":"2010","unstructured":"Varadhan KK et al (2010) The enhanced recovery after surgery (ERAS) pathway for patients undergoing major elective open colorectal surgery: a meta-analysis of randomized controlled trials. Clin Nutr 29(4):434\u2013440","journal-title":"Clin Nutr"},{"key":"4159_CR45","doi-asserted-by":"publisher","first-page":"110638","DOI":"10.1016\/j.jclinane.2021.110638","volume":"78","author":"M Campfort","year":"2022","unstructured":"Campfort M et al (2022) Early quality of recovery according to QoR-15 score is associated with one-month postoperative complications after elective surgery. J Clin Anesth 78:110638","journal-title":"J Clin Anesth"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-026-04159-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00228-026-04159-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-026-04159-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:55:42Z","timestamp":1787036142000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00228-026-04159-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["4159"],"URL":"https:\/\/doi.org\/10.1007\/s00228-026-04159-8","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"17 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable. This study is based entirely on data derived from published randomized controlled trials and did not involve human subjects or require institutional approval.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The author(s) declared no potential conflicts of interest with respect to the research, authorship, and\/or publication of this article.","order":3,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"During manuscript preparation, the authors used ChatGPT solely for sentence paraphrasing. We explicitly declare that artificial intelligence tools were not used to perform statistical analyses, generate study figures, or format reference lists. Following AI assistance, the authors reviewed and edited all content. The authors assume full responsibility for the publication's content.","order":4,"name":"Ethics","label":"Generative AI and AI-assisted technologies in the writing process","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"226"}}