{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:12:59Z","timestamp":1789456379901,"version":"build-2803163510"},"reference-count":2,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum RWTH Aachen"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We clarify that our analyses were exploratory and hypothesis-generating, with systematic stratification across CYP2D6 metaboliser groups rather than selection based on an interaction\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.2 threshold. A post-hoc Benjamini\u2013Hochberg sensitivity analysis provided supportive, but not confirmatory, evidence for the hypothesised stronger association between anticholinergic burden and cognitive function among individuals with reduced CYP2D6 activity. Given the limited subgroup sizes, ceiling effects, and generally high cognitive performance of the cohort, these findings should be considered hypothesis-generating.\n                  <\/jats:p>","DOI":"10.1007\/s00228-026-04183-8","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:55:32Z","timestamp":1789005332000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Response to \u201cComment on cognitive function in the context of pharmacogenetic CYP2D6 variability and anticholinergic burden in older adults \u2013 results from the ActiFE study\u201d"],"prefix":"10.1007","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3050-5232","authenticated-orcid":false,"given":"Linda","family":"Lorenz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5463-7777","authenticated-orcid":false,"given":"Judith","family":"Berres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8097-060X","authenticated-orcid":false,"given":"Michael D.","family":"Denkinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3563-2791","authenticated-orcid":false,"given":"Dietrich","family":"Rothenbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Braig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3665-7023","authenticated-orcid":false,"given":"Dhayana","family":"Dallmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6782-8078","authenticated-orcid":false,"given":"Katja S.","family":"Just","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"issue":"8","key":"4183_CR1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s00228-026-04155-y","volume":"82","author":"L Lorenz","year":"2026","unstructured":"Lorenz L, Berres J, Denkinger MD, Rothenbacher D, Braig S, Dallmeier D, Just KS (2026) Cognitive function in the context of pharmacogenetic CYP2D6 variability and anticholinergic burden in older adults - results from the ActiFE study. Eur J Clin Pharmacol 82(8):225. https:\/\/doi.org\/10.1007\/s00228-026-04155-y","journal-title":"Eur J Clin Pharmacol"},{"key":"4183_CR2","unstructured":"Gopaiah KV, Krishna CHG, Priya JS (2026) Comment on Cognitive function in the context of pharmacogenetic CYP2D6 variability and anticholinergic burden in older adults \u2013 results from the ActiFE study. Eur J Clin Pharmacol. ; in press."}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-026-04183-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00228-026-04183-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-026-04183-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:47:33Z","timestamp":1789454853000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00228-026-04183-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":2,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["4183"],"URL":"https:\/\/doi.org\/10.1007\/s00228-026-04183-8","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"3 September 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"247"}}