{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:15:16Z","timestamp":1791270916311,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1-3","license":[{"start":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T00:00:00Z","timestamp":1186617600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Membrane Biol"],"published-print":{"date-parts":[[2007,11,28]]},"DOI":"10.1007\/s00232-007-9055-7","type":"journal-article","created":{"date-parts":[[2007,8,8]],"date-time":"2007-08-08T14:21:19Z","timestamp":1186582879000},"page":"9-17","source":"Crossref","is-referenced-by-count":95,"title":["Some Oculodentodigital Dysplasia-Associated Cx43 Mutations Cause Increased Hemichannel Activity in Addition to Deficient Gap Junction Channels"],"prefix":"10.1007","volume":"219","author":[{"given":"Radoslaw","family":"Dobrowolski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Sommershof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Willecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,8,9]]},"reference":[{"key":"9055_CR1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1050-3862(99)00021-2","volume":"15","author":"J Attal","year":"1999","unstructured":"Attal J, Theron MC, Houdebine LM (1999) The optimal use of IRES (internal ribosome entry site) in expression vectors. Genet Anal 15:161\u2013165","journal-title":"Genet Anal"},{"key":"9055_CR2","doi-asserted-by":"crossref","first-page":"9689","DOI":"10.1074\/jbc.M311438200","volume":"279","author":"X Bao","year":"2004","unstructured":"Bao X, Chen Y, Reuss L, Altenberg GA (2004) Functional expression in Xenopus oocytes of gap-junctional hemichannels formed by a cysteine-less connexin 43. J Biol Chem 279:9689\u20139692","journal-title":"J Biol Chem"},{"key":"9055_CR3","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1073\/pnas.0603154104","volume":"104","author":"X Bao","year":"2007","unstructured":"Bao X, Lee SC, Reuss L, Altenberg GA (2007) Change in permeant size selectivity by phosphorylation of connexin 43 gap-junctional hemichannels by PKC. Proc Natl Acad Sci USA 104:4919\u20134924","journal-title":"Proc Natl Acad Sci USA"},{"key":"9055_CR4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1043-4682(10)80006-6","volume":"3","author":"MVL Bennett","year":"1992","unstructured":"Bennett MVL, Verselis VK (1992) Biophysics of gap junctions. Semin Cell Biol 3:29\u201347","journal-title":"Semin Cell Biol"},{"key":"9055_CR5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1096\/fj.00-0566fje","volume":"15","author":"S Bruzzone","year":"2001","unstructured":"Bruzzone S, Guida L, Zocchi E, Franco L, De Flora A (2001) Connexin 43 hemichannels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells. FASEB J 15:10\u201312","journal-title":"FASEB J"},{"key":"9055_CR6","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0006-3495(92)81803-9","volume":"62","author":"G Dahl","year":"1992","unstructured":"Dahl G, Werner R, Levine E, Rabadan-Diehl C (1992) Mutational analysis of gap junction formation. Biophys J 62:172\u2013180","journal-title":"Biophys J"},{"key":"9055_CR7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1091\/mbc.e06-03-0182","volume":"18","author":"E Vuyst De","year":"2007","unstructured":"De Vuyst E, Decrock E, De Bock M, Yamasaki H, Naus CC, Evans WH, Leybaert L (2007) Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor. Mol Biol Cell 18:34\u201346","journal-title":"Mol Biol Cell"},{"key":"9055_CR8","doi-asserted-by":"crossref","first-page":"36706","DOI":"10.1074\/jbc.M207016200","volume":"277","author":"HS Duffy","year":"2002","unstructured":"Duffy HS, Sorgen PL, Girvin ME, O\u2019Donnell P, Coombs W, Taffet SM, Delmar M, Spray DC (2002) pH-dependent intramolecular binding and structure involving Cx43 cytoplasmic domains. J Biol Chem 277:36706\u201336714","journal-title":"J Biol Chem"},{"key":"9055_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20060175","volume":"397","author":"WH Evans","year":"2006","unstructured":"Evans WH, De Vuyst E, Leybaert L (2006) The gap junction cellular internet: connexin hemichannels enter the signalling limelight. Biochem J 397:1\u201314","journal-title":"Biochem J"},{"key":"9055_CR10","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.molcel.2004.08.016","volume":"15","author":"SJ Fleishman","year":"2004","unstructured":"Fleishman SJ, Unger VM, Yeager M, Ben-Tal N (2004) A Calpha model for the transmembrane alpha helices of gap junction intercellular channels. Mol Cell 15:879\u2013888","journal-title":"Mol Cell"},{"key":"9055_CR11","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1083\/jcb.140.5.1187","volume":"140","author":"CI Foote","year":"1998","unstructured":"Foote CI, Zhou L, Zhu X, Nicholson BJ (1998) The pattern of disulfide linkages in the extracellular loop regions of connexin 32 suggests a model for the docking interface of gap junctions. J Cell Biol 140:1187\u20131197","journal-title":"J Cell Biol"},{"key":"9055_CR12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1152\/ajpcell.00626.2006","volume":"293","author":"DA Gerido","year":"2007","unstructured":"Gerido DA, Derosa AM, Richard G, White TW (2007) Aberrant hemichannel properties of Cx26 mutations causing skin disease and deafness. Am J Physiol Cell Physiol 293:337\u2013345","journal-title":"Am J Physiol Cell Physiol"},{"key":"9055_CR13","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1001\/archneur.60.4.605","volume":"60","author":"CO Hanemann","year":"2003","unstructured":"Hanemann CO, Bergmann C, Senderek J, Zerres K, Sperfeld AD (2003) Transient, recurrent, white matter lesions in X-linked Charcot-Marie-Tooth disease with novel connexin 32 mutation. Arch Neurol 60:605\u2013609","journal-title":"Arch Neurol"},{"key":"9055_CR14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s002329900362","volume":"162","author":"B Hertlein","year":"1998","unstructured":"Hertlein B, Butterweck A, Haubrich S, Willecke K, Traub O (1998) Phosphorylated carboxy terminal serine residues stabilize the mouse gap junction protein connexin45 against degradation. J Membr Biol 162:247\u2013257","journal-title":"J Membr Biol"},{"key":"9055_CR15","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1529\/biophysj.105.066373","volume":"90","author":"X Hu","year":"2006","unstructured":"Hu X, Ma M, Dahl G (2006) Conductance of connexin hemichannels segregates with the first transmembrane segment. Biophys J 90:140\u2013150","journal-title":"Biophys J"},{"key":"9055_CR16","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1242\/jcs.02770","volume":"119","author":"A Lai","year":"2006","unstructured":"Lai A, Le D-N, Paznekas WA, Gifford WD, Wang Jabs E, Charles AC (2006) Oculodentodigital dysplasia connexin43 mutations result in non-functional connexin hemichannels and gap junctions in C6 glioma cells. J Cell Sci 119: 532\u2013541","journal-title":"J Cell Sci"},{"key":"9055_CR17","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1083\/jcb.131.5.1193","volume":"131","author":"DW Laird","year":"1995","unstructured":"Laird DW, Castillo M, Kasprzak L (1995) Gap junction turnover, intracellular trafficking, and phosphorylation of connexin43 in brefeldin A-treated rat mammary tumor cells. J Cell Biol 131:1193\u20131203","journal-title":"J Cell Biol"},{"key":"9055_CR18","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1242\/jcs.03089","volume":"119","author":"PD Lampe","year":"2006","unstructured":"Lampe PD, Cooper CD, King TJ, Burt JM (2006) Analysis of connexin43 phosphorylated at S325, S328 and S330 in normoxic and ischemic heart. J Cell Sci 119:3435\u20133442","journal-title":"J Cell Sci"},{"key":"9055_CR19","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/ana.20459","volume":"57","author":"SG Lin Liang","year":"2005","unstructured":"Lin Liang SG, de Miguel M, Gomez-Hernandez JM, Glass JD, Scherer SS, Mintz M, Barrio LC, Fischbeck KH (2005) Severe neuropathy with leaky connexin32 hemichannels. Ann Neurol 57:749\u2013754","journal-title":"Ann Neurol"},{"key":"9055_CR20","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1242\/jcs.114.21.3845","volume":"114","author":"PE Martin","year":"2001","unstructured":"Martin PE, Blundell G, Ahmad S, Errington RJ, Evans WH (2001) Multiple pathways in the trafficking and assembly of connexin 26, 32 and 43 into gap junction intercellular communication channels. J Cell Sci 114:3845\u20133855","journal-title":"J Cell Sci"},{"key":"9055_CR21","first-page":"250","volume":"60","author":"SY Oh","year":"1993","unstructured":"Oh SY, Dupont E, Madhukar BV, Briand JP, Chang CC, Beyer E, Trosko JE (1993) Characterization of gap junctional communication-deficient mutants of a rat liver epithalial cell line. Eur J Cell Biol 60:250\u2013255","journal-title":"Eur J Cell Biol"},{"key":"9055_CR22","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1086\/346090","volume":"72","author":"WA Paznekas","year":"2003","unstructured":"Paznekas WA, Boyadjiev SA, Shapiro RE, et al. (2003) Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia. Am J Hum Genet 72:408\u2013418","journal-title":"Am J Hum Genet"},{"key":"9055_CR23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbamem.2005.01.014","volume":"1711","author":"JC Saez","year":"2005","unstructured":"Saez JC, Retamal MA, Basilio D, Bukauskas FF, Bennett MV (2005) Connexin-based gap junction hemichannels: gating mechanisms. Biochim Biophys Acta 1711:215\u2013224","journal-title":"Biochim Biophys Acta"},{"key":"9055_CR24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/cac.10.4-6.173.180","volume":"10","author":"G Soehl","year":"2003","unstructured":"Soehl G, Willecke K (2003) An update on connexin genes and their nomenclature in mouse and man. Cell Commun Adhes 10:173\u2013180","journal-title":"Cell Commun Adhes"},{"key":"9055_CR25","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/glia.20429","volume":"547","author":"DC Spray","year":"2006","unstructured":"Spray DC, Ye ZC, Ransom BR (2006) Functional connexin \u201chemichannels\u201d: a critical appraisal. Glia 547:758\u2013773","journal-title":"Glia"},{"key":"9055_CR26","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1097\/01.mlg.0000241944.77192.d2","volume":"116","author":"BC Stong","year":"2006","unstructured":"Stong BC, Chang Q, Ahmad S, Lin X (2006) A novel mechanism for connexin 26 mutation linked deafness: cell death caused by leaky gap junction hemichannels. Laryngoscope 116:2205\u20132210","journal-title":"Laryngoscope"},{"key":"9055_CR27","doi-asserted-by":"crossref","first-page":"10482","DOI":"10.1074\/jbc.M109902200","volume":"12","author":"CE Stout","year":"2002","unstructured":"Stout CE, Costantin JL, Naus CCG, Charles AC (2002) Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels. J Biol Chem 12:10482\u201310488","journal-title":"J Biol Chem"},{"key":"9055_CR28","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/ijc.2910510404","volume":"51","author":"KK Wilgenbus","year":"1992","unstructured":"Wilgenbus KK, Kirkpatrick CJ, Knuechel R, Willecke K, Traub O (1992) Expression of Cx26, Cx32 and Cx43 gap junction proteins in normal and neoplastic human tissues. Int J Cancer 51:522\u2013529","journal-title":"Int J Cancer"},{"key":"9055_CR29","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1046\/j.1365-2133.2003.05245.x","volume":"148","author":"S Yotsumoto","year":"2003","unstructured":"Yotsumoto S, Hashiguchi T, Chen X, Ohtake N, Tomitaka A, Akamatsu H, Matsunaga K, Shiraishi S, Miura H, Adachi J, Kanzaki T (2003) Novel mutations in GJB2 encoding connexin-26 in Japanese patients with keratitis-ichthyosis-deafness syndrome. Br J Dermatol 148:649\u2013653","journal-title":"Br J Dermatol"}],"container-title":["Journal of Membrane Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00232-007-9055-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00232-007-9055-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00232-007-9055-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T11:08:28Z","timestamp":1629544108000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00232-007-9055-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,9]]},"references-count":29,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2007,11,28]]}},"alternative-id":["9055"],"URL":"https:\/\/doi.org\/10.1007\/s00232-007-9055-7","relation":{},"ISSN":["0022-2631","1432-1424"],"issn-type":[{"value":"0022-2631","type":"print"},{"value":"1432-1424","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,9]]}}}