{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:47:42Z","timestamp":1774464462106,"version":"3.50.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,12,3]],"date-time":"2010-12-03T00:00:00Z","timestamp":1291334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Membrane Biol"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1007\/s00232-010-9331-9","type":"journal-article","created":{"date-parts":[[2010,12,2]],"date-time":"2010-12-02T04:17:51Z","timestamp":1291263471000},"page":"123-130","source":"Crossref","is-referenced-by-count":11,"title":["UT-B1 Mediates Transepithelial Urea Flux in the Rat Gastrointestinal Tract"],"prefix":"10.1007","volume":"239","author":[{"given":"Danielle","family":"Collins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caragh","family":"Walpole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desmond","family":"Winter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Baird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,12,3]]},"reference":[{"key":"9331_CR1","doi-asserted-by":"crossref","first-page":"G190","DOI":"10.1152\/ajpgi.00216.2009","volume":"298","author":"K Abdoun","year":"2010","unstructured":"Abdoun K, Stumpff F, Rabbani I, Martens H (2010) Modulation of urea transport across sheep rumen epithelium in vitro by SCFA and CO2. Am J Physiol Gastrointest Liver Physiol 298:G190\u2013G202","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"9331_CR2","doi-asserted-by":"crossref","first-page":"G345","DOI":"10.1152\/ajpgi.00405.2009","volume":"298","author":"D Collins","year":"2010","unstructured":"Collins D, Winter DC, Hogan AM, Schirmer L, Baird AW, Stewart GS (2010) Differential protein abundance and function of UT-B urea transporters in human colon. Am J Physiol Gastrointest Liver Physiol 298:G345\u2013G351","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"9331_CR3","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1007\/s004240000440","volume":"441","author":"BM Fihn","year":"2001","unstructured":"Fihn BM, Jodal M (2001) Permeability of the proximal and distal rat colon crypt and surface epithelium to hydrophilic molecules. Pflugers Arch 441:656\u2013662","journal-title":"Pflugers Arch"},{"key":"9331_CR4","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1211\/0022357021778583","volume":"54","author":"AM Hopkins","year":"2002","unstructured":"Hopkins AM, McDonnell C, Breslin NP, O\u2019Morain CA, Baird AW (2002) Omeprazole increases permeability across isolated rat gastric mucosa pre-treated with an acid secretagogue. J Pharm Pharmacol 54:341\u2013347","journal-title":"J Pharm Pharmacol"},{"key":"9331_CR5","doi-asserted-by":"crossref","first-page":"C30","DOI":"10.1152\/ajpcell.00443.2003","volume":"287","author":"H Inoue","year":"2004","unstructured":"Inoue H, Jackson SD, Vikulina T, Klein JD, Tomita K, Bagnasco SM (2004) Identification and characterization of a Kidd antigen\/UT-B urea transporter expressed in human colon. Am J Physiol Cell Physiol 287:C30\u2013C35","journal-title":"Am J Physiol Cell Physiol"},{"key":"9331_CR6","doi-asserted-by":"crossref","first-page":"F451","DOI":"10.1152\/ajprenal.00376.2004","volume":"289","author":"H Inoue","year":"2005","unstructured":"Inoue H, Kozlowski SD, Klein JD, Bailey JL, Sands JM, Bagnasco SM (2005) Regulated expression of renal and intestinal UT-B urea transporter in response to varying urea load. Am J Physiol Renal Physiol 289:F451\u2013F458","journal-title":"Am J Physiol Renal Physiol"},{"key":"9331_CR7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2220\/biomedres.27.243","volume":"27","author":"T Iwanga","year":"2006","unstructured":"Iwanga T, Takebe K, Kato I, Karaki S, Kuwahara A (2006) Cellular expression of monocarboxylate transporters in the digestive tract of mouse, rats and humans, with special reference to slc5a8. Biomed Res 27:243\u2013254","journal-title":"Biomed Res"},{"key":"9331_CR8","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1113\/expphysiol.2009.046797","volume":"94","author":"D Kirat","year":"2009","unstructured":"Kirat D, Kondo K, Shimada R, Kato S (2009) Dietary pectin up-regulates monocarboxylate transporter 1 in the rat gastrointestinal tract. Exp Physiol 94:422\u2013433","journal-title":"Exp Physiol"},{"key":"9331_CR9","doi-asserted-by":"crossref","first-page":"R1046","DOI":"10.1152\/ajpregu.00286.2004","volume":"288","author":"N Lucien","year":"2005","unstructured":"Lucien N, Bruneval P, Lasbennes F, Belair MF, Mandet C, Cartron JP, Bailly P, Trinh-Trang-Tan MM (2005) UT-B1 urea transporter is expressed along the urinary and gastrointestinal tracts of the mouse. Am J Physiol Regul Integr Comp Physiol 288:R1046\u2013R1056","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"9331_CR10","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.2527\/jas.2008-1399","volume":"87","author":"PA Ludden","year":"2009","unstructured":"Ludden PA, Stohrer RM, Austin KJ, Atkinson RL, Belden EL, Harlow HJ (2009) Effect of protein supplementation on expression and distribution of urea transporter B in lambs fed low-quality forage. J Anim Sci 87:1354\u20131365","journal-title":"J Anim Sci"},{"key":"9331_CR11","doi-asserted-by":"crossref","first-page":"F956","DOI":"10.1152\/ajprenal.00229.2007","volume":"294","author":"B MacIver","year":"2008","unstructured":"MacIver B, Smith CP, Hill WG, Zeidel ML (2008) Functional characterization of mouse urea transporters UT-A2 and UT-A3 expressed in purified Xenopus laevis oocyte plasma membranes. Am J Physiol Renal Physiol 294:F956\u2013F964","journal-title":"Am J Physiol Renal Physiol"},{"key":"9331_CR12","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1136\/gut.48.4.571","volume":"48","author":"SG Nugent","year":"2001","unstructured":"Nugent SG, Kumar D, Rampton DS, Evans DF (2001) Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs. Gut 48:571\u2013577","journal-title":"Gut"},{"key":"9331_CR13","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.2527\/jas.2008-1710","volume":"87","author":"NL Simmons","year":"2009","unstructured":"Simmons NL, Chaudhry AS, Graham C, Scriven ES, Thistlethwaite A, Smith CP, Stewart GS (2009) Dietary regulation of ruminal bovine UT-B urea transporter expression and localization. J Anim Sci 87:3288\u20133299","journal-title":"J Anim Sci"},{"key":"9331_CR14","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1113\/expphysiol.2008.043042","volume":"94","author":"CP Smith","year":"2008","unstructured":"Smith CP (2008) Mammalian urea transporters. Exp Physiol 94:180\u2013185","journal-title":"Exp Physiol"},{"key":"9331_CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00232-001-0048-7","volume":"183","author":"CP Smith","year":"2001","unstructured":"Smith CP, Rousselet G (2001) Urea transporters. J Membr Biol 183:1\u201314","journal-title":"J Membr Biol"},{"key":"9331_CR16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1079\/NRR200498","volume":"18","author":"GS Stewart","year":"2005","unstructured":"Stewart GS, Smith CP (2005) Urea nitrogen salvage mechanisms and their relevance to ruminants, non-ruminants and man. Nutr Res Rev 18:49\u201362","journal-title":"Nutr Res Rev"},{"key":"9331_CR17","doi-asserted-by":"crossref","first-page":"F979","DOI":"10.1152\/ajprenal.00334.2003","volume":"286","author":"GS Stewart","year":"2004","unstructured":"Stewart GS, Fenton RA, Wang W, Kwon TH, White SJ, Collins VM, Cooper GJ, Nielsen S, Smith CP (2004) The basolateral expression of mUT-A3 in the mouse kidney. Am J Physiol Renal Physiol 286:F979\u2013F987","journal-title":"Am J Physiol Renal Physiol"},{"key":"9331_CR18","doi-asserted-by":"crossref","first-page":"R605","DOI":"10.1152\/ajpregu.00127.2005","volume":"289","author":"GS Stewart","year":"2005","unstructured":"Stewart GS, Graham C, Cattell S, Smith TPL, Simmons NL, Smith CP (2005) UT-B is expressed in bovine rumen: a potential role in ruminal urea transport. Am J Physiol Regul Integr Comp Physiol 289:R605\u2013R612","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"9331_CR19","doi-asserted-by":"crossref","first-page":"F642","DOI":"10.1152\/ajprenal.90660.2008","volume":"296","author":"GS Stewart","year":"2009","unstructured":"Stewart GS, Thistlethwaite A, Lees H, Cooper GJ, Smith CP (2009) Vasopressin regulation of the renal UT-A3 urea transporter. Am J Physiol Renal Physiol 296:F642\u2013F648","journal-title":"Am J Physiol Renal Physiol"},{"key":"9331_CR20","doi-asserted-by":"crossref","first-page":"G358","DOI":"10.1152\/ajpgi.00151.2010","volume":"299","author":"C Talbot","year":"2010","unstructured":"Talbot C, Lytle C (2010) Segregation of Na\/H exchanger-3 and Cl\/HCO3 exchanger SLC26A3 (DRA) in rodent cecum and colon. Am J Physiol Gastrointest Liver Physiol 299:G358\u2013G367","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"9331_CR21","doi-asserted-by":"crossref","first-page":"R323","DOI":"10.1152\/ajpregu.00199.2009","volume":"297","author":"P Tickle","year":"2009","unstructured":"Tickle P, Thistlethwaite A, Smith CP, Stewart GS (2009) Novel bUT-B2 urea transporter isoform is constitutively activated. Am J Physiol Regul Integr Comp Physiol 297:R323\u2013R329","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"9331_CR22","doi-asserted-by":"crossref","first-page":"C1318","DOI":"10.1152\/ajpcell.2001.281.4.C1318","volume":"281","author":"RT Timmer","year":"2001","unstructured":"Timmer RT, Klein JD, Bagnasco SM, Doran JJ, Verlander JW, Gunn RB, Sands JM (2001) Localization of the urea transporter UT-B protein in human and rat erythrocytes and tissues. Am J Physiol Cell Physiol 281:C1318\u2013C1325","journal-title":"Am J Physiol Cell Physiol"},{"key":"9331_CR23","doi-asserted-by":"crossref","first-page":"F912","DOI":"10.1152\/ajprenal.00359.2001","volume":"283","author":"MM Trinh-Trang-Tan","year":"2002","unstructured":"Trinh-Trang-Tan MM, Lasbennes F, Gane P, Roudier N, Ripoche R, Cartron JP, Bailly P (2002) UT-B1 proteins in rat: tissue distribution and regulation by antidiuretic hormone in kidney. Am J Physiol Renal Physiol 283:F912\u2013F922","journal-title":"Am J Physiol Renal Physiol"},{"key":"9331_CR24","doi-asserted-by":"crossref","first-page":"F881","DOI":"10.1152\/ajprenal.00367.2004","volume":"288","author":"B Yang","year":"2005","unstructured":"Yang B, Bankir L (2005) Urea and urine concentrating ability: new insights from studies in mice. Am J Physiol Renal Physiol 288:F881\u2013F896","journal-title":"Am J Physiol Renal Physiol"},{"key":"9331_CR25","doi-asserted-by":"crossref","first-page":"36782","DOI":"10.1074\/jbc.M206948200","volume":"277","author":"B Yang","year":"2002","unstructured":"Yang B, Verkman AS (2002) Analysis of double knockout mice lacking aquaporin 1 and urea transporter UT-B. Evidence for UT-B facilitated water transport in erythrocytes. J Biol Chem 277:36782\u201336786","journal-title":"J Biol Chem"},{"key":"9331_CR26","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.bbamem.2007.04.010","volume":"1768","author":"D Zhao","year":"2007","unstructured":"Zhao D, Sonawane ND, Levin MH, Yang B (2007) Comparative transport efficiencies of urea analogues through urea transporter UT-B. Biochim Biophys Acta 1768:1815\u20131821","journal-title":"Biochim Biophys Acta"}],"container-title":["The Journal of Membrane Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00232-010-9331-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00232-010-9331-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00232-010-9331-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T14:54:12Z","timestamp":1559832852000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00232-010-9331-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,3]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["9331"],"URL":"https:\/\/doi.org\/10.1007\/s00232-010-9331-9","relation":{},"ISSN":["0022-2631","1432-1424"],"issn-type":[{"value":"0022-2631","type":"print"},{"value":"1432-1424","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,3]]}}}