{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:28:47Z","timestamp":1759541327638},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T00:00:00Z","timestamp":1354060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Membrane Biol"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1007\/s00232-012-9520-9","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T12:46:22Z","timestamp":1354193182000},"page":"189-197","source":"Crossref","is-referenced-by-count":18,"title":["Up-Regulation of the Inwardly Rectifying K+ Channel Kir2.1 (KCNJ2) by Protein Kinase B (PKB\/Akt) and PIKfyve"],"prefix":"10.1007","volume":"246","author":[{"given":"Carlos","family":"Munoz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Almilaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwan","family":"Setiawan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"F\u00f6ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,11,28]]},"reference":[{"key":"9520_CR1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000276569","volume":"25","author":"IS Alesutan","year":"2010","unstructured":"Alesutan IS, Ureche ON, Laufer J, Klaus F, Z\u00fcrn A, Lindner R, Strutz-Seebohm N, Tavar\u00e9 JM, Boehmer C, Palmada M, Lang UE, Seebohm G, Lang F (2010) Regulation of the glutamate transporter EAAT4 by PIKfyve. Cell Physiol Biochem 25:187\u2013194","journal-title":"Cell Physiol Biochem"},{"key":"9520_CR2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1651-2227.1971.tb06990.x","volume":"60","author":"ED Andersen","year":"1971","unstructured":"Andersen ED, Krasilnikoff PA, Overvad H (1971) Intermittent muscular weakness, extrasystoles, and multiple developmental anomalies. A new syndrome? Acta Paediatr Scand 60:559\u2013564","journal-title":"Acta Paediatr Scand"},{"key":"9520_CR3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000099197","volume":"19","author":"S Becker","year":"2007","unstructured":"Becker S, Reinehr R, Graf D, vom Dahl S, H\u00e4ussinger D (2007) Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation. Cell Physiol Biochem 19:89\u201398","journal-title":"Cell Physiol Biochem"},{"key":"9520_CR4","doi-asserted-by":"crossref","first-page":"5985","DOI":"10.1242\/jcs.01517","volume":"117","author":"DC Berwick","year":"2004","unstructured":"Berwick DC, Dell GC, Welsh GI, Heesom KJ, Hers I, Fletcher LM, Cooke FT, Tavar\u00e9 JM (2004) Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles. J Cell Sci 117:5985\u20135993","journal-title":"J Cell Sci"},{"key":"9520_CR5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/ki.2011.67","volume":"80","author":"M Bhandaru","year":"2011","unstructured":"Bhandaru M, Kempe DS, Rotte A, Capuano P, Pathare G, Sopjani M, Alesutan I, Tyan L, Huang DY, Siraskar B, Judenhofer MS, Stange G, Pichler BJ, Biber J, Quintanilla-Martinez L, Wagner CA, Pearce D, F\u00f6ller M, Lang F (2011) Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3. Kidney Int 80:61\u201367","journal-title":"Kidney Int"},{"key":"9520_CR6","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.bbrc.2005.02.035","volume":"329","author":"C Boehmer","year":"2005","unstructured":"Boehmer C, Rajamanickam J, Schniepp R, Kohler K, Wulff P, Kuhl D, Palmada M, Lang F (2005) Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3. Biochem Biophys Res Commun 329:738\u2013742","journal-title":"Biochem Biophys Res Commun"},{"key":"9520_CR7","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1471-4159.2006.03629.x","volume":"97","author":"C Boehmer","year":"2006","unstructured":"Boehmer C, Palmada M, Rajamanickam J, Schniepp R, Amara S, Lang F (2006) Post-translational regulation of EAAT2 function by co-expressed ubiquitin ligase Nedd4-2 is impacted by SGK kinases. J Neurochem 97:911\u2013921","journal-title":"J Neurochem"},{"key":"9520_CR8","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1159\/000315092","volume":"25","author":"C B\u00f6hmer","year":"2010","unstructured":"B\u00f6hmer C, Sopjani M, Klaus F, Lindner R, Laufer J, Jeyaraj S, Lang F, Palmada M (2010) The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19. Cell Physiol Biochem 25:723\u2013732","journal-title":"Cell Physiol Biochem"},{"key":"9520_CR9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1098\/rstb.1981.0056","volume":"293","author":"A Boiteux","year":"1981","unstructured":"Boiteux A, Hess B (1981) Design of glycolysis. Philos Trans R Soc Lond B Biol Sci 293:5\u201322","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"9520_CR10","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00424-004-1266-5","volume":"448","author":"CD Bortner","year":"2004","unstructured":"Bortner CD, Cidlowski JA (2004) The role of apoptotic volume decrease and ionic homeostasis in the activation and repression of apoptosis. Pflugers Arch 448:313\u2013318","journal-title":"Pflugers Arch"},{"key":"9520_CR11","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1073\/pnas.75.3.1242","volume":"75","author":"R Bravo","year":"1978","unstructured":"Bravo R, Otero C, Allende CC, Allende JE (1978) Amphibian oocyte maturation and protein synthesis: related inhibition by cyclic AMP, theophylline, and papaverine. Proc Natl Acad Sci USA 75:1242\u20131246","journal-title":"Proc Natl Acad Sci USA"},{"key":"9520_CR12","doi-asserted-by":"crossref","first-page":"35815","DOI":"10.1074\/jbc.M206032200","volume":"277","author":"A Collins","year":"2002","unstructured":"Collins A, Larson M (2002) Differential sensitivity of inward rectifier K+ channels to metabolic inhibitors. J Biol Chem 277:35815\u201335818","journal-title":"J Biol Chem"},{"key":"9520_CR13","doi-asserted-by":"crossref","first-page":"20499","DOI":"10.1074\/jbc.M101425200","volume":"276","author":"C Dart","year":"2001","unstructured":"Dart C, Leyland ML (2001) Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1. J Biol Chem 276:20499\u201320505","journal-title":"J Biol Chem"},{"key":"9520_CR14","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1600-0854.2009.00915.x","volume":"10","author":"J Lartigue de","year":"2009","unstructured":"de Lartigue J, Polson H, Feldman M, Shokat K, Tooze SA, Urb\u00e9 S, Clague MJ (2009) PIKfyve regulation of endosome-linked pathways. Traffic 10:883\u2013893","journal-title":"Traffic"},{"key":"9520_CR15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000331737","volume":"28","author":"M D\u00ebrmaku-Sopjani","year":"2011","unstructured":"D\u00ebrmaku-Sopjani M, Sopjani M, Saxena A, Shojaiefard M, Bogatikov E, Alesutan I, Eichenm\u00fcller M, Lang F (2011) Downregulation of NaPi-IIa and NaPi-IIb Na-coupled phosphate transporters by coexpression of Klotho. Cell Physiol Biochem 28:251\u2013258","journal-title":"Cell Physiol Biochem"},{"key":"9520_CR16","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1161\/01.RES.0000137727.34938.35","volume":"95","author":"RJ Diaz","year":"2004","unstructured":"Diaz RJ, Zobel C, Cho HC, Batthish M, Hinek A, Backx PH, Wilson GJ (2004) Selective inhibition of inward rectifier K+ channels (Kir2.1 or Kir2.2) abolishes protection by ischemic preconditioning in rabbit ventricular cardiomyocytes. Circ Res 95:325\u2013332","journal-title":"Circ Res"},{"key":"9520_CR17","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/oby.2004.104","volume":"12","author":"M Dieter","year":"2004","unstructured":"Dieter M, Palmada M, Rajamanickam J, Aydin A, Busjahn A, Boehmer C, Luft FC, Lang F (2004) Regulation of glucose transporter SGLT1 by ubiquitin ligase Nedd4-2 and kinases SGK1, SGK3, and PKB. Obes Res 12:862\u2013870","journal-title":"Obes Res"},{"key":"9520_CR18","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1212\/01.WNL.0000072261.14060.47","volume":"60","author":"MR Donaldson","year":"2003","unstructured":"Donaldson MR, Jensen JL, Tristani-Firouzi M, Tawil R, Bendahhou S, Suarez WA, Cobo AM, Poza JJ, Behr E, Wagstaff J, Szepetowski P, Pereira S, Mozaffar T, Escolar DM, Fu YH, Pt\u00e1cek LJ (2003) PIP2 binding residues of Kir2.1 are common targets of mutations causing Andersen syndrome. Neurology 60:1811\u20131816","journal-title":"Neurology"},{"key":"9520_CR19","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1159\/000322318","volume":"26","author":"K Eckey","year":"2010","unstructured":"Eckey K, Strutz-Seebohm N, Katz G, Fuhrmann G, Henrion U, Pott L, Linke WA, Arad M, Lang F, Seebohm G (2010) Modulation of human ether a gogo related channels by CASQ2 contributes to etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT). Cell Physiol Biochem 26:503\u2013512","journal-title":"Cell Physiol Biochem"},{"key":"9520_CR20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000094125","volume":"17","author":"M F\u00f6ller","year":"2006","unstructured":"F\u00f6ller M, Kasinathan RS, Duranton C, Wieder T, Huber SM, Lang F (2006) PGE2-induced apoptotic cell death in K562 human leukaemia cells. Cell Physiol Biochem 17:201\u2013210","journal-title":"Cell Physiol Biochem"},{"key":"9520_CR21","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.bbrc.2009.10.084","volume":"390","author":"EM Gehring","year":"2009","unstructured":"Gehring EM, Lam RS, Siraskar G, Koutsouki E, Seebohm G, Ureche ON, Ureche L, Baltaev R, Tavare JM, Lang F (2009a) PIKfyve upregulates CFTR activity. Biochem Biophys Res Commun 390:952\u2013957","journal-title":"Biochem Biophys Res Commun"},{"key":"9520_CR22","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000257428","volume":"24","author":"EM Gehring","year":"2009","unstructured":"Gehring EM, Zurn A, Klaus F, Laufer J, Sopjani M, Lindner R, Strutz-Seebohm N, Tavar\u00e9 JM, Boehmer C, Palmada M, Lang UE, Seebohm G, Lang F (2009b) Regulation of the glutamate transporter EAAT2 by PIKfyve. Cell Physiol Biochem 24:361\u2013368","journal-title":"Cell Physiol Biochem"},{"issue":"pt 3","key":"9520_CR23","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1113\/jphysiol.1996.sp021625","volume":"495","author":"P Henry","year":"1996","unstructured":"Henry P, Pearson WL, Nichols CG (1996) Protein kinase C inhibition of cloned inward rectifier (HRK1\/KIR2.3) K+ channels expressed in Xenopus oocytes. J Physiol 495(pt 3):681\u2013688","journal-title":"J Physiol"},{"key":"9520_CR24","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1152\/physrev.00021.2009","volume":"90","author":"H Hibino","year":"2010","unstructured":"Hibino H, Inanobe A, Furutani K, Murakami S, Findlay I, Kurachi Y (2010) Inwardly rectifying potassium channels: their structure, function, and physiological roles. Physiol Rev 90:291\u2013366","journal-title":"Physiol Rev"},{"key":"9520_CR25","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.bbrc.2010.05.134","volume":"397","author":"EV Hill","year":"2010","unstructured":"Hill EV, Hudson CA, Vertommen D, Rider MH, Tavar\u00e9 JM (2010) Regulation of PIKfyve phosphorylation by insulin and osmotic stress. Biochem Biophys Res Commun 397:650\u2013655","journal-title":"Biochem Biophys Res Commun"},{"key":"9520_CR26","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1159\/000335763","volume":"28","author":"Z Hosseinzadeh","year":"2011","unstructured":"Hosseinzadeh Z, Bhavsar SK, Sopjani M, Alesutan I, Saxena A, D\u00ebrmaku-Sopjani M, Lang F (2011) Regulation of the glutamate transporters by JAK2. Cell Physiol Biochem 28:693\u2013702","journal-title":"Cell Physiol Biochem"},{"key":"9520_CR27","doi-asserted-by":"crossref","first-page":"26141","DOI":"10.1074\/jbc.M101722200","volume":"276","author":"OC Ikonomov","year":"2001","unstructured":"Ikonomov OC, Sbrissa D, Shisheva A (2001) Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve. J Biol Chem 276:26141\u201326147","journal-title":"J Biol Chem"},{"key":"9520_CR28","doi-asserted-by":"crossref","first-page":"9206","DOI":"10.1074\/jbc.M108750200","volume":"277","author":"OC Ikonomov","year":"2002","unstructured":"Ikonomov OC, Sbrissa D, Mlak K, Kanzaki M, Pessin J, Shisheva A (2002) Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5\u2013P2 production for endomembrane integrity. J Biol Chem 277:9206\u20139211","journal-title":"J Biol Chem"},{"key":"9520_CR29","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1091\/mbc.E03-04-0222","volume":"14","author":"OC Ikonomov","year":"2003","unstructured":"Ikonomov OC, Sbrissa D, Foti M, Carpentier JL, Shisheva A (2003) PIKfyve controls fluid phase endocytosis but not recycling\/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis. Mol Biol Cell 14:4581\u20134591","journal-title":"Mol Biol Cell"},{"key":"9520_CR30","doi-asserted-by":"crossref","first-page":"C393","DOI":"10.1152\/ajpcell.00019.2006","volume":"291","author":"OC Ikonomov","year":"2006","unstructured":"Ikonomov OC, Sbrissa D, Shisheva A (2006) Localized PtdIns 3,5\u2013P2 synthesis to regulate early endosome dynamics and fusion. Am J Physiol Cell Physiol 291:C393\u2013C404","journal-title":"Am J Physiol Cell Physiol"},{"key":"9520_CR31","doi-asserted-by":"crossref","first-page":"35794","DOI":"10.1074\/jbc.M109.037515","volume":"284","author":"OC Ikonomov","year":"2009","unstructured":"Ikonomov OC, Sbrissa D, Fenner H, Shisheva A (2009) PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis. J Biol Chem 284:35794\u201335806","journal-title":"J Biol Chem"},{"key":"9520_CR32","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1124\/mol.64.4.987","volume":"64","author":"SV Jones","year":"2003","unstructured":"Jones SV (2003) Role of the small GTPase Rho in modulation of the inwardly rectifying potassium channel Kir2.1. Mol Pharmacol 64:987\u2013993","journal-title":"Mol Pharmacol"},{"key":"9520_CR33","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/cm.21051","volume":"69","author":"KC Kirkbride","year":"2012","unstructured":"Kirkbride KC, Hong NH, French CL, Clark ES, Jerome WG, Weaver AM (2012) Regulation of late endosomal\/lysosomal maturation and trafficking by cortactin affects Golgi morphology. Cytoskeleton (Hoboken) 69:625\u2013643","journal-title":"Cytoskeleton (Hoboken)"},{"key":"9520_CR34","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1113\/jphysiol.2007.146191","volume":"586","author":"F Klaus","year":"2008","unstructured":"Klaus F, Palmada M, Lindner R, Laufer J, Jeyaraj S, Lang F, Boehmer C (2008) Up-regulation of hypertonicity-activated myo-inositol transporter SMIT1 by the cell volume-sensitive protein kinase SGK1. J Physiol 586:1539\u20131547","journal-title":"J Physiol"},{"key":"9520_CR35","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.bbrc.2009.02.053","volume":"381","author":"F Klaus","year":"2009","unstructured":"Klaus F, Laufer J, Czarkowski K, Strutz-Seebohm N, Seebohm G, Lang F (2009) PIKfyve-dependent regulation of the Cl\u2212 channel ClC-2. Biochem Biophys Res Commun 381:407\u2013411","journal-title":"Biochem Biophys Res Commun"},{"key":"9520_CR36","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1083\/jcb.116.5.1071","volume":"116","author":"RD Klausner","year":"1992","unstructured":"Klausner RD, Donaldson JG, Lippincott-Schwartz J (1992) Brefeldin A: insights into the control of membrane traffic and organelle structure. J Cell Biol 116:1071\u20131080","journal-title":"J Cell Biol"},{"key":"9520_CR37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1992.72.1.1","volume":"72","author":"F Lang","year":"1992","unstructured":"Lang F, Rehwald W (1992) Potassium channels in renal epithelial transport regulation. Physiol Rev 72:1\u201332","journal-title":"Physiol Rev"},{"key":"9520_CR38","doi-asserted-by":"crossref","first-page":"F953","DOI":"10.1152\/ajpcell.1986.250.1.C138","volume":"250","author":"F Lang","year":"1986","unstructured":"Lang F, Messner G, Rehwald W (1986) Electrophysiology of sodium-coupled transport in proximal renal tubules. Am J Physiol 250:F953\u2013F962","journal-title":"Am J Physiol"},{"key":"9520_CR39","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1152\/physrev.1998.78.1.247","volume":"78","author":"F Lang","year":"1998","unstructured":"Lang F, Busch GL, Ritter M, V\u00f6lkl H, Waldegger S, Gulbins E, H\u00e4ussinger D (1998) Functional significance of cell volume regulatory mechanisms. Physiol Rev 78:247\u2013306","journal-title":"Physiol Rev"},{"key":"9520_CR40","doi-asserted-by":"crossref","first-page":"19051","DOI":"10.1074\/jbc.M400284200","volume":"279","author":"D Leonoudakis","year":"2004","unstructured":"Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004) A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. J Biol Chem 279:19051\u201319063","journal-title":"J Biol Chem"},{"key":"9520_CR41","doi-asserted-by":"crossref","first-page":"43427","DOI":"10.1074\/jbc.M407575200","volume":"279","author":"ML Leyland","year":"2004","unstructured":"Leyland ML, Dart C (2004) An alternatively spliced isoform of PSD-93\/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1. J Biol Chem 279:43427\u201343436","journal-title":"J Biol Chem"},{"key":"9520_CR42","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1469-7793.2001.0115g.x","volume":"532","author":"GX Liu","year":"2001","unstructured":"Liu GX, Derst C, Schlichth\u00f6rl G, Heinen S, Seebohm G, Br\u00fcggemann A, Kummer W, Veh RW, Daut J, Preisig-M\u00fcller R (2001a) Comparison of cloned Kir2 channels with native inward rectifier K+ channels from guinea-pig cardiomyocytes. J Physiol 532:115\u2013126","journal-title":"J Physiol"},{"key":"9520_CR43","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1124\/mol.59.5.1061","volume":"59","author":"Y Liu","year":"2001","unstructured":"Liu Y, Liu D, Heath L, Meyers DM, Krafte DS, Wagoner PK, Silvia CP, Yu W, Curran ME (2001b) Direct activation of an inwardly rectifying potassium channel by arachidonic acid. Mol Pharmacol 59:1061\u20131068","journal-title":"Mol Pharmacol"},{"key":"9520_CR44","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1006\/jmcc.1997.0548","volume":"29","author":"NJ Lodge","year":"1997","unstructured":"Lodge NJ, Normandin DE (1997) Alterations in Ito1, IKr and Ik1 density in the BIO TO-2 strain of syrian myopathic hamsters. J Mol Cell Cardiol 29:3211\u20133221","journal-title":"J Mol Cell Cardiol"},{"key":"9520_CR45","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1006\/jmcc.2001.1344","volume":"33","author":"AN Lopatin","year":"2001","unstructured":"Lopatin AN, Nichols CG (2001) Inward rectifiers in the heart: an update on I(K1). J Mol Cell Cardiol 33:625\u2013638","journal-title":"J Mol Cell Cardiol"},{"key":"9520_CR46","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000204110","volume":"23","author":"A Lupescu","year":"2009","unstructured":"Lupescu A, Geiger C, Zahir N, Aberle S, Lang PA, Kramer S, Wesselborg S, Kandolf R, Foller M, Lang F, Bock CT (2009) Inhibition of Na+\/H+ exchanger activity by parvovirus B19 protein NS1. Cell Physiol Biochem 23:211\u2013220","journal-title":"Cell Physiol Biochem"},{"key":"9520_CR47","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1159\/000324004","volume":"26","author":"MR Mohamed","year":"2010","unstructured":"Mohamed MR, Alesutan I, F\u00f6ller M, Sopjani M, Bress A, Baur M, Salama RH, Bakr MS, Mohamed MA, Blin N, Lang F, Pfister M (2010) Functional analysis of a novel I71\u00a0N mutation in the GJB2 gene among Southern Egyptians causing autosomal recessive hearing loss. Cell Physiol Biochem 26:959\u2013966","journal-title":"Cell Physiol Biochem"},{"key":"9520_CR48","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0076-6879(07)34005-6","volume":"434","author":"AJ Morris","year":"2007","unstructured":"Morris AJ, Smyth SS (2007) Measurement of autotaxin\/lysophospholipase D activity. Methods Enzymol 434:89\u2013104","journal-title":"Methods Enzymol"},{"key":"9520_CR49","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1523\/JNEUROSCI.20-01-00156.2000","volume":"20","author":"RB Nehring","year":"2000","unstructured":"Nehring RB, Wischmeyer E, D\u00f6ring F, Veh RW, Sheng M, Karschin A (2000) Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95\/SAP90 family. J Neurosci 20:156\u2013162","journal-title":"J Neurosci"},{"key":"9520_CR50","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/0012-1606(76)90249-9","volume":"52","author":"CM O\u2019Connor","year":"1976","unstructured":"O\u2019Connor CM, Smith LD (1976) Inhibition of oocyte maturation by theophylline: possible mechanism of action. Dev Biol 52:318\u2013322","journal-title":"Dev Biol"},{"key":"9520_CR51","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.bbrc.2005.03.159","volume":"331","author":"M Palmada","year":"2005","unstructured":"Palmada M, Speil A, Jeyaraj S, B\u00f6hmer C, Lang F (2005) The serine\/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2. Biochem Biophys Res Commun 331:272\u2013277","journal-title":"Biochem Biophys Res Commun"},{"key":"9520_CR52","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0092-8674(01)00342-7","volume":"105","author":"NM Plaster","year":"2001","unstructured":"Plaster NM, Tawil R, Tristani-Firouzi M, Can\u00fan S, Bendahhou S, Tsunoda A, Donaldson MR, Iannaccone ST, Brunt E, Barohn R, Clark J, Deymeer F, George AL Jr, Fish FA, Hahn A, Nitu A, Ozdemir C, Serdaroglu P, Subramony SH, Wolfe G, Fu YH, Pt\u00e1cek LJ (2001) Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen\u2019s syndrome. Cell 105:511\u2013519","journal-title":"Cell"},{"key":"9520_CR53","doi-asserted-by":"crossref","first-page":"7774","DOI":"10.1073\/pnas.102609499","volume":"99","author":"R Preisig-M\u00fcller","year":"2002","unstructured":"Preisig-M\u00fcller R, Schlichth\u00f6rl G, Goerge T, Heinen S, Br\u00fcggemann A, Rajan S, Derst C, Veh RW, Daut J (2002) Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen\u2019s syndrome. Proc Natl Acad Sci USA 99:7774\u20137779","journal-title":"Proc Natl Acad Sci USA"},{"key":"9520_CR54","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1159\/000322331","volume":"26","author":"R Rexhepaj","year":"2010","unstructured":"Rexhepaj R, D\u00ebrmaku-Sopjani M, Gehring EM, Sopjani M, Kempe DS, F\u00f6ller M, Lang F (2010) Stimulation of electrogenic glucose transport by glycogen synthase kinase 3. Cell Physiol Biochem 26:641\u2013646","journal-title":"Cell Physiol Biochem"},{"key":"9520_CR55","doi-asserted-by":"crossref","first-page":"36065","DOI":"10.1074\/jbc.274.51.36065","volume":"274","author":"T Roh\u00e1cs","year":"1999","unstructured":"Roh\u00e1cs T, Chen J, Prestwich GD, Logothetis DE (1999) Distinct specificities of inwardly rectifying K(+) channels for phosphoinositides. J Biol Chem 274:36065\u201336072","journal-title":"J Biol Chem"},{"key":"9520_CR56","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1529\/biophysj.104.043273","volume":"87","author":"VG Romanenko","year":"2004","unstructured":"Romanenko VG, Fang Y, Byfield F, Travis AJ, Vandenberg CA, Rothblat GH, Levitan I (2004) Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels. Biophys J 87:3850\u20133861","journal-title":"Biophys J"},{"key":"9520_CR57","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1091\/mbc.E06-03-0239","volume":"17","author":"TE Rusten","year":"2006","unstructured":"Rusten TE, Rodahl LM, Pattni K, Englund C, Samakovlis C, Dove S, Brech A, Stenmark H (2006) Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors. Mol Biol Cell 17:3989\u20134001","journal-title":"Mol Biol Cell"},{"key":"9520_CR58","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1242\/jcs.03153","volume":"119","author":"AC Rutherford","year":"2006","unstructured":"Rutherford AC, Traer C, Wassmer T, Pattni K, Bujny MV, Carlton JG, Stenmark H, Cullen PJ (2006) The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport. J Cell Sci 119:3944\u20133957","journal-title":"J Cell Sci"},{"key":"9520_CR59","doi-asserted-by":"crossref","first-page":"41988","DOI":"10.1074\/jbc.M307479200","volume":"278","author":"LJ Sampson","year":"2003","unstructured":"Sampson LJ, Leyland ML, Dart C (2003) Direct interaction between the actin-binding protein filamin-A and the inwardly rectifying potassium channel, Kir2.1. J Biol Chem 278:41988\u201341997","journal-title":"J Biol Chem"},{"key":"9520_CR60","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/ana.410420306","volume":"42","author":"V Sansone","year":"1997","unstructured":"Sansone V, Griggs RC, Meola G, Pt\u00e1cek LJ, Barohn R, Iannaccone S, Bryan W, Baker N, Janas SJ, Scott W, Ririe D, Tawil R (1997) Andersen\u2019s syndrome: a distinct periodic paralysis. Ann Neurol 42:305\u2013312","journal-title":"Ann Neurol"},{"key":"9520_CR61","doi-asserted-by":"crossref","first-page":"21589","DOI":"10.1074\/jbc.274.31.21589","volume":"274","author":"D Sbrissa","year":"1999","unstructured":"Sbrissa D, Ikonomov OC, Shisheva A (1999) PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin. J Biol Chem 274:21589\u201321597","journal-title":"J Biol Chem"},{"key":"9520_CR62","doi-asserted-by":"crossref","first-page":"47276","DOI":"10.1074\/jbc.M207576200","volume":"277","author":"D Sbrissa","year":"2002","unstructured":"Sbrissa D, Ikonomov OC, Deeb R, Shisheva A (2002) Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells. J Biol Chem 277:47276\u201347284","journal-title":"J Biol Chem"},{"key":"9520_CR63","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.1210\/en.2004-0489","volume":"145","author":"D Sbrissa","year":"2004","unstructured":"Sbrissa D, Ikonomov OC, Strakova J, Shisheva A (2004) Role for a novel signaling intermediate, phosphatidylinositol 5-phosphate, in insulin-regulated F-actin stress fiber breakdown and GLUT4 translocation. Endocrinology 145:4853\u20134865","journal-title":"Endocrinology"},{"key":"9520_CR64","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000104151","volume":"20","author":"J Schneider","year":"2007","unstructured":"Schneider J, Nicolay JP, Foller M, Wieder T, Lang F (2007) Suicidal erythrocyte death following cellular K+ loss. Cell Physiol Biochem 20:35\u201344","journal-title":"Cell Physiol Biochem"},{"key":"9520_CR65","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/01.RES.0000260250.83824.8f","volume":"100","author":"G Seebohm","year":"2007","unstructured":"Seebohm G, Strutz-Seebohm N, Birkin R, Dell G, Bucci C, Spinosa MR, Baltaev R, Mack AF, Korniychuk G, Choudhury A, Marks D, Pagano RE, Attali B, Pfeufer A, Kass RS, Sanguinetti MC, Tavare JM, Lang F (2007) Regulation of endocytic recycling of KCNQ1\/KCNE1 potassium channels. Circ Res 100:686\u2013692","journal-title":"Circ Res"},{"key":"9520_CR66","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1159\/000097607","volume":"18","author":"T Shimizu","year":"2006","unstructured":"Shimizu T, Wehner F, Okada Y (2006) Inhibition of hypertonicity-induced cation channels sensitizes HeLa cells to shrinkage-induced apoptosis. Cell Physiol Biochem 18:295\u2013302","journal-title":"Cell Physiol Biochem"},{"key":"9520_CR67","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.bbrc.2005.06.164","volume":"334","author":"M Shojaiefard","year":"2005","unstructured":"Shojaiefard M, Christie DL, Lang F (2005) Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3. Biochem Biophys Res Commun 334:742\u2013746","journal-title":"Biochem Biophys Res Commun"},{"key":"9520_CR68","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.bbrc.2007.05.111","volume":"359","author":"M Shojaiefard","year":"2007","unstructured":"Shojaiefard M, Strutz-Seebohm N, Tavar\u00e9 JM, Seebohm G, Lang F (2007) Regulation of the Na(+), glucose cotransporter by PIKfyve and the serum and glucocorticoid inducible kinase SGK1. Biochem Biophys Res Commun 359:843\u2013847","journal-title":"Biochem Biophys Res Commun"},{"key":"9520_CR69","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0014-5793(01)02136-6","volume":"490","author":"M Soom","year":"2001","unstructured":"Soom M, Sch\u00f6nherr R, Kubo Y, Kirsch C, Klinger R, Heinemann SH (2001) Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium channels. FEBS Lett 490:49\u201353","journal-title":"FEBS Lett"},{"key":"9520_CR70","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00232-009-9222-0","volume":"233","author":"M Sopjani","year":"2010","unstructured":"Sopjani M, Kunert A, Czarkowski K, Klaus F, Laufer J, F\u00f6ller M, Lang F (2010) Regulation of the Ca(2+) channel TRPV6 by the kinases SGK1, PKB\/Akt, and PIKfyve. J Membr Biol 233:35\u201341","journal-title":"J Membr Biol"},{"key":"9520_CR71","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1159\/000110433","volume":"20","author":"N Strutz-Seebohm","year":"2007","unstructured":"Strutz-Seebohm N, Shojaiefard M, Christie D, Tavare J, Seebohm G, Lang F (2007) PIKfyve in the SGK1 mediated regulation of the creatine transporter SLC6A8. Cell Physiol Biochem 20:729\u2013734","journal-title":"Cell Physiol Biochem"},{"key":"9520_CR72","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1159\/000329965","volume":"27","author":"N Strutz-Seebohm","year":"2011","unstructured":"Strutz-Seebohm N, Pusch M, Wolf S, Stoll R, Tapken D, Gerwert K, Attali B, Seebohm G (2011) Structural basis of slow activation gating in the cardiac I Ks channel complex. Cell Physiol Biochem 27:443\u2013452","journal-title":"Cell Physiol Biochem"},{"key":"9520_CR73","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/ana.410350313","volume":"35","author":"R Tawil","year":"1994","unstructured":"Tawil R, Ptacek LJ, Pavlakis SG, DeVivo DC, Penn AS, Ozdemir C, Griggs RC (1994) Andersen\u2019s syndrome: potassium-sensitive periodic paralysis, ventricular ectopy, and dysmorphic features. Ann Neurol 35:326\u2013330","journal-title":"Ann Neurol"},{"key":"9520_CR74","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00424-010-0820-6","volume":"460","author":"M Tristani-Firouzi","year":"2010","unstructured":"Tristani-Firouzi M, Etheridge SP (2010) Kir 2.1 channelopathies: the Andersen-Tawil syndrome. Pflugers Arch 460:289\u2013294","journal-title":"Pflugers Arch"},{"key":"9520_CR75","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1083\/jcb.200903028","volume":"187","author":"F Tsuruta","year":"2009","unstructured":"Tsuruta F, Green EM, Rousset M, Dolmetsch RE (2009) PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death. J Cell Biol 187:279\u2013294","journal-title":"J Cell Biol"},{"key":"9520_CR76","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000129629","volume":"21","author":"ON Ureche","year":"2008","unstructured":"Ureche ON, Baltaev R, Ureche L, Strutz-Seebohm N, Lang F, Seebohm G (2008) Novel insights into the structural basis of pH-sensitivity in inward rectifier K+ channels Kir2.3. Cell Physiol Biochem 21:347\u2013356","journal-title":"Cell Physiol Biochem"},{"key":"9520_CR77","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.febslet.2004.07.030","volume":"572","author":"R Vicente","year":"2004","unstructured":"Vicente R, Coma M, Busquets S, Moore-Carrasco R, L\u00f3pez-Soriano FJ, Argil\u00e9s JM, Felipe A (2004) The systemic inflammatory response is involved in the regulation of K(+) channel expression in brain via TNF-alpha-dependent and -independent pathways. FEBS Lett 572:189\u2013194","journal-title":"FEBS Lett"},{"key":"9520_CR78","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.tibs.2006.02.007","volume":"31","author":"RT Watson","year":"2006","unstructured":"Watson RT, Pessin JE (2006) Bridging the GAP between insulin signaling and GLUT4 translocation. Trends Biochem Sci 31:215\u2013222","journal-title":"Trends Biochem Sci"},{"key":"9520_CR79","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1042\/BST0330346","volume":"33","author":"GI Welsh","year":"2005","unstructured":"Welsh GI, Hers I, Berwick DC, Dell G, Wherlock M, Birkin R, Leney S, Tavar\u00e9 JM (2005) Role of protein kinase B in insulin-regulated glucose uptake. Biochem Soc Trans 33:346\u2013349","journal-title":"Biochem Soc Trans"},{"key":"9520_CR80","doi-asserted-by":"crossref","first-page":"34063","DOI":"10.1074\/jbc.273.51.34063","volume":"273","author":"E Wischmeyer","year":"1998","unstructured":"Wischmeyer E, Doring F, Karschin A (1998) Acute suppression of inwardly rectifying Kir2.1 channels by direct tyrosine kinase phosphorylation. J Biol Chem 273:34063\u201334068","journal-title":"J Biol Chem"},{"key":"9520_CR81","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.bbrc.2005.05.054","volume":"332","author":"M Xia","year":"2005","unstructured":"Xia M, Jin Q, Bendahhou S, He Y, Larroque MM, Chen Y, Zhou Q, Yang Y, Liu Y, Liu B, Zhu Q, Zhou Y, Lin J, Liang B, Li L, Dong X, Pan Z, Wang R, Wan H, Qiu W, Xu W, Eurlings P, Barhanin J, Chen Y (2005) A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation. Biochem Biophys Res Commun 332:1012\u20131019","journal-title":"Biochem Biophys Res Commun"},{"key":"9520_CR82","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nn1090","volume":"6","author":"J Xiao","year":"2003","unstructured":"Xiao J, Zhen XG, Yang J (2003) Localization of PIP2 activation gate in inward rectifier K+ channels. Nat Neurosci 6:811\u2013818","journal-title":"Nat Neurosci"},{"key":"9520_CR83","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuint.2004.03.028","volume":"45","author":"Q Zheng","year":"2004","unstructured":"Zheng Q, Bobich JA (2004) ADP-ribosylation factor6 regulates both [3H]-noradrenaline and [14C]-glutamate exocytosis through phosphatidylinositol 4,5-bisphosphate. Neurochem Int 45:633\u2013640","journal-title":"Neurochem Int"},{"key":"9520_CR84","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.cardiores.2004.02.015","volume":"63","author":"E Zitron","year":"2004","unstructured":"Zitron E, Kiesecker C, L\u00fcck S, Kath\u00f6fer S, Thomas D, Kreye VA, Kiehn J, Katus HA, Schoels W, Karle CA (2004) Human cardiac inwardly rectifying current IKir2.2 is upregulated by activation of protein kinase A. Cardiovasc Res 63:520\u2013527","journal-title":"Cardiovasc Res"}],"container-title":["The Journal of Membrane Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00232-012-9520-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00232-012-9520-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00232-012-9520-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T06:23:00Z","timestamp":1562394180000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00232-012-9520-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,28]]},"references-count":84,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["9520"],"URL":"https:\/\/doi.org\/10.1007\/s00232-012-9520-9","relation":{},"ISSN":["0022-2631","1432-1424"],"issn-type":[{"value":"0022-2631","type":"print"},{"value":"1432-1424","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,28]]}}}