{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:25:29Z","timestamp":1778570729476,"version":"3.51.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National University of Defense Technology Project","award":["No. JC13-02-16"],"award-info":[{"award-number":["No. JC13-02-16"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Membrane Biol"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s00232-017-9965-y","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T04:56:35Z","timestamp":1496897795000},"page":"315-325","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Molecular Dynamics Simulation Reveals Unique Interplays Between a Tarantula Toxin and Lipid Membranes"],"prefix":"10.1007","volume":"250","author":[{"given":"Lei","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Si","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Er","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,6,8]]},"reference":[{"issue":"1","key":"9965_CR1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.addr.2012.09.037","volume":"65","author":"TM Allen","year":"2013","unstructured":"Allen TM, Cullis PR (2013) Liposomal drug delivery systems: from concept to clinical applications. Adv Drug Deliv Rev 65(1):36\u201348","journal-title":"Adv Drug Deliv Rev"},{"issue":"27","key":"9965_CR2","doi-asserted-by":"crossref","first-page":"6646","DOI":"10.1021\/acs.jpcb.6b02334","volume":"120","author":"F Aydin","year":"2016","unstructured":"Aydin F, Dutt M (2016) Surface reconfiguration of binary lipid vesicles via electrostatically induced nanoparticle adsorption. J Phys Chem B 120(27):6646\u20136656","journal-title":"J Phys Chem B"},{"issue":"9","key":"9965_CR3","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1021\/ct300400x","volume":"8","author":"RB Best","year":"2012","unstructured":"Best RB, Zhu X, Shim J, Lopes PE, Mittal J, Feig M, MacKerell AD Jr (2012) ) Optimization of the additive charmm all-atom protein force field targeting improved sampling of the backbone \n$$\\phi$$\n                        \n                            \n                                            \n                                \u03d5\n                            \n                        \n                    , \n$$\\psi$$\n                        \n                            \n                                            \n                                \u03c8\n                            \n                        \n                     and side-chain \n$$\\chi (1)$$\n                        \n                            \n                                            \n                                \n                                    \u03c7\n                                    (\n                                    1\n                                    )\n                                \n                            \n                        \n                     and \n$$\\chi (2)$$\n                        \n                            \n                                            \n                                \n                                    \u03c7\n                                    (\n                                    2\n                                    )\n                                \n                            \n                        \n                     dihedral angles. J Chem Theory Comput 8(9):3257\u20133273","journal-title":"J Chem Theory Comput"},{"issue":"15","key":"9965_CR4","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1007\/s00018-008-8135-x","volume":"65","author":"J Chen","year":"2008","unstructured":"Chen J, Deng M, He Q, Meng E, Jiang L, Liao Z, Rong M, Liang S (2008) Molecular diversity and evolution of cystine knot toxins of the tarantula chilobrachys jingzhao. Cell Mol Life Sci 65(15):2431\u20132444","journal-title":"Cell Mol Life Sci"},{"issue":"11","key":"9965_CR5","doi-asserted-by":"crossref","first-page":"113702","DOI":"10.1063\/1.4896273","volume":"105","author":"A Choubey","year":"2014","unstructured":"Choubey A, Nomura KI, Kalia RK, Nakano A, Vashishta P (2014) Small interfering ribonucleic acid induces liquid-to-ripple phase transformation in a phospholipid membrane. Appl Phys Lett 105(11):113702","journal-title":"Appl Phys Lett"},{"issue":"4","key":"9965_CR6","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.bbamem.2016.02.002","volume":"1858","author":"E Deplazes","year":"2016","unstructured":"Deplazes E, Henriques ST, Smith JJ, King GF, Craik DJ, Mark AE, Schroeder CI (2016) Membrane-binding properties of gating modifier and pore-blocking toxins: membrane interaction is not a prerequisite for modification of channel gating. Biochim Biophys Acta Biomembr 1858(4):872\u2013882","journal-title":"Biochim Biophys Acta Biomembr"},{"issue":"6","key":"9965_CR7","first-page":"2592","volume":"61","author":"RE Eliaz","year":"2001","unstructured":"Eliaz RE, Szoka FC (2001) Liposome-encapsulated doxorubicin targeted to CD44. Cancer Res 61(6):2592\u20132601","journal-title":"Cancer Res"},{"issue":"2","key":"9965_CR8","doi-asserted-by":"crossref","first-page":"83a","DOI":"10.1016\/j.bpj.2012.11.501","volume":"104","author":"MR Fowler","year":"2013","unstructured":"Fowler MR, Busath DD (2013) Simulations of the phase transition of dppc bilayer with and without DPH or TMA-DPH using charmm36. Biophys J 104(2):83a","journal-title":"Biophys J"},{"key":"9965_CR9","doi-asserted-by":"crossref","first-page":"17049","DOI":"10.1074\/jbc.M116.729095","volume":"291","author":"ST Henriques","year":"2016","unstructured":"Henriques ST, Deplazes E, Lawrence N, Cheneval O, Chaousis S, Inserra M, Thongyoo P, King GF, Mark AE, Vetter I (2016) Interaction of tarantula venom peptide protx-ii with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel Nav1.7. J Biol Chem 291:17049\u201317065","journal-title":"J Biol Chem"},{"issue":"1","key":"9965_CR10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","volume":"14","author":"W Humphrey","year":"1996","unstructured":"Humphrey W, Dalke A, Schulten K (1996) Vmd: visual molecular dynamics. J Mol Graph 14(1):33\u201338","journal-title":"J Mol Graph"},{"issue":"2","key":"9965_CR11","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.bpj.2010.04.061","volume":"99","author":"HH Jung","year":"2010","unstructured":"Jung HH, Jung HJ, Milescu M, Lee CW, Lee S, Lee JY, Eu YJ, Kim HH, Swartz KJ, Kim JI (2010) Structure and orientation of a voltage-sensor toxin in lipid membranes. Biophys J 99(2):638\u2013646","journal-title":"Biophys J"},{"issue":"16","key":"9965_CR12","doi-asserted-by":"crossref","first-page":"6015","DOI":"10.1021\/bi0477034","volume":"44","author":"HJ Jung","year":"2005","unstructured":"Jung HJ, Lee JY, Kim SH, Eu YJ, Shin SY, Milescu M, Swartz KJ, Kim JI (2005) Solution structure and lipid membrane partitioning of VSTx1, an inhibitor of the kvap potassium channel. Biochemistry 44(16):6015\u20136023","journal-title":"Biochemistry"},{"issue":"2","key":"9965_CR13","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.bbrc.2005.12.046","volume":"340","author":"HJ Jung","year":"2006","unstructured":"Jung HJ, Kim PI, Lee SK, Lee CW, Eu YJ, Dong GL, Earm YE, Kim JI (2006) Lipid membrane interaction and antimicrobial activity of GsMTx-4, an inhibitor of mechanosensitive channel. Biochem Biophys Res Commun 340(2):633\u2013638","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"9965_CR14","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1016\/j.bpj.2010.09.022","volume":"99","author":"K Kamaraju","year":"2010","unstructured":"Kamaraju K, Gottlieb PA, Sachs F, Sukharev S (2010) Effects of gsmtx4 on bacterial mechanosensitive channels in inside-out patches from giant spheroplasts. Biophys J 99(9):2870\u20132878","journal-title":"Biophys J"},{"issue":"2","key":"9965_CR15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bpj.2013.11.1297","volume":"106","author":"S Katira","year":"2014","unstructured":"Katira S, Rangamani P, Oster G, Smit B (2014) Molecular origins of the ripple phase. Biophys J 106(2):221\u2013222","journal-title":"Biophys J"},{"issue":"11","key":"9965_CR16","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1517\/14712598.2011.621940","volume":"11","author":"GF King","year":"2011","unstructured":"King GF (2011) Venoms as a platform for human drugs: translating toxins into therapeutics. Expert Opin Biol Ther 11(11):1469\u20131484","journal-title":"Expert Opin Biol Ther"},{"key":"9965_CR17","doi-asserted-by":"crossref","first-page":"7830","DOI":"10.1021\/jp101759q","volume":"114","author":"JB Klauda","year":"2010","unstructured":"Klauda JB, Venable RM, Freites JA, O\u2019Connor JW, Tobias DJ, Mondragonramirez C, Vorobyov I, MacKerell AD Jr, Pastor RW (2010) Update of the charmm all-atom additive force field for lipids: validation on six lipid types. J Phys Chem B 114:7830\u20137843","journal-title":"J Phys Chem B"},{"issue":"14","key":"9965_CR18","doi-asserted-by":"crossref","first-page":"6553","DOI":"10.1021\/jp0457646","volume":"109","author":"M Kranenburg","year":"2005","unstructured":"Kranenburg M, Smit B (2005) Phase behavior of model lipid bilayers. J Phys Chem B 109(14):6553\u20136563","journal-title":"J Phys Chem B"},{"issue":"430","key":"9965_CR19","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature02632","volume":"430","author":"SY Lee","year":"2004","unstructured":"Lee SY, Mackinnon R (2004) A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature 430(430):232\u2013235","journal-title":"Nature"},{"issue":"13","key":"9965_CR20","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1002\/jcc.21224","volume":"30","author":"L Mart\u2019\u0142nez","year":"2009","unstructured":"Mart\u2019\u0142nez L, Andrade R, Birgin EG, Mart\u2019\u0142nez JM (2009) Packmol : a package for building initial configurations for molecular dynamics simulations. J Comput Chem 30(13):2157\u20132164","journal-title":"J Comput Chem"},{"issue":"4","key":"9965_CR21","first-page":"4569","volume":"4","author":"E Meng","year":"2013","unstructured":"Meng E, Cai TF, Zhang H, Tang S, Li MJ, Li WY, Huang PF, Liu K, Wu L, Zhu LY (2013) Screening for voltage-gated sodium channel interacting peptides. Sci Rep 4(4):4569\u20134569","journal-title":"Sci Rep"},{"issue":"50","key":"9965_CR22","doi-asserted-by":"crossref","first-page":"E5463","DOI":"10.1073\/pnas.1415324111","volume":"111","author":"M Mihailescu","year":"2014","unstructured":"Mihailescu M, Krepkiy D, Milescu M, Gawrisch K, Swartz KJ, White S (2014) Structural interactions of a voltage sensor toxin with lipid membranes. Proc Natl Acad Sci 111(50):E5463\u2013E5470","journal-title":"Proc Natl Acad Sci"},{"issue":"5","key":"9965_CR23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1085\/jgp.200709869","volume":"130","author":"M Milescu","year":"2007","unstructured":"Milescu M, Vobecky J, Roh SH, Kim SH, Jung HJ, Kim JI, Swartz KJ (2007) Tarantula toxins interact with voltage sensors within lipid membranes. J Gen Physiol 130(5):497\u2013511","journal-title":"J Gen Physiol"},{"issue":"12","key":"9965_CR24","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1529\/biophysj.106.101071","volume":"92","author":"M Nishizawa","year":"2007","unstructured":"Nishizawa M, Nishizawa K (2007) Molecular dynamics simulations of a stretch-activated channel inhibitor GsMTx4 with lipid membranes: two binding modes and effects of lipid structure. Biophys J 92(12):4233\u20134243","journal-title":"Biophys J"},{"issue":"10","key":"9965_CR25","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1002\/pro.5560031022","volume":"3","author":"PK Pallaghy","year":"1994","unstructured":"Pallaghy PK, Norton RS, Nielsen KJ, Craik DJ (1994) A common structural motif incorporating a cystine knot and a triple-stranded \n$$\\beta$$\n                        \n                            \n                                            \n                                \u03b2\n                            \n                        \n                    -sheet in toxic and inhibitory polypeptides. Protein Sci 3(10):1833\u20131839","journal-title":"Protein Sci"},{"issue":"16","key":"9965_CR26","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/jcc.20289","volume":"26","author":"JC Phillips","year":"2005","unstructured":"Phillips JC, Braun R, Wang W, Gumbart J, Tajkhorshid E, Villa E, Chipot C, Skeel RD, Kal\u2019 L, Schulten K (2005) Scalable molecular dynamics with NAMD. J Comput Chem 26(16):1781\u20131802","journal-title":"J Comput Chem"},{"key":"9965_CR27","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1021\/acs.jpcb.6b01870","volume":"120","author":"K Pluhackova","year":"2016","unstructured":"Pluhackova K, Kirsch S, Jing H, Sun L, Jiang Z, Unruh T, B\u00f6ckmann RA (2016) A critical comparison of biomembrane force fields: structure and dynamics of model DMPC, POPC, and POPE bilayers. J Phys Chem B 120:3888\u20133903","journal-title":"J Phys Chem B"},{"issue":"9","key":"9965_CR28","first-page":"3177","volume":"25","author":"M Rong","year":"2011","unstructured":"Rong M, Chen J, Tao H, Wu Y, Jiang P, Lu M, Su H, Chi Y, Cai T, Zhao L (2011) Molecular basis of the tarantula toxin jingzhaotoxin-iii (\/beta-trtx-cj1\/alpha) interacting with voltage sensors in sodium channel subtype Nav1.5. Faseb J Off Publ Fed Am Soc Exp Biol 25(9):3177\u20133185","journal-title":"Faseb J Off Publ Fed Am Soc Exp Biol"},{"issue":"3","key":"9965_CR29","doi-asserted-by":"crossref","first-page":"76a","DOI":"10.1016\/j.bpj.2015.11.477","volume":"110","author":"S Troeira Henriques","year":"2016","unstructured":"Troeira Henriques S, Craik DJ, Schroeder CI (2016) Structure-activity relationship studies reveal that the spider toxin protx-ii has unusual membrane-binding properties and inhibits Nav1.7 channel at the membrane surface. Biophys J 110(3):76a\u201376a","journal-title":"Biophys J"},{"issue":"4","key":"9965_CR30","first-page":"1169","volume":"4","author":"RK Upadhyay","year":"2011","unstructured":"Upadhyay RK, Ahmad S (2011) A review on spider toxins a useful source of pharmacological peptides. J Pharm Res 4(4):1169\u20131172","journal-title":"J Pharm Res"},{"issue":"47","key":"9965_CR31","doi-asserted-by":"crossref","first-page":"18171","DOI":"10.1073\/pnas.0807296105","volume":"105","author":"B Wang","year":"2008","unstructured":"Wang B, Zhang L, Bae SC, Granick S (2008) Nanoparticle-induced surface reconstruction of phospholipid membranes. Proc Natl Acad Sci 105(47):18171\u201318175","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"9965_CR32","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1021\/ct900652s","volume":"6","author":"CL Wee","year":"2010","unstructured":"Wee CL, Ulmschneider MB, Sansom MSP (2010) Membrane\/toxin interaction energetics via serial multiscale molecular dynamics simulations. J Chem Theory Comput 6(3):966\u2013976","journal-title":"J Chem Theory Comput"},{"issue":"25","key":"9965_CR33","doi-asserted-by":"crossref","first-page":"26220","DOI":"10.1074\/jbc.M401387200","volume":"279","author":"Y Xiao","year":"2004","unstructured":"Xiao Y, Tang Y, Yang Y, Wang M, Hu W, Xie J, Zeng X, Liang S (2004) Jingzhaotoxin-iii, a novel spider toxin inhibiting activation of voltage-gated sodium channel in rat cardiac myocytes. J Biol Chem 279(25):26220\u201326226","journal-title":"J Biol Chem"},{"issue":"6","key":"9965_CR34","first-page":"825","volume":"25","author":"X Zeng","year":"2007","unstructured":"Zeng X, Pi J, Liang S (2007) Determination of jingzhaotoxin-i phospholipid membrane-binding activities by high performance liquid chromatography with fluorescence detection. Se pu 25(6):825\u2013829","journal-title":"Se pu"}],"container-title":["The Journal of Membrane Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00232-017-9965-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00232-017-9965-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00232-017-9965-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T06:31:03Z","timestamp":1498631463000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00232-017-9965-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["9965"],"URL":"https:\/\/doi.org\/10.1007\/s00232-017-9965-y","relation":{},"ISSN":["0022-2631","1432-1424"],"issn-type":[{"value":"0022-2631","type":"print"},{"value":"1432-1424","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}