{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T01:48:06Z","timestamp":1783993686784,"version":"3.55.0"},"reference-count":121,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["386417-2010"],"award-info":[{"award-number":["386417-2010"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Membrane Biol"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s00232-017-9997-3","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T08:22:12Z","timestamp":1509610932000},"page":"105-117","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mycobacterial Membrane Proteins QcrB and AtpE: Roles in Energetics, Antibiotic Targets, and Associated Mechanisms of Resistance"],"prefix":"10.1007","volume":"251","author":[{"given":"Luke","family":"Bown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh K.","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon M.","family":"Piercey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa K.","family":"McIsaac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kapil","family":"Tahlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,2]]},"reference":[{"key":"9997_CR1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/370621a0","volume":"370","author":"JP Abrahams","year":"1994","unstructured":"Abrahams JP, Leslie AG, Lutter R, Walker JE (1994) Structure at 2.8\u00a0\u00c5 resolution of F1-ATPase from bovine heart mitochondria. Nature 370:621\u2013628","journal-title":"Nature"},{"key":"9997_CR2","doi-asserted-by":"crossref","first-page":"e52951","DOI":"10.1371\/journal.pone.0052951","volume":"7","author":"KA Abrahams","year":"2012","unstructured":"Abrahams KA et al (2012) Identification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB. PLoS ONE 7:e52951","journal-title":"PLoS ONE"},{"key":"9997_CR3","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.biopha.2017.04.105","volume":"91","author":"M AlMatar","year":"2017","unstructured":"AlMatar M, AlMandeal H, Var I, Kayar B, K\u00f6ksal F (2017) New drugs for the treatment of Mycobacterium tuberculosis infection. Biomed Pharmacother 91:546\u2013558","journal-title":"Biomed Pharmacother"},{"key":"9997_CR4","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1128\/AAC.00753-16","volume":"60","author":"D Almeida","year":"2016","unstructured":"Almeida D et al (2016) Mutations in pepQ confer low-level resistance to bedaquiline and clofazimine in Mycobacterium tuberculosis. Antimicrob Agents Chemother 60:4590\u20134599","journal-title":"Antimicrob Agents Chemother"},{"key":"9997_CR5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1126\/science.1106753","volume":"307","author":"K Andries","year":"2005","unstructured":"Andries K et al (2005) A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 307:223\u2013227","journal-title":"Science"},{"key":"9997_CR6","doi-asserted-by":"crossref","first-page":"e102135","DOI":"10.1371\/journal.pone.0102135","volume":"9","author":"K Andries","year":"2014","unstructured":"Andries K et al (2014) Acquired resistance of Mycobacterium tuberculosis to bedaquiline. PLoS ONE 9:e102135","journal-title":"PLoS ONE"},{"key":"9997_CR7","doi-asserted-by":"crossref","first-page":"7170","DOI":"10.1093\/emboj\/17.24.7170","volume":"J17","author":"I Arnold","year":"1998","unstructured":"Arnold I, Pfeiffer K, Neupert W, Stuart RA, Sch\u00e4gger H (1998) Yeast mitochondrial F1 F0-ATP synthase exists as a dimer: identification of three dimer-specific subunits. EMBO J17:7170\u20137178","journal-title":"EMBO"},{"key":"9997_CR8","doi-asserted-by":"crossref","first-page":"6962","DOI":"10.1128\/AAC.03486-14","volume":"58","author":"K Arora","year":"2014","unstructured":"Arora K et al (2014) Respiratory flexibility in response to inhibition of cytochrome c oxidase in Mycobacterium tuberculosis. Antimicrob Agents Chemother 58:6962\u20136965","journal-title":"Antimicrob Agents Chemother"},{"key":"9997_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6968.2010.01959.x","volume":"308","author":"D Bald","year":"2010","unstructured":"Bald D, Koul A (2010) Respiratory ATP synthesis: the new generation of mycobacterial drug targets? FEMS Microbiol Lett 308:1\u20137","journal-title":"FEMS Microbiol Lett"},{"key":"9997_CR10","doi-asserted-by":"crossref","first-page":"e00272","DOI":"10.1128\/mBio.00272-17","volume":"8","author":"D Bald","year":"2017","unstructured":"Bald D, Villellas C, Lu P, Koul A (2017) Targeting energy metabolism in Mycobacterium tuberculosis, a new paradigm in antimycobacterial drug discovery. mBio 8:e00272","journal-title":"mBio"},{"key":"9997_CR11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/cmdc.201200428","volume":"8","author":"L Ballell","year":"2013","unstructured":"Ballell L et al (2013) Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis. ChemMedChem 8:313\u2013321","journal-title":"ChemMedChem"},{"key":"9997_CR12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2036.1995.tb00363.x","volume":"9","author":"K Bardhan","year":"1995","unstructured":"Bardhan K, Hawkey C, Long R, Morgan A, Wormsley K, Moules I, Brocklebank D (1995) Lansoprazole versus ranitidine for the treatment of reflux oesophagitis. Aliment Pharmacol Thera 9:145\u2013151","journal-title":"Aliment Pharmacol Thera"},{"key":"9997_CR13","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1056\/NEJMc1505196","volume":"373","author":"GV Bloemberg","year":"2015","unstructured":"Bloemberg GV et al (2015) Acquired resistance to bedaquiline and delamanid in therapy for tuberculosis. N Engl J Med 373:1986\u20131988","journal-title":"N Engl J Med"},{"key":"9997_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mib.2015.05.008","volume":"27","author":"T Bollenbach","year":"2015","unstructured":"Bollenbach T (2015) Antimicrobial interactions: mechanisms and implications for drug discovery and resistance evolution. Curr Opin Microbiol 27:1\u20139","journal-title":"Curr Opin Microbiol"},{"key":"9997_CR15","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1146\/annurev.biochem.66.1.717","volume":"66","author":"PD Boyer","year":"1997","unstructured":"Boyer PD (1997) The ATP synthase-a splendid molecular machine. Annu Rev Biochem 66:717\u2013749","journal-title":"Annu Rev Biochem"},{"key":"9997_CR16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.bi.64.070195.000333","volume":"64","author":"PJ Brennan","year":"1995","unstructured":"Brennan PJ, Nikaido H (1995) The envelope of mycobacteria. Annu Rev Biochem 64:29\u201363","journal-title":"Annu Rev Biochem"},{"key":"9997_CR17","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1126\/science.aaf8156","volume":"354","author":"JM Bryant","year":"2016","unstructured":"Bryant JM et al (2016) Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium. Science 354:751\u2013757","journal-title":"Science"},{"key":"9997_CR18","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S1473-3099(10)70139-0","volume":"10","author":"JA Caminero","year":"2010","unstructured":"Caminero JA, Sotgiu G, Zumla A, Migliori GB (2010) Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis. Lancet Infect Dis 10:621\u2013629","journal-title":"Lancet Infect Dis"},{"key":"9997_CR19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0014-5793(81)81170-2","volume":"132","author":"KR Carter","year":"1981","unstructured":"Carter KR, Ah-lim T, Graham P (1981) The coordination environment of mitochondrial cytochromes b. FEBS Lett 132:243\u2013246","journal-title":"FEBS Lett"},{"key":"9997_CR20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1146\/annurev.micro.112408.134043","volume":"64","author":"MC Chao","year":"2010","unstructured":"Chao MC, Rubin EJ (2010) Letting sleeping dogs lie: does dormancy play a role in tuberculosis? Annu Rev Microbiol 64:293\u2013311","journal-title":"Annu Rev Microbiol"},{"key":"9997_CR21","doi-asserted-by":"crossref","first-page":"e87483","DOI":"10.1371\/journal.pone.0087483","volume":"9","author":"Y Cheng","year":"2014","unstructured":"Cheng Y, Moraski GC, Cramer J, Miller MJ, Schorey JS (2014) Bactericidal activity of an imidazo[1,2-a]pyridine using a mouse M. tuberculosis infection model. PLoS ONE 9:e87483","journal-title":"PLoS ONE"},{"key":"9997_CR22","first-page":"1283","volume":"2","author":"T Christophe","year":"2010","unstructured":"Christophe T, Ewann F, Jeon HK, Cechetto J, Brodin P (2010) High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery. Future 2:1283\u20131293","journal-title":"Future"},{"key":"9997_CR23","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/35059006","volume":"409","author":"S Cole","year":"2001","unstructured":"Cole S et al (2001) Massive gene decay in the leprosy bacillus. Nature 409:1007\u20131011","journal-title":"Nature"},{"issue":"6","key":"9997_CR24","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/ddr.20456","volume":"72","author":"MB Conde","year":"2011","unstructured":"Conde MB, de Silva JRL (2011) New regimens for reducing the duration of the treatment of drug susceptible pulmonary tuberculosis. Drug Drv Res 72(6):501\u2013508","journal-title":"Drug Drv Res"},{"key":"9997_CR25","first-page":"3","volume":"2","author":"GM Cook","year":"2014","unstructured":"Cook GM, Hards K, Vilch\u00e8ze C, Hartman T, Berney M (2014) Energetics of respiration and oxidative phosphorylation in mycobacteria. Microbiol Spectr 2:3","journal-title":"Microbiol Spectr"},{"key":"9997_CR26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1128\/microbiolspec.TBTB2-0014-2016","volume":"5","author":"G Cook","year":"2017","unstructured":"Cook G et al (2017) Oxidative phosphorylation as a target space for tuberculosis: success, caution, and future directions. Microbiol Spectr 5:3","journal-title":"Microbiol Spectr"},{"key":"9997_CR27","doi-asserted-by":"crossref","first-page":"15121","DOI":"10.1021\/bi001585c","volume":"39","author":"GS Cottrell","year":"2000","unstructured":"Cottrell GS, Hooper NM, Turner AJ (2000) Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese (II)-dependent enzyme. Biochemistry 39:15121\u201315128","journal-title":"Biochemistry"},{"key":"9997_CR28","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1146\/annurev.physiol.66.032102.150251","volume":"66","author":"AR Crofts","year":"2004","unstructured":"Crofts AR (2004) The cytochrome bc 1 complex: function in the context of structure. Annu Rev Physiol 66:689\u2013733","journal-title":"Annu Rev Physiol"},{"key":"9997_CR29","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0959-440X(98)80129-2","volume":"8","author":"AR Crofts","year":"1998","unstructured":"Crofts AR, Berry EA (1998) Structure and function of the cytochrome bc 1 complex of mitochondria and photosynthetic bacteria. Curr Opin Struct Biol 8:501\u2013509","journal-title":"Curr Opin Struct Biol"},{"issue":"7","key":"9997_CR30","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/jac\/dkr173","volume":"66","author":"PEA Silva da","year":"2011","unstructured":"da Silva PEA, Palomino JC (2011) Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs. Antimicrob Chemother 66(7):1417\u20131430","journal-title":"Antimicrob Chemother"},{"key":"9997_CR31","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/prot.21376","volume":"67","author":"MR Jonge de","year":"2007","unstructured":"de Jonge MR, Koymans LH, Guillemont JE, Koul A, Andries K (2007) A computational model of the inhibition of Mycobacterium tuberculosis ATPase by a new drug candidate R207910. Proteins 67:971\u2013980","journal-title":"Proteins"},{"key":"9997_CR32","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1432-1033.1970.tb01174.x","volume":"17","author":"P Dehm","year":"1970","unstructured":"Dehm P, Nordwig A (1970) The cleavage of prolyl peptides by kidney peptidases. Eur J Biochem 17:364\u2013371","journal-title":"Eur J Biochem"},{"key":"9997_CR33","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrmicro2077","volume":"7","author":"C Demangel","year":"2009","unstructured":"Demangel C, Stinear TP, Cole ST (2009) Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans. Nat Rev Microbiol 7:50\u201360","journal-title":"Nat Rev Microbiol"},{"key":"9997_CR34","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0005-2728(00)00092-X","volume":"1458","author":"RJ Devenish","year":"2000","unstructured":"Devenish RJ, Prescott M, Roucou X, Nagley P (2000) Insights into ATP synthase assembly and function through the molecular genetic manipulation of subunits of the yeast mitochondrial enzyme complex. Biochim Biophys Acta 1458:428\u2013442","journal-title":"Biochim Biophys Acta"},{"key":"9997_CR35","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.chembiol.2011.09.016","volume":"18","author":"CK Dong","year":"2011","unstructured":"Dong CK et al (2011) Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc 1 inhibitors. Chem Biol 18:1602\u20131610","journal-title":"Chem Biol"},{"key":"9997_CR36","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1177\/2040622315582325","volume":"6","author":"SK Field","year":"2015","unstructured":"Field SK (2015) Bedaquiline for the treatment of multidrug-resistant tuberculosis: great promise or disappointment? Ther Adv Chronic Dis 6:170\u2013184","journal-title":"Ther Adv Chronic Dis"},{"key":"9997_CR37","doi-asserted-by":"crossref","first-page":"26441","DOI":"10.1074\/jbc.M113.503722","volume":"288","author":"CS Gajadeera","year":"2013","unstructured":"Gajadeera CS, Weber J (2013) Escherichia coli F1F0-ATP synthase with a b\/\u03b4 fusion protein allows analysis of the function of the individual b subunits. J Biol Chem 288:26441\u201326447","journal-title":"J Biol Chem"},{"key":"9997_CR38","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/bst0220203","volume":"22","author":"B Geier","year":"1994","unstructured":"Geier B, Haase U, Von Jagow G (1994) Inhibitor binding to the Qp-site of bc 1 complex: comparative studies of yeast mutants and natural inhibitor resistant fungi. Biochem Soc Trans 22:203\u2013209","journal-title":"Biochem Soc Trans"},{"key":"9997_CR39","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1574-6976.2012.00331.x","volume":"36","author":"M Gengenbacher","year":"2012","unstructured":"Gengenbacher M, Kaufmann SH (2012) Mycobacterium tuberculosis: success through dormancy. FEMS Microbiol Rev 36:514\u2013532","journal-title":"FEMS Microbiol Rev"},{"key":"9997_CR40","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.7164\/antibiotics.33.1474","volume":"33","author":"K Gerth","year":"1980","unstructured":"Gerth K, Irschik H, Reichenbach H, Trowitzsch W (1980) Myxothiazol, an antibiotic from Myxococcus fulvus (Myxobacterales). J Antibiot 33:1474\u20131479","journal-title":"J Antibiot"},{"key":"9997_CR41","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.tube.2013.09.003","volume":"93","author":"RC Goldman","year":"2013","unstructured":"Goldman RC (2013) Why are membrane targets discovered by phenotypic screens and genome sequencing in Mycobacterium tuberculosis? Tuberculosis 93:569\u2013588","journal-title":"Tuberculosis"},{"key":"9997_CR42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tube.2003.08.003","volume":"84","author":"JE Gomez","year":"2004","unstructured":"Gomez JE, McKinney JD (2004) M. tuberculosis persistence, latency, and drug tolerance. Tuberculosis 84:29\u201344","journal-title":"Tuberculosis"},{"key":"9997_CR43","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1358\/dot.2013.49.6.1970865","volume":"49","author":"J Gras","year":"2013","unstructured":"Gras J (2013) Bedaquiline for the treatment of pulmonary, multidrug-resistant tuberculosis in adults. Drugs Today 49:353\u2013361","journal-title":"Drugs Today"},{"issue":"3","key":"9997_CR44","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1128\/AAC.04271-14","volume":"59","author":"TH Grossman","year":"2015","unstructured":"Grossman TH, Shoen CM, Jones SM, Jones PL, Cynamon MH, Locher CP (2015) The efflux pump inhibitor timcodar improves the potency of antimycobacterial agents. Antimicrob Agents Chemother 59(3):1534\u20131541","journal-title":"Antimicrob Agents Chemother"},{"key":"9997_CR45","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1128\/AAC.01462-13","volume":"58","author":"S Gupta","year":"2014","unstructured":"Gupta S, Cohen KA, Winglee K, Malga M, Diarra B, Bishal WR (2014) Efflux inhibition with verapamil potentiates bedaquiline in Mycobacterium tuberculosis. Antimicrob Agents Chemother 58:574\u2013576","journal-title":"Antimicrob Agents Chemother"},{"key":"9997_CR46","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1128\/AAC.04019-14","volume":"59","author":"S Gupta","year":"2015","unstructured":"Gupta S, Tyagi S, Bishai WR (2015) Verapamil increases the bactericidal activity of bedaquiline against Mycobacterium tuberculosis in a mouse model. Antimicrob Agents Chemother 59:673\u2013676","journal-title":"Antimicrob Agents Chemother"},{"key":"9997_CR47","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1177\/1753465808099522","volume":"2","author":"ES Guy","year":"2008","unstructured":"Guy ES, Mallampalli A (2008) Managing TB in the 21st century: existing and novel drug therapies. Ther Adv Chronic Dis 2:401\u2013408","journal-title":"Ther Adv Chronic Dis"},{"key":"9997_CR48","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1128\/AAC.01393-08","volume":"53","author":"AC Haagsma","year":"2009","unstructured":"Haagsma AC et al (2009) Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue. Antimicrob Agents Chemother 53:1290\u20131292","journal-title":"Antimicrob Agents Chemother"},{"key":"9997_CR49","doi-asserted-by":"crossref","first-page":"e23575","DOI":"10.1371\/journal.pone.0023575","volume":"6","author":"AC Haagsma","year":"2011","unstructured":"Haagsma AC, Podasca I, Koul A, Andries K, Guillemont J, Lill H, Bald D (2011) Probing the interaction of the diarylquinoline TMC207 with its target mycobacterial ATP synthase. PLoS ONE 6:e23575","journal-title":"PLoS ONE"},{"key":"9997_CR50","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1093\/jac\/dkv054","volume":"70","author":"K Hards","year":"2015","unstructured":"Hards K et al (2015) Bactericidal mode of action of bedaquiline. J Antimicrob Chemo 70:2028\u20132037","journal-title":"J Antimicrob Chemo"},{"key":"9997_CR51","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1101\/gr.652803","volume":"13","author":"JK Harris","year":"2003","unstructured":"Harris JK, Kelley ST, Spiegelman GB, Pace NR (2003) The genetic core of the universal ancestor. Genome Res 13:407\u2013412","journal-title":"Genome Res"},{"key":"9997_CR52","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1128\/AAC.00037-14","volume":"58","author":"RC Hartkoorn","year":"2014","unstructured":"Hartkoorn RC, Uplekar S, Cole ST (2014) Cross-resistance between clofazimine and bedaquiline through upregulation of MmpL5 in Mycobacterium tuberculosis. Antimicrob Agents Chemother 58:2979\u20132981","journal-title":"Antimicrob Agents Chemother"},{"key":"9997_CR53","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.copbio.2017.03.023","volume":"48","author":"J Herrmann","year":"2017","unstructured":"Herrmann J, Rybniker J, Muller R (2017) Novel and revisited approaches in antituberculosis drug discovery. Curr Opin Biotechnol 48:94\u2013101","journal-title":"Curr Opin Biotechnol"},{"key":"9997_CR54","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.addr.2016.04.026","volume":"102","author":"DT Hoagland","year":"2016","unstructured":"Hoagland DT, Liu J, Lee RB, Lee RE (2016) New agents for the treatment of drug-resistant Mycobacterium tuberculosis. Adv Drug Deliv Rev 102:55\u201372","journal-title":"Adv Drug Deliv Rev"},{"key":"9997_CR55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.ampbs.2015.04.002","volume":"66","author":"LV Holyoake","year":"2015","unstructured":"Holyoake LV, Poole RK, Shepherd M (2015) The CydDC family of transporters and their roles in oxidase assembly and homeostasis. Adv Microb Physiol 66:1\u201353","journal-title":"Adv Microb Physiol"},{"key":"9997_CR56","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1128\/AAC.00181-07","volume":"51","author":"E Huitric","year":"2007","unstructured":"Huitric E, Verhasselt P, Andries K, Hoffner SE (2007) In vitro antimycobacterial spectrum of a diarylquinoline ATP synthase inhibitor. Antimicrob Agents Chemother 51:4202\u20134204","journal-title":"Antimicrob Agents Chemother"},{"key":"9997_CR57","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1128\/AAC.01611-09","volume":"54","author":"E Huitric","year":"2010","unstructured":"Huitric E, Verhasselt P, Koul A, Andries K, Hoffner S, Andersson DI (2010) Rates and mechanisms of resistance development in Mycobacterium tuberculosis to a novel diarylquinoline ATP synthase inhibitor. Antimicrob Agents Chemother 54:1022\u20131028","journal-title":"Antimicrob Agents Chemother"},{"key":"9997_CR58","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/iub.1120","volume":"65","author":"R Iino","year":"2013","unstructured":"Iino R, Noji H (2013) Operation mechanism of FoF1-adenosine triphosphate synthase revealed by its structure and dynamics. IUBMB Life 65:238\u2013246","journal-title":"IUBMB Life"},{"key":"9997_CR59","doi-asserted-by":"crossref","first-page":"a021105","DOI":"10.1101\/cshperspect.a021105","volume":"4","author":"M Jackson","year":"2014","unstructured":"Jackson M (2014) The mycobacterial cell envelope-lipids. Cold Spring Harb Perspect Med 4:a021105","journal-title":"Cold Spring Harb Perspect Med"},{"key":"9997_CR60","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02637-16","author":"J Jang","year":"2017","unstructured":"Jang J, Kim R, Woo M, Jeong J, Park DE, Kim G, Delorme V (2017) Efflux attenuates the antibacterial activity of Q203 in Mycobacterium tuberculosis. Antimicrob Agents Chemother. https:\/\/doi.org\/10.1128\/AAC.02637-16","journal-title":"Antimicrob Agents Chemother"},{"key":"9997_CR61","first-page":"210","volume":"6","author":"MM Johnson","year":"2014","unstructured":"Johnson MM, Odell JA (2014) Nontuberculous mycobacterial pulmonary infections. J Thorac Dis 6:210","journal-title":"J Thorac Dis"},{"key":"9997_CR62","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/(SICI)1096-9063(199902)55:2<213::AID-PS875>3.0.CO;2-N","volume":"55","author":"DB Jordan","year":"1999","unstructured":"Jordan DB et al (1999) Oxazolidinones: a new chemical class of fungicides and inhibitors of mitochondrial cytochrome bc 1 function. Pest Manag Sci 55:213\u2013215","journal-title":"Pest Manag Sci"},{"key":"9997_CR63","doi-asserted-by":"crossref","first-page":"7426","DOI":"10.1073\/pnas.1706139114","volume":"114","author":"NP Kalia","year":"2017","unstructured":"Kalia NP et al (2017) Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection. Proc Natl Acad Sci USA 114:7426\u20137431","journal-title":"Proc Natl Acad Sci USA"},{"key":"9997_CR64","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.tube.2014.10.003","volume":"94","author":"BD Kana","year":"2014","unstructured":"Kana BD, Karakousis PC, Parish T, Dick T (2014) Future target-based drug discovery for tuberculosis? Tuberculosis 94:551\u2013556","journal-title":"Tuberculosis"},{"key":"9997_CR65","first-page":"290","volume":"120","author":"V Katoch","year":"2004","unstructured":"Katoch V (2004) Infections due to non-tuberculous mycobacteria (NTM). Indian J Med Res 120:290","journal-title":"Indian J Med Res"},{"key":"9997_CR66","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1021\/acs.orglett.6b01886","volume":"18","author":"I Kavianinia","year":"2016","unstructured":"Kavianinia I, Kunalingam L, Harris PW, Cook GM, Brimble MA (2016) Total synthesis and stereochemical revision of the anti-tuberculosis peptaibol trichoderin A. Org Lett 18:3878\u20133881","journal-title":"Org Lett"},{"key":"9997_CR67","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.bbabio.2011.09.017","volume":"1807","author":"T Kleinschroth","year":"2011","unstructured":"Kleinschroth T, Castellani M, Trinh CH, Morgner N, Brutschy B, Ludwig B, Hunte C (2011) X-ray structure of the dimeric cytochrome bc 1 complex from the soil bacterium Paracoccus denitrificans at 2.7\u00a0\u00c5 resolution. Biochim Biophys Acta 1807:1606\u20131615","journal-title":"Biochim Biophys Acta"},{"key":"9997_CR68","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/bkcs.10765","volume":"37","author":"Y Ko","year":"2016","unstructured":"Ko Y, Choi I (2016) Putative 3D structure of QcrB from Mycobacterium tuberculosis cytochrome bc1 complex, a novel drug-target for new series of antituberculosis agent Q203. Bull Korean Chem Soc 37:725\u2013731","journal-title":"Bull Korean Chem Soc"},{"key":"9997_CR69","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nchembio884","volume":"3","author":"A Koul","year":"2007","unstructured":"Koul A et al (2007) Diarylquinolines target subunit-c of mycobacterial ATP synthase. Nat Chem Biol 3:323","journal-title":"Nat Chem Biol"},{"key":"9997_CR70","doi-asserted-by":"crossref","first-page":"12393","DOI":"10.1038\/ncomms12393","volume":"7","author":"DA Lamprecht","year":"2016","unstructured":"Lamprecht DA et al (2016) Turning the respiratory flexibility of Mycobacterium tuberculosis against itself. Nat Comm 7:12393","journal-title":"Nat Comm"},{"key":"9997_CR71","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1128\/AAC.00689-09","volume":"53","author":"N Lounis","year":"2009","unstructured":"Lounis N, Gevers T, Van Den Berg J, Vranckx L, Andries K (2009) ATP synthase inhibition of Mycobacterium avium is not bactericidal. Antimicrob Agents Chemother 53:4927\u20134929","journal-title":"Antimicrob Agents Chemother"},{"key":"9997_CR72","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.bbabio.2014.01.022","volume":"1837","author":"P Lu","year":"2014","unstructured":"Lu P, Lill H, Bald D (2014) ATP synthase in mycobacteria: special features and implications for a function as drug target. Biochim Biophys Acta 1837:1208\u20131218","journal-title":"Biochim Biophys Acta"},{"key":"9997_CR73","doi-asserted-by":"crossref","first-page":"10333","DOI":"10.1038\/srep10333","volume":"5","author":"P Lu","year":"2015","unstructured":"Lu P et al (2015) The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress. Sci Rep 5:10333","journal-title":"Sci Rep"},{"key":"9997_CR74","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1021\/cb2004884","volume":"7","author":"PA Mak","year":"2012","unstructured":"Mak PA et al (2012) A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis. ACS Chem Biol 7:1190\u20131197","journal-title":"ACS Chem Biol"},{"key":"9997_CR75","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/scientificamerican0871-48","volume":"225","author":"L Margulis","year":"1971","unstructured":"Margulis L (1971) Symbiosis and evolution. Sci Am 225:48\u201361","journal-title":"Sci Am"},{"key":"9997_CR76","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nature01250","volume":"421","author":"LO Martinez","year":"2003","unstructured":"Martinez LO et al (2003) Ectopic \u03b2-chain of ATP synthase is an apolipoprotein AI receptor in hepatic HDL endocytosis. Nature 421:75\u201379","journal-title":"Nature"},{"key":"9997_CR77","doi-asserted-by":"crossref","first-page":"6300","DOI":"10.1128\/JB.187.18.6300-6308.2005","volume":"187","author":"LG Matsoso","year":"2005","unstructured":"Matsoso LG et al (2005) Function of the cytochrome bc 1 -aa 3 branch of the respiratory network in mycobacteria and network adaptation occurring in response to its disruption. J Bac 187:6300\u20136308","journal-title":"J Bac"},{"key":"9997_CR78","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tube.2008.08.003","volume":"89","author":"A Milano","year":"2009","unstructured":"Milano A et al (2009) Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5\u2013MmpL5 efflux system. Tuberculosis 89:84\u201390","journal-title":"Tuberculosis"},{"key":"9997_CR79","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1021\/ml200036r","volume":"2","author":"GC Moraski","year":"2011","unstructured":"Moraski GC, Markley LD, Hipskind PA, Boshoff H, Cho S, Franzblau SG, Miller MJ (2011) Advent of imidazo[1, 2-a]pyridine-3-carboxamides with potent multi-and extended drug resistant antituberculosis activity. ACS Med Chem Lett 2:466\u2013470","journal-title":"ACS Med Chem Lett"},{"key":"9997_CR80","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1021\/id500008t","volume":"1","author":"GC Moraski","year":"2015","unstructured":"Moraski GC et al (2015) Putting tuberculosis (TB) to rest: transformation of the sleep aid, Ambien, and \u201canagrams\u201d generated potent antituberculosis agents. ACS Infect Dis 1:85\u201390","journal-title":"ACS Infect Dis"},{"key":"9997_CR81","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1021\/acsinfecdis.5b00154","volume":"2","author":"GC Moraski","year":"2016","unstructured":"Moraski GC et al (2016) Arrival of imidazo[2,1-b] thiazole-5-carboxamides: potent anti-tuberculosis agents that target QcrB. ACS Infect Dis 2:393\u2013398","journal-title":"ACS Infect Dis"},{"key":"9997_CR82","doi-asserted-by":"crossref","first-page":"e00253-15","DOI":"10.1128\/mBio.00253-15","volume":"6","author":"Moreira","year":"2015","unstructured":"Moreira et al (2015) Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in Mycobacteria. mBio 6:e00253-15","journal-title":"mBio"},{"key":"9997_CR83","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/386299a0","volume":"386","author":"H Noji","year":"1997","unstructured":"Noji H, Yasuda R, Yoshida M, Kinosita K Jr (1997) Direct observation of the rotation of F1-ATPase. Nature 386:299","journal-title":"Nature"},{"key":"9997_CR84","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1021\/bi035820d","volume":"43","author":"KF Nowak","year":"2004","unstructured":"Nowak KF, McCarty RE (2004) Regulatory role of the C-terminus of the \u03b5 subunit from the chloroplast ATP synthase. Biochemistry 43:3273\u20133279","journal-title":"Biochemistry"},{"key":"9997_CR85","first-page":"e02627","volume":"61","author":"Y Pang","year":"2017","unstructured":"Pang Y, Zheng H, Tan Y, Song Y, Zhao Y (2017) In vitro activity of bedaquiline against nontuberculous mycobacteria in China. Antimicrob Agents Chemother 61:e02627","journal-title":"Antimicrob Agents Chemother"},{"key":"9997_CR86","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0014-5793(00)01082-6","volume":"466","author":"G Paradies","year":"2000","unstructured":"Paradies G, Petrosillo G, Pistolese M, Ruggiero FM (2000) The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles. FEBS Lett 466:323\u2013326","journal-title":"FEBS Lett"},{"key":"9997_CR87","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/nm.3262","volume":"19","author":"K Pethe","year":"2013","unstructured":"Pethe K et al (2013) Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat Med 19:1157\u20131160","journal-title":"Nat Med"},{"key":"9997_CR88","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1128\/AAC.00244-06","volume":"50","author":"S Petrella","year":"2006","unstructured":"Petrella S, Cambau E, Chauffour A, Andries K, Jarlier V, Sougakoff W (2006) Genetic basis for natural and acquired resistance to the diarylquinoline R207910 in mycobacteria. Antimicrob Agents Chemother 50:2853\u20132856","journal-title":"Antimicrob Agents Chemother"},{"key":"9997_CR89","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1039\/C6MD00236F","volume":"7","author":"N Phummarin","year":"2016","unstructured":"Phummarin N, Boshoff HI, Tsang PS, Dalton J, Wiles S, Barry CE 3rd, Copp BR (2016) SAR and identification of 2-(quinolin-4-yloxy)acetamides as Mycobacterium tuberculosis cytochrome bc 1 inhibitors. MedChemComm 7:2122\u20132127","journal-title":"MedChemComm"},{"key":"9997_CR90","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1021\/acsmedchemlett.5b00324","volume":"7","author":"K Pissinate","year":"2016","unstructured":"Pissinate K et al (2016) 2-(Quinolin-4-yloxy)acetamides are active against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains. ACS Med Chem Lett 7:235\u2013239","journal-title":"ACS Med Chem Lett"},{"key":"9997_CR91","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.5588\/ijtld.13.0075","volume":"18","author":"A Piubello","year":"2014","unstructured":"Piubello A et al (2014) High cure rate with standardised short-course multidrug-resistant tuberculosis treatment in Niger: no relapses. Int J Tuberc Lung Dis 18:1188\u20131194","journal-title":"Int J Tuberc Lung Dis"},{"key":"9997_CR92","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/nsmb.1678","volume":"16","author":"D Pogoryelov","year":"2009","unstructured":"Pogoryelov D, Yildiz \u00d6, Faraldo-G\u00f3mez JD, Meier T (2009) High-resolution structure of the rotor ring of a proton-dependent ATP synthase. Nat Struct Mol Biol 16:1068\u20131073","journal-title":"Nat Struct Mol Biol"},{"key":"9997_CR93","doi-asserted-by":"crossref","first-page":"e1500106","DOI":"10.1126\/sciadv.1500106","volume":"1","author":"L Preiss","year":"2015","unstructured":"Preiss L, Langer JD, Yildiz \u00d6, Eckhardt-Strelau L, Guillemont JE, Koul A, Meier T (2015) Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline. Sci Adv 1:e1500106","journal-title":"Sci Adv"},{"key":"9997_CR94","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1016\/j.bmcl.2010.04.100","volume":"20","author":"P Pruksakorn","year":"2010","unstructured":"Pruksakorn P et al (2010) Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria. Bioorg Med Chem Lett 20:3658\u20133663","journal-title":"Bioorg Med Chem Lett"},{"key":"9997_CR95","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1248\/bpb.34.1287","volume":"34","author":"P Pruksakorn","year":"2011","unstructured":"Pruksakorn P, Arai M, Liu L, Moodley P, Jacobs WR Jr, Kobayashi M (2011) Action-mechanism of trichoderin A, an anti-dormant mycobacterial aminolipopeptide from marine sponge-derived Trichoderma sp. Biol Pharm Bull 34:1287\u20131290","journal-title":"Biol Pharm Bull"},{"key":"9997_CR96","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1021\/ac701690d","volume":"80","author":"PK Rao","year":"2008","unstructured":"Rao PK, Roxas BA, Li Q (2008a) Determination of global protein turnover in stressed mycobacterium cells using hybrid-linear ion trap-fourier transform mass spectrometry. Anal Chem 80:396\u2013406","journal-title":"Anal Chem"},{"key":"9997_CR97","doi-asserted-by":"crossref","first-page":"11945","DOI":"10.1073\/pnas.0711697105","volume":"105","author":"SP Rao","year":"2008","unstructured":"Rao SP, Alonso S, Rand L, Dick T, Pethe K (2008b) The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis. Proc Nat Acad Sci USA 105:11945\u201311950","journal-title":"Proc Nat Acad Sci USA"},{"key":"9997_CR98","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.tube.2011.05.005","volume":"92","author":"RC Reynolds","year":"2012","unstructured":"Reynolds RC et al (2012) High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv. Tuberculosis 92:72\u201383","journal-title":"Tuberculosis"},{"key":"9997_CR99","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.bbabio.2007.10.011","volume":"1777","author":"FA Rotsaert","year":"2008","unstructured":"Rotsaert FA, Ding MG, Trumpower BL (2008) Differential efficacy of inhibition of mitochondrial and bacterial cytochrome bc 1 complexes by center N inhibitors antimycin, ilicicolin H and funiculosin. Biochim Biophys Acta 1777:211\u2013219","journal-title":"Biochim Biophys Acta"},{"key":"9997_CR100","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.chom.2014.09.008","volume":"16","author":"J Rybniker","year":"2014","unstructured":"Rybniker J et al (2014) Anticytolytic screen identifies inhibitors of mycobacterial virulence protein secretion. Cell Host Microbe 16:538\u2013548","journal-title":"Cell Host Microbe"},{"key":"9997_CR101","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8659","author":"J Rybniker","year":"2015","unstructured":"Rybniker J, Vocat A, Sala C, Busso P, Pojer F, Benjak A, Cole ST (2015) Lansoprazole is an antituberculous prodrug targeting cytochrome bc 1 . Nat Commun. https:\/\/doi.org\/10.1038\/ncomms8659","journal-title":"Nat Commun"},{"key":"9997_CR102","first-page":"749","volume":"1","author":"LV Sacks","year":"2009","unstructured":"Sacks LV, Behrman RE (2009) Challenges, successes and hopes in the development of novel TB therapeutics. Future 1:749\u2013756","journal-title":"Future"},{"key":"9997_CR103","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1177\/1087057112438769","volume":"17","author":"JG Sarver","year":"2012","unstructured":"Sarver JG, Trendel JA, Bearss NR, Wang L, Luniwal A, Erhardt PW, Viola RE (2012) Early stage efficacy and toxicology screening for antibiotics and enzyme inhibitors. J Biomol Screen 17:673\u2013682","journal-title":"J Biomol Screen"},{"key":"9997_CR104","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1128\/AAC.06154-11","volume":"56","author":"E Segala","year":"2012","unstructured":"Segala E, Sougakoff W, Nevejans-Chauffour A, Jarlier V, Petrella S (2012) New mutations in the mycobacterial ATP synthase: new insights into the binding of the diarylquinoline TMC207 to the ATP synthase C-ring structure. Antimicrob Agents Chemother 56:2326\u20132334","journal-title":"Antimicrob Agents Chemother"},{"key":"9997_CR105","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.bmc.2014.12.060","volume":"23","author":"S Singh","year":"2015","unstructured":"Singh S et al (2015) Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis. Bioorg Med Chem 23:742\u2013752","journal-title":"Bioorg Med Chem"},{"key":"9997_CR106","first-page":"53","volume":"374","author":"T Smith","year":"2013","unstructured":"Smith T, Wolff KA, Nguyen L (2013) Molecular biology of drug resistance in Mycobacterium tuberculosis. Curr Top Microbiol Immunol 374:53\u201380","journal-title":"Curr Top Microbiol Immunol"},{"key":"9997_CR107","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1021\/acs.jmedchem.6b01358","volume":"60","author":"SJ Tantry","year":"2017","unstructured":"Tantry SJ et al (2017) Discovery of imidazo[1,2-a]pyridine ethers and squaramides as selective and potent inhibitors of mycobacterial adenosine triphosphate (ATP) synthesis. J Med Chem 60:1379\u20131399","journal-title":"J Med Chem"},{"key":"9997_CR108","doi-asserted-by":"crossref","first-page":"5023","DOI":"10.1128\/JB.187.14.5023-5028.2005","volume":"187","author":"SL Tran","year":"2005","unstructured":"Tran SL, Cook GM (2005) The F1Fo-ATP synthase of Mycobacterium smegmatis is essential for growth. J Bac 187:5023\u20135028","journal-title":"J Bac"},{"key":"9997_CR109","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1128\/MMBR.54.2.101-129.1990","volume":"54","author":"BL Trumpower","year":"1990","unstructured":"Trumpower BL (1990) Cytochrome bc 1 complexes of microorganisms. Microbiol Rev 54:101\u2013129","journal-title":"Microbiol Rev"},{"key":"9997_CR110","doi-asserted-by":"crossref","first-page":"9371","DOI":"10.1021\/acs.jmedchem.5b01542","volume":"58","author":"R Westhuyzen van der","year":"2015","unstructured":"van der Westhuyzen R et al (2015) Pyrrolo[3, 4-c]pyridine-1, 3(2H)-diones: a novel antimycobacterial class targeting mycobacterial respiration. J Med Chem 58:9371\u20139381","journal-title":"J Med Chem"},{"key":"9997_CR111","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1164\/rccm.201001-0077OC","volume":"182","author":"A Deun Van","year":"2010","unstructured":"Van Deun A, Maug AKJ, Salim MAH, Das PK, Sarker MR, Daru P, Rieder HL (2010) Short, highly effective, and inexpensive standardized treatment of multidrug-resistant tuberculosis. Am J Respir Crit Care Med 182:684\u2013692","journal-title":"Am J Respir Crit Care Med"},{"key":"9997_CR112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2012.02.033","volume":"51","author":"B Villemagne","year":"2012","unstructured":"Villemagne B, Crauste C, Flipo M, Baulard AR, D\u00e9prez B, Willand N (2012) Tuberculosis: the drug development pipeline at a glance. Eur J Med Chem 51:1\u201316","journal-title":"Eur J Med Chem"},{"key":"9997_CR113","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1146\/annurev.biophys.37.032807.130018","volume":"37","author":"C Ballmoos von","year":"2008","unstructured":"von Ballmoos C, Cook GM, Dimroth P (2008) Unique rotary ATP synthase and its biological diversity. Annu Rev Biophys 37:43\u201364","journal-title":"Annu Rev Biophys"},{"key":"9997_CR114","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.1016\/S0021-9258(20)82143-7","volume":"259","author":"G Jagow Von","year":"1984","unstructured":"Von Jagow G, Ljungdahl PO, Graf P, Ohnishi T, Trumpower B (1984) An inhibitor of mitochondrial respiration which binds to cytochrome b and displaces quinone from the iron-sulfur protein of the cytochrome bc 1 complex. J Biol Chem 259:6318\u20136326","journal-title":"J Biol Chem"},{"issue":"10","key":"9997_CR115","doi-asserted-by":"crossref","first-page":"e1002287","DOI":"10.1371\/journal.ppat.1002287","volume":"7","author":"S Watanabe","year":"2011","unstructured":"Watanabe S, Zimmermann M, Goodwin MB, Sauer U, Barry CE, Boshoff HI (2011) Fumerate reductase activity maintains an energized membrane in anaerobic Mycobacterium tuberculosis. PLoS Pathog 7(10):e1002287","journal-title":"PLoS Pathog"},{"key":"9997_CR116","volume-title":"Global tuberculosis report","author":"WHO","year":"2016","unstructured":"WHO (2016) Global tuberculosis report. World Health Organization, Geneva"},{"key":"9997_CR117","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1126\/science.277.5322.60","volume":"277","author":"D Xia","year":"1997","unstructured":"Xia D et al (1997) Crystal structure of the cytochrome bc 1 complex from bovine heart mitochondria. Science 277:60\u201366","journal-title":"Science"},{"key":"9997_CR118","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.bbabio.2012.11.008","volume":"1827","author":"D Xia","year":"2013","unstructured":"Xia D, Esser L, Tang W-K, Zhou F, Zhou Y, Yu L, Yu C-A (2013) Structural analysis of cytochrome bc 1 complexes: implications to the mechanism of function. Biochim Biophys Acta 1827:1278\u20131294","journal-title":"Biochim Biophys Acta"},{"key":"9997_CR119","doi-asserted-by":"crossref","first-page":"10276","DOI":"10.1074\/jbc.M110.200501","volume":"286","author":"T Yano","year":"2011","unstructured":"Yano T, Kassovska-Bratinova S, The JS, Winkler J, Sullivan K, Isaacs A, Schechter NM, Rubin H (2011) Reduction of clofazimine by mycobacterial type 2 NADH: quinone oxidoreductase. J Biol Chem 286:10276\u201310287","journal-title":"J Biol Chem"},{"key":"9997_CR120","volume-title":"Development of new antituberculosis drugs","author":"W Yew","year":"2006","unstructured":"Yew W (2006) Development of new antituberculosis drugs. Nova Science Publishers, New York"},{"key":"9997_CR121","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbabio.2006.04.029","volume":"1757","author":"DB Zorov","year":"2006","unstructured":"Zorov DB, Juhaszova M, Sollott SJ (2006) Mitochondrial ROS-induced ROS release: an update and review. Biochim Biophys Acta 1757:509\u2013517","journal-title":"Biochim Biophys Acta"}],"container-title":["The Journal of Membrane Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00232-017-9997-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00232-017-9997-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00232-017-9997-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T21:41:36Z","timestamp":1693172496000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00232-017-9997-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,2]]},"references-count":121,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["9997"],"URL":"https:\/\/doi.org\/10.1007\/s00232-017-9997-3","relation":{},"ISSN":["0022-2631","1432-1424"],"issn-type":[{"value":"0022-2631","type":"print"},{"value":"1432-1424","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,2]]}}}