{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:04:52Z","timestamp":1740107092810,"version":"3.37.3"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022QB126","ZR2021QC044"],"award-info":[{"award-number":["ZR2022QB126","ZR2021QC044"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21906065"],"award-info":[{"award-number":["21906065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Membrane Biol"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1007\/s00232-024-00305-4","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T11:02:51Z","timestamp":1704970971000},"page":"131-142","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Chemical Fixatives on Kinetic Measurements of Biomolecular Interaction on Cell Membrane"],"prefix":"10.1007","volume":"257","author":[{"given":"Tianbao","family":"Dong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengyang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaru","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengcheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"305_CR1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s00232-019-00081-6","volume":"252","author":"MJ Akhunzada","year":"2019","unstructured":"Akhunzada MJ, Sagresti L, Catte A, Bhattacharjee N, D\u2019Agostino T, Brancato G (2019) Temperature dependence of the structure and dynamics of a dye-labeled lipid in a planar phospholipid bilayer: a computational study. J Membr Biol 252:227\u2013240","journal-title":"J Membr Biol"},{"key":"305_CR2","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.cell.2010.04.033","volume":"141","author":"SJ Altschuler","year":"2010","unstructured":"Altschuler SJ, Wu LF (2010) Cellular heterogeneity: do differences make a difference? Cell 141:559\u2013563","journal-title":"Cell"},{"key":"305_CR3","volume-title":"Concanavalin A as a Tool","author":"H Bittiger","year":"1976","unstructured":"Bittiger H, Schnebli P (1976) Concanavalin A as a Tool. Wiley, London"},{"key":"305_CR4","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.apradiso.2005.06.007","volume":"64","author":"H Bj\u00f6rke","year":"2006","unstructured":"Bj\u00f6rke H, Andersson K (2006) Measuring the affinity of a radioligand with its receptor using a rotating cell dish with in situ reference area. Appl Radiat Isot 64:32\u201337","journal-title":"Appl Radiat Isot"},{"key":"305_CR6","doi-asserted-by":"publisher","first-page":"4154","DOI":"10.1021\/mp500379d","volume":"11","author":"S Bondza","year":"2014","unstructured":"Bondza S, Stenberg J, Nestor M, Andersson K, Bj\u00f6rkelund H (2014) Conjugation effects on antibody-drug conjugates: evaluation of interaction kinetics in real time on living cells. Mol Pharm 11:4154\u20134163","journal-title":"Mol Pharm"},{"key":"305_CR5","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3389\/fimmu.2017.00455","volume":"8","author":"S Bondza","year":"2017","unstructured":"Bondza S, Foy E, Brooks J, Andersson K, Robinson J, Richalet P, Buijs J (2017) Real-time characterization of antibody binding to receptors on living immune cells. Front Immunol 8:455","journal-title":"Front Immunol"},{"key":"305_CR7","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1097\/00006231-199301000-00013","volume":"14","author":"V Boonkitticharoen","year":"1993","unstructured":"Boonkitticharoen V, Laohathai K (1993) Variables influencing cell binding assays for antibody binding kinetics. Nucl Med Commun 14:70\u201375","journal-title":"Nucl Med Commun"},{"key":"305_CR8","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/978-3-7091-1312-7_14","volume-title":"The Chemistry of mycotoxins","author":"S Br\u00e4se","year":"2013","unstructured":"Br\u00e4se S, Gl\u00e4ser F, Kramer CS, Lindner S, Linsenmeier AM, Masters K-S, Meister AC, Ruff BM, Zhong S (2013) Cytochalasans. In: Br\u00e4se S, Gl\u00e4ser F, Kramer C, Lindner S, Linsenmeier AM, Masters K-S, Meister AC, Ruff BM, Zhong S (eds) The Chemistry of mycotoxins. Springer Vienna, Vienna, pp 207\u2013223"},{"key":"305_CR49","doi-asserted-by":"publisher","unstructured":"Chazotte B (2011) Labeling nuclear DNA using DAPI. Cold Spring Harb Protoc. https:\/\/doi.org\/10.1101\/pdb.prot5556","DOI":"10.1101\/pdb.prot5556"},{"key":"305_CR9","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.bios.2017.08.032","volume":"99","author":"JY Chen","year":"2018","unstructured":"Chen JY, Penn LS, Xi J (2018) Quartz crystal microbalance: sensing cell-substrate adhesion and beyond. Biosens Bioelectron 99:593\u2013602","journal-title":"Biosens Bioelectron"},{"key":"305_CR10","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/nature01392","volume":"421","author":"H-S Cho","year":"2003","unstructured":"Cho H-S, Mason K, Ramyar KX, Stanley AM, Gabelli SB, Denney DW, Leahy DJ (2003) Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature 421:756\u2013760","journal-title":"Nature"},{"key":"305_CR11","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s00216-021-03623-x","volume":"414","author":"M Conrad","year":"2022","unstructured":"Conrad M, Fechner P, Proll G, Gauglitz G (2022) Comparison of methods for quantitative biomolecular interaction analysis. Anal Bioanal Chem 414:661\u2013673","journal-title":"Anal Bioanal Chem"},{"key":"305_CR12","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/aja.1001070105","volume":"107","author":"WT Dempster","year":"1960","unstructured":"Dempster WT (1960) Rates of penetration of fixing fluids. Am J Anat 107:59\u201372","journal-title":"Am J Anat"},{"key":"305_CR13","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jpba.2018.03.065","volume":"155","author":"B Donczo","year":"2018","unstructured":"Donczo B, Guttman A (2018) Biomedical analysis of formalin-fixed, paraffin-embedded tissue samples: the Holy Grail for molecular diagnostics. J Pharm Biomed Anal 155:125\u2013134","journal-title":"J Pharm Biomed Anal"},{"key":"305_CR14","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1021\/acs.molpharmaceut.2c01047","volume":"20","author":"T Dong","year":"2023","unstructured":"Dong T, Han C, Liu X, Wang Z, Wang Y, Kang Q, Wang P, Zhou F (2023) Live cells versus fixated cells: kinetic measurements of biomolecular interactions with the LigandTracer method and surface plasmon resonance microscopy. Mol Pharm 20:2094\u20132104","journal-title":"Mol Pharm"},{"key":"305_CR15","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1179\/his.2001.24.3.173","volume":"24","author":"I Eltoum","year":"2001","unstructured":"Eltoum I, Fredenburgh J, Myers RB, Grizzle WE (2001) Introduction to the theory and practice of fixation of tissues. J Histotechnol 24:173\u2013190","journal-title":"J Histotechnol"},{"key":"305_CR16","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.acthis.2018.11.006","volume":"121","author":"A Gnerucci","year":"2019","unstructured":"Gnerucci A, Faraoni P, Romano G, Fusi F (2019) Unstained cell imaging: morphological insights from coupled fixation and darkfield microscopy. Acta Histochem 121:248\u2013252","journal-title":"Acta Histochem"},{"key":"305_CR17","doi-asserted-by":"publisher","first-page":"746822","DOI":"10.3389\/fmolb.2021.746822","volume":"8","author":"A Goumenou","year":"2021","unstructured":"Goumenou A, Delaunay N, Pichon V (2021) Recent advances in lectin-based affinity sorbents for protein glycosylation studies. Front Mol Biosci 8:746822","journal-title":"Front Mol Biosci"},{"key":"305_CR18","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/hae.13110","volume":"23","author":"J Grandoni","year":"2017","unstructured":"Grandoni J, Perret G, Forier C (2017) Kinetic analysis and binding studies of a new recombinant human factor VIIa for treatment of haemophilia. Haemophilia 23:300\u2013308","journal-title":"Haemophilia"},{"key":"305_CR19","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.tips.2021.05.006","volume":"42","author":"E Gulezian","year":"2021","unstructured":"Gulezian E, Crivello C, Bednenko J, Zafra C, Zhang Y, Colussi P, Hussain S (2021) Membrane protein production and formulation for drug discovery. Trends Pharmacol Sci 42:657\u2013674","journal-title":"Trends Pharmacol Sci"},{"key":"305_CR20","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41580-021-00413-2","volume":"23","author":"RS Hegde","year":"2022","unstructured":"Hegde RS, Keenan RJ (2022) The mechanisms of integral membrane protein biogenesis. Nat Rev Mol Cell Biol 23:107\u2013124","journal-title":"Nat Rev Mol Cell Biol"},{"key":"305_CR21","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.acthis.2018.10.011","volume":"121","author":"VVV Hira","year":"2019","unstructured":"Hira VVV, de Jong AL, Ferro K, Khurshed M, Molenaar RJ, Van Noorden CJF (2019) Comparison of different methodologies and cryostat versus paraffin sections for chromogenic immunohistochemistry. Acta Histochem 121:125\u2013134","journal-title":"Acta Histochem"},{"key":"305_CR22","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.vibspec.2016.10.012","volume":"91","author":"AJ Hobro","year":"2017","unstructured":"Hobro AJ, Smith NI (2017) An evaluation of fixation methods: spatial and compositional cellular changes observed by Raman imaging. Vib Spectrosc 91:31\u201345","journal-title":"Vib Spectrosc"},{"key":"305_CR23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/978-3-319-19944-3_2","volume-title":"Plant microtechniques and protocols","author":"BQ Huang","year":"2015","unstructured":"Huang BQ, Yeung EC (2015) Chemical and physical fixation of cells and tissues: an overview. In: Yeung ECT, Stasolla C, Sumner MJ, Huang BQ (eds) Plant microtechniques and protocols. Springer International Publishing, Cham, pp 23\u201343"},{"key":"305_CR24","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/s42003-022-03437-2","volume":"5","author":"T Ichikawa","year":"2022","unstructured":"Ichikawa T, Wang D, Miyazawa K, Miyata K, Oshima M, Fukuma T (2022) Chemical fixation creates nanoscale clusters on the cell surface by aggregating membrane proteins. Commun Biol 5:487","journal-title":"Commun Biol"},{"key":"305_CR25","first-page":"165","volume":"9","author":"H Jijakli","year":"2002","unstructured":"Jijakli H, Zhang HX, Dura E, Ramirez R, Sener A, Malaisse WJ (2002) Effects of cytochalasin B and D upon insulin release and pancreatic islet cell metabolism. Int J Mol Med 9:165\u2013172","journal-title":"Int J Mol Med"},{"key":"305_CR26","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1177\/002215540305100315","volume":"51","author":"H Jockusch","year":"2003","unstructured":"Jockusch H, Voigt S, Eberhard D (2003) Localization of GFP in frozen sections from unfixed mouse tissues: immobilization of a highly soluble marker protein by formaldehyde vapor. J Histochem Cytochem 51:401\u2013404","journal-title":"J Histochem Cytochem"},{"key":"305_CR27","doi-asserted-by":"publisher","first-page":"6429","DOI":"10.1021\/la4012229","volume":"29","author":"R Kawamura","year":"2013","unstructured":"Kawamura R, Mishima M, Ryu S, Arai Y, Okose M, Silberberg YR, Rao SR, Nakamura C (2013) Controlled cell adhesion using a biocompatible anchor for membrane-conjugated bovine serum albumin\/bovine serum albumin mixed layer. Langmuir 29:6429\u20136433","journal-title":"Langmuir"},{"key":"305_CR28","doi-asserted-by":"publisher","first-page":"35787","DOI":"10.1039\/C8RA07059H","volume":"8","author":"H Khalili","year":"2018","unstructured":"Khalili H, Brocchini S, Khaw PT, Filippov SK (2018) Comparative thermodynamic analysis in solution of a next generation antibody mimetic to VEGF. RSC Adv 8:35787\u201335793","journal-title":"RSC Adv"},{"key":"305_CR29","doi-asserted-by":"publisher","first-page":"10577","DOI":"10.3390\/ijms221910577","volume":"22","author":"SM Kremsreiter","year":"2021","unstructured":"Kremsreiter SM, Kroell AH, Weinberger K, Boehm H (2021) Glycan-lectin interactions in cancer and viral infections and how to disrupt them. Int J Mol Sci 22:10577","journal-title":"Int J Mol Sci"},{"key":"305_CR30","doi-asserted-by":"publisher","first-page":"e201800203","DOI":"10.1002\/jbio.201800203","volume":"12","author":"SM Levchenko","year":"2019","unstructured":"Levchenko SM, Peng X, Liu L, Qu J (2019) The impact of cell fixation on coherent anti-stokes Raman scattering signal intensity in neuronal and glial cell lines. J Biophotonics 12:e201800203","journal-title":"J Biophotonics"},{"key":"305_CR31","doi-asserted-by":"publisher","first-page":"4123","DOI":"10.3390\/ijms22084123","volume":"22","author":"CW Lin","year":"2021","unstructured":"Lin CW, Lerner RA (2021) Antibody libraries as tools to discover functional antibodies and receptor pleiotropism. Int J Mol Sci 22:4123","journal-title":"Int J Mol Sci"},{"key":"305_CR32","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1002\/jps.20178","volume":"93","author":"ED Lobo","year":"2004","unstructured":"Lobo ED, Hansen RJ, Balthasar JP (2004) Antibody pharmacokinetics and pharmacodynamics. J Pharm Sci 93:2645\u20132668","journal-title":"J Pharm Sci"},{"key":"305_CR33","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1007\/s00216-009-3411-7","volume":"396","author":"AD Meade","year":"2010","unstructured":"Meade AD, Clarke C, Draux F, Sockalingum GD, Manfait M, Lyng FM, Byrne HJ (2010) Studies of chemical fixation effects in human cell lines using Raman microspectroscopy. Anal Bioanal Chem 396:1781\u20131791","journal-title":"Anal Bioanal Chem"},{"key":"305_CR34","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S0079-6336(00)80001-7","volume":"35","author":"V Mizuhira","year":"2000","unstructured":"Mizuhira V, Hasegawa H, Notoya M (2000) Fixation and imaging of biological elements: heavy metals, diffusible substances, ions, peptides, and lipids. Prog Histochem Cytochem 35:67\u2013183","journal-title":"Prog Histochem Cytochem"},{"key":"305_CR35","doi-asserted-by":"publisher","first-page":"4286","DOI":"10.1016\/S0021-9258(19)43770-8","volume":"248","author":"KD Noonan","year":"1973","unstructured":"Noonan KD, Burger MM (1973) Binding of [3H] concanavalin A to normal and transformed cells. J Biol Chem 248:4286\u20134292","journal-title":"J Biol Chem"},{"key":"305_CR36","doi-asserted-by":"publisher","first-page":"43006","DOI":"10.1038\/srep43006","volume":"7","author":"D Peiris","year":"2017","unstructured":"Peiris D, Spector AF, Lomax-Browne H, Azimi T, Ramesh B, Loizidou M, Welch H, Dwek MV (2017) Cellular glycosylation affects herceptin binding and sensitivity of breast cancer cells to doxorubicin and growth factors. Sci Rep 7:43006","journal-title":"Sci Rep"},{"key":"305_CR37","doi-asserted-by":"publisher","first-page":"7479","DOI":"10.1158\/1078-0432.CCR-09-0636","volume":"15","author":"PR Pohlmann","year":"2009","unstructured":"Pohlmann PR, Mayer IA, Mernaugh R (2009) Resistance to trastuzumab in breast cancer. Clin Cancer Res 15:7479\u20137491","journal-title":"Clin Cancer Res"},{"key":"305_CR38","doi-asserted-by":"publisher","first-page":"349","DOI":"10.2174\/1568009618666180628101059","volume":"19","author":"G Poiroux","year":"2019","unstructured":"Poiroux G, Barre A, Roug\u00e9 P, Benoist H (2019) Targeting glycosylation aberrations to improve the efficiency of cancer phototherapy. Curr Cancer Drug Targets 19:349\u2013359","journal-title":"Curr Cancer Drug Targets"},{"key":"305_CR39","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/978-1-4939-7172-5_5","volume":"1641","author":"JA Ramos-Vara","year":"2017","unstructured":"Ramos-Vara JA (2017) Principles and methods of immunohistochemistry. Methods Mol Biol 1641:115\u2013128","journal-title":"Methods Mol Biol"},{"key":"305_CR40","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/s41581-019-0129-4","volume":"15","author":"C Reily","year":"2019","unstructured":"Reily C, Stewart TJ, Renfrow MB, Novak J (2019) Glycosylation in health and disease. Nat Rev Nephrol 15:346\u2013366","journal-title":"Nat Rev Nephrol"},{"key":"305_CR41","doi-asserted-by":"publisher","first-page":"099689","DOI":"10.1101\/pdb.prot099689","volume":"2020","author":"SJ Rodig","year":"2020","unstructured":"Rodig SJ (2020) Fixing attached cells for staining. Cold Spring Harb Protoc 2020:099689","journal-title":"Cold Spring Harb Protoc"},{"key":"305_CR42","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1369\/0022155418824092","volume":"67","author":"SR Sompuram","year":"2019","unstructured":"Sompuram SR, Vani K, Schaedle AK, Balasubramanian A, Bogen SA (2019) Selecting an optimal positive IHC control for verifying antigen retrieval. J Histochem Cytochem 67:275\u2013289","journal-title":"J Histochem Cytochem"},{"key":"305_CR43","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1007\/s00249-021-01560-2","volume":"50","author":"D Spiegelberg","year":"2021","unstructured":"Spiegelberg D, Stenberg J, Richalet P, Vanhove M (2021) KD determination from time-resolved experiments on live cells with LigandTracer and reconciliation with end-point flow cytometry measurements. Eur Biophys J 50:979\u2013991","journal-title":"Eur Biophys J"},{"key":"305_CR44","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ab.2017.05.009","volume":"530","author":"F Steinicke","year":"2017","unstructured":"Steinicke F, Oltmann-Norden I, W\u00e4tzig H (2017) Long term kinetic measurements revealing precision and general performance of surface plasmon resonance biosensors. Anal Biochem 530:94\u2013103","journal-title":"Anal Biochem"},{"key":"305_CR45","doi-asserted-by":"publisher","first-page":"1260419","DOI":"10.1126\/science.1260419","volume":"347","author":"M Uhl\u00e9n","year":"2015","unstructured":"Uhl\u00e9n M, Fagerberg L, Hallstr\u00f6m BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson \u00c5, Kampf C, Sj\u00f6stedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pont\u00e9n F (2015) Proteomics. Tissue-based map of the human proteome. Science 347:1260419","journal-title":"Science"},{"key":"305_CR46","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/nchem.1434","volume":"4","author":"W Wang","year":"2012","unstructured":"Wang W, Yang Y, Wang S, Nagaraj VJ, Liu Q, Wu J, Tao N (2012) Label-free measuring and mapping of binding kinetics of membrane proteins in single living cells. Nat Chem 4:846\u2013853","journal-title":"Nat Chem"},{"key":"305_CR47","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev-bioeng-092115-025322","volume":"18","author":"H Yin","year":"2016","unstructured":"Yin H, Flynn AD (2016) Drugging membrane protein interactions. Annu Rev Biomed Eng 18:51\u201376","journal-title":"Annu Rev Biomed Eng"},{"key":"305_CR48","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1002\/anie.201908806","volume":"59","author":"XL Zhou","year":"2020","unstructured":"Zhou XL, Yang Y, Wang S, Liu XW (2020) Surface plasmon resonance microscopy: from single-molecule sensing to single-cell imaging. Angew Chem Int Ed Engl 59:1776\u20131785","journal-title":"Angew Chem Int Ed Engl"}],"container-title":["The Journal of Membrane Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00232-024-00305-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00232-024-00305-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00232-024-00305-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T10:02:05Z","timestamp":1712743325000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00232-024-00305-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,11]]},"references-count":49,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["305"],"URL":"https:\/\/doi.org\/10.1007\/s00232-024-00305-4","relation":{},"ISSN":["0022-2631","1432-1424"],"issn-type":[{"type":"print","value":"0022-2631"},{"type":"electronic","value":"1432-1424"}],"subject":[],"published":{"date-parts":[[2024,1,11]]},"assertion":[{"value":"18 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There are no conflicts to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}