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However, although many of them have been functionally characterized, they remain underutilized as pharmacological agents, despite their evident therapeutic potential. In this review, we discuss the physicochemical properties of short scorpion venom antimicrobial peptides (ssAMPs). Being generally short (13\u201325 aa) and amidated, their proven antimicrobial activity is generally explained by parameters such as their net charge, the hydrophobic moment, or the degree of helicity. However, for a complete understanding of their biological activities, also considering the properties of the target membranes is of great relevance. Here, with an extensive analysis of the physicochemical, structural, and thermodynamic parameters associated with these biomolecules, we propose a theoretical framework for the rational design of new antimicrobial drugs. Through a comparison of these physicochemical properties with the bioactivity of ssAMPs in pathogenic bacteria such as\n Staphylococcus aureus<\/jats:italic>\n or\n Acinetobacter baumannii<\/jats:italic>\n , it is evident that in addition to the net charge, the hydrophobic moment, electrostatic energy, or intrinsic flexibility are determining parameters to understand their performance. Although the correlation between these parameters is very complex, the consensus of our analysis suggests that there is a delicate balance between them and that modifying one affects the rest. Understanding the contribution of lipid composition to their bioactivities is also underestimated, which suggests that for each peptide, there is a physiological context to consider for the rational design of new drugs.\n <\/jats:p>\n \n Graphical Abstract<\/jats:bold>\n <\/jats:p>","DOI":"10.1007\/s00232-024-00315-2","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T02:01:45Z","timestamp":1720663305000},"page":"165-205","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A Critical Review of Short Antimicrobial Peptides from Scorpion Venoms, Their Physicochemical Attributes, and Potential for the Development of New Drugs"],"prefix":"10.1007","volume":"257","author":[{"given":"Pedro Alejandro","family":"Fong-Coronado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Quintero-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Balleza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"issue":"12","key":"315_CR1","doi-asserted-by":"publisher","DOI":"10.1002\/psc.3219","volume":"25","author":"ICC Acevedo","year":"2019","unstructured":"Acevedo ICC, Silva PI Jr, Silva FD, Ara\u00fajo I, Alves FL, Oliveira CS, Oliveira VX Jr (2019) IsCT-based analogs intending better biological activity. 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