{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:58:18Z","timestamp":1778162298473,"version":"3.51.4"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,6,17]],"date-time":"2018-06-17T00:00:00Z","timestamp":1529193600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuroradiology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s00234-018-2045-x","type":"journal-article","created":{"date-parts":[[2018,6,16]],"date-time":"2018-06-16T23:57:36Z","timestamp":1529193456000},"page":"813-820","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Rhinencephalon changes in tuberous sclerosis complex"],"prefix":"10.1007","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5130-3971","authenticated-orcid":false,"given":"Renzo","family":"Manara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Brotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuela","family":"Bugin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Federica","family":"Pelizza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Sartori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margherita","family":"Nosadini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Azzolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Iaconetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Parazzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Murgia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Peron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Canevini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Labriola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aglaia","family":"Vignoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Toldo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,6,17]]},"reference":[{"issue":"4","key":"2045_CR1","doi-asserted-by":"publisher","first-page":"e166","DOI":"10.3928\/19382359-20170320-01","volume":"46","author":"SC Randle","year":"2017","unstructured":"Randle SC (2017) Tuberous sclerosis complex: a review. Pediatr Ann 46(4):e166\u2013e171","journal-title":"Pediatr Ann"},{"key":"2045_CR2","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/S1474-4422(15)00069-1","volume":"14","author":"P Curatolo","year":"2015","unstructured":"Curatolo P, Moavero R, de Vries PJ (2015) Neurological and neuropsychiatric aspects of tuberous sclerosis complex. Lancet Neurol 14:733\u2013745","journal-title":"Lancet Neurol"},{"key":"2045_CR3","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.pediatrneurol.2013.08.001","volume":"49","author":"H Northrup","year":"2013","unstructured":"Northrup H, Krueger DA, on behalf of the International Tuberous Sclerosis Complex Consensus Group: Tuberous Sclerosis Complex Diagnostic Criteria Update (2013) Recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference. Pediatr Neurol 49:243\u2013254","journal-title":"Pediatr Neurol"},{"issue":"2","key":"2045_CR4","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.ejpn.2015.11.011","volume":"20","author":"C Kingswood","year":"2016","unstructured":"Kingswood C, Bolton P, Crawford P, Harland C, Johnson SR, Sampson JR, Shepherd C, Spink J, Demuth D, Lucchese L, Nasuti P, Gray E, Pinnegar A, Magestro M (2016) The clinical profile of tuberous sclerosis complex (TSC) in the United Kingdom: a retrospective cohort study in the Clinical Practice Research Datalink (CPRD). Eur J Paediatr Neurol 20(2):296\u2013308","journal-title":"Eur J Paediatr Neurol"},{"issue":"6","key":"2045_CR5","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1440-1789.2008.00920.x","volume":"28","author":"K Boer","year":"2008","unstructured":"Boer K, Troost D, Jansen F, Nellist M, van den Ouweland AM, Geurts JJ, Spliet WG, Crino P, Aronica E (2008) Clinicopathological and immunohistochemical findings in an autopsy case of tuberous sclerosis complex. Neuropathology 28(6):577\u2013590","journal-title":"Neuropathology"},{"key":"2045_CR6","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1177\/0883073813492386","volume":"29","author":"S Boronat","year":"2014","unstructured":"Boronat S, Shaaya EA, Auladell M, Thiele EA, Caruso P (2014) Intracranial arteriopathy in tuberous sclerosis complex. J Child Neurol 29:912\u2013919","journal-title":"J Child Neurol"},{"key":"2045_CR7","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/b137533","volume-title":"Pediatric neuroradiology brain","author":"P Tortori-Donati","year":"2005","unstructured":"Tortori-Donati P, Rossi A (2005) Pediatric neuroradiology brain. Springer-Verlag, Berlin, pp 785\u2013800"},{"issue":"6","key":"2045_CR8","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1177\/0883073816685192","volume":"32","author":"HB Sarnat","year":"2017","unstructured":"Sarnat HB, Flores-Sarnat L (2017) Olfactory development, part 2: neuroanatomic maturation and dysgeneses. J Child Neurol 32(6):579\u2013593","journal-title":"J Child Neurol"},{"issue":"9","key":"2045_CR9","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.3174\/ajnr.A3946","volume":"35","author":"R Manara","year":"2014","unstructured":"Manara R, Salvalaggio A, Favaro A, Palumbo V, Citton V, Elefante A, Brunetti A, Di Salle F, Bonanni G, Sinisi AA (2014) Kallmann syndrome neuroradiological study group. Brain changes in Kallmann syndrome. AJNR Am J Neuroradiol 35(9):1700\u20131706","journal-title":"AJNR Am J Neuroradiol"},{"issue":"8","key":"2045_CR10","first-page":"3010","volume":"81","author":"R Quinton","year":"1996","unstructured":"Quinton R, Duke VM, de Zoysa PA, Platts AD, Valentine A, Kendall B, Pickman S, Kirk JM, Besser GM, Jacobs HS, Bouloux PM (1996) The neuroradiology of Kallmann\u2019s syndrome: a genotypic and phenotypic analysis. J Clin Endocrinol Metab 81(8):3010\u20133017","journal-title":"J Clin Endocrinol Metab"},{"issue":"2\u20133","key":"2045_CR11","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/0022-510X(88)90244-4","volume":"87","author":"GA Le\u00f3n de","year":"1988","unstructured":"de Le\u00f3n GA, Zaeri N, Foley CM (1988) Olfactory hamartomas in tuberous sclerosis. J Neurol Sci 87(2\u20133):187\u2013194","journal-title":"J Neurol Sci"},{"issue":"4","key":"2045_CR12","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1093\/hmg\/ddr511","volume":"21","author":"DM Feliciano","year":"2012","unstructured":"Feliciano DM, Quon JL, Su T, Taylor MM, Bordey A (2012) Postnatal neurogenesis generates heterotopias, olfactory micronodules and cortical infiltration following single-cell Tsc1 deletion. Hum Mol Genet 21(4):799\u2013810","journal-title":"Hum Mol Genet"},{"key":"2045_CR13","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.3174\/ajnr.A3507","volume":"34","author":"AM Wong","year":"2013","unstructured":"Wong AM, Wang HS, Schwartz ES, Toh CH, Zimmerman RA, Liu PL, Wu YM, Ng SH, Wang JJ (2013) Cerebral diffusion tensor MR tractography in tuberous sclerosis complex: correlation with neurologic severity and tract-based spatial statistical analysis. AJNR Am J Neuroradiol 34:1829\u20131835","journal-title":"AJNR Am J Neuroradiol"},{"issue":"9","key":"2045_CR14","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/alr.21550","volume":"5","author":"G Ottaviano","year":"2015","unstructured":"Ottaviano G, Cantone E, D'Errico A, Salvalaggio A, Citton V, Scarpa B, Favaro A, Sinisi AA, Liuzzi R, Bonanni G, Di Salle F, Elefante A, Manara R, Staffieri A, Martini A, Brunetti A (2015) Sniffin\u2019 Sticks and olfactory system imaging in patients with Kallmann syndrome. Int Forum Allergy Rhinol 5(9):855\u2013861","journal-title":"Int Forum Allergy Rhinol"},{"issue":"3","key":"2045_CR15","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1517\/14740338.2013.782000","volume":"12","author":"SM Cabrera","year":"2013","unstructured":"Cabrera SM, Rogol AD (2013) Testosterone exposure in childhood: discerning pathology from physiology. Expert Opin Drug Saf 12(3):375\u2013388","journal-title":"Expert Opin Drug Saf"},{"key":"2045_CR16","doi-asserted-by":"crossref","unstructured":"Manara R, Bugin S, Pelizza MF, Sartori S, Nosadini M, Labriola F, Canevini P, Vignoli A, Toldo I (2018) Genetic and imaging features of cerebellar abnormalities in tuberous sclerosis complex: more insights into their pathogenesis. Dev Med Child Neurol 60(7):724-725","DOI":"10.1111\/dmcn.13769"},{"issue":"10","key":"2045_CR17","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1111\/dmcn.13499","volume":"59","author":"S Boronat","year":"2017","unstructured":"Boronat S, Thiele EA, Caruso P (2017) Cerebellar lesions are associated with TSC2 mutations in tuberous sclerosis complex: a retrospective record review study. Dev Med Child Neurol 59(10):1071\u20131076","journal-title":"Dev Med Child Neurol"},{"key":"2045_CR18","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1097\/GIM.0b013e31803068c7","volume":"9","author":"KS Au","year":"2007","unstructured":"Au KS, Williams AT, Roach ES, Batchelor L, Sparagana SP, Delgado MR, Wheless JW, Baumgartner JE, Roa BB, Wilson CM, Smith-Knuppel TK, Cheung MY, Whittemore VH, King TM, Northrup H (2007) Genotype\/phenotype correlation in 325 individuals referred for a diagnosis of tuberous sclerosis complex in the United States. Genet Med 9:88\u2013100","journal-title":"Genet Med"}],"container-title":["Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00234-018-2045-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00234-018-2045-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00234-018-2045-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T14:38:14Z","timestamp":1720363094000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00234-018-2045-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,17]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["2045"],"URL":"https:\/\/doi.org\/10.1007\/s00234-018-2045-x","relation":{},"ISSN":["0028-3940","1432-1920"],"issn-type":[{"value":"0028-3940","type":"print"},{"value":"1432-1920","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,17]]},"assertion":[{"value":"24 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"No funding was received for this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of retrospective study formal consent is not required.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}