{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:42:59Z","timestamp":1775576579135,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Nicolaus Copernicus University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuroradiology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Purpose<\/jats:title>\n<jats:p>The aim of this study is to use functional magnetic resonance (fMRI) to analyse the cortical presentation of selected language functions in patients after a total laryngectomy.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Eighteen patients after total laryngectomy treated with electrolarynx speech and 18 volunteers were included. The mean number of patients\u2019 post-operative speech rehabilitation sessions was five (range of 3\u20138 sessions). Four paradigms were used, including noun generation, pseudoword reading, reading phrases with pseudowords, and nonliteral sign reproduction.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>In noun, the most significant difference between the groups was the stronger activation of both lingual gyri in the volunteers. Pseudoword reading resulted in stronger activations in patients than in volunteers in the lingual gyri, the right cerebellum, the right Broca\u2019s area, and the right parietal operculum. Reading phrases with pseudowords involved different parts of the Brodmann area 40. During nonliteral sign reproduction, there was a stronger activation of the left Broca\u2019s area in volunteers and a stronger activation of the left premotor cortex in patients.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This study provides evidence of altered cortical activation in response to language tasks in patients after a laryngectomy compared with healthy volunteers, which may be considered brain plasticity in response to a laryngectomy.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00234-020-02407-x","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T17:03:18Z","timestamp":1586192598000},"page":"843-849","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cortical presentation of language functions in patients after total laryngectomy: a fMRI study"],"prefix":"10.1007","volume":"62","author":[{"given":"Aleksandra","family":"Wypych","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Wierzchowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Burduk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"Zawada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Nadolska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbigniew","family":"Serafin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,4,6]]},"reference":[{"key":"2407_CR1","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1111\/j.1749-6632.1976.tb25546.x","volume":"280","author":"JE Bogen","year":"1976","unstructured":"Bogen JE, Bogen GM (1976) Wernicke\u2019s region-where is it? Ann N Y Acad Sci 280:834\u2013843","journal-title":"Ann N Y Acad Sci"},{"key":"2407_CR2","doi-asserted-by":"publisher","first-page":"2518","DOI":"10.1038\/s41598-019-39696-z","volume":"9","author":"IE Bramati","year":"2019","unstructured":"Bramati IE, Rodrigues EC, Sim\u00f5es EL, Melo B, H\u00f6fle S, Moll J, Lent R, Tovar-Moll F (2019) Lower limb amputees undergo long-distance plasticity in sensorimotor functional connectivity. Sci Rep 9:2518","journal-title":"Sci Rep"},{"key":"2407_CR3","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/MOO.0000000000000358","volume":"25","author":"A Hurren","year":"2017","unstructured":"Hurren A, Miller N (2017) Voice outcomes post total laryngectomy. Curr Opin Otolaryngol Head Neck Surg 25:205\u2013210","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"2407_CR4","doi-asserted-by":"publisher","first-page":"4689","DOI":"10.1093\/cercor\/bhu152","volume":"25","author":"J Fridriksson","year":"2015","unstructured":"Fridriksson J, Fillmore P, Guo D, Rorden C (2015) Chronic Broca\u2019s aphasia is caused by damage to Broca\u2019s and Wernicke\u2019s areas. Cereb Cortex 25:4689\u20134696","journal-title":"Cereb Cortex"},{"key":"2407_CR5","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1006\/brln.1998.1953","volume":"64","author":"L Friedman","year":"1998","unstructured":"Friedman L, Kenny JT, Wise AL, Wu D, Stuve TA, Miller DA, Jesberger JA, Lewin JS (1998) Brain activation during silent word generation evaluated with functional MRI. Brain Lang 64:231\u2013256","journal-title":"Brain Lang"},{"key":"2407_CR6","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1093\/cercor\/bht428","volume":"25","author":"S Guediche","year":"2015","unstructured":"Guediche S, Holt LL, Laurent P, Lim SJ, Fiez JA (2015) Evidence for cerebellar contributions to adaptive plasticity in speech perception. Cereb Cortex 25:1867\u20131877","journal-title":"Cereb Cortex"},{"key":"2407_CR7","first-page":"1071","volume":"3","author":"T Hauck","year":"2018","unstructured":"Hauck T, Probst M, Zimmer C, Ringel F, Meyer B, Wohlschlaeger A, Krieg SM (2018) Language function shows comparable cortical patterns by functional MRI and repetitive nTMS in healthy volunteers. Brain Imaging Behav 3:1071\u20131092","journal-title":"Brain Imaging Behav"},{"key":"2407_CR8","doi-asserted-by":"publisher","first-page":"262","DOI":"10.4414\/sanp.2013.00211","volume":"164","author":"H Krestel","year":"2013","unstructured":"Krestel H (2013) Language and brain: historical introduction to models of language and aphasia. Swiss Arch Neurol Psychiatr Psychother 164:262\u2013265","journal-title":"Swiss Arch Neurol Psychiatr Psychother"},{"key":"2407_CR9","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S1361-8415(01)00036-6","volume":"5","author":"M Jenkinson","year":"2001","unstructured":"Jenkinson M, Smith SM (2001) A global optimisation method for robust affine registration of brain images. Med Image Anal 5:143\u2013156","journal-title":"Med Image Anal"},{"key":"2407_CR10","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1006\/nimg.2001.0931","volume":"14","author":"MW Woolrich","year":"2001","unstructured":"Woolrich MW, Ripley BD, Brady JM, Smith SM (2001) Temporal autocorrelation in univariate linear modelling of FMRI data. NeuroImage 14:1370\u20131386","journal-title":"NeuroImage"},{"key":"2407_CR11","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3389\/fmed.2017.00081","volume":"26","author":"KJ Lorenz","year":"2017","unstructured":"Lorenz KJ (2017) Rehabilitation after total laryngectomy\u2014a tribute to the pioneers of voice restoration in the last two centuries. Front Med 26:81","journal-title":"Front Med"},{"key":"2407_CR12","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.oraloncology.2018.08.023","volume":"86","author":"J Zenga","year":"2018","unstructured":"Zenga J, Goldsmith T, Bunting G, Deschler DG (2018) State of the art: rehabilitation of speech and swallowing after total laryngectomy. Oral Oncol 86:38\u201347","journal-title":"Oral Oncol"},{"key":"2407_CR13","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1080\/17483107.2017.1319428","volume":"13","author":"J Mertl","year":"2018","unstructured":"Mertl J, \u017d\u00e1\u010dkov\u00e1 E, \u0158epov\u00e1 B (2018) Quality of life of patients after total laryngectomy: the struggle against stigmatization and social exclusion using speech synthesis. Disabil Rehabil Assist Technol 13:342\u2013352","journal-title":"Disabil Rehabil Assist Technol"},{"key":"2407_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00405-017-4790-6","volume":"275","author":"KE van Sluis","year":"2018","unstructured":"van Sluis KE, van der Molen L, van Son RJJH, Bhairosing PA, van den Brekel MWM (2018) Objective and subjective voice outcomes after total laryngectomy: a systematic review. Eur Arch Otorhinolaryngol 275:11\u201326","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2407_CR15","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/S0030-6657(11)70672-2","volume":"65","author":"M Wierzchowska","year":"2011","unstructured":"Wierzchowska M, Burduk PK (2011) Early and late complications after implantation of the Provox 2 voice prosthesis in patients after total laryngectomy. Otolaryngol Pol 65:184\u2013187","journal-title":"Otolaryngol Pol"},{"key":"2407_CR16","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0030-6657(07)70424-9","volume":"61","author":"R Bilewicz","year":"2007","unstructured":"Bilewicz R, Burduk PK, Kopczynski A, Wierzchowska M (2007) The surgery voice rehabilitation after total laryngectomy with the Provox system. Otolaryngol Pol 61:265\u2013270","journal-title":"Otolaryngol Pol"},{"key":"2407_CR17","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1212\/WNL.0000000000002219","volume":"85","author":"JR Binder","year":"2015","unstructured":"Binder JR (2015) The Wernicke area: modern evidence and a reinterpretation. Neurology 85:2170\u20132175","journal-title":"Neurology"},{"key":"2407_CR18","doi-asserted-by":"publisher","first-page":"E65","DOI":"10.3174\/ajnr.A5345","volume":"38","author":"DF Black","year":"2017","unstructured":"Black DF, Vachha B, Mian A, Faro SH, Maheshwari M, Sair HI, Petrella JR, Pillai JJ, Welker K (2017) American Society of Functional Neuroradiology-recommended fMRI paradigm algorithms for presurgical language assessment. AJNR Am J Neuroradiol 38:E65\u2013E73","journal-title":"AJNR Am J Neuroradiol"},{"key":"2407_CR19","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/jmri.22604","volume":"34","author":"A Mahdavi","year":"2011","unstructured":"Mahdavi A, Houshmand S, Oghabian MA, Zarei M, Mahdavi A, Shoar MH, Ghanaati H (2011) Developing optimized fMRI protocol for clinical use: comparison of different language paradigms. J Magn Reson Imaging 34:413\u2013419","journal-title":"J Magn Reson Imaging"},{"key":"2407_CR20","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.brainres.2012.02.001","volume":"1447","author":"Y Wang","year":"2012","unstructured":"Wang Y, Holland SK, Vannest J (2012) Concordance of MEG and fMRI patterns in adolescents during verb generation. Brain Res 1447:79\u201390","journal-title":"Brain Res"},{"key":"2407_CR21","doi-asserted-by":"publisher","first-page":"236","DOI":"10.5709\/acp-0272-4","volume":"15","author":"M Popp","year":"2019","unstructured":"Popp M, Trumpp NM, Kiefer M (2019) Brain activation during conceptual processing of action and sound verbs. Adv Cogn Psychol 15:236\u2013255","journal-title":"Adv Cogn Psychol"},{"key":"2407_CR22","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1006\/nimg.2002.1132","volume":"17","author":"M Jenkinson","year":"2002","unstructured":"Jenkinson M, Bannister P, Brady M, Smith S (2002) Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimagine 17:825\u2013841","journal-title":"Neuroimagine"},{"key":"2407_CR23","unstructured":"Worsley KJ (2012) Statistical analysis of activation images. Ch 14, in functional MRI: an introduction to methods. Oxford Scholarship Online"},{"key":"2407_CR24","doi-asserted-by":"crossref","unstructured":"Amunts K, Kedo O, Kindler M, Pieperhoff P, Mohlberg H, Shah NJ, Habel U, Schneider F, Zilles K (2005) Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: intersubject variability and probability maps. Anat Embryol 210:343\u2013352","DOI":"10.1007\/s00429-005-0025-5"},{"key":"2407_CR25","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1093\/brain\/121.6.1013","volume":"121","author":"MM Mesulam","year":"1998","unstructured":"Mesulam MM (1998) From sensation to cognition. Brain 121:1013\u20131052","journal-title":"Brain"},{"key":"2407_CR26","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1093\/brain\/awx051","volume":"140","author":"Y Nakai","year":"2017","unstructured":"Nakai Y, Jeong JW, Brown EC, Rothermel R, Kojima K, Kambara T, Shah A, Mittal S, Sood S, Asano E (2017) Three- and four-dimensional mapping of speech and language in patients with epilepsy. Brain 140:1351\u20131370","journal-title":"Brain"},{"key":"2407_CR27","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/S0028-3932(96)00104-2","volume":"35","author":"DA Nathaniel-James","year":"1997","unstructured":"Nathaniel-James DA, Fletcher P, Frith CD (1997) The functional anatomy of verbal initiation and suppression using the Hayling test. Neuropsychologia 35:559\u2013566","journal-title":"Neuropsychologia"},{"key":"2407_CR28","doi-asserted-by":"publisher","first-page":"173","DOI":"10.17486\/gyr.3.1037","volume":"3","author":"N Prpic","year":"2015","unstructured":"Prpic N (2015) Language processing\u2013role of inferior parietal lobule. Gyrus 3:173\u2013175","journal-title":"Gyrus"},{"key":"2407_CR29","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.neuroimage.2012.06.022","volume":"63","author":"AM Rapp","year":"2012","unstructured":"Rapp AM, Mutschler DE, Erb M (2012) Where in the brain is nonliteral language? A coordinate-based meta-analysis of functional magnetic resonance imaging studies. Neuroimage 63:600\u2013610","journal-title":"Neuroimage"},{"key":"2407_CR30","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.neuropsychologia.2018.10.015","volume":"121","author":"E Ripamonti","year":"2018","unstructured":"Ripamonti E, Frustaci M, Zonca G, Aggujaro S, Molteni F, Luzzatti C (2018) Disentangling phonological and articulatory processing: a neuroanatomical study in aphasia. Neuropsychologia 121:175\u2013185","journal-title":"Neuropsychologia"},{"key":"2407_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0168-0102(00)00205-4","volume":"39","author":"KL Sakai","year":"2001","unstructured":"Sakai KL, Hashimoto R, Homae F (2001) Sentence processing in the cerebral cortex. Neurosci Res 39:1\u201310","journal-title":"Neurosci Res"},{"key":"2407_CR32","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0926-6410(00)00069-0","volume":"11","author":"RI Schubotz","year":"2001","unstructured":"Schubotz RI, von Cramon DY (2001) Functional organization of the lateral premotor cortex: fMRI reveals different regions activated by anticipation of object properties, location and speed. Brain Res Cogn Brain Res 11:97\u2013112","journal-title":"Brain Res Cogn Brain Res"},{"key":"2407_CR33","first-page":"1166","volume":"29","author":"M Shibata","year":"2007","unstructured":"Shibata M, Abe J, Terao A, Miyamoto T (2007) Neural mechanisms involved in the comprehension of metaphoric and literal sentences: an fMRI study. Brain Res 29:1166\u20131192","journal-title":"Brain Res"},{"key":"2407_CR34","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1037\/a0030266","volume":"139","author":"JS Taylor","year":"2013","unstructured":"Taylor JS, Rastle K, Davis MH (2013) Can cognitive models explain brain activation during word and pseudoword reading? A meta-analysis of 36 neuroimaging studies. Psychol Bull 139:766\u2013791","journal-title":"Psychol Bull"},{"key":"2407_CR35","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.cogbrainres.2005.02.009","volume":"24","author":"M Thioux","year":"2005","unstructured":"Thioux M, Pesenti M, Costes N, De Volder A, Seron X (2005) Task-independent semantic activation for numbers and animals. Brain Res Cogn Brain Res 24:284\u2013290","journal-title":"Brain Res Cogn Brain Res"},{"key":"2407_CR36","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1001\/archneur.1970.00480210090013","volume":"22","author":"K Wernicke","year":"1970","unstructured":"Wernicke K (1970) The aphasia symptom-complex: a psychological study on an anatomical basis. Arch Neurol 22:280\u2013282","journal-title":"Arch Neurol"},{"key":"2407_CR37","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1162\/jocn.2009.21056","volume":"21","author":"C Whitney","year":"2009","unstructured":"Whitney C, Weis S, Krings T, Huber W, Grossman M, Kircher T (2009) Task-dependent modulations of prefrontal and hippocampal activity during intrinsic word production. J Cogn Neurosci 21:697\u2013712","journal-title":"J Cogn Neurosci"},{"key":"2407_CR38","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.neulet.2004.08.078","volume":"371","author":"H Wiese","year":"2004","unstructured":"Wiese H, Stude P, Nebel K, de Greiff A, Forsting M, Diener HC, Keidel M (2004) Movement preparation in self-initiated versus externally triggered movements: an event-related fMRI-study. Neurosci Lett 371:220\u2013225","journal-title":"Neurosci Lett"},{"key":"2407_CR39","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.brainres.2005.10.094","volume":"1068","author":"TS Woodward","year":"2006","unstructured":"Woodward TS, Ruff CC, Ngan ET (2006) Short- and long-term changes in anterior cingulate activation during resolution of task-set competition. Brain Res 1068:161\u2013169","journal-title":"Brain Res"},{"key":"2407_CR40","doi-asserted-by":"crossref","unstructured":"Worsley KJ (2001) Statistical analysis of activation images. In: Jezzard P, Matthews PM, Smith SM. (Eds.) Functional MRI: an introduction to methods. Oxford Scholarship Online","DOI":"10.1093\/acprof:oso\/9780192630711.003.0014"},{"key":"2407_CR41","unstructured":"Wright A (2019) Higher cortical functions: language. Neuroscience Online. McGovern Medical School at UTHealth, Department of Neurobiology and Anatomy. Available via https:\/\/nba.uth.tmc.edu\/neuroscience\/m\/s4\/chapter08.html. Accessed 14 Sep 2019"},{"key":"2407_CR42","doi-asserted-by":"publisher","unstructured":"Wu SJ, Jenkins LM, Apple AC, Petersen J, Xiao F, Wang L, Yang FG (2019) Longitudinal fMRI task reveals neural plasticity in default mode network with disrupted executive-default coupling and selective attention after traumatic brain injury. Brain Imaging Behav:1\u201313. https:\/\/doi.org\/10.1007\/s11682-019-00094-8","DOI":"10.1007\/s11682-019-00094-8"},{"key":"2407_CR43","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1007\/s10548-015-0427-5","volume":"29","author":"J Yang","year":"2016","unstructured":"Yang J, Shu H (2016) Involvement of the motor system in comprehension of non-literal action language: a meta-analysis study. Brain Topogr 29:94\u2013107","journal-title":"Brain Topogr"}],"container-title":["Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00234-020-02407-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00234-020-02407-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00234-020-02407-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T23:19:32Z","timestamp":1617664772000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00234-020-02407-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,6]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["2407"],"URL":"https:\/\/doi.org\/10.1007\/s00234-020-02407-x","relation":{},"ISSN":["0028-3940","1432-1920"],"issn-type":[{"value":"0028-3940","type":"print"},{"value":"1432-1920","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,6]]},"assertion":[{"value":"4 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Institutional Review Board.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}