{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:25:14Z","timestamp":1778714714117,"version":"3.51.4"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007195","name":"Universit\u00e0 degli Studi di Napoli Federico II","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007195","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuroradiology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Recent evidences have suggested the possible presence of an involvement of the extrapyramidal system in Fabry disease (FD), a rare X-linked lysosomal storage disorder. We aimed to investigate the microstructural integrity of the main tracts of the cortico-striatal-thalamo-cortical loop in FD patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Forty-seven FD patients (mean age\u2009=\u200942.3\u2009\u00b1\u200916.3\u00a0years, M\/F\u2009=\u200928\/21) and 49 healthy controls (mean age\u2009=\u200942.3\u2009\u00b1\u200913.1\u00a0years, M\/F\u2009=\u200919\/28) were enrolled in this study. Fractional anisotropy (FA), axial (AD), radial (RD), and mean diffusivity (MD) maps were computed for each subject, and connectomes were built using a standard atlas. Diffusion metrics and connectomes were then combined to carry on a diffusion MRI tractometry analysis. The main afferent and efferent pathways of the cortico-striatal-thalamo-cortical loop (namely, bundles connecting the precentral gyrus (PreCG) with the striatum and the thalamus) were evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We found the presence of a microstructural involvement of cortico-striatal-thalamo-cortical loop in FD patients, predominantly affecting the left side. In particular, we found significant lower mean FA values of the left cortico-striatal fibers (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), coupled to higher MD (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) and RD (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) values, as well as higher MD (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) and RD (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) values at the level of the thalamo-cortical fibers.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We confirmed the presence of an alteration of the extrapyramidal system in FD patients, in line with recent evidences suggesting the presence of brain changes as a possible reflection of the subtle motor symptoms present in this condition. Our results suggest that, along with functional changes, microstructural damage of this pathway is also present in FD patients.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00234-020-02497-7","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T19:03:38Z","timestamp":1595444618000},"page":"1459-1466","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Microstructural damage of the cortico-striatal and thalamo-cortical fibers in Fabry disease: a diffusion MRI tractometry study"],"prefix":"10.1007","volume":"62","author":[{"given":"Sirio","family":"Cocozza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Schiavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5425-1890","authenticated-orcid":false,"given":"Giuseppe","family":"Pontillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Battocchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Riccio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Caccavallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodolinda","family":"Di Risi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Pisani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Daducci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Brunetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"2497_CR1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1750-1172-5-30","volume":"5","author":"DP Germain","year":"2010","unstructured":"Germain DP (2010) Fabry disease. Orphanet J Rare Dis 5:30. https:\/\/doi.org\/10.1186\/1750-1172-5-30","journal-title":"Orphanet J Rare Dis"},{"issue":"1","key":"2497_CR2","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1161\/STROKEAHA.114.006283","volume":"46","author":"E Kolodny","year":"2015","unstructured":"Kolodny E, Fellgiebel A, Hilz MJ, Sims K, Caruso P, Phan TG, Politei J, Manara R, Burlina A (2015) Cerebrovascular involvement in Fabry disease: current status of knowledge. Stroke 46(1):302\u2013313. https:\/\/doi.org\/10.1161\/STROKEAHA.114.006283","journal-title":"Stroke"},{"issue":"14","key":"2497_CR3","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1212\/WNL.0000000000001450","volume":"84","author":"M Lohle","year":"2015","unstructured":"Lohle M, Hughes D, Milligan A, Richfield L, Reichmann H, Mehta A, Schapira AH (2015) Clinical prodromes of neurodegeneration in Anderson-Fabry disease. Neurology 84(14):1454\u20131464. https:\/\/doi.org\/10.1212\/WNL.0000000000001450","journal-title":"Neurology"},{"issue":"6","key":"2497_CR4","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1007\/s13244-018-0664-8","volume":"9","author":"S Cocozza","year":"2018","unstructured":"Cocozza S, Russo C, Pontillo G, Pisani A, Brunetti A (2018) Neuroimaging in Fabry disease: current knowledge and future directions. Insights Imaging 9(6):1077\u20131088. https:\/\/doi.org\/10.1007\/s13244-018-0664-8","journal-title":"Insights Imaging"},{"issue":"19","key":"2497_CR5","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1212\/WNL.0000000000003913","volume":"88","author":"S Cocozza","year":"2017","unstructured":"Cocozza S, Pisani A, Olivo G, Sacca F, Ugga L, Riccio E, Migliaccio S, Brescia Morra V, Brunetti A, Quarantelli M, Tedeschi E (2017) Alterations of functional connectivity of the motor cortex in Fabry disease: an RS-fMRI study. Neurology 88(19):1822\u20131829. https:\/\/doi.org\/10.1212\/WNL.0000000000003913","journal-title":"Neurology"},{"key":"2497_CR6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.parkreldis.2018.07.011","volume":"57","author":"C Russo","year":"2018","unstructured":"Russo C, Pontillo G, Pisani A, Sacca F, Riccio E, Macera A, Rusconi G, Stanzione A, Borrelli P, Brescia Morra V, Tedeschi E, Brunetti A, Cocozza S, Palma G (2018) Striatonigral involvement in Fabry disease: a quantitative and volumetric magnetic resonance imaging study. Parkinsonism Relat Disord 57:27\u201332. https:\/\/doi.org\/10.1016\/j.parkreldis.2018.07.011","journal-title":"Parkinsonism Relat Disord"},{"issue":"9","key":"2497_CR7","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1136\/jnnp.2006.112987","volume":"78","author":"J Albrecht","year":"2007","unstructured":"Albrecht J, Dellani PR, Muller MJ, Schermuly I, Beck M, Stoeter P, Gerhard A, Fellgiebel A (2007) Voxel based analyses of diffusion tensor imaging in Fabry disease. J Neurol Neurosurg Psychiatry 78(9):964\u2013969. https:\/\/doi.org\/10.1136\/jnnp.2006.112987","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"2497_CR8","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1002\/hbm.23949","volume":"39","author":"S Cocozza","year":"2018","unstructured":"Cocozza S, Pontillo G, Quarantelli M, Sacca F, Riccio E, Costabile T, Olivo G, Brescia Morra V, Pisani A, Brunetti A, Tedeschi E (2018) Default mode network modifications in Fabry disease: a resting-state fMRI study with structural correlations. Hum Brain Mapp 39(4):1755\u20131764. https:\/\/doi.org\/10.1002\/hbm.23949","journal-title":"Hum Brain Mapp"},{"issue":"5","key":"2497_CR9","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00234-012-1131-8","volume":"55","author":"T Paavilainen","year":"2013","unstructured":"Paavilainen T, Lepomaki V, Saunavaara J, Borra R, Nuutila P, Kantola I, Parkkola R (2013) Diffusion tensor imaging and brain volumetry in Fabry disease patients. Neuroradiology 55(5):551\u2013558. https:\/\/doi.org\/10.1007\/s00234-012-1131-8","journal-title":"Neuroradiology"},{"issue":"3","key":"2497_CR10","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","volume":"31","author":"RS Desikan","year":"2006","unstructured":"Desikan RS, Segonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D, Buckner RL, Dale AM, Maguire RP, Hyman BT, Albert MS, Killiany RJ (2006) An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. NeuroImage 31(3):968\u2013980. https:\/\/doi.org\/10.1016\/j.neuroimage.2006.01.021","journal-title":"NeuroImage"},{"key":"2497_CR11","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3389\/fneur.2018.00672","volume":"9","author":"G Pontillo","year":"2018","unstructured":"Pontillo G, Cocozza S, Brunetti A, Brescia Morra V, Riccio E, Russo C, Sacca F, Tedeschi E, Pisani A, Quarantelli M (2018) Reduced intracranial volume in Fabry disease: evidence of abnormal neurodevelopment? Front Neurol 9:672. https:\/\/doi.org\/10.3389\/fneur.2018.00672","journal-title":"Front Neurol"},{"key":"2497_CR12","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.neuroimage.2015.10.019","volume":"125","author":"JLR Andersson","year":"2016","unstructured":"Andersson JLR, Sotiropoulos SN (2016) An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. NeuroImage 125:1063\u20131078. https:\/\/doi.org\/10.1016\/j.neuroimage.2015.10.019","journal-title":"NeuroImage"},{"key":"2497_CR13","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.neuroimage.2013.05.028","volume":"81","author":"J Veraart","year":"2013","unstructured":"Veraart J, Sijbers J, Sunaert S, Leemans A, Jeurissen B (2013) Weighted linear least squares estimation of diffusion MRI parameters: strengths, limitations, and pitfalls. NeuroImage 81:335\u2013346. https:\/\/doi.org\/10.1016\/j.neuroimage.2013.05.028","journal-title":"NeuroImage"},{"issue":"3","key":"2497_CR14","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1016\/j.neuroimage.2012.06.005","volume":"62","author":"RE Smith","year":"2012","unstructured":"Smith RE, Tournier JD, Calamante F, Connelly A (2012) Anatomically-constrained tractography: improved diffusion MRI streamlines tractography through effective use of anatomical information. NeuroImage 62(3):1924\u20131938. https:\/\/doi.org\/10.1016\/j.neuroimage.2012.06.005","journal-title":"NeuroImage"},{"issue":"2","key":"2497_CR15","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/s1053-8119(02)91132-8","volume":"17","author":"M Jenkinson","year":"2002","unstructured":"Jenkinson M, Bannister P, Brady M, Smith S (2002) Improved optimization for the robust and accurate linear registration and motion correction of brain images. NeuroImage 17(2):825\u2013841. https:\/\/doi.org\/10.1016\/s1053-8119(02)91132-8","journal-title":"NeuroImage"},{"issue":"1","key":"2497_CR16","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.neuroimage.2009.06.060","volume":"48","author":"DN Greve","year":"2009","unstructured":"Greve DN, Fischl B (2009) Accurate and robust brain image alignment using boundary-based registration. NeuroImage 48(1):63\u201372. https:\/\/doi.org\/10.1016\/j.neuroimage.2009.06.060","journal-title":"NeuroImage"},{"issue":"4","key":"2497_CR17","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/j.neuroimage.2007.02.016","volume":"35","author":"JD Tournier","year":"2007","unstructured":"Tournier JD, Calamante F, Connelly A (2007) Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution. NeuroImage 35(4):1459\u20131472. https:\/\/doi.org\/10.1016\/j.neuroimage.2007.02.016","journal-title":"NeuroImage"},{"issue":"12","key":"2497_CR18","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1002\/nbm.3017","volume":"26","author":"JD Tournier","year":"2013","unstructured":"Tournier JD, Calamante F, Connelly A (2013) Determination of the appropriate b value and number of gradient directions for high-angular-resolution diffusion-weighted imaging. NMR Biomed 26(12):1775\u20131786. https:\/\/doi.org\/10.1002\/nbm.3017","journal-title":"NMR Biomed"},{"key":"2497_CR19","unstructured":"Tournier JDC, Connelly F (2010) A improved probabilistic streamlines tractography by 2nd order integration over fibre orientation distributions. In: ISMRM"},{"issue":"12","key":"2497_CR20","doi-asserted-by":"publisher","first-page":"a009621","DOI":"10.1101\/cshperspect.a009621","volume":"2","author":"JL Lanciego","year":"2012","unstructured":"Lanciego JL, Luquin N, Obeso JA (2012) Functional neuroanatomy of the basal ganglia. Cold Spring Harb Perspect Med 2(12):a009621. https:\/\/doi.org\/10.1101\/cshperspect.a009621","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"Suppl 3","key":"2497_CR21","doi-asserted-by":"publisher","first-page":"S548","DOI":"10.1002\/mds.22062","volume":"23","author":"JA Obeso","year":"2008","unstructured":"Obeso JA, Rodriguez-Oroz MC, Benitez-Temino B, Blesa FJ, Guridi J, Marin C, Rodriguez M (2008) Functional organization of the basal ganglia: therapeutic implications for Parkinson\u2019s disease. Mov Disord 23(Suppl 3):S548\u2013S559. https:\/\/doi.org\/10.1002\/mds.22062","journal-title":"Mov Disord"},{"key":"2497_CR22","unstructured":"Bells S, Cercignani M, Deoni S, Assaf Y, Pasternak O, Evans CJ, Leemans A, Jones DK (2011) Tractometry\u2013comprehensive multi-modal quantitative assessment of white matter along specific tracts. In: Proc. Intl. Soc. Mag. Reson. Med., vol 19"},{"issue":"4","key":"2497_CR23","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1002\/ana.410310410","volume":"31","author":"GA deVeber","year":"1992","unstructured":"deVeber GA, Schwarting GA, Kolodny EH, Kowall NW (1992) Fabry disease: immunocytochemical characterization of neuronal involvement. Ann Neurol 31(4):409\u2013415. https:\/\/doi.org\/10.1002\/ana.410310410","journal-title":"Ann Neurol"},{"issue":"5","key":"2497_CR24","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1002\/ana.410230513","volume":"23","author":"EM Kaye","year":"1988","unstructured":"Kaye EM, Kolodny EH, Logigian EL, Ullman MD (1988) Nervous system involvement in Fabry\u2019s disease: clinicopathological and biochemical correlation. Ann Neurol 23(5):505\u2013509. https:\/\/doi.org\/10.1002\/ana.410230513","journal-title":"Ann Neurol"},{"issue":"2","key":"2497_CR25","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1212\/WNL.0000000000002841","volume":"87","author":"KR Patel","year":"2016","unstructured":"Patel KR, Ramsey LE, Metcalf NV, Shulman GL, Corbetta M (2016) Early diffusion evidence of retrograde transsynaptic degeneration in the human visual system. Neurology 87(2):198\u2013205. https:\/\/doi.org\/10.1212\/WNL.0000000000002841","journal-title":"Neurology"},{"issue":"1","key":"2497_CR26","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ajpath.2012.03.030","volume":"181","author":"A Kanamori","year":"2012","unstructured":"Kanamori A, Catrinescu MM, Belisle JM, Costantino S, Levin LA (2012) Retrograde and Wallerian axonal degeneration occur synchronously after retinal ganglion cell axotomy. Am J Pathol 181(1):62\u201373. https:\/\/doi.org\/10.1016\/j.ajpath.2012.03.030","journal-title":"Am J Pathol"},{"key":"2497_CR27","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.nicl.2017.07.011","volume":"16","author":"C Atkinson-Clement","year":"2017","unstructured":"Atkinson-Clement C, Pinto S, Eusebio A, Coulon O (2017) Diffusion tensor imaging in Parkinson\u2019s disease: review and meta-analysis. NeuroImage Clinical 16:98\u2013110. https:\/\/doi.org\/10.1016\/j.nicl.2017.07.011","journal-title":"NeuroImage Clinical"},{"issue":"9","key":"2497_CR28","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1212\/WNL.0b013e318284070c","volume":"80","author":"CJ Cochrane","year":"2013","unstructured":"Cochrane CJ, Ebmeier KP (2013) Diffusion tensor imaging in parkinsonian syndromes: a systematic review and meta-analysis. Neurology 80(9):857\u2013864. https:\/\/doi.org\/10.1212\/WNL.0b013e318284070c","journal-title":"Neurology"},{"issue":"1","key":"2497_CR29","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1249\/JES.0000000000000003","volume":"42","author":"PJ Planetta","year":"2014","unstructured":"Planetta PJ, McFarland NR, Okun MS, Vaillancourt DE (2014) MRI reveals brain abnormalities in drug-naive Parkinson\u2019s disease. Exerc Sport Sci Rev 42(1):12\u201322. https:\/\/doi.org\/10.1249\/JES.0000000000000003","journal-title":"Exerc Sport Sci Rev"},{"issue":"10","key":"2497_CR30","doi-asserted-by":"publisher","first-page":"3327","DOI":"10.1007\/s00330-015-4178-1","volume":"26","author":"JP Mole","year":"2016","unstructured":"Mole JP, Subramanian L, Bracht T, Morris H, Metzler-Baddeley C, Linden DE (2016) Increased fractional anisotropy in the motor tracts of Parkinson\u2019s disease suggests compensatory neuroplasticity or selective neurodegeneration. Eur Radiol 26(10):3327\u20133335. https:\/\/doi.org\/10.1007\/s00330-015-4178-1","journal-title":"Eur Radiol"},{"issue":"12","key":"2497_CR31","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1212\/WNL.0000000000000243","volume":"82","author":"D Arkadir","year":"2014","unstructured":"Arkadir D, Bergman H, Fahn S (2014) Redundant dopaminergic activity may enable compensatory axonal sprouting in Parkinson disease. Neurology 82(12):1093\u20131098. https:\/\/doi.org\/10.1212\/WNL.0000000000000243","journal-title":"Neurology"},{"issue":"3","key":"2497_CR32","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.nurt.2007.05.011","volume":"4","author":"AL Alexander","year":"2007","unstructured":"Alexander AL, Lee JE, Lazar M, Field AS (2007) Diffusion tensor imaging of the brain. Neurotherapeutics 4(3):316\u2013329. https:\/\/doi.org\/10.1016\/j.nurt.2007.05.011","journal-title":"Neurotherapeutics"},{"issue":"5","key":"2497_CR33","doi-asserted-by":"publisher","first-page":"427","DOI":"10.2217\/iim.13.49","volume":"5","author":"WY Aung","year":"2013","unstructured":"Aung WY, Mar S, Benzinger TL (2013) Diffusion tensor MRI as a biomarker in axonal and myelin damage. Imaging Med 5(5):427\u2013440. https:\/\/doi.org\/10.2217\/iim.13.49","journal-title":"Imaging Med"},{"key":"2497_CR34","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3389\/fneur.2018.00092","volume":"9","author":"PJ Winklewski","year":"2018","unstructured":"Winklewski PJ, Sabisz A, Naumczyk P, Jodzio K, Szurowska E, Szarmach A (2018) Understanding the physiopathology behind axial and radial diffusivity changes-what do we know? Front Neurol 9:92. https:\/\/doi.org\/10.3389\/fneur.2018.00092","journal-title":"Front Neurol"},{"issue":"3","key":"2497_CR35","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1179\/016164106X98242","volume":"28","author":"RE Kelley","year":"2006","unstructured":"Kelley RE (2006) Ischemic demyelination. Neurol Res 28(3):334\u2013340. https:\/\/doi.org\/10.1179\/016164106X98242","journal-title":"Neurol Res"},{"issue":"3","key":"2497_CR36","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1136\/svn-2016-000035","volume":"1","author":"Y Shi","year":"2016","unstructured":"Shi Y, Wardlaw JM (2016) Update on cerebral small vessel disease: a dynamic whole-brain disease. Stroke Vasc Neurol 1(3):83\u201392. https:\/\/doi.org\/10.1136\/svn-2016-000035","journal-title":"Stroke Vasc Neurol"},{"issue":"6","key":"2497_CR37","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1161\/STROKEAHA.115.012065","volume":"47","author":"M Pasi","year":"2016","unstructured":"Pasi M, van Uden IW, Tuladhar AM, de Leeuw FE, Pantoni L (2016) White matter microstructural damage on diffusion tensor imaging in cerebral small vessel disease: clinical consequences. Stroke 47(6):1679\u20131684. https:\/\/doi.org\/10.1161\/STROKEAHA.115.012065","journal-title":"Stroke"},{"key":"2497_CR38","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.neulet.2018.12.007","volume":"694","author":"R Raja","year":"2019","unstructured":"Raja R, Rosenberg G, Caprihan A (2019) Review of diffusion MRI studies in chronic white matter diseases. Neurosci Lett 694:198\u2013207. https:\/\/doi.org\/10.1016\/j.neulet.2018.12.007","journal-title":"Neurosci Lett"},{"issue":"11","key":"2497_CR39","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1016\/j.ejrad.2014.07.012","volume":"83","author":"J Deverdun","year":"2014","unstructured":"Deverdun J, Menjot de Champfleur S, Cabello-Aguilar S, Maury F, Molino F, Charif M, Leboucq N, Ayrignac X, Labauge P, Bonafe A, Castelnovo G, Le Bars E, Geny C, Menjot de Champfleur N (2014) Diffusion tensor imaging differentiates vascular parkinsonism from parkinsonian syndromes of degenerative origin in elderly subjects. Eur J Radiol 83(11):2074\u20132079. https:\/\/doi.org\/10.1016\/j.ejrad.2014.07.012","journal-title":"Eur J Radiol"},{"key":"2497_CR40","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.parkreldis.2019.02.046","volume":"63","author":"M Salsone","year":"2019","unstructured":"Salsone M, Caligiuri ME, Vescio V, Arabia G, Cherubini A, Nicoletti G, Morelli M, Quattrone A, Vescio B, Nistico R, Novellino F, Cascini GL, Sabatini U, Montilla M, Rektor I, Quattrone A (2019) Microstructural changes of normal-appearing white matter in vascular parkinsonism. Parkinsonism Relat Disord 63:60\u201365. https:\/\/doi.org\/10.1016\/j.parkreldis.2019.02.046","journal-title":"Parkinsonism Relat Disord"},{"issue":"18","key":"2497_CR41","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1212\/WNL.0000000000002082","volume":"85","author":"HM van der Holst","year":"2015","unstructured":"van der Holst HM, van Uden IW, Tuladhar AM, de Laat KF, van Norden AG, Norris DG, van Dijk EJ, Esselink RA, Platel B, de Leeuw FE (2015) Cerebral small vessel disease and incident parkinsonism: the RUN DMC study. Neurology 85(18):1569\u20131577. https:\/\/doi.org\/10.1212\/WNL.0000000000002082","journal-title":"Neurology"},{"issue":"10","key":"2497_CR42","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1001\/archneurol.2012.633","volume":"69","author":"HC Wang","year":"2012","unstructured":"Wang HC, Hsu JL, Leemans A (2012) Diffusion tensor imaging of vascular parkinsonism: structural changes in cerebral white matter and the association with clinical severity. Arch Neurol 69(10):1340\u20131348. https:\/\/doi.org\/10.1001\/archneurol.2012.633","journal-title":"Arch Neurol"},{"issue":"9","key":"2497_CR43","doi-asserted-by":"publisher","first-page":"4475","DOI":"10.1007\/s00429-015-1178-5","volume":"221","author":"S Angstmann","year":"2016","unstructured":"Angstmann S, Madsen KS, Skimminge A, Jernigan TL, Baare WF, Siebner HR (2016) Microstructural asymmetry of the corticospinal tracts predicts right-left differences in circle drawing skill in right-handed adolescents. Brain Struct Funct 221(9):4475\u20134489. https:\/\/doi.org\/10.1007\/s00429-015-1178-5","journal-title":"Brain Struct Funct"},{"key":"2497_CR44","doi-asserted-by":"publisher","first-page":"177","DOI":"10.7551\/mitpress\/9780262014137.003.0136","volume-title":"The two halves of the brain: information processing in the cerebral hemispheres","author":"M Catani","year":"2010","unstructured":"Catani M, Forkel SJ, Thiebaut De Schotten M (2010) Asymmetry of white matter pathways. In: Hugdahl K, Westerhausen R (eds) The two halves of the brain: information processing in the cerebral hemispheres. MIT Press, Cambridge, pp 177\u2013210"},{"issue":"Pt 2","key":"2497_CR45","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/brain\/113.2.303","volume":"113","author":"PW Nathan","year":"1990","unstructured":"Nathan PW, Smith MC, Deacon P (1990) The corticospinal tracts in man. Course and location of fibres at different segmental levels. Brain J Neurol 113(Pt 2):303\u2013324. https:\/\/doi.org\/10.1093\/brain\/113.2.303","journal-title":"Brain J Neurol"},{"issue":"6","key":"2497_CR46","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1203\/PDR.0b013e3181bbc6b5","volume":"66","author":"R Trivedi","year":"2009","unstructured":"Trivedi R, Agarwal S, Rathore RK, Saksena S, Tripathi RP, Malik GK, Pandey CM, Gupta RK (2009) Understanding development and lateralization of major cerebral fiber bundles in pediatric population through quantitative diffusion tensor tractography. Pediatr Res 66(6):636\u2013641. https:\/\/doi.org\/10.1203\/PDR.0b013e3181bbc6b5","journal-title":"Pediatr Res"},{"issue":"9","key":"2497_CR47","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1038\/sj.jcbfm.9600455","volume":"27","author":"SB Tekkok","year":"2007","unstructured":"Tekkok SB, Ye Z, Ransom BR (2007) Excitotoxic mechanisms of ischemic injury in myelinated white matter. J Cereb Blood Flow Metab 27(9):1540\u20131552. https:\/\/doi.org\/10.1038\/sj.jcbfm.9600455","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"2497_CR48","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1037\/bul0000229","volume":"146","author":"M Papadatou-Pastou","year":"2020","unstructured":"Papadatou-Pastou M, Ntolka E, Schmitz J, Martin M, Munafo MR, Ocklenburg S, Paracchini S (2020) Human handedness: a meta-analysis. Psychol Bull 146(6):481\u2013524. https:\/\/doi.org\/10.1037\/bul0000229","journal-title":"Psychol Bull"},{"issue":"Pt B","key":"2497_CR49","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.neuroimage.2017.11.033","volume":"180","author":"HJ Park","year":"2018","unstructured":"Park HJ, Friston KJ, Pae C, Park B, Razi A (2018) Dynamic effective connectivity in resting state fMRI. NeuroImage 180(Pt B):594\u2013608. https:\/\/doi.org\/10.1016\/j.neuroimage.2017.11.033","journal-title":"NeuroImage"},{"issue":"1","key":"2497_CR50","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.1038\/s41598-018-20076-y","volume":"8","author":"XY Deng","year":"2018","unstructured":"Deng XY, Wang L, Yang TT, Li R, Yu G (2018) A meta-analysis of diffusion tensor imaging of substantia nigra in patients with Parkinson\u2019s disease. Sci Rep 8(1):2941. https:\/\/doi.org\/10.1038\/s41598-018-20076-y","journal-title":"Sci Rep"},{"issue":"7","key":"2497_CR51","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1002\/hbm.23192","volume":"37","author":"J Langley","year":"2016","unstructured":"Langley J, Huddleston DE, Merritt M, Chen X, McMurray R, Silver M, Factor SA, Hu X (2016) Diffusion tensor imaging of the substantia nigra in Parkinson\u2019s disease revisited. Hum Brain Mapp 37(7):2547\u20132556. https:\/\/doi.org\/10.1002\/hbm.23192","journal-title":"Hum Brain Mapp"},{"key":"2497_CR52","doi-asserted-by":"publisher","first-page":"17283","DOI":"10.1038\/srep17283","volume":"5","author":"WQ Tan","year":"2015","unstructured":"Tan WQ, Yeoh CS, Rumpel H, Nadkarni N, Lye WK, Tan EK, Chan LL (2015) Deterministic tractography of the nigrostriatal-nigropallidal pathway in Parkinson\u2019s disease. Sci Rep 5:17283. https:\/\/doi.org\/10.1038\/srep17283","journal-title":"Sci Rep"},{"key":"2497_CR53","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.nicl.2017.09.009","volume":"16","author":"F Theisen","year":"2017","unstructured":"Theisen F, Leda R, Pozorski V, Oh JM, Adluru N, Wong R, Okonkwo O, Dean DC 3rd, Bendlin BB, Johnson SC, Alexander AL, Gallagher CL (2017) Evaluation of striatonigral connectivity using probabilistic tractography in Parkinson\u2019s disease. NeuroImage Clinical 16:557\u2013563. https:\/\/doi.org\/10.1016\/j.nicl.2017.09.009","journal-title":"NeuroImage Clinical"},{"issue":"9","key":"2497_CR54","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1002\/mds.26251","volume":"30","author":"Y Zhang","year":"2015","unstructured":"Zhang Y, Wu IW, Buckley S, Coffey CS, Foster E, Mendick S, Seibyl J, Schuff N (2015) Diffusion tensor imaging of the nigrostriatal fibers in Parkinson\u2019s disease. Mov Disord 30(9):1229\u20131236. https:\/\/doi.org\/10.1002\/mds.26251","journal-title":"Mov Disord"}],"container-title":["Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00234-020-02497-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00234-020-02497-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00234-020-02497-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T23:35:40Z","timestamp":1626910540000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00234-020-02497-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,22]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["2497"],"URL":"https:\/\/doi.org\/10.1007\/s00234-020-02497-7","relation":{},"ISSN":["0028-3940","1432-1920"],"issn-type":[{"value":"0028-3940","type":"print"},{"value":"1432-1920","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,22]]},"assertion":[{"value":"9 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"S.C. received fees for speaking from Genzyme and Shire and fees for adv.board from Amicus.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}