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Demographic differences in the anatomic distribution of moderate (grade 3) or greater SCS and NFS were calculated by sex, and age and within-group differences for NFS symmetry (left vs. right) were calculated as odds ratios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty-three thousand two hundred fifty-five LMRI reports (34,947 unique patients, mean age = 54.7; sex = 54.9% women) interpreted by 152 radiologists were studied. Prevalence of significant SCS and NFS increased caudally from T12-L1 to L4-5 though less at L5-S1. NFS was asymmetrically more prevalent on the left at L2-L3 and L5-S1 (<jats:italic>p<\/jats:italic>&lt; 0.001). SCS and NFS were more prevalent in men and SCS increased with age at all levels, but the effect size of age was largest at T12-L3. Younger patients (&lt; 50 years) had relatively higher NFS prevalence at L5-S1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NLP can identify patterns of lumbar spine degeneration through analysis of a large corpus of radiologist interpretations. Demographic differences in stenosis prevalence shed light on the natural history and pathogenesis of LSDD.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00234-021-02670-6","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T10:05:34Z","timestamp":1613729134000},"page":"959-966","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effects of age and sex on the distribution and symmetry of lumbar spinal and neural foraminal stenosis: a natural language processing analysis of 43,255 lumbar MRI reports"],"prefix":"10.1007","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1581-7702","authenticated-orcid":false,"suffix":"Jr","given":"Michael","family":"Travis Caton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter F.","family":"Wiggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart R.","family":"Pomerantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine P.","family":"Andriole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"2670_CR1","first-page":"21","volume":"88","author":"JN Katz","year":"2006","unstructured":"Katz JN (2006) Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. 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