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This study evaluates the addition of <jats:sup>11<\/jats:sup>C-methionine positron emission tomography (MET-PET) to the regular MRI follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This prospective pilot study included patients with predominantly WHO grade I meningiomas at the skull base or near large vascular structures. Previous SRT was part of their oncological treatment. A MET-PET in adjunct to their regular MRI follow-up was performed. The standardized uptake value (SUV) was determined for the tumor and the healthy brain, on the pre-SRT target delineation MET-PET and the follow-up MET-PET. Tumor-to-normal ratios were calculated, and <jats:sup>11<\/jats:sup>C-methionine uptake over time was analyzed. Agreement between the combined MRI\/MET-PET report and the MRI-only report was determined using Cohen\u2019s \u03ba.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Twenty patients with stable disease underwent an additional MET-PET, with a median follow-up of 84 months after SRT. Post-SRT SUV T\/N ratios ranged between 2.16 and 3.17. When comparing the pre-SRT and the post-SRT MET-PET, five categories of SUV T\/N ratios did not change significantly. Only the SUV<jats:sub>peak<\/jats:sub> T\/N<jats:sub>cortex<\/jats:sub> decreased significantly from 2.57 (SD 1.02) to 2.20 (SD 0.87) [<jats:italic>p<\/jats:italic> = 0.004]. A \u03ba of 0.77 was found, when comparing the MRI\/MET-PET report to the MRI-only report, indicating no major change in interpretation of follow-up data.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In this pilot study, <jats:sup>11<\/jats:sup>C-methionine uptake remained remarkably high in meningiomas with long-term follow-up after SRT. Adding MET-PET to the regular MRI follow-up had no impact on the interpretation of follow-up imaging.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00234-021-02683-1","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T17:04:42Z","timestamp":1615395882000},"page":"1791-1799","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Study on intracranial meningioma using PET ligand investigation during follow-up over years (SIMPLIFY)"],"prefix":"10.1007","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3529-2707","authenticated-orcid":false,"given":"Hanne-Rinck","family":"Jeltema","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marnix R.","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriaan R. 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