{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:42:36Z","timestamp":1772109756467,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuroradiology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s00234-022-03094-6","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T19:35:49Z","timestamp":1669923349000},"page":"845-853","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Qualitative and quantitative evaluation for the heterogeneity of cortical tubers using structural imaging and diffusion-weighted imaging to predict the epileptogenicity in tuberous sclerosis complex patients"],"prefix":"10.1007","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2837-8286","authenticated-orcid":false,"given":"Akira","family":"Yogi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Linetsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin M.","family":"Ellingson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Salamon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"3094_CR1","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1177\/08830738040190090601","volume":"19","author":"P Prather","year":"2004","unstructured":"Prather P, de Vries PJ (2004) Behavioral and cognitive aspects of tuberous sclerosis complex. J Child Neurol 19:666\u2013674. https:\/\/doi.org\/10.1177\/08830738040190090601","journal-title":"J Child Neurol"},{"key":"3094_CR2","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1086\/302381","volume":"64","author":"AC Jones","year":"1999","unstructured":"Jones AC, Shyamsundar MM, Thomas MW et al (1999) Comprehensive mutation analysis of TSC1 and TSC2-and phenotypic correlations in 150 families with tuberous sclerosis. Am J Hum Genet 64:1305\u20131315. https:\/\/doi.org\/10.1086\/302381","journal-title":"Am J Hum Genet"},{"key":"3094_CR3","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1111\/j.1528-1167.2006.00627.x","volume":"47","author":"PS Chandra","year":"2006","unstructured":"Chandra PS, Salamon N, Huang J et al (2006) FDG-PET\/MRI coregistration and diffusion-tensor imaging distinguish epileptogenic tubers and cortex in patients with tuberous sclerosis complex: a preliminary report. Epilepsia 47:1543\u20131549. https:\/\/doi.org\/10.1111\/j.1528-1167.2006.00627.x","journal-title":"Epilepsia"},{"key":"3094_CR4","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1212\/01.wnl.0000208412.59491.9b","volume":"66","author":"JY Wu","year":"2006","unstructured":"Wu JY, Sutherling WW, Koh S et al (2006) Magnetic source imaging localizes epileptogenic zone in children with tuberous sclerosis complex. Neurology 66:1270\u20131272. https:\/\/doi.org\/10.1212\/01.wnl.0000208412.59491.9b","journal-title":"Neurology"},{"key":"3094_CR5","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1212\/WNL.0000000000002202","volume":"85","author":"A Yogi","year":"2015","unstructured":"Yogi A, Hirata Y, Karavaeva E et al (2015) DTI of tuber and perituberal tissue can predict epileptogenicity in tuberous sclerosis complex. Neurology 85:2011\u20132015. https:\/\/doi.org\/10.1212\/WNL.0000000000002202","journal-title":"Neurology"},{"key":"3094_CR6","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1212\/01.wnl.0000345365.92821.86","volume":"72","author":"CJ Chu-Shore","year":"2009","unstructured":"Chu-Shore CJ, Major P, Montenegro M, Thiele E (2009) Cyst-like tubers are associated with TSC2 and epilepsy in tuberous sclerosis complex. Neurology 72:1165\u20131169. https:\/\/doi.org\/10.1212\/01.wnl.0000345365.92821.86","journal-title":"Neurology"},{"key":"3094_CR7","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1007\/s00415-010-5535-2","volume":"257","author":"A Gallagher","year":"2010","unstructured":"Gallagher A, Grant EP, Madan N et al (2010) MRI findings reveal three different types of tubers in patients with tuberous sclerosis complex. J Neurol 257:1373\u20131381. https:\/\/doi.org\/10.1007\/s00415-010-5535-2","journal-title":"J Neurol"},{"key":"3094_CR8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.eplepsyres.2009.09.001","volume":"87","author":"A Gallagher","year":"2009","unstructured":"Gallagher A, Chu-Shore CJ, Montenegro MA et al (2009) Associations between electroencephalographic and magnetic resonance imaging findings in tuberous sclerosis complex. Epilepsy Res 87:197\u2013202. https:\/\/doi.org\/10.1016\/j.eplepsyres.2009.09.001","journal-title":"Epilepsy Res"},{"key":"3094_CR9","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/epi.12545","volume":"55","author":"V Ruppe","year":"2014","unstructured":"Ruppe V, Dilsiz P, Reiss CS et al (2014) Developmental brain abnormalities in tuberous sclerosis complex: a comparative tissue analysis of cortical tubers and perituberal cortex. Epilepsia 55:539\u2013550. https:\/\/doi.org\/10.1111\/epi.12545","journal-title":"Epilepsia"},{"key":"3094_CR10","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1177\/08830738040190091301","volume":"19","author":"PB Crino","year":"2004","unstructured":"Crino PB (2004) Molecular pathogenesis of tuber formation in tuberous sclerosis complex. J Child Neurol 19:716\u2013725. https:\/\/doi.org\/10.1177\/08830738040190091301","journal-title":"J Child Neurol"},{"key":"3094_CR11","doi-asserted-by":"publisher","first-page":"2648","DOI":"10.1111\/j.1528-1167.2009.02193.x","volume":"50","author":"CJ Chu-Shore","year":"2009","unstructured":"Chu-Shore CJ, Frosch MP, Grant PE, Thiele EA (2009) Progressive multifocal cystlike cortical tubers in tuberous sclerosis complex: Clinical and neuropathologic findings. Epilepsia 50:2648\u20132651. https:\/\/doi.org\/10.1111\/j.1528-1167.2009.02193.x","journal-title":"Epilepsia"},{"key":"3094_CR12","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/J.PEDIATRNEUROL.2013.08.001","volume":"49","author":"H Northrup","year":"2013","unstructured":"Northrup H, Krueger DA, Roberds S et al (2013) Tuberous sclerosis complex diagnostic criteria update: Recommendations of the 2012 international tuberous sclerosis complex consensus conference. Pediatr Neurol 49:243\u2013254. https:\/\/doi.org\/10.1016\/J.PEDIATRNEUROL.2013.08.001","journal-title":"Pediatr Neurol"},{"key":"3094_CR13","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1016\/S1474-4422(14)70156-5","volume":"13","author":"P Ryvlin","year":"2014","unstructured":"Ryvlin P, Cross JH, Rheims S (2014) Epilepsy surgery in children and adults. Lancet Neurol 13:1114\u20131126. https:\/\/doi.org\/10.1016\/S1474-4422(14)70156-5","journal-title":"Lancet Neurol"},{"key":"3094_CR14","first-page":"149","volume":"16","author":"CW Shepherd","year":"1995","unstructured":"Shepherd CW, Houser OW, Gomez MR (1995) MR findings in tuberous sclerosis complex and correlation with seizure development and mental impairment. Am J Neuroradiol 16:149\u2013155","journal-title":"Am J Neuroradiol"},{"key":"3094_CR15","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1002\/ana.21342","volume":"63","author":"DM Talos","year":"2008","unstructured":"Talos DM, Kwiatkowski DJ, Cordero K et al (2008) Cell-specific alterations of glutamate receptor expression in tuberous sclerosis complex cortical tubers. Ann Neurol 63:454\u2013465. https:\/\/doi.org\/10.1002\/ana.21342","journal-title":"Ann Neurol"},{"key":"3094_CR16","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1528-1167.2008.01814.x","volume":"50","author":"P Major","year":"2009","unstructured":"Major P, Rakowski S, Simon MV et al (2009) Are cortical tubers epileptogenic? Evidence from electrocorticography. Epilepsia 50:147\u2013154. https:\/\/doi.org\/10.1111\/j.1528-1167.2008.01814.x","journal-title":"Epilepsia"},{"key":"3094_CR17","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1001\/archneur.60.11.1580","volume":"60","author":"FE Jansen","year":"2003","unstructured":"Jansen FE, Braun KPJ, van Nieuwenhuizen O et al (2003) Diffusion-weighted magnetic resonance imaging and identification of the epileptogenic tuber in patients with tuberous sclerosis. Arch Neurol 60:1580\u20131584. https:\/\/doi.org\/10.1001\/archneur.60.11.1580","journal-title":"Arch Neurol"},{"key":"3094_CR18","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.ejpn.2007.07.002","volume":"12","author":"IJ Chou","year":"2008","unstructured":"Chou IJ, Lin KL, Wong AM et al (2008) Neuroimaging correlation with neurological severity in tuberous sclerosis complex. Eur J Paediatr Neurol 12:108\u2013112. https:\/\/doi.org\/10.1016\/j.ejpn.2007.07.002","journal-title":"Eur J Paediatr Neurol"},{"key":"3094_CR19","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1007\/s00381-011-1488-8","volume":"27","author":"I Pascual-Castroviejo","year":"2011","unstructured":"Pascual-Castroviejo I (2011) Neurosurgical treatment of tuberous sclerosis complex lesions. Childs Nerv Syst 27:1211\u20131219. https:\/\/doi.org\/10.1007\/s00381-011-1488-8","journal-title":"Childs Nerv Syst"},{"key":"3094_CR20","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1212\/WNL.0000000000002055","volume":"85","author":"JM Peters","year":"2015","unstructured":"Peters JM, Prohl AK, Tomas-Fernandez XK et al (2015) Tubers are neither static nor discrete: Evidence from serial diffusion tensor imaging. Neurology 85:1536\u20131545. https:\/\/doi.org\/10.1212\/WNL.0000000000002055","journal-title":"Neurology"},{"key":"3094_CR21","doi-asserted-by":"publisher","unstructured":"Nijman M, Yang E, Jaimes C et al (2022) Limited utility of structural MRI to identify the epileptogenic zone in young children with tuberous sclerosis. J Neuroimaging:991\u20131000. https:\/\/doi.org\/10.1111\/jon.13016","DOI":"10.1111\/jon.13016"},{"key":"3094_CR22","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1212\/WNL.0b013e3182a08f3f","volume":"81","author":"HT Chugani","year":"2013","unstructured":"Chugani HT, Luat AF, Kumar A et al (2013) alpha-[11C]-Methyl-L-tryptophan--PET in 191 patients with tuberous sclerosis complex. Neurology 81:674\u2013680. https:\/\/doi.org\/10.1212\/WNL.0b013e3182a08f3f","journal-title":"Neurology"},{"key":"3094_CR23","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1002\/epi4.12529","volume":"6","author":"HM Hulshof","year":"2021","unstructured":"Hulshof HM, Benova B, Krsek P et al (2021) The epileptogenic zone in children with tuberous sclerosis complex is characterized by prominent features of focal cortical dysplasia. Epilepsia Open 6:663\u2013671. https:\/\/doi.org\/10.1002\/epi4.12529","journal-title":"Epilepsia Open"}],"container-title":["Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00234-022-03094-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00234-022-03094-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00234-022-03094-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T02:23:50Z","timestamp":1679538230000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00234-022-03094-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["3094"],"URL":"https:\/\/doi.org\/10.1007\/s00234-022-03094-6","relation":{},"ISSN":["0028-3940","1432-1920"],"issn-type":[{"value":"0028-3940","type":"print"},{"value":"1432-1920","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,1]]},"assertion":[{"value":"1 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The Institutional Review Board at our institute approved the use of human subjects. The need for written informed consent and signed patient consent-to-disclose forms was waived because all testing was deemed clinically relevant to patient care.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}