{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T17:07:52Z","timestamp":1775581672736,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuroradiology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Diffusion-weighted imaging (DWI) b0 may be able to substitute T2*-weighted gradient echo (GRE) or susceptibility-weighted imaging (SWI) in case of comparable detection of intracranial hemorrhage (ICH), thereby reducing MRI examination time. We evaluated the diagnostic accuracy of DWI b0 compared to T2*GRE or SWI for detection of ICH after reperfusion therapy for ischemic stroke.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We pooled 300 follow-up MRI scans acquired within 1\u00a0week after reperfusion therapy. Six neuroradiologists each rated DWI images (b0 and b1000; b0 as index test) of 100 patients and, after a minimum of 4\u00a0weeks, T2*GRE or SWI images (reference standard) paired with DWI images of the same patients. Readers assessed the presence of ICH (yes\/no) and type of ICH according to the Heidelberg Bleeding Classification. We determined the sensitivity and specificity of DWI b0 for detection of any ICH, and the sensitivity for detection of hemorrhagic infarction (HI1 &amp; HI2) and parenchymal hematoma (PH1 &amp; PH2).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We analyzed 277 scans of ischemic stroke patients with complete image series and sufficient image quality (median age 65\u00a0years [interquartile range, 54\u201375], 158 [57%] men). For detection of any ICH on DWI b0, the sensitivity was 62% (95%\u00a0CI: 50\u201376) and specificity 96% (95%\u00a0CI: 93\u201399). The sensitivity of DWI b0 was 52% (95%\u00a0CI: 28\u201368) for detection of hemorrhagic infarction and 84% (95%\u00a0CI: 70\u201392) for parenchymal hematoma.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>DWI b0 is inferior for detection of ICH compared to T2*GRE\/SWI, especially for smaller and more subtle hemorrhages. Follow-up MRI protocols should include T2*GRE\/SWI for detection of ICH after reperfusion therapy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00234-023-03180-3","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T03:32:46Z","timestamp":1688009566000},"page":"1649-1655","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of diffusion weighted imaging b0 with T2*-weighted gradient echo or susceptibility weighted imaging for intracranial hemorrhage detection after reperfusion therapy for ischemic stroke"],"prefix":"10.1007","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6905-3296","authenticated-orcid":false,"given":"Sven P. R.","family":"Luijten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4681-8388","authenticated-orcid":false,"given":"Nadinda A. 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RB reports funding from the Netherlands Organisation for Health Research and Development, the Dutch Ministry of Economic Affairs and Climate Policy, and an unrestricted grant from Siemens Healthineers. UWA reports funding from \u201cHelse-Vest\u201d and from the University of Bergen for research. DD and AvdL report funding from the Dutch Heart Foundation, Brain Foundation Netherlands, The Netherlands Organisation for Health Research and Development, Health Holland Top Sector Life Sciences & Health, and unrestricted grants from Penumbra Inc., Stryker, Medtronic, Thrombolytic Science, LLC and Cerenovus for research, all paid to institution. The other authors report no conflicts.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Findings in this study are based on data obtained from two stroke trial, NORTEST and THRACE, and a local cohort of stroke patients from Erasmus MC University Medical Center. NORTEST and THRACE were approved by local review boards. Study protocols for the local stroke cohort were reviewed and approved by the Erasmus MC University Medical Center Ethics Committee. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All patients or their legal representatives provided written informed consent for use of clinical and imaging data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All patients or their legal representatives provided written informed consent for publication of data and images presented in the article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}