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Intrinsic connectivity contrast (ICC) and time-shift analysis (TSA) of the rs-fMRI data allowed the assessment of regional hemodynamic and functional connectivity disturbances and their coupling (or uncoupling). Thirty-nine healthy age- and gender-matched participants were also examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with chronic mTBI displayed hypoconnectivity in bilateral hippocampi and parahippocampal gyri and increased connectivity in parietal areas (right angular gyrus and left superior parietal lobule (SPL)). Slower perfusion (hemodynamic lag) in the left anterior hippocampus was associated with higher self-reported symptoms of depression (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2009\u2212\u20090.53,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0006) and anxiety (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2009\u2212\u20090.484,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.002), while faster perfusion (hemodynamic lead) in the left SPL was associated with lower semantic fluency (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2009\u2212\u20090.474,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.002). Finally, functional coupling (high connectivity and hemodynamic lead) in the right anterior cingulate cortex (ACC)) was associated with lower performance on attention and visuomotor coordination (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2009\u2212\u20090.50,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001), while dysfunctional coupling (low connectivity and hemodynamic lag) in the left ventral posterior cingulate cortex (PCC) and right SPL was associated with lower scores on immediate passage memory (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2009\u2212\u20090.52,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001;\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2009\u2212\u20090.53,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0006, respectively). Uncoupling in the right extrastriate visual cortex and posterior middle temporal gyrus was negatively associated with cognitive flexibility (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2009\u2212\u20090.50,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hemodynamic and functional connectivity differences, indicating neurovascular (un)coupling, may be linked to mental health and neurocognitive indices in patients with chronic mTBI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00234-024-03352-9","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T20:01:26Z","timestamp":1712865686000},"page":"985-998","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Functional connectivity-hemodynamic (un)coupling changes in chronic mild brain injury are associated with mental health and neurocognitive indices: a resting state fMRI study"],"prefix":"10.1007","volume":"66","author":[{"given":"Antonios","family":"Kagialis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Simos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katina","family":"Manolitsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Vakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Simos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3428-8298","authenticated-orcid":false,"given":"Efrosini","family":"Papadaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"issue":"1","key":"3352_CR1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/S1474-4422(18)30415-0","volume":"18","author":"GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators","year":"2019","unstructured":"GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators (2019) Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016. 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The University Hospital of Heraklion research review board approved this study (number of approval\u2009=\u20091008\/02122020), and the procedure was thoroughly explained to all patients who signed informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval\/informed consent"}},{"value":"The group of chronic mTBI patients in this study was similar, but not identical, to that of the reference 28, while the battery of neuropsychological tests and the parameters of the brain MRI sequences (including rs-fMRI), as well as the initial fMRI data preparation steps are the same with those of the reference 28.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Relation of this study to previous publications"}}]}}