{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:03:38Z","timestamp":1791378218307,"version":"4.3.2"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004505","name":"Universit\u00e0 degli Studi di Catania","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004505","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuroradiology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Haemolytic Uraemic Syndrome (HUS) is a rare medical condition characterised by microangiopathic haemolytic anaemia, thrombocytopenia, and acute kidney injury. Neurological complications are documented but rarely involve the cerebellum. We present a unique case of a 23-month-old male with HUS triggered by <jats:italic>Escherichia coli<\/jats:italic>-O157 (<jats:italic>E.coli-<\/jats:italic>O157) infection leading to an isolated cerebellar stroke.<\/jats:p><jats:p>The patient initially presented with fever, bloody stools, and seizures. Confirmation of <jats:italic>E.coli-<\/jats:italic>O157 infection was obtained, and MRI revealed an isolated cerebellar stroke. Treatment included supportive care, anticoagulation for a right atrial thrombus, with gradual improvement observed.<\/jats:p><jats:p>This case highlights the unusual occurrence of isolated cerebellar stroke in HUS patients, emphasising the importance of promptly recognizing manifestations of the central nervous system and the necessity for a multidisciplinary approach. Finally, a comprehensive literature review was conducted to identify cases of HUS patients with cerebellar involvement.<\/jats:p>","DOI":"10.1007\/s00234-024-03407-x","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T21:01:23Z","timestamp":1719435683000},"page":"1859-1865","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Isolated cerebellar stroke in a paediatric patient with typical haemolytic uraemic syndrome: a case report and literature review"],"prefix":"10.1007","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5413-419X","authenticated-orcid":false,"given":"Manuela","family":"Lo Bianco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9368-7088","authenticated-orcid":false,"given":"Sergio","family":"Rinella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7396-591X","authenticated-orcid":false,"given":"Felice","family":"D\u2019Arco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0422-1727","authenticated-orcid":false,"given":"Evangelia","family":"Ioannidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6299-9866","authenticated-orcid":false,"given":"Marios","family":"Kaliakatsos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"3407_CR1","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.pcl.2022.07.006","volume":"69","author":"O Boyer","year":"2022","unstructured":"Boyer O, Niaudet P (2022) Hemolytic-Uremic Syndrome in Children. 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Special care was taken to protect the privacy and confidentiality of the information of the paediatric patients involved. No identifiable personal data were included in the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"In compliance with the ethical principles on research involving minors, written informed consent was obtained from the parents of the minor for the publication of this case report and related information. This consent covers the use of clinical data and any associated images with the utmost confidentiality and without compromising the anonymity of the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}