{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T06:49:17Z","timestamp":1793342957728,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Chungbuk National University Hospital","award":["3-202207002-001"],"award-info":[{"award-number":["3-202207002-001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuroradiology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s00234-024-03521-w","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T04:51:29Z","timestamp":1734324689000},"page":"163-170","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["DTI-ALPS index as a predictor of cognitive decline over 1 year"],"prefix":"10.1007","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3586-2646","authenticated-orcid":false,"given":"Joo","family":"Jungwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3621-6806","authenticated-orcid":false,"given":"Ji Hyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4137-7376","authenticated-orcid":false,"given":"Chi-Hoon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9533-848X","authenticated-orcid":false,"given":"Jeonghwan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"3521_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s42466-021-00102-7","volume":"3","author":"I Silva","year":"2021","unstructured":"Silva I, Silva J, Ferreira R, Trigo D (2021) Glymphatic system, AQP4, and their implications in Alzheimer\u2019s disease. Neurol Res Pract 3:5. https:\/\/doi.org\/10.1186\/s42466-021-00102-7","journal-title":"Neurol Res Pract"},{"key":"3521_CR2","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1172\/jci11013","volume":"106","author":"DE Kang","year":"2000","unstructured":"Kang DE, Pietrzik CU, Baum L et al (2000) Modulation of amyloid \u03b2-protein clearance and Alzheimer\u2019s disease susceptibility by the LDL receptor\u2013related protein pathway. J Clin Invest 106:1159\u20131166. https:\/\/doi.org\/10.1172\/jci11013","journal-title":"J Clin Invest"},{"key":"3521_CR3","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1007\/s00018-024-05225-z","volume":"81","author":"K Yamada","year":"2024","unstructured":"Yamada K, Iwatsubo T (2024) Involvement of the glymphatic\/meningeal lymphatic system in Alzheimer\u2019s disease: insights into proteostasis and future directions. Cell Mol Life Sci 81:192. https:\/\/doi.org\/10.1007\/s00018-024-05225-z","journal-title":"Cell Mol Life Sci"},{"key":"3521_CR4","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s00234-023-03270-2","volume":"66","author":"G Ringstad","year":"2024","unstructured":"Ringstad G (2024) Glymphatic imaging: a critical look at the DTI-ALPS index. Neuroradiology 66:157\u2013160. https:\/\/doi.org\/10.1007\/s00234-023-03270-2","journal-title":"Neuroradiology"},{"key":"3521_CR5","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1007\/s11604-017-0617-z","volume":"35","author":"T Taoka","year":"2017","unstructured":"Taoka T, Masutani Y, Kawai H et al (2017) Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer\u2019s disease cases. Jpn J Radiol 35:172\u2013178. https:\/\/doi.org\/10.1007\/s11604-017-0617-z","journal-title":"Jpn J Radiol"},{"key":"3521_CR6","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s11604-021-01187-5","volume":"40","author":"T Taoka","year":"2021","unstructured":"Taoka T, Ito R, Nakamichi R et al (2021) Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function: CHanges in Alps index on multiple conditiON acquIsition eXperiment (CHAMONIX) study. Jpn J Radiol 40:147\u2013158. https:\/\/doi.org\/10.1007\/s11604-021-01187-5","journal-title":"Jpn J Radiol"},{"key":"3521_CR7","doi-asserted-by":"publisher","first-page":"105767","DOI":"10.1016\/j.parkreldis.2023.105767","volume":"114","author":"YJ Bae","year":"2023","unstructured":"Bae YJ, Kim J-M, Choi BS et al (2023) Glymphatic function assessment in Parkinson\u2019s disease using diffusion tensor image analysis along the perivascular space. Parkinsonism Relat Disord 114:105767. https:\/\/doi.org\/10.1016\/j.parkreldis.2023.105767","journal-title":"Parkinsonism Relat Disord"},{"key":"3521_CR8","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1161\/strokeaha.123.045857","volume":"55","author":"H Hong","year":"2024","unstructured":"Hong H, Tozer DJ, Markus HS (2024) Relationship of Perivascular Space markers with Incident Dementia in Cerebral Small Vessel Disease. Stroke 55:1032\u20131040. https:\/\/doi.org\/10.1161\/strokeaha.123.045857","journal-title":"Stroke"},{"key":"3521_CR9","doi-asserted-by":"publisher","first-page":"976089","DOI":"10.3389\/fneur.2022.976089","volume":"13","author":"CM Heo","year":"2022","unstructured":"Heo CM, Lee DA, Park KM et al (2022) Glymphatic system dysfunction in patients with early chronic kidney disease. Front Neurol 13:976089. https:\/\/doi.org\/10.3389\/fneur.2022.976089","journal-title":"Front Neurol"},{"key":"3521_CR10","doi-asserted-by":"publisher","first-page":"1383780","DOI":"10.3389\/fnins.2024.1383780","volume":"18","author":"S Yu","year":"2024","unstructured":"Yu S, Jiang H, Yu L et al (2024) DTI-ALPS index decreased in patients with type 2 diabetes Mellitus. Front Neurosci 18:1383780. https:\/\/doi.org\/10.3389\/fnins.2024.1383780","journal-title":"Front Neurosci"},{"key":"3521_CR11","doi-asserted-by":"publisher","first-page":"108647","DOI":"10.1016\/j.isci.2023.108647","volume":"27","author":"L Wu","year":"2024","unstructured":"Wu L, Zhang Z, Liang X et al (2024) Glymphatic system dysfunction in recovered patients with mild COVID-19: a DTI-ALPS study. iScience 27:108647. https:\/\/doi.org\/10.1016\/j.isci.2023.108647","journal-title":"iScience"},{"key":"3521_CR12","doi-asserted-by":"publisher","first-page":"afad107","DOI":"10.1093\/ageing\/afad107","volume":"52","author":"J Wang","year":"2023","unstructured":"Wang J, Zhou Y, Zhang K et al (2023) Glymphatic function plays a protective role in ageing-related cognitive decline. Age Ageing 52:afad107. https:\/\/doi.org\/10.1093\/ageing\/afad107","journal-title":"Age Ageing"},{"key":"3521_CR13","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/jon.12837","volume":"31","author":"CE Steward","year":"2021","unstructured":"Steward CE, Venkatraman VK, Lui E et al (2021) Assessment of the DTI-ALPS parameter along the Perivascular Space in older adults at risk of Dementia. J Neuroimaging 31:569\u2013578. https:\/\/doi.org\/10.1111\/jon.12837","journal-title":"J Neuroimaging"},{"key":"3521_CR14","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1212\/wnl.46.6.1746","volume":"46","author":"G Dooneief","year":"1996","unstructured":"Dooneief G, Marder K, Tang M-X, Stern Y (1996) The clinical dementia rating scale. Neurology 46:1746\u20131749. https:\/\/doi.org\/10.1212\/wnl.46.6.1746","journal-title":"Neurology"},{"key":"3521_CR15","doi-asserted-by":"publisher","first-page":"102","DOI":"10.4306\/pi.2010.7.2.102","volume":"7","author":"TH Kim","year":"2010","unstructured":"Kim TH, Jhoo JH, Park JH et al (2010) Korean version of Mini Mental Status Examination for Dementia Screening and its\u2019 short form. Psychiatry Invest 7:102\u2013108. https:\/\/doi.org\/10.4306\/pi.2010.7.2.102","journal-title":"Psychiatry Invest"},{"key":"3521_CR16","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1017\/s1355617704101094","volume":"10","author":"DY Lee","year":"2004","unstructured":"Lee DY, Lee KU, Lee JH et al (2004) A normative study of the CERAD neuropsychological assessment battery in the Korean elderly. J Int Neuropsychol Soc 10:72\u201381. https:\/\/doi.org\/10.1017\/s1355617704101094","journal-title":"J Int Neuropsychol Soc"},{"key":"3521_CR17","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s13195-024-01477-w","volume":"16","author":"M Koivum\u00e4ki","year":"2024","unstructured":"Koivum\u00e4ki M, Ekblad L, Lantero-Rodriguez J et al (2024) Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE \u03b54-enriched cognitively unimpaired elderly. Alzheimers Res Ther 16:112. https:\/\/doi.org\/10.1186\/s13195-024-01477-w","journal-title":"Alzheimers Res Ther"},{"key":"3521_CR18","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1212\/wnl.0000000000004336","volume":"89","author":"YY Lim","year":"2017","unstructured":"Lim YY, Mormino EC, Initiative F, the ADN et al (2017) APOE genotype and early \u03b2-amyloid accumulation in older adults without dementia. Neurology 89:1028\u20131034. https:\/\/doi.org\/10.1212\/wnl.0000000000004336","journal-title":"Neurology"},{"key":"3521_CR19","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13024-024-00711-1","volume":"19","author":"X Zeng","year":"2024","unstructured":"Zeng X, Chen Y, Sehrawat A et al (2024) Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting. Mol Neurodegener 19:40. https:\/\/doi.org\/10.1186\/s13024-024-00711-1","journal-title":"Mol Neurodegener"},{"key":"3521_CR20","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.dadm.2019.02.002","volume":"11","author":"M R\u00f3zga","year":"2019","unstructured":"R\u00f3zga M, Bittner T, Batrla R, Karl J (2019) Preanalytical sample handling recommendations for Alzheimer\u2019s disease plasma biomarkers. Alzheimers Dement (Amst) 11:291\u2013300. https:\/\/doi.org\/10.1016\/j.dadm.2019.02.002","journal-title":"Alzheimers Dement (Amst)"},{"key":"3521_CR21","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.4978980","author":"F Yeh","year":"2021","unstructured":"Yeh F (2021) DSI studio. Zenodo. https:\/\/doi.org\/10.5281\/zenodo.4978980","journal-title":"Zenodo"},{"key":"3521_CR22","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1038\/ng.440","volume":"41","author":"D Harold","year":"2009","unstructured":"Harold D, Abraham R, Hollingworth P et al (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer\u2019s disease. Nat Genet 41:1088\u20131093. https:\/\/doi.org\/10.1038\/ng.440","journal-title":"Nat Genet"},{"key":"3521_CR23","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41398-022-01899-w","volume":"12","author":"D Shi","year":"2022","unstructured":"Shi D, Xie S, Li A et al (2022) APOE-\u03b54 modulates the association among plasma A\u03b242\/A\u03b240, vascular diseases, neurodegeneration and cognitive decline in non-demented elderly adults. Transl Psychiatry 12:128. https:\/\/doi.org\/10.1038\/s41398-022-01899-w","journal-title":"Transl Psychiatry"},{"key":"3521_CR24","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3233\/adr-230029","volume":"7","author":"MV Pais","year":"2023","unstructured":"Pais MV, Forlenza OV, Diniz BS (2023) Plasma biomarkers of Alzheimer\u2019s disease: a review of available assays, recent developments, and implications for clinical practice. J Alzheimer\u2019s Dis Rep 7:355\u2013380. https:\/\/doi.org\/10.3233\/adr-230029","journal-title":"J Alzheimer\u2019s Dis Rep"},{"key":"3521_CR25","doi-asserted-by":"publisher","first-page":"555","DOI":"10.2147\/cia.s357994","volume":"17","author":"J Wang","year":"2022","unstructured":"Wang J, Gao L, Liu J et al (2022) The Association of Plasma Amyloid-\u03b2 and cognitive decline in cognitively Unimpaired Population. Clin Interv Aging 17:555\u2013565. https:\/\/doi.org\/10.2147\/cia.s357994","journal-title":"Clin Interv Aging"},{"key":"3521_CR26","doi-asserted-by":"publisher","first-page":"34","DOI":"10.14283\/jpad.2018.41","volume":"6","author":"V P\u00e9rez-Grijalba","year":"2019","unstructured":"P\u00e9rez-Grijalba V, Romero J, Pesini P et al (2019) Plasma A\u03b242\/40 ratio detects early stages of Alzheimer\u2019s Disease and correlates with CSF and neuroimaging biomarkers in the AB255 study. J Prev Alzheimer\u2019s Dis 6:34\u201341. https:\/\/doi.org\/10.14283\/jpad.2018.41","journal-title":"J Prev Alzheimer\u2019s Dis"},{"key":"3521_CR27","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s13195-023-01296-5","volume":"15","author":"S Bun","year":"2023","unstructured":"Bun S, Ito D, Tezuka T et al (2023) Performance of plasma A\u03b242\/40, measured using a fully automated immunoassay, across a broad patient population in identifying amyloid status. Alzheimer\u2019s Res Ther 15:149. https:\/\/doi.org\/10.1186\/s13195-023-01296-5","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"3521_CR28","doi-asserted-by":"publisher","unstructured":"Doecke JD, P\u00e9rez-Grijalba V, Fandos N et al (2020) Total A\u03b242\/A\u03b240 ratio in plasma predicts amyloid-PET status, independent of clinical AD diagnosis. Neurology 94. https:\/\/doi.org\/10.1212\/WNL.0000000000009240","DOI":"10.1212\/WNL.0000000000009240"},{"key":"3521_CR29","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.dadm.2017.07.004","volume":"8","author":"N Fandos","year":"2017","unstructured":"Fandos N, P\u00e9rez-Grijalba V, Pesini P et al (2017) Plasma amyloid \u03b2 42\/40 ratios as biomarkers for amyloid \u03b2 cerebral deposition in cognitively normal individuals. Alzheimer\u2019s Dement Diagnosis Assess Dis Monit 8:179\u2013187. https:\/\/doi.org\/10.1016\/j.dadm.2017.07.004","journal-title":"Alzheimer\u2019s Dement Diagnosis Assess Dis Monit"},{"key":"3521_CR30","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s13195-018-0444-1","volume":"10","author":"I de Rojas","year":"2018","unstructured":"de Rojas I, Romero J, Rodr\u00edguez-Gomez O et al (2018) Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundaci\u00f3 ACE Healthy Brain Initiative (FACEHBI). Alzheimers Res Ther 10:119. https:\/\/doi.org\/10.1186\/s13195-018-0444-1","journal-title":"Alzheimers Res Ther"},{"key":"3521_CR31","doi-asserted-by":"publisher","first-page":"20220315","DOI":"10.1259\/bjr.20220315","volume":"96","author":"T Liang","year":"2023","unstructured":"Liang T, Chang F, Huang Z et al (2023) Evaluation of glymphatic system activity by diffusion tensor image analysis along the perivascular space (DTI-ALPS) in dementia patients. Br J Radiol 96:20220315. https:\/\/doi.org\/10.1259\/bjr.20220315","journal-title":"Br J Radiol"},{"key":"3521_CR32","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13195-024-01407-w","volume":"16","author":"H Hong","year":"2024","unstructured":"Hong H, Hong L, Luo X et al (2024) The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer\u2019s disease continuum participants. Alzheimers Res Ther 16:43. https:\/\/doi.org\/10.1186\/s13195-024-01407-w","journal-title":"Alzheimers Res Ther"},{"key":"3521_CR33","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1007\/s00330-023-10122-3","volume":"34","author":"X Zhang","year":"2024","unstructured":"Zhang X, Wang Y, Jiao B et al (2024) Glymphatic system impairment in Alzheimer\u2019s disease: associations with perivascular space volume and cognitive function. Eur Radiol 34:1314\u20131323. https:\/\/doi.org\/10.1007\/s00330-023-10122-3","journal-title":"Eur Radiol"},{"key":"3521_CR34","doi-asserted-by":"publisher","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","volume":"26","author":"H Hampel","year":"2021","unstructured":"Hampel H, Hardy J, Blennow K et al (2021) The Amyloid-\u03b2 pathway in Alzheimer\u2019s Disease. Mol Psychiatry 26:5481\u20135503. https:\/\/doi.org\/10.1038\/s41380-021-01249-0","journal-title":"Mol Psychiatry"},{"key":"3521_CR35","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1161\/strokeaha.108.536839","volume":"40","author":"EE Smith","year":"2009","unstructured":"Smith EE, Greenberg SM (2009) \u03b2-Amyloid, blood vessels, and brain function. Stroke 40:2601\u20132606. https:\/\/doi.org\/10.1161\/strokeaha.108.536839","journal-title":"Stroke"}],"container-title":["Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00234-024-03521-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00234-024-03521-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00234-024-03521-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T05:34:14Z","timestamp":1738820054000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00234-024-03521-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["3521"],"URL":"https:\/\/doi.org\/10.1007\/s00234-024-03521-w","relation":{},"ISSN":["0028-3940","1432-1920"],"issn-type":[{"value":"0028-3940","type":"print"},{"value":"1432-1920","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,16]]},"assertion":[{"value":"8 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Institutional Review Board of Chungbuk National University Hospital approved the study (CBNUH 2022-05-008-001).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All participants provided signed informed content.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All of authors have no conflicts of interest to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}