{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:17:16Z","timestamp":1786979836128,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171151"],"award-info":[{"award-number":["82171151"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuroradiology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1007\/s00234-025-03556-7","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T09:41:11Z","timestamp":1738921271000},"page":"1485-1493","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reduced DTI-ALPS index in tinnitus patients: DTI-ALPS as a mediator of sleep on tinnitus"],"prefix":"10.1007","volume":"67","author":[{"given":"Yinfei","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-quan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo-mi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen-di","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-qi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-cheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2464-5965","authenticated-orcid":false,"given":"Xiang-li","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"issue":"4","key":"3556_CR1","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1002\/cpp.2708","volume":"29","author":"M Czornik","year":"2022","unstructured":"Czornik M, Malekshahi A et al (2022) Psychophysiological treatment of chronic tinnitus: a review. Clin Psychol Psychother 29(4):1236\u20131253","journal-title":"Clin Psychol Psychother"},{"issue":"45","key":"3556_CR2","doi-asserted-by":"publisher","first-page":"14972","DOI":"10.1523\/JNEUROSCI.4028-10.2010","volume":"30","author":"LE Roberts","year":"2010","unstructured":"Roberts LE, Eggermont JJ et al (2010) Ringing ears: the neuroscience of tinnitus. J Neuroscience: Official J Soc Neurosci 30(45):14972\u201314979","journal-title":"J Neuroscience: Official J Soc Neurosci"},{"key":"3556_CR3","doi-asserted-by":"crossref","unstructured":"Schecklmann M, Pregler M et al (2015) Psychophysiological associations between chronic tinnitus and sleep: a cross validation of tinnitus and insomnia questionnaires. BioMed Res Int 2015:461090","DOI":"10.1155\/2015\/461090"},{"issue":"11","key":"3556_CR4","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1177\/000348941312201107","volume":"122","author":"K Izuhara","year":"2013","unstructured":"Izuhara K, Wada K et al (2013) Association between tinnitus and sleep disorders in the general Japanese population. Ann Otol Rhinol Laryngol 122(11):701\u2013706","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"10","key":"3556_CR5","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1097\/CM9.0000000000001382","volume":"134","author":"BX Fang","year":"2021","unstructured":"Fang BX, Liang YF et al (2021) Acute exacerbation of chronic subjective tinnitus: a cross-sectional study. Chin Med J (Engl) 134(10):1242\u20131244","journal-title":"Chin Med J (Engl)"},{"issue":"10","key":"3556_CR6","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1177\/0003489414532779","volume":"123","author":"GS Miguel","year":"2014","unstructured":"Miguel GS, Yaremchuk K et al (2014) The effect of insomnia on tinnitus. Ann Otol Rhinol Laryngol 123(10):696\u2013700","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"4","key":"3556_CR7","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1044\/2015_AJA-15-0020","volume":"24","author":"T Pan","year":"2015","unstructured":"Pan T, Tyler RS et al (2015) Differences among patients that make their Tinnitus worse or better. Am J Audiol 24(4):469\u2013476","journal-title":"Am J Audiol"},{"issue":"3","key":"3556_CR8","doi-asserted-by":"publisher","first-page":"399","DOI":"10.5664\/jcsm.10882","volume":"20","author":"JA Weingarten","year":"2024","unstructured":"Weingarten JA, Islam A et al (2024) The association of subjective and objective sleep measures with chronic tinnitus. J Clin Sleep Med 20(3):399\u2013405","journal-title":"J Clin Sleep Med"},{"issue":"11","key":"3556_CR9","first-page":"1016","volume":"17","author":"MK Rasmussen","year":"2018","unstructured":"Rasmussen MK, Mestre H et al (2018) The glymphatic pathway in neurological disorders. The Lancet. Neurology 17(11):1016\u20131024","journal-title":"Neurology"},{"issue":"3","key":"3556_CR10","doi-asserted-by":"publisher","first-page":"e2002574118","DOI":"10.1073\/pnas.2002574118","volume":"118","author":"\u00c9 Mezey","year":"2021","unstructured":"Mezey \u00c9, Szalayova I et al (2021) An immunohistochemical study of lymphatic elements in the human brain. Proc Natl Acad Sci USA 118(3):e2002574118","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"3556_CR11","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/s41531-022-00437-1","volume":"8","author":"T Shen","year":"2022","unstructured":"Shen T, Yue Y et al (2022) Diffusion along perivascular spaces as marker for impairment of glymphatic system in Parkinson\u2019s disease. NPJ Parkinson\u2019s Disease 8(1):174","journal-title":"NPJ Parkinson\u2019s Disease"},{"issue":"17","key":"3556_CR12","doi-asserted-by":"publisher","first-page":"4483","DOI":"10.1073\/pnas.1721694115","volume":"115","author":"E Shokri-Kojori","year":"2018","unstructured":"Shokri-Kojori E, Wang G et al (2018) \u03b2-Amyloid accumulation in the human brain after one night of sleep deprivation. Proc Natl Acad Sci USA 115(17):4483\u20134488","journal-title":"Proc Natl Acad Sci USA"},{"key":"3556_CR13","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/biomedicines10092261","volume":"10","author":"FR Buccellato","year":"2022","unstructured":"Buccellato FR, D\u2019Anca M et al (2022) The role of Glymphatic System in Alzheimer\u2019s and Parkinson\u2019s Disease Pathogenesis. Biomedicines 10:9","journal-title":"Biomedicines"},{"issue":"4","key":"3556_CR14","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1007\/s11604-017-0617-z","volume":"35","author":"T Taoka","year":"2017","unstructured":"Taoka T, Masutani Y et al (2017) Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer\u2019s disease cases. Japanese J Radiol 35(4):172\u2013178","journal-title":"Japanese J Radiol"},{"key":"3556_CR15","doi-asserted-by":"publisher","first-page":"101917","DOI":"10.1016\/j.pneurobio.2020.101917","volume":"198","author":"J Christensen","year":"2021","unstructured":"Christensen J, Yamakawa GR et al (2021) Is the glymphatic system the missing link between sleep impairments and neurological disorders? Examining the implications and uncertainties. Prog Neurobiol 198:101917","journal-title":"Prog Neurobiol"},{"issue":"12","key":"3556_CR16","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","volume":"40","author":"NA Jessen","year":"2015","unstructured":"Jessen NA, Munk ASF et al (2015) The Glymphatic System: a beginner\u2019s guide. Neurochem Res 40(12):2583\u20132599","journal-title":"Neurochem Res"},{"key":"3556_CR17","doi-asserted-by":"crossref","unstructured":"Xuan X, Zhou G et al (2022) Glymphatic system: emerging therapeutic target for neurological diseases. Oxidative Med Cell Longev 2022:6189170","DOI":"10.1155\/2022\/6189170"},{"issue":"1","key":"3556_CR18","doi-asserted-by":"publisher","first-page":"4411","DOI":"10.1038\/s41467-020-18115-2","volume":"11","author":"LM Hablitz","year":"2020","unstructured":"Hablitz LM, Pl\u00e1 V et al (2020) Circadian control of brain glymphatic and lymphatic fluid flow. Nat Commun 11(1):4411","journal-title":"Nat Commun"},{"issue":"6156","key":"3556_CR19","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1126\/science.1241224","volume":"342","author":"L Xie","year":"2013","unstructured":"Xie L, Kang H et al (2013) Sleep drives metabolite clearance from the adult brain. Sci (New York N Y) 342(6156):373\u2013377","journal-title":"Sci (New York N Y)"},{"issue":"1","key":"3556_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40675-014-0004-6","volume":"1","author":"J O\u2019Donnell","year":"2015","unstructured":"O\u2019Donnell J, Ding F et al (2015) Distinct functional states of astrocytes during sleep and wakefulness: is norepinephrine the master regulator? Curr Sleep Med Rep 1(1):1\u20138","journal-title":"Curr Sleep Med Rep"},{"key":"3556_CR21","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.smrv.2015.08.005","volume":"28","author":"JM Krueger","year":"2016","unstructured":"Krueger JM, Frank MG et al (2016) Sleep function: toward elucidating an enigma. Sleep Med Rev 28:46\u201354","journal-title":"Sleep Med Rev"},{"issue":"8","key":"3556_CR22","doi-asserted-by":"publisher","first-page":"e829","DOI":"10.1212\/WNL.0000000000013215","volume":"98","author":"TY Siow","year":"2022","unstructured":"Siow TY, Toh CH et al (2022) Association of Sleep, Neuropsychological Performance, and Gray Matter volume with glymphatic function in Community-Dwelling older adults. Neurology 98(8):e829\u2013e838","journal-title":"Neurology"},{"issue":"2","key":"3556_CR23","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","volume":"28","author":"DJ Buysse","year":"1989","unstructured":"Buysse DJ, Reynolds CFR et al (1989) The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 28(2):193\u2013213","journal-title":"Psychiatry Res"},{"issue":"2","key":"3556_CR24","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0167-4943(03)00028-1","volume":"37","author":"R Asplund","year":"2003","unstructured":"Asplund R (2003) Sleepiness and sleep in elderly persons with tinnitus. Arch Gerontol Geriatr 37(2):139\u2013145","journal-title":"Arch Gerontol Geriatr"},{"issue":"4","key":"3556_CR25","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1097\/AUD.0b013e31827bc436","volume":"34","author":"G Attanasio","year":"2013","unstructured":"Attanasio G, Russo FY et al (2013) Sleep architecture variation in chronic tinnitus patients. Ear Hear 34(4):503\u2013507","journal-title":"Ear Hear"},{"issue":"5","key":"3556_CR26","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.jfma.2021.07.022","volume":"121","author":"YL Li","year":"2022","unstructured":"Li YL, Hsu YC et al (2022) Sleep disturbance and psychological distress in adult patients with tinnitus. J Formos Med Assoc 121(5):995\u20131002","journal-title":"J Formos Med Assoc"},{"issue":"1","key":"3556_CR27","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.smrv.2012.04.003","volume":"17","author":"E Wallh\u00e4usser-Franke","year":"2013","unstructured":"Wallh\u00e4usser-Franke E, Schredl M et al (2013) Tinnitus and Insomnia: is hyperarousal the common denominator? Sleep Med Rev 17(1):65\u201374","journal-title":"Sleep Med Rev"},{"issue":"9","key":"3556_CR28","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1177\/0271678X221090747","volume":"42","author":"PK Eide","year":"2022","unstructured":"Eide PK, Pripp AH et al (2022) Altered glymphatic enhancement of cerebrospinal fluid tracer in individuals with chronic poor sleep quality. J Cereb Blood Flow Metabolism 42(9):1676\u20131692","journal-title":"J Cereb Blood Flow Metabolism"},{"issue":"1","key":"3556_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/RLI.0000000000000969","volume":"59","author":"S Naganawa","year":"2024","unstructured":"Naganawa S, Taoka T et al (2024) The Glymphatic System in humans: investigations with magnetic resonance imaging. Invest Radiol 59(1):1\u201312","journal-title":"Invest Radiol"},{"issue":"6512","key":"3556_CR30","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1126\/science.abb8739","volume":"370","author":"M Nedergaard","year":"2020","unstructured":"Nedergaard M, Goldman SA (2020) Glymphatic failure as a final common pathway to dementia. Sci (New York N Y) 370(6512):50\u201356","journal-title":"Sci (New York N Y)"},{"issue":"5955","key":"3556_CR31","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1126\/science.1180962","volume":"326","author":"J Kang","year":"2009","unstructured":"Kang J, Lim MM et al (2009) Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science (New York, N.Y.) 326(5955):1005\u20131007","journal-title":"Science (New York, N.Y.)"},{"issue":"150","key":"3556_CR32","doi-asserted-by":"publisher","first-page":"150ra122","DOI":"10.1126\/scitranslmed.3004291","volume":"4","author":"JH Roh","year":"2012","unstructured":"Roh JH, Huang Y et al (2012) Disruption of the sleep-wake cycle and diurnal fluctuation of \u03b2-amyloid in mice with Alzheimer\u2019s disease pathology. Sci Transl Med 4(150):150ra122","journal-title":"Sci Transl Med"}],"container-title":["Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00234-025-03556-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00234-025-03556-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00234-025-03556-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T04:46:20Z","timestamp":1757133980000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00234-025-03556-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,7]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["3556"],"URL":"https:\/\/doi.org\/10.1007\/s00234-025-03556-7","relation":{},"ISSN":["0028-3940","1432-1920"],"issn-type":[{"value":"0028-3940","type":"print"},{"value":"1432-1920","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,7]]},"assertion":[{"value":"23 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by Medical Ethics Committee of the Third Affiliated Hospital of Sun Yat-sen University(Approval No: [2022]02-286-01).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that there is no potential conflict of interests regarding the publication of this paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}