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Vessel stenoses can lead to delayed hemodynamic responses. We aimed to investigate whether delay correction improves the quality of bh-fMRI compared to the diagnostic standard [\n                      <jats:sup>15<\/jats:sup>\n                      O]water PET.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The bh-fMRI data sets of 25 patients with Moyamoya Angiopathy were analyzed retrospectively without and with delay correction. Delay correction was calculated using time-to-peak (TTP) maps derived from dynamic susceptibility contrast (DSC) perfusion MRI. [\n                      <jats:sup>15<\/jats:sup>\n                      O]water PET maps and bh-fMRI maps without and with delay correction were presented blinded for delay correction to two neuroradiologists. The agreement between bh-fMRI without and with delay correction and [\n                      <jats:sup>15<\/jats:sup>\n                      O]water PET was independently and consensually rated on a 4-point-Likert scale (1\u2009=\u2009poor, 2\u2009=\u2009moderate, 3\u2009=\u2009good, 4\u2009=\u2009excellent) and compared with Wilcoxon signed-rank test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The agreement between bh-fMRI and [\n                      <jats:sup>15<\/jats:sup>\n                      O]water PET without delay correction was good\/excellent (median\u2009=\u20093, modus\u2009=\u20094), and improved significantly after delay correction with medium effect size (median\u2009=\u20094, modus\u2009=\u20094, z = -2.121,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034,\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.42).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Delay correction improves the quality of bh-fMRI and seems to be helpful in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00234-025-03649-3","type":"journal-article","created":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T04:03:33Z","timestamp":1748059413000},"page":"2121-2129","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Measuring cerebrovascular reactivity with breath-hold fMRI in patients with Moyamoya angiopathy: MR perfusion based delay correction significantly improves agreement to [15O]water PET"],"prefix":"10.1007","volume":"67","author":[{"given":"Leonie","family":"Zerweck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Klose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"Roder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Staber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emely","family":"Renger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganna","family":"Blazhenets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Grundmann-Hauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp T.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Ernemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till-Karsten","family":"Hauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,24]]},"reference":[{"key":"3649_CR1","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s00234-022-03088-4","volume":"65","author":"L Zerweck","year":"2023","unstructured":"Zerweck L, Hauser TK, Roder C, Blazhenets G, Khan N, Ernemann U et al (2023) Evaluation of the cerebrovascular reactivity in patients with Moyamoya angiopathy by use of breath-hold fMRI: investigation of voxel-wise hemodynamic delay correction in comparison to [(15)O]water PET. 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