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Subjects with significant cognitive impairment, white matter disease, other CNS disorders, or poor-quality diffusion data were excluded. ALPS indices were calculated from projection and association fibre regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both PD (mean ALPS = 1.34 \u00b1 0.19) and ET ( 1.31 \u00b1 0.13) groups exhibited 12 significantly lower ALPS values than HC ( 1.54\u00b10.11 P &lt; 0.05), but no difference was 13 found between PD and ET.<\/jats:p>\n                    <jats:p>In PD, lower ALPS correlated with greater tremor severity and older age, particularly in the right hemisphere (R\u00b2=0.80, p=0.003). ET showed weaker clinical associations though MoCA correlated positively with right-hemisphere ALPS (\u03c1=0.462, p=0.018).\u00a0<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings indicate perivascular diffusivity is reduced in both tremor-dominant PD and ET, supporting a role for glymphatic dysfunction in their pathophysiology, though larger, prospective studies are needed to validate this observation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00234-025-03840-6","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T07:29:22Z","timestamp":1763623762000},"page":"483-491","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Similar DTI-ALPS metrics in Parkinson\u2019s disease and essential tremor: a cross-sectional comparative analysis"],"prefix":"10.1007","volume":"68","author":[{"given":"Federico","family":"Bruno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Innocenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierfrancesco","family":"Badini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Cella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Santobuono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Pertici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Catalucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Saporito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Sucapane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierpaolo","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Arrigoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Barile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Di Cesare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pistoia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Splendiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"issue":"147","key":"3840_CR1","doi-asserted-by":"publisher","first-page":"147ra11","DOI":"10.1126\/scitranslmed.3003748","volume":"4","author":"JJ Iliff","year":"2012","unstructured":"Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA et al (2012) A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. 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