{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:52:36Z","timestamp":1781632356143,"version":"3.54.5"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002332","name":"Semmelweis University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuroradiology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Here we report the first human observation of an imaging pattern in early hyperacute ischemic stroke, in which restricted diffusion is detectable on ADC maps before it becomes appreciable on DWI. The pattern\u2014an ADC\/DWI mismatch\u2014was incidentally captured in a thalamic infarct during MRI obtained after a transient ischemic attack in a different vascular territory, enabling observation at an early hyperacute stage. Quantitative measurements at three time points demonstrated falling relative ADC and slower-rising relative DWI signal, aligning with thresholds for visual detectability. Although anticipated by animal data, this dissociation has not, to our knowledge, been documented in humans. Recognition of this putative earliest stage of ischemia may refine stroke diagnosis and inform MRI acquisition and interpretation protocols.<\/jats:p>","DOI":"10.1007\/s00234-026-03910-3","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:52:12Z","timestamp":1769147532000},"page":"711-716","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discordant ADC and DWI signal evolution in hyperacute stroke: implications for early imaging interpretation"],"prefix":"10.1007","volume":"68","author":[{"given":"Anna","family":"Sz\u0151cs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1t\u00e9","family":"Magyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e1l","family":"Maurovich-Horvat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Barsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"issue":"9","key":"3910_CR1","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1161\/01.str.29.9.1783","volume":"29","author":"KJ van Everdingen","year":"1998","unstructured":"van Everdingen KJ, van der Grond J, Kappelle LJ, Ramos LM, Mali WP (1998) Diffusion-weighted magnetic resonance imaging in acute stroke. 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Institutional requirements state that ethics approval is not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable, as this retrospective case report describes routine clinical care and did not involve research participation.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Written informed consent for publication of anonymised clinical data and radiological images was obtained from the patient.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}