{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:14:34Z","timestamp":1778649274343,"version":"3.51.4"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100018936","name":"Universit\u00e4tsklinikum Heidelberg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018936","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuroradiology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Flat-detector computed tomography (FDCT) is increasingly used for periinterventional cerebral imaging. The recently introduced Sine Spin FDCT (S-FDCT) aims to improve cerebral soft tissue contrast compared with conventional FDCT (C-FDCT). Reliable visualization of healthy brain parenchyma is essential for detecting pathological changes. This study compared gray\u2013white matter differentiation between intraindividually acquired S-FDCT and C-FDCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of a prospectively maintained database included patients with ischemic stroke treated by mechanical thrombectomy who underwent both S-FDCT and C-FDCT within the same interventional session on a latest-generation angiography system. Quantitative image quality was assessed using the contrast-to-noise ratio (CNR). Qualitative image quality was evaluated using a five-point scale at basal ganglia and supratentorial cortex. Analyses focused on healthy brain parenchyma contralateral to infarction. Radiation dose was assessed using entrance-skin dose and dose-area product (DAP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty patients (74.2\u2009\u00b1\u200915.3 years) were analyzed. S-FDCT demonstrated a higher CNR than C-FDCT (mean CNR\u2009\u00b1\u2009SD: 2.62\u2009\u00b1\u20091.36 versus 1.03\u2009\u00b1\u20090.38;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Qualitative ratings were higher for S-FDCT at the basal ganglia (2.45\u2009\u00b1\u20090.71 versus 1.54\u2009\u00b1\u20090.53;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and supratentorial cortex (3.01\u2009\u00b1\u20090.80 versus 1.71\u2009\u00b1\u20090.60;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Inter-reader agreement was good (\u03ba\u2009=\u20090.798). S-FDCT showed a moderately higher radiation dose than C-FDCT (DAP: 50.6\u2009\u00b1\u20093.10 versus 46.89\u2009\u00b1\u20092.86\u00a0Gy\u00b7cm\u00b2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>S-FDCT improves cerebral soft tissue visualization compared with C-FDCT in periinterventional imaging. These findings highlight the potential of Sine Spin technology to enhance FDCT image quality and support its role in advanced angiography-suite\u2013based neuroimaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00234-026-04033-5","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:45:49Z","timestamp":1778647549000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sine spin flat-detector CT for enhanced brain parenchyma visualization: an intraindividual comparison on a latest-generation angiography system"],"prefix":"10.1007","author":[{"given":"Marvin","family":"Heinrich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph M.","family":"Mooshage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael O.","family":"Breckwoldt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Preisner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kianush","family":"Karimian-Jazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Hubert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Hilgenfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Herweh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Wucherpfennig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Bendszus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik F.","family":"Vollherbst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus A.","family":"M\u00f6hlenbruch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2509-5459","authenticated-orcid":false,"given":"Niclas","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"issue":"5","key":"4033_CR1","doi-asserted-by":"publisher","first-page":"052115","DOI":"10.1117\/1.JMI.8.5.052115","volume":"8","author":"R Fahrig","year":"2021","unstructured":"Fahrig R, Jaffray DA, Sechopoulos I, Webster Stayman J (2021) Flat-panel conebeam CT in the clinic: history and current state. 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MO Breckwoldt received funding from DFG (SFB1389 and Emmy Noether program, BR 6153\/1-1), EKFS and Novartis Pharma GmbH, unrelated to this work. K Karimian-Jazi received research support from Novartis Pharma GmbH, unrelated to this work (N\u00fcrnberg, Germany) and acknowledges a clinician scientist fellowship of the Medical Faculty, University of Heidelberg. C Herweh reports Consultancy payments by Brainomix & Lecture fees by Stryker. L Wucherpfennig was participant of the Career Development Program funded by the medical faculty of the University of Heidelberg, and reports speaker fees from Vertex Pharmaceuticals and consulting fees from Antaros Medical and Boehringer Ingelheim, all paid to the institution and unrelated to the present study. M Bendszus reports funding from the European Union Horizon 2020 and Deutsche Forschungsgemeinschaft (payments to the institution); honoraria for lectures from Novartis, Boehringer Ingelheim, and Seagen; consulting fees from NeuroScios and Boehringer Ingelheim; and a role as Editor-in-Chief of Clinical Neuroradiology (Springer), outside the submitted work. DF Vollherbst reports consultancy for Medtronic and payed lectures for Cerenovus, and a research grant by MicroVention, unrelated to this work. MA M\u00f6hlenbruch reportsgrants from Balt, Medtronic, MicroVention, and Stryker; consulting feesf rom Siemens; and support for attending meetings or travel from Europa Group, outside the submitted work. N Schmitt reports travel support from Medtronic, MicroVention, and Johnson & Johnson, as well as technical and financial research support from Siemens Healthineers, outside the submitted work.M Heinrich, F Preisner, D Schwarz, A Hubert, and T Hilgenfeld report no disclosures relevant for this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}