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Given the differential properties along the hippocampal longitudinal axis, this study aimed to evaluate anterior-posterior subregional hippocampal volume differences among ADc, SNAP, and biomarker-negative participants, and their associations with CSF biomarkers and clinical presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data from 1242 participants in the Alzheimer\u2019s Disease Neuroimaging Initiative were analyzed. Biomarker-negative participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009234) had normal CSF A\u03b242 (\u2265\u2009192 pg\/ml), total tau (&lt;\u200993 pg\/ml), and phosphorylated tau at threonine 181 (&lt;\u200923 pg\/ml). ADc individuals (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009784) had abnormal A\u03b242, and SNAP (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009224) showed normal A\u03b242 with elevated tau. T1-weighted MRI scans were used to segment the hippocampus into anterior, intermediate, and posterior subregions. Controlling for age, sex, and multiple comparisons, groups were compared using one-way ANOVA, and Pearson correlation coefficients were calculated to assess the relationships between volumetric variables and age, CSF biomarkers, or neuropsychological scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ADc individuals showed significantly lower total and subregional hippocampal volumes compared with SNAP and biomarker-negative participants (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Normalized volumes to total ipsilateral hippocampal volume revealed greater posterior atrophy (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and relatively higher anterior volume (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) in ADc. SNAP and biomarker-negative participants showed stronger correlations between hippocampal volumes and age. Several subregional hippocampal volumes correlated with CSF biomarkers, cognitive performance, neuropsychiatric symptoms, and functional impairment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study reveals distinct patterns of hippocampal atrophy in ADc and SNAP, enhancing our understanding of their differential pathophysiology and associated clinical features.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00234-026-04061-1","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:49:13Z","timestamp":1780732153000},"page":"2947-2961","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential atrophy along the longitudinal axis of the hippocampus in Alzheimer\u2019s disease and suspected non-Alzheimer\u2019s disease pathophysiology (SNAP)"],"prefix":"10.1007","volume":"68","author":[{"given":"Torcato","family":"Meira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela","family":"Morais-Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Jesus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Gil","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,6]]},"reference":[{"key":"4061_CR1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3233\/JAD-130011","volume":"37","author":"BA Gordon","year":"2013","unstructured":"Gordon BA, Blazey T, Benzinger TLS, Head D (2013) Effects of aging and Alzheimer\u2019s disease along the longitudinal axis of the hippocampus. 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