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In a secondary analysis of a previously reported single-center cohort, we compared MT for isolated M2\/M3 occlusions within versus beyond 6\u00a0h from last known well.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients treated between January 2020 and August 2023 were retrospectively stratified by last-known-well-to-groin-puncture time (\u2264\u20096\u00a0h vs.\u2009&gt;\u20096\u00a0h). The primary outcome was functional independence (modified Rankin Scale [mRS] 0\u20132) at 90 days. Because all patients underwent MT, superiority over medical management cannot be addressed. Logistic regression was adjusted for age and baseline NIHSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy-six patients were analyzed (56 early, 20 late). No significant difference was detected in 90-day functional independence (8\/20 [40.0%] vs. 22\/56 [39.3%]; absolute risk difference + 0.7%, 95% confidence interval [CI] \u2212 24.3 to + 25.7;\n                      <jats:italic>p<\/jats:italic>\n                      = 1.00), the ordinal 90-day mRS (median 3 vs. 3;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.56), or 90-day mortality (15.0% vs. 10.7%;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.69). After adjustment, late-window treatment was not associated with functional independence (adjusted odds ratio 0.75, 95% CI 0.22\u20132.56). Late-window procedures required more retrieval maneuvers (median 2 [1\u20133] vs. 1 [1, 2];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.017) and rescue therapy (50.0% vs. 14.3%;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004) and numerically achieved complete first-pass reperfusion less often (20.0% vs. 46.4%;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.070). Symptomatic intracranial hemorrhage was numerically higher in the late group (10.0% vs. 1.8%;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.17).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>No statistically significant 90-day outcome difference was detected, although wide confidence intervals do not exclude clinically meaningful differences and a medical-management comparator was absent. Late-window procedures involved greater procedural effort. Findings are descriptive and hypothesis-generating.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00234-026-04168-5","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:40:56Z","timestamp":1788342056000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early- versus Late-Window Mechanical Thrombectomy for Isolated M2\/M3 Middle Cerebral Artery Occlusions: 90-Day Outcomes and Procedural Characteristics in a Single-Center Cohort"],"prefix":"10.1007","author":[{"given":"Weis","family":"Naziri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel Cedric","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan Daniel","family":"Gheorghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Simgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah","family":"Aburub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"issue":"9","key":"4168_CR1","doi-asserted-by":"publisher","first-page":"634","DOI":"10.2471\/BLT.16.181636","volume":"94","author":"W Johnson","year":"2016","unstructured":"Johnson W, Onuma O, Owolabi M et al (2016) Stroke: a global response is needed. 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Ethical approval was obtained from the responsible ethics committees of the participating institutions (no. 2022-16455-retrospektiv).","order":1,"name":"Ethics","label":"Ethics Statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Because of the retrospective design, the requirement for informed consent was waived by the ethics committees.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable (no identifiable patient data are presented).","order":4,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}}]}}