{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:25:45Z","timestamp":1791606345892,"version":"4.3.4"},"reference-count":74,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Evol"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1007\/s00239-008-9067-7","type":"journal-article","created":{"date-parts":[[2008,2,5]],"date-time":"2008-02-05T15:27:04Z","timestamp":1202225224000},"page":"151-166","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Rapid Evolution by Positive Selection and Gene Gain and Loss: PLA2 Venom Genes in Closely Related Sistrurus Rattlesnakes with Divergent Diets"],"prefix":"10.1007","volume":"66","author":[{"given":"H. Lisle","family":"Gibbs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Rossiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,2,6]]},"reference":[{"key":"9067_CR1","doi-asserted-by":"crossref","first-page":"9742","DOI":"10.1016\/S0021-9258(17)39301-8","volume":"260","author":"S Brunie","year":"1985","unstructured":"Brunie S, Bolin J, Gewirth D et al (1985) The refined crystal structure of dimeric phospholipase A2 at 25 \u00c5. J Biol Chem 260:9742\u20139749","journal-title":"J Biol Chem"},{"key":"9067_CR2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0041-0101(97)00051-2","volume":"36","author":"E Carredano","year":"1998","unstructured":"Carredano E, Westerlund B, Persson B et al (1998) The threedimensional structures of two toxins from snake venom throw light on the anticoagulant and neurotoxic sites of phospholipase A2. Toxicon 36:75\u201392","journal-title":"Toxicon"},{"key":"9067_CR3","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s002510050323","volume":"47","author":"N Cereb","year":"1997","unstructured":"Cereb N, Hughes AL, Yang SY (1997) Locus-specific conservation of the HLA class I introns by intra-locus homogenization. Immunogenetics 47:30\u201336","journal-title":"Immunogenetics"},{"key":"9067_CR4","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1042\/BJ20040058","volume":"381","author":"Y Chen","year":"2004","unstructured":"Chen Y, Wang Y, Hseu M et al (2004) Molecular evolution and structure-function relationships of crototoxin-like and asparagines-6-containing phosphlolipase A2 in pit viper venoms. Biochem J 381:25\u201334","journal-title":"Biochem J"},{"key":"9067_CR5","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1042\/0264-6021:3470491","volume":"347","author":"T Chijiwa","year":"2000","unstructured":"Chijiwa T, Deshimaru M, Nobuhisha I et al (2000) Regional evolution of venom-gland phospholipase A2 isoenzymes of Trimeresurus flavoviridis snakes in the southwestern islands of Japan. Biochem J 347:491\u2013499","journal-title":"Biochem J"},{"key":"9067_CR6","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1007\/s00239-002-2400-7","volume":"56","author":"T Chijiwa","year":"2003","unstructured":"Chijiwa T, Yamaguchi Y, Ogawa T et al (2003) Interisland evolution of Trimeresurus flavoviridis venom phospholipase A2 isozymes. J Mol Evol 56:286\u2013293","journal-title":"J Mol Evol"},{"key":"9067_CR7","volume-title":"A field guide to reptiles & amphibians of eastern & central North America","author":"R Conant","year":"1998","unstructured":"Conant R, Collins JT (1998) A field guide to reptiles & amphibians of eastern & central North America. 3rd ed. Houghton Mifflin, New York","edition":"3"},{"key":"9067_CR8","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1098\/rspb.2004.2969","volume":"272","author":"JA Cotton","year":"2005","unstructured":"Cotton JA, Page RDM (2005) Rates and patterns of gene duplication and loss in the human genome. Proc Roy Soc Lond 272:277\u2013283","journal-title":"Proc Roy Soc Lond"},{"key":"9067_CR9","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s00239-002-2403-4","volume":"56","author":"S Creer","year":"2003","unstructured":"Creer S, Malhotra A, Thorpe RS, et al (2003) Genetic and ecological correlates of intraspecific variation in pitviper venom composition detected using matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF-MS) and isoelectric focusing. J Mol Evol 56:317\u2013329","journal-title":"J Mol Evol"},{"key":"9067_CR10","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/379537a0","volume":"379","author":"JC Daltry","year":"1996","unstructured":"Daltry JC, Wuster W, Thorpe RS (1996) Diet and snake venom evolution. Nature 379:537\u2013540","journal-title":"Nature"},{"key":"9067_CR11","first-page":"29","volume-title":"Venom phospholipse A2 enzymes: structure, function, and mechanism","author":"JM Danse","year":"1997","unstructured":"Danse JM, Gasparini S, Menez A (1997) Molecular biology of snake venom phospholipase A2. In: Kini RM (ed) Venom phospholipse A2 enzymes: structure, function, and mechanism. J. Wiley and Sons, Chichester, UK, pp 29\u201371"},{"key":"9067_CR12","unstructured":"Demuth JP, Bie TD, Stajich JE et al (2006) The evolution of mammalian gene families. PLoS ONE 1:e85 doi:101371\/journal.pone.0000085"},{"key":"9067_CR13","doi-asserted-by":"publisher","first-page":"3353","DOI":"10.1111\/j.1365-294X.2006.03007.x","volume":"15","author":"ME Douglas","year":"2006","unstructured":"Douglas ME, Douglas MR, Schuett GW et al (2006) Evolution of rattlesnakes (Viperidae; Crotalus) in the warm deserts of western North America shaped by Neogene vicariance and Quaternary climate change. Mol Ecol 15:3353\u20133374","journal-title":"Mol Ecol"},{"key":"9067_CR14","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/nrg1128","volume":"4","author":"ME Feder","year":"2003","unstructured":"Feder ME, Mitchell-Olds T (2003) Evolutionary and ecological functional genomics. Nature Rev Genet 4:649\u2013655","journal-title":"Nature Rev Genet"},{"key":"9067_CR15","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1101\/gr.3228405","volume":"15","author":"BG Fry","year":"2005","unstructured":"Fry BG (2005) From genome to \u2018venome\u2019: molecular origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences and related body proteins. Genome Res 15:403\u2013420","journal-title":"Genome Res"},{"key":"9067_CR16","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1093\/molbev\/msh091","volume":"21","author":"BG Fry","year":"2004","unstructured":"Fry BG, W\u00fcster W (2004) Assembling an arsenal: origin and evolution ofthe snake venom proteome inferred from phylogenetic analysis of toxin sequences. Mol Biol Evol 21:870\u2013883","journal-title":"Mol Biol Evol"},{"key":"9067_CR17","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s00239-003-2461-2","volume":"57","author":"BG Fry","year":"2003","unstructured":"Fry BG, W\u00fcster W, Kini RM et al (2003) Molecular evolution of elapid snake venom three finger toxins. J Mol Evol 57:110\u2013129","journal-title":"J Mol Evol"},{"key":"9067_CR18","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/nature04328","volume":"439","author":"BG Fry","year":"2006","unstructured":"Fry BG, Vidal N, Norman JA et al (2006) Early evolution of the venom system in lizards and snakes. Nature 439:584\u2013588","journal-title":"Nature"},{"key":"9067_CR19","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1385\/1-59259-890-0:571","volume-title":"The proteomics protocols handbook","author":"E Gasteiger","year":"2005","unstructured":"Gasteiger E, Hoogland C, Gattiker A et al (2005) Protein identification and analysis tools on the ExPASy server. In: Walker JM (ed) The proteomics protocols handbook. Humana Press, New York, pp 571\u2013607"},{"key":"9067_CR20","volume-title":"The causes of molecular evolution","author":"JH Gillespie","year":"1994","unstructured":"Gillespie JH (1994). The causes of molecular evolution. Oxford University Press, Oxford"},{"key":"9067_CR21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/oxfordjournals.molbev.a025932","volume":"15","author":"GB Golding","year":"1998","unstructured":"Golding GB, Dean AM (1998) The structural basis of molecular adaptation. Mol Biol Evol 15:355\u2013369","journal-title":"Mol Biol Evol"},{"key":"9067_CR22","first-page":"73","volume-title":"Venom phospholipse A2 enzymes: structure, function, and mechanism","author":"F Gubensek","year":"1997","unstructured":"Gubensek F, Kordis D (1997) Venom phospholipase A2 genes and their molecular evolution. In: Kini RM (ed) Venom phospholipse A2 enzymes: structure, function, and mechanism. J. Wiley and Sons, Chichester, UK, pp 73\u201395"},{"key":"9067_CR23","doi-asserted-by":"publisher","first-page":"627","DOI":"10.2307\/2409071","volume":"43","author":"M Hasegawa","year":"1989","unstructured":"Hasegawa M, Kishino H (1989) Confidence limits on the maximum-likelihood estimate of the hominoid tree from mitochondrial-DNA sequences. Evolution 43:627\u2013677","journal-title":"Evolution"},{"key":"9067_CR24","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S0041-0101(97)00081-0","volume":"36","author":"H Heatwole","year":"1998","unstructured":"Heatwole H, Powell J (1998) Resistance of eels (Gymnothorax) to the venom of sea kraits (Laticauda colubrina): a test of coevolution. Toxicon 36:619\u2013625","journal-title":"Toxicon"},{"key":"9067_CR25","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1111\/j.1558-5646.2007.00105.x","volume":"61","author":"HE Hoekstra","year":"2007","unstructured":"Hoekstra HE, Coyne J (2007) The locus of evolution: evo devo and the genetics of adaptation. Evolution 61:995\u20131016","journal-title":"Evolution"},{"key":"9067_CR26","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1670\/0022-1511(2002)036[0454:VITDOS]2.0.CO;2","volume":"36","author":"AT Holycross","year":"2002","unstructured":"Holycross AT, Mackessey SP (2002) Variation in the diet of Sistrurus catenatus (massasauga) with emphasis on Sistrurus catenatus edwardsii (desert massasauga). J Herpetol 36:454\u2013464","journal-title":"J Herpetol"},{"key":"9067_CR27","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/PL00006211","volume":"45","author":"AL Hughes","year":"1997","unstructured":"Hughes AL, Yeager M (1997) Comparative evolutionary rates of introns and exons in murine rodents. J Mol Evol 45:125\u2013130","journal-title":"J Mol Evol"},{"key":"9067_CR28","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0378-1119(94)90761-7","volume":"139","author":"TR John","year":"1994","unstructured":"John TR, Smith L, Kaiser I (1994) Genomic sequences encoding the acidic and basic subunits of Mojave toxin:unusually high sequence identity of non-coding regions. Gene 139:229\u2013234","journal-title":"Gene"},{"key":"9067_CR29","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S1532-0456(00)00215-5","volume":"128","author":"NJ Jorge da Silva","year":"2001","unstructured":"Jorge da Silva NJ, Aird SD (2001) Prey specificity, comparative lethality and compositional differences of coral snake venoms. Comp Biochem Physiol C Toxicol Pharmacol 128:425\u2013456","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"9067_CR30","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0378-1119(02)01080-6","volume":"299","author":"ILM Junqueira-de-Azevedo","year":"2002","unstructured":"Junqueira-de-Azevedo ILM, Ho PL (2002) A survey of gene expression and diversity in the venom glands of the pitviper snake Bothrops insularis through the generation of expressed sequence tags (ESTs). Gene 299:279\u2013291","journal-title":"Gene"},{"key":"9067_CR31","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1534\/genetics.106.056515","volume":"173","author":"ILM Junqueira-de-Azevedo","year":"2006","unstructured":"Junqueira-de-Azevedo ILM, Ching ATC, Carvalho E et al (2006) Lachesis muta (Viperidae) cDNAs reveal diverging pit viper molecules and scaffolds typical of Cobra (Elapidae) venoms: implications for snake toxin repertoire evolution. Genetics 173:877\u2013889","journal-title":"Genetics"},{"key":"9067_CR32","volume-title":"Venom phospholipase A2 enzymes: structure, function, and mechanism","year":"1997","unstructured":"Kini RM, ed. (1997) Venom phospholipase A2 enzymes: structure, function, and mechanism. J. Wiley and Sons, Chichester, UK"},{"key":"9067_CR33","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.toxicon.2003.11.002","volume":"42","author":"RM Kini","year":"2003","unstructured":"Kini RM (2003) Excitement ahead: structure, function, and mechanism of snake venom phospholipase A2 enzymes. Toxicon 42:827\u2013840","journal-title":"Toxicon"},{"key":"9067_CR34","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/j.toxicon.2005.02.018","volume":"45","author":"RM Kini","year":"2005","unstructured":"Kini RM (2005) Structure-function relationships and mechanism of anticoagulant phospholipase A2 enzymes from snake venoms. Toxicon 45:1147\u20131161","journal-title":"Toxicon"},{"key":"9067_CR35","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/PL00006450","volume":"48","author":"RM Kini","year":"1999","unstructured":"Kini RM, Chan YM (1999) Accelerated evolution and molecular surface of venom phospholipase A2 enzymes. J Mol Evol 48:125\u2013132","journal-title":"J Mol Evol"},{"key":"9067_CR36","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/0041-0101(89)90013-5","volume":"27","author":"RM Kini","year":"1989","unstructured":"Kini RM, Evans HJ (1989) A model to explain the pharmacological effects of snake venom phospholipases A2. Toxicon 27:613\u2013635","journal-title":"Toxicon"},{"key":"9067_CR37","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1006\/bbrc.1998.9528","volume":"251","author":"D Kordis","year":"1998","unstructured":"Kordis D, Bdolah A, Gubensek F (1998) Positive Darwinian selection in Vipera palestinae phospholipase genes is unexpectantly limited to the third exon. Biochem Biophys Res Commun 251:613\u2013619","journal-title":"Biochem Biophys Res Commun"},{"key":"9067_CR38","first-page":"401","volume-title":"Perspectives in molecular toxinology","author":"D Kordis","year":"2002","unstructured":"Kordis D, Krizaj I, Gubensek F (2002) Funtional diversification of animal toxins by adaptive evolution. In: Menez A (ed) Perspectives in molecular toxinology. J. Wiley and Sons, New York, pp 401\u2013419"},{"key":"9067_CR39","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1093\/bib\/5.2.150","volume":"5","author":"S Kumar","year":"2004","unstructured":"Kumar S, Tamura K, Nei M (2004) MEGA3: integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Brief Bioinform 5:150\u2013163","journal-title":"Brief Bioinform"},{"key":"9067_CR40","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s00239-004-0138-0","volume":"60","author":"M Li","year":"2005","unstructured":"Li M, Fry BG, Kini RM (2005) Eggs only diet: the shift in preferred prey by the marbled sea snake (Aipysurus eydouxii) resulting in a loss of postsynaptic neurotoxicity. J Mol Evol 60:81\u20139","journal-title":"J Mol Evol"},{"key":"9067_CR41","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1093\/molbev\/msi077","volume":"22","author":"M Li","year":"2005","unstructured":"Li M, Fry BG, Kini RM (2005) Putting the brakes on snake venom evolution: the unique molecular evolutionary patterns of Aipysurus eydouxii (marbled sea snake) phospholipase A2 toxins. Mol Biol Evol 22:934\u2013941","journal-title":"Mol Biol Evol"},{"key":"9067_CR42","doi-asserted-by":"crossref","first-page":"29867","DOI":"10.1016\/S0021-9258(18)43961-0","volume":"269","author":"B Lomonte","year":"1994","unstructured":"Lomonte B, Moreno E, Tarkowski A et al (1994) Neutralizing interaction between heparins and myotoxin II, a lysine 49 phospholipase A2 from Bothrops asper snake venom. Identification of a heparin-binding and cytolytic toxin region by the use of synthetic peptides and molecular modeling. J Biol Chem 269:29867\u201329873","journal-title":"J Biol Chem"},{"key":"9067_CR43","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1471-2148-7-2","volume":"7","author":"VJ Lynch","year":"2007","unstructured":"Lynch VJ (2007) Inventing an arsenal: adaptive evolution and neofunctionalization of snake venom phospholipase A2 genes. BMC Evol Biol 7:2","journal-title":"BMC Evol Biol"},{"key":"9067_CR44","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1126\/science.290.5494.1151","volume":"293","author":"M Lynch","year":"2000","unstructured":"Lynch M, Conery JS (2000) The evolutionary fate and consequences of duplicate genes. Science 293:1151\u20131155","journal-title":"Science"},{"key":"9067_CR45","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1023\/A:1022696612931","volume":"3","author":"M Lynch","year":"2003","unstructured":"Lynch M, Conery JS (2003) The evolutionary demography of duplicate genes. J Struct Funct Genom 3:35\u201344","journal-title":"J Struct Funct Genom"},{"key":"9067_CR46","volume-title":"Perspectives in molecular toxinology","author":"A Menez","year":"2002","unstructured":"Menez A (2002) Perspectives in molecular toxinology. J. Wiley & Sons, New York"},{"key":"9067_CR47","doi-asserted-by":"publisher","first-page":"10676","DOI":"10.1073\/pnas.95.18.10676","volume":"95","author":"EC Metz","year":"1998","unstructured":"Metz EC, Robles-Sikisaka R, Vacquier VD (1998) Nonsynonymous substitution in abalone sperm fertilization genes exceeds substitution in introns and mitochondrial DNA. Proc Natl Acad Sci USA 95:10676\u201310681","journal-title":"Proc Natl Acad Sci USA"},{"key":"9067_CR48","doi-asserted-by":"publisher","first-page":"5964","DOI":"10.1073\/pnas.90.13.5964","volume":"90","author":"K Nakashima","year":"1993","unstructured":"Nakashima K, Nobuhisa I, Deshimaru M et al (1993) Accelerated evolution of Trimeresurus flavoviridis venom gland phospholipase A2 isozymes. Proc Natl Acad Sci USA 90:5964\u20135968","journal-title":"Proc Natl Acad Sci USA"},{"key":"9067_CR49","doi-asserted-by":"publisher","first-page":"5605","DOI":"10.1073\/pnas.92.12.5605","volume":"92","author":"K Nakashima","year":"1995","unstructured":"Nakashima K, Nobuhisa I, Deshimaru M et al (1995) Accelerated evolution in the protein-coding regions is universal in crotalinae snake venom gland phospholipase A2 isozyme genes. Proc Natl Acad Sci USA 92:5605\u20135609","journal-title":"Proc Natl Acad Sci USA"},{"key":"9067_CR50","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1146\/annurev.genet.39.073003.112240","volume":"39","author":"M Nei","year":"2005","unstructured":"Nei M, Rooney AP (2005) Concerted and birth-and-death evolution of multigene families. Annu Rev Genet 39:121\u2013152","journal-title":"Annu Rev Genet"},{"key":"9067_CR51","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/0378-1119(96)00186-2","volume":"172","author":"I Nobuhisa","year":"1996","unstructured":"Nobuhisa I, Nakashima K, Deshimaru M et al (1996) Accelerated evolution of Trimeresurus okinavensis venom gland phospholipase A2 isozyme-encoding genes. Gene 172:267\u2013272","journal-title":"Gene"},{"key":"9067_CR52","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.toxicon.2003.11.003","volume":"42","author":"M Ohno","year":"2003","unstructured":"Ohno M, Chijiwa T, Oda-Ueda N et al (2003) Molecular evolution of myotixic phospholipases A2 from snake venom. Toxicon 42:841\u2013854","journal-title":"Toxicon"},{"key":"9067_CR53","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1093\/bioinformatics\/14.9.819","volume":"14","author":"RDM Page","year":"1998","unstructured":"Page RDM (1998). GeneTree:comparing gene and species phylogenies using reconciled trees. Bioinformatics 14:819\u2013820","journal-title":"Bioinformatics"},{"key":"9067_CR54","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1042\/bst0240274","volume":"24","author":"MC Peitsch","year":"1996","unstructured":"Peitsch MC (1996) ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling. Biochem Soc Trans 24:274\u2013279","journal-title":"Biochem Soc Trans"},{"key":"9067_CR55","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1042\/0264-6021:3630353","volume":"363","author":"T Petan","year":"2002","unstructured":"Petan T, Krizaj I, Gubensek F et al (2002) Phenylalanine-24 in the N-terminal region of ammodytoxins is important for both enzymic activity and presynaptic toxicity. Biochem. J 363:353\u2013358","journal-title":"Biochem. J"},{"key":"9067_CR56","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1093\/bioinformatics\/14.9.817","volume":"14","author":"D Posada","year":"1998","unstructured":"Posada D, Crandall KA (1998) Modeltest: testing the model of DNA substitution. Bioinformatics 14:817\u2013818","journal-title":"Bioinformatics"},{"key":"9067_CR57","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1042\/0264-6021:3520251","volume":"352","author":"P Prijatelj","year":"2000","unstructured":"Prijatelj P, Copic A, Krizaj I et al (2000) Charge reversal of ammodytoxin A, a phospholipase A2-toxin, does not abolish its neurotoxicity. Biochem J 352:251\u2013255","journal-title":"Biochem J"},{"key":"9067_CR58","doi-asserted-by":"publisher","first-page":"5759","DOI":"10.1046\/j.1432-1033.2002.03301.x","volume":"269","author":"P Prijatelj","year":"2002","unstructured":"Prijatelj P, Krizaj I, Kralj B et al (2002) The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicity. Eur J Biochem 269:5759\u20135764","journal-title":"Eur J Biochem"},{"key":"9067_CR59","doi-asserted-by":"publisher","first-page":"2496","DOI":"10.1093\/bioinformatics\/btg359","volume":"19","author":"J Rozas","year":"2003","unstructured":"Rozas J, S\u00e1nchez-DelBarrio J C, Messeguer X et al (2003) DnaSP, DNA polymorphism analyses by the coalescent and other methods. Bioinformatics 19:2496\u20132497","journal-title":"Bioinformatics"},{"key":"9067_CR60","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1093\/protein\/15.8.659","volume":"15","author":"U Samanta","year":"2002","unstructured":"Samanta U, Bahadur RP, Chakrabarti P (2002) Quantifying the accessible surface area of protein residues in their local environment. Protein Eng 15:659\u2013667","journal-title":"Protein Eng"},{"key":"9067_CR61","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1021\/pr0602500","volume":"5","author":"L Sanz","year":"2006","unstructured":"Sanz L, Gibbs HL, Mackessy SP et al (2006) Venom proteomes of closely related Sistrurus rattlesnakes with divergent diets. J Proteome Res 5:2098\u20132112","journal-title":"J Proteome Res"},{"key":"9067_CR62","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/0076-6879(90)83018-5","volume":"183","author":"P Senepathy","year":"1990","unstructured":"Senepathy P, Shapiro MB, Harris NL (1990) Splice junctions, branch point sites, and exons: sequence statistics, identification, and applications to genome project. Methods Enzymol 183:252\u2013278","journal-title":"Methods Enzymol"},{"key":"9067_CR63","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1006\/jmbi.2001.4550","volume":"307","author":"G Singh","year":"2001","unstructured":"Singh G, Gourinath S, Sharma S et al (2001) Sequence and crystal structure determination of a basic phospholipase A2 from common krait (Bungarus caeruleus) at 24 \u00c5 resolution: identification and characterization of its pharmacological sites. J Mol Biol 307:1049\u20131059","journal-title":"J Mol Biol"},{"key":"9067_CR64","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1006\/mpev.1997.0434","volume":"8","author":"JB Slowinski","year":"1997","unstructured":"Slowinski JB, Knight A, Rooney AP (1997) Inferring species trees from gene trees: a phylogenetic analysis of the elapidae (Serpentes) based on the amino acid sequences of venom proteins. Mol Phylogenet Evol 8:349\u2013362","journal-title":"Mol Phylogenet Evol"},{"key":"9067_CR65","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.0014-3820.2000.tb00544.x","volume":"54","author":"DL Stern","year":"2000","unstructured":"Stern DL (2000) Evolutionary developmental biology and the problem of variation. Evolution 54:1079\u20131091","journal-title":"Evolution"},{"key":"9067_CR66","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1093\/molbev\/msh098","volume":"21","author":"Y Suzuki","year":"2004","unstructured":"Suzuki Y, Nei M (2004) False-positive selection identifed by ML-based methods: examples from the Sig1 gene of the diatom Thalassiosira weissflogii and the tax gene of a human T-cell lymphotropic virus. Mol Biol Evol 21:914\u2013921","journal-title":"Mol Biol Evol"},{"key":"9067_CR67","volume-title":"PAUP*. Phylogenetic Analysis Using Parsimony (*and other methods). Version 4","author":"DL Swofford","year":"2003","unstructured":"Swofford DL (2003) PAUP*. Phylogenetic Analysis Using Parsimony (*and other methods). Version 4. Sinauer Associates, Sunderland, MA"},{"key":"9067_CR68","doi-asserted-by":"publisher","first-page":"7708","DOI":"10.1073\/pnas.1230533100","volume":"100","author":"A Tatsuya","year":"2003","unstructured":"Tatsuya A, Shiina T, Kimura N et al (2003) Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions\/deletions as the major path to genomic divergence. Proc Natl Acad Sci USA 100:7708\u20137713","journal-title":"Proc Natl Acad Sci USA"},{"key":"9067_CR69","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S0003-9861(02)00747-6","volume":"411","author":"I-H Tsai","year":"2003","unstructured":"Tsai I-H, Wang Y-M, Chen Y-H et al (2003) Geographic variations, cloning, and functional analyses of the venom acidic phospholipases A2 of Crotalus viridis viridis. Arch Biochem Biophys 411:289\u2013296","journal-title":"Arch Biochem Biophys"},{"key":"9067_CR70","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1042\/BJ20030818","volume":"377","author":"I Tsai","year":"2004","unstructured":"Tsai I, Wang Y, Chen Y et al (2004) Venom phospholipase A2 of bamboo viper (Trimeresurus stejnegeri): molecular characterization, geographic variations and evidence for multiple ancestries. Biochem J 377:215\u2013223","journal-title":"Biochem J"},{"key":"9067_CR71","first-page":"555","volume":"13","author":"WSW Wong","year":"2004","unstructured":"Wong WSW, Yang Z, Goldman N et al (2004) Accuracy and power of statistical methods for detecting adaptive evolution in protein coding sequences and for identifying positively selected sites. Genetics Z (1997) PAML: a program package for phylogenetic analysis by maximum likelihood. Comput Appl BioSci 13:555\u2013556","journal-title":"Comput Appl BioSci"},{"key":"9067_CR72","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/S0959-437X(02)00348-9","volume":"12","author":"Z Yang","year":"2002","unstructured":"Yang Z (2002) Inference of selection from multiple species alignments. Curr Opin Genet Dev 12:688\u2013694","journal-title":"Curr Opin Genet Dev"},{"key":"9067_CR73","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1093\/molbev\/msi097","volume":"22","author":"Z Yang","year":"2005","unstructured":"Yang Z, Wong WSW, Nielsen R (2005) Bayes empirical Bayes inference of amino acid sites under positive selection. Mol Biol Evol 22:1107\u20131118","journal-title":"Mol Biol Evol"},{"key":"9067_CR74","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/S0041-0101(99)00193-2","volume":"38","author":"K Zhao","year":"2000","unstructured":"Zhao K, Zhou Y, Lin Z (2000) Structure of basic phospholipase A2 from Agkistrodon halys Pallas: implications for its association, hemolytic and anticoagulant activities. Toxicon 38:901\u2013916","journal-title":"Toxicon"}],"container-title":["Journal of Molecular Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00239-008-9067-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00239-008-9067-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00239-008-9067-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00239-008-9067-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:12:05Z","timestamp":1652659925000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00239-008-9067-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":74,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["9067"],"URL":"https:\/\/doi.org\/10.1007\/s00239-008-9067-7","relation":{},"ISSN":["0022-2844","1432-1432"],"issn-type":[{"value":"0022-2844","type":"print"},{"value":"1432-1432","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2]]},"assertion":[{"value":"14 June 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}