{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:52:18Z","timestamp":1782996738438,"version":"3.54.5"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,1,5]],"date-time":"2010-01-05T00:00:00Z","timestamp":1262649600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mol Evol"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1007\/s00239-009-9318-2","type":"journal-article","created":{"date-parts":[[2010,1,4]],"date-time":"2010-01-04T10:53:35Z","timestamp":1262602415000},"page":"167-180","source":"Crossref","is-referenced-by-count":13,"title":["Comparative Genomic and Phylogenetic Analyses Reveal the Evolution of the Core Two-Component Signal Transduction Systems in Enterobacteria"],"prefix":"10.1007","volume":"70","author":[{"given":"Mingsheng","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Jie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Caetano-Anoll\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youfu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,1,5]]},"reference":[{"key":"9318_CR1","doi-asserted-by":"crossref","first-page":"e143","DOI":"10.1371\/journal.pcbi.0020143","volume":"2","author":"E Alm","year":"2006","unstructured":"Alm E, Huang K, Arkin A (2006) The evolution of two-component systems in bacteria reveals different strategies for niche adaptation. PLoS Comput Biol 2:e143","journal-title":"PLoS Comput Biol"},{"key":"9318_CR2","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","author":"SF Altschul","year":"1997","unstructured":"Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25:3389\u20133402","journal-title":"Nucleic Acids Res"},{"key":"9318_CR3","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.mib.2003.09.003","volume":"6","author":"L Aravind","year":"2003","unstructured":"Aravind L, Anantharaman V, Iyer LM (2003) Evolutionary connections between bacterial and eukaryotic signaling systems: a genomic perspective. Curr Opin Microbiol 6:490\u2013497","journal-title":"Curr Opin Microbiol"},{"key":"9318_CR4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/1471-2164-10-315","volume":"10","author":"M Barakat","year":"2009","unstructured":"Barakat M, Ortet P, Jourlin-Castelli C, Ansaldi M, Mejean V, Whitworth DE (2009) P2CS: a two-component system resource for prokaryotic signal transduction research. BMC Genomics 10:315","journal-title":"BMC Genomics"},{"key":"9318_CR5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.mib.2006.01.005","volume":"9","author":"D Beier","year":"2006","unstructured":"Beier D, Gross R (2006) Regulation of bacterial virulence by two-component systems. Curr Opin Microbiol 9:143\u2013152","journal-title":"Curr Opin Microbiol"},{"key":"9318_CR6","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0966-842X(03)00176-8","volume":"11","author":"JJ Bijlsma","year":"2003","unstructured":"Bijlsma JJ, Groisman EA (2003) Making informed decisions: regulatory interactions between two-component systems. Trends Microbiol 11:359\u2013366","journal-title":"Trends Microbiol"},{"key":"9318_CR7","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1099\/mic.0.2006\/003202-0","volume":"153","author":"K Brzostek","year":"2007","unstructured":"Brzostek K, Brz\u00f3stkowska M, Bukowska I, Karwicka E, Raczkowska A (2007) OmpR negatively regulates expression of invasin in Yersinia enterocolitica. Microbiology 153:2416\u20132425","journal-title":"Microbiology"},{"key":"9318_CR8","doi-asserted-by":"crossref","first-page":"9358","DOI":"10.1073\/pnas.0701214104","volume":"10","author":"G Caetano-Anoll\u00e9s","year":"2007","unstructured":"Caetano-Anoll\u00e9s G, Kim HS, Mittenthal JE (2007) The origins of modern metabolic networks inferred from phylogenomic analysis of protein structure. Proc Natl Acad Sci USA 10:9358\u20139363","journal-title":"Proc Natl Acad Sci USA"},{"key":"9318_CR9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/BJ20082063","volume":"417","author":"G Caetano-Anoll\u00e9s","year":"2009","unstructured":"Caetano-Anoll\u00e9s G, Wang M, Caetano-Anoll\u00e9s D, Mittenthal JE (2009) The origin, evolution and structure of the protein world. Biochem J 417:621\u2013637","journal-title":"Biochem J"},{"key":"9318_CR10","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1126\/science.1123061","volume":"311","author":"FD Ciccarelli","year":"2006","unstructured":"Ciccarelli FD, Doerks T, von Mering C, Creevey CJ, Snel B, Bork P (2006) Toward automatic reconstruction of a highly resolved tree of life. Science 311:1283\u20131287","journal-title":"Science"},{"key":"9318_CR11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00239-006-0180-1","volume":"64","author":"PJ Cock","year":"2007","unstructured":"Cock PJ, Whitworth DE (2007a) Evolution of gene overlaps: relative reading frame bias in prokaryotic two-component system genes. J Mol Evol 64:457\u2013462","journal-title":"J Mol Evol"},{"key":"9318_CR12","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1093\/molbev\/msm170","volume":"24","author":"PJ Cock","year":"2007","unstructured":"Cock PJ, Whitworth DE (2007b) Evolution of prokaryotic two-component system signaling pathways: gene fusions and fissions. Mol Biol Evol 24:2355\u20132357","journal-title":"Mol Biol Evol"},{"key":"9318_CR14","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1073\/pnas.98.4.1883","volume":"98","author":"C Dale","year":"2001","unstructured":"Dale C, Young SA, Haydon DT, Welburn SC (2001) The insect endosymbiont Sodalis glossinidius utilizes a type III secretion system for cell invasion. Proc Natl Acad Sci USA 98:1883\u20131888","journal-title":"Proc Natl Acad Sci USA"},{"key":"9318_CR13","doi-asserted-by":"crossref","first-page":"D271","DOI":"10.1093\/nar\/gkl949","volume":"35","author":"M D\u2019Souza","year":"2007","unstructured":"D\u2019Souza M, Glass EM, Syed MH, Zhang Y, Rodriguez A, Maltsev N, Galperin MY (2007) Sentra: a database of signal transduction proteins for comparative genome analysis. Nucleic Acids Res 35:D271\u2013D273","journal-title":"Nucleic Acids Res"},{"key":"9318_CR15","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1038\/nbt886","volume":"21","author":"E Duchaud","year":"2003","unstructured":"Duchaud E, Rusniok C, Frangeul L et al (2003) The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens. Nat Biotechnol 21:1307\u20131313","journal-title":"Nat Biotechnol"},{"key":"9318_CR16","volume-title":"The prokaryotes: a handbook on the biology of bacteria. Volume 6: Proteobacteria: gamma subclass","year":"2006","unstructured":"Dworkin M, Falkow S, Rosenberg E, Schleifer KH, Stackebrandt E (eds) (2006) The prokaryotes: a handbook on the biology of bacteria. Volume 6: Proteobacteria: gamma subclass, 3rd edn. Springer, New York","edition":"3"},{"key":"9318_CR17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2307\/2413326","volume":"34","author":"GF Estabrook","year":"1985","unstructured":"Estabrook GF, McMorris FR, Meacham CA (1985) Comparison of undirected phylogenetic trees based on subtrees of four evolutionary units. Syst Zool 34:193\u2013200","journal-title":"Syst Zool"},{"key":"9318_CR18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/oxfordjournals.molbev.a025575","volume":"13","author":"J Felsenstein","year":"1996","unstructured":"Felsenstein J, Churchill GA (1996) A Hidden Markov Model approach to variation among sites in rate of evolution. Mol Biol Evol 13:93\u2013104","journal-title":"Mol Biol Evol"},{"key":"9318_CR19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2180-5-35","volume":"5","author":"MY Galperin","year":"2005","unstructured":"Galperin MY (2005) A census of membrane-bound and intracellular signal transduction proteins in bacteria: bacterial IQ, extroverts and introverts. BMC Microbiol 5:35\u201353","journal-title":"BMC Microbiol"},{"key":"9318_CR20","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1128\/JB.01887-05","volume":"188","author":"MY Galperin","year":"2006","unstructured":"Galperin MY (2006) Structural classification of bacterial response regulators: diversity of output domains and domain combinations. J Bacteriol 188:4169\u20134182","journal-title":"J Bacteriol"},{"key":"9318_CR21","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0923-2508(94)90096-5","volume":"145","author":"E Garcia V\u00e9scovi","year":"1994","unstructured":"Garcia V\u00e9scovi E, Soncini FC, Groisman EA (1994) The role of the PhoP\/PhoQ regulon in Salmonella virulence. Res Microbiol 145:473\u2013480","journal-title":"Res Microbiol"},{"key":"9318_CR22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81003-X","volume":"84","author":"E Garc\u00eda V\u00e9scovi","year":"1996","unstructured":"Garc\u00eda V\u00e9scovi E, Soncini FC, Groisman EA (1996) Mg2+ as an extracellular signal: environmental regulation of Salmonella virulence. Cell 84:165\u2013174","journal-title":"Cell"},{"key":"9318_CR23","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1128\/JB.183.6.1835-1842.2001","volume":"183","author":"EA Groisman","year":"2001","unstructured":"Groisman EA (2001) The pleiotropic two-component regulatory system PhoP-PhoQ. J Bacteriol 183:1835\u20131842","journal-title":"J Bacteriol"},{"key":"9318_CR24","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1094\/MPMI.2001.14.12.1351","volume":"14","author":"S Heeb","year":"2001","unstructured":"Heeb S, Haas D (2001) Regulatory roles of the GacS\/GacA two-component system in plant-associated and other gram-negative bacteria. Mol Plant Microbe Interact 14:1351\u20131363","journal-title":"Mol Plant Microbe Interact"},{"key":"9318_CR25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2164-9-40","volume":"9","author":"R Heermann","year":"2008","unstructured":"Heermann R, Fuchs TM (2008) Comparative analysis of the Photorhabdus luminescens and the Yersinia enterocolitica genomes: uncovering candidate genes involved in insect pathogenicity. BMC Genomics 9:40","journal-title":"BMC Genomics"},{"key":"9318_CR26","volume-title":"Two-component signal transduction","year":"1995","unstructured":"Hoch JA, Silhavy TJ (eds) (1995) Two-component signal transduction. ASM Press, Washington, DC"},{"key":"9318_CR27","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.resmic.2005.11.005","volume":"157","author":"YH Huang","year":"2006","unstructured":"Huang YH, Ferri\u00e8res L, Clarke DJ (2006) The role of the Rcs phosphorelay in Enterobacteriaceae. Res Microbiol 157:206\u2013212","journal-title":"Res Microbiol"},{"key":"9318_CR28","volume-title":"Histidine kinases in signal transduction","year":"2003","unstructured":"Inouye M, Dutta R (eds) (2003) Histidine kinases in signal transduction. Academic Press, New York"},{"key":"9318_CR29","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0968-0004(98)01285-7","volume":"23","author":"F Jeanmougin","year":"1998","unstructured":"Jeanmougin F, Thompson JD, Gouy M, Higgins DG, Gibson TJ (1998) Multiple sequence alignment with Clustal X. Trends Biochem Sci 23:403\u2013405","journal-title":"Trends Biochem Sci"},{"key":"9318_CR30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/978-0-387-78885-2_2","volume":"631","author":"A Kato","year":"2008","unstructured":"Kato A, Groisman EA (2008) The PhoQ\/PhoP regulatory network of Salmonella enterica. Adv Exp Med Biol 631:7\u201321","journal-title":"Adv Exp Med Biol"},{"key":"9318_CR31","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1099\/00221287-147-5-1197","volume":"147","author":"D Kim","year":"2001","unstructured":"Kim D, Forst S (2001) Genomic analysis of the histidine kinase family in bacteria and archaea. Microbiology 147:1197\u20131212","journal-title":"Microbiology"},{"key":"9318_CR32","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1073\/pnas.0308653100","volume":"101","author":"KT Konstantinidis","year":"2004","unstructured":"Konstantinidis KT, Tiedje JM (2004) Trends between gene content and genome size in prokaryotic species with larger genomes. Proc Natl Acad Sci USA 101:3160\u20133165","journal-title":"Proc Natl Acad Sci USA"},{"key":"9318_CR33","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1093\/oxfordjournals.molbev.a026297","volume":"17","author":"KK Koretke","year":"2000","unstructured":"Koretke KK, Lupas AN, Warren PV, Rosenberg M, Brown JR (2000) Evolution of two-component signal transduction. Mol Biol Evol 17:1956\u20131970","journal-title":"Mol Biol Evol"},{"key":"9318_CR34","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","volume":"305","author":"A Krogh","year":"2001","unstructured":"Krogh A, Larsson B, von Heijne G, Sonnhammer EL (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol 305:567\u2013580","journal-title":"J Mol Biol"},{"key":"9318_CR35","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1111\/j.1462-2920.2008.01639.x","volume":"10","author":"M Kube","year":"2008","unstructured":"Kube M, Migdoll AM, M\u00fcller I, Kuhl H, Beck A, Reinhardt R, Geider K (2008) The genome of Erwinia tasmaniensis strain Et1\/99, a non-pathogenic bacterium in the genus Erwinia. Environ Microbiol 10:2211\u20132222","journal-title":"Environ Microbiol"},{"key":"9318_CR36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2958.2007.06042.x","volume":"67","author":"K Lapouge","year":"2008","unstructured":"Lapouge K, Schubert M, Allain FH, Haas D (2008) Gac\/Rsm signal transduction pathway of gamma-proteobacteria: from RNA recognition to regulation of social behaviour. Mol Microbiol 67:241\u2013253","journal-title":"Mol Microbiol"},{"key":"9318_CR37","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1186\/1471-2164-8-397","volume":"8","author":"JL Lav\u00edn","year":"2007","unstructured":"Lav\u00edn JL, Kiil K, Resano O, Ussery DW, Oguiza JA (2007) Comparative genomic analysis of two-component regulatory proteins in Pseudomonas syringae. BMC Genomics 8:397","journal-title":"BMC Genomics"},{"key":"9318_CR38","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1462-2920.2007.01473.x","volume":"10","author":"A Lebeau","year":"2008","unstructured":"Lebeau A, Reverchon S, Gaubert S, Kraepiel Y, Simond-C\u00f4te E, Nasser W, Van Gijsegem F (2008) The GacA global regulator is required for the appropriate expression of Erwinia chrysanthemi 3937 pathogenicity genes during plant infection. Environ Microbiol 10:545\u2013559","journal-title":"Environ Microbiol"},{"key":"9318_CR39","doi-asserted-by":"crossref","first-page":"D257","DOI":"10.1093\/nar\/gkj079","volume":"34","author":"I Letunic","year":"2006","unstructured":"Letunic I, Copley RR, Pils B, Pinkert S, Schultz J, Bork P (2006) SMART 5: domains in the context of genomes and networks. Nucleic Acids Res 34:D257\u2013D260","journal-title":"Nucleic Acids Res"},{"key":"9318_CR40","doi-asserted-by":"crossref","first-page":"7116","DOI":"10.1073\/pnas.0700266104","volume":"104","author":"R Liu","year":"2007","unstructured":"Liu R, Ochman H (2007) Stepwise formation of the bacterial flagellar system. Proc Natl Acad Sci USA 104:7116\u20137121","journal-title":"Proc Natl Acad Sci USA"},{"key":"9318_CR41","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1146\/annurev.micro.59.050405.101230","volume":"59","author":"N Majdalani","year":"2005","unstructured":"Majdalani N, Gottesman S (2005) The Rcs phosphorelay: a complex signal transduction system. Annu Rev Microbiol 59:379\u2013405","journal-title":"Annu Rev Microbiol"},{"key":"9318_CR42","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nature07660","volume":"458","author":"MJ Mandel","year":"2009","unstructured":"Mandel MJ, Wollenberg MS, Stabb EV, Visick KL, Ruby EG (2009) A single regulatory gene is sufficient to alter bacterial host range. Nature 458:215\u2013218","journal-title":"Nature"},{"key":"9318_CR43","doi-asserted-by":"crossref","first-page":"D192","DOI":"10.1093\/nar\/gki069","volume":"33","author":"A Marchler-Bauer","year":"2005","unstructured":"Marchler-Bauer A, Anderson JB, Cherukuri PF et al (2005) CDD: a conserved domain database for protein classification. Nucleic Acids Res 33:D192\u2013D196","journal-title":"Nucleic Acids Res"},{"key":"9318_CR44","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1101\/gad.353705","volume":"19","author":"F Mika","year":"2005","unstructured":"Mika F, Hengge R (2005) A two-component phosphotransfer network involving ArcB, ArcA, and RssB coordinates synthesis and proteolysis of \u03c3S (RpoS) in E. coli. Genes Dev 19:2770\u20132781","journal-title":"Genes Dev"},{"key":"9318_CR45","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1101\/gad.1700308","volume":"22","author":"AY Mitrophanov","year":"2008","unstructured":"Mitrophanov AY, Groisman EA (2008) Signal integration in bacterial two-component regulatory systems. Genes Dev 22:2601\u20132611","journal-title":"Genes Dev"},{"key":"9318_CR46","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.tim.2007.06.005","volume":"15","author":"BM Mole","year":"2007","unstructured":"Mole BM, Baltrus DA, Dangl JL, Grant SR (2007) Global virulence regulation networks in phytopathogenic bacteria. Trends Microbiol 15:363\u2013371","journal-title":"Trends Microbiol"},{"key":"9318_CR47","first-page":"536","volume":"247","author":"A Murzin","year":"1995","unstructured":"Murzin A, Brenner SE, Hubbard T, Chothia C (1995) SCOP: a structural classification of proteins database for the investigation of sequences and structures. J Mol Biol 247:536\u2013540","journal-title":"J Mol Biol"},{"key":"9318_CR48","volume-title":"COMPONENT: tree comparison software for Microsoft Windows, version 2.0","author":"RDM Page","year":"1993","unstructured":"Page RDM (1993) COMPONENT: tree comparison software for Microsoft Windows, version 2.0. The Natural History Museum, London"},{"key":"9318_CR49","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1094\/MPMI-21-2-0151","volume":"21","author":"W Qian","year":"2008","unstructured":"Qian W, Han ZJ, He C (2008) Two-component signal transduction systems of Xanthomonas spp.: a lesson from genomics. Mol Plant Microbe Interact 21:151\u2013161","journal-title":"Mol Plant Microbe Interact"},{"key":"9318_CR50","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1128\/AEM.70.4.1999-2012.2004","volume":"70","author":"SF Sarkar","year":"2004","unstructured":"Sarkar SF, Guttman DS (2004) Evolution of the core genome of Pseudomonas syringae, a highly clonal, endemic plant pathogen. Appl Environ Microbiol 70:1999\u20132012","journal-title":"Appl Environ Microbiol"},{"key":"9318_CR51","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.biochem.69.1.183","volume":"69","author":"AM Stock","year":"2000","unstructured":"Stock AM, Robinson VL, Goudreau PN (2000) Two-component signal transduction. Annu Rev Biochem 69:183\u2013215","journal-title":"Annu Rev Biochem"},{"key":"9318_CR52","volume-title":"PAUP*. Phylogenetic analysis using parsimony (* and other methods). Version 4","author":"DL Swofford","year":"2003","unstructured":"Swofford DL (2003) PAUP*. Phylogenetic analysis using parsimony (* and other methods). Version 4. Sinauer Associates, Sunderland"},{"key":"9318_CR53","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.pbi.2005.04.001","volume":"8","author":"IK Toth","year":"2005","unstructured":"Toth IK, Birch PR (2005) Rotting softly and stealthily. Curr Opin Plant Biol 8:424\u2013429","journal-title":"Curr Opin Plant Biol"},{"key":"9318_CR54","doi-asserted-by":"crossref","first-page":"D386","DOI":"10.1093\/nar\/gkl932","volume":"35","author":"LE Ulrich","year":"2007","unstructured":"Ulrich LE, Zhulin IB (2007) MiST: a microbial signal transduction database. Nucleic Acids Res 35:D386\u2013D390","journal-title":"Nucleic Acids Res"},{"key":"9318_CR55","volume-title":"Bacterial signal transduction: networks and drug targets","year":"2008","unstructured":"Utsumi R (ed) (2008) Bacterial signal transduction: networks and drug targets. Springer, New York"},{"key":"9318_CR56","doi-asserted-by":"crossref","DOI":"10.1079\/9780851992945.0000","volume-title":"Fire blight: the disease and its causative agent, Erwinia amylovora","author":"JL Vanneste","year":"2000","unstructured":"Vanneste JL (2000) Fire blight: the disease and its causative agent, Erwinia amylovora. CABI Publishing, New York"},{"key":"9318_CR57","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1364-3703.2008.00531.x","volume":"10","author":"D Wang","year":"2009","unstructured":"Wang D, Korban SS, Zhao YF (2009) The Rcs phosphorelay system is essential for pathogenicity in Erwinia amylovora. Mol Plant Pathol 10:277\u2013290","journal-title":"Mol Plant Pathol"},{"key":"9318_CR58","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1126\/science.1083202","volume":"301","author":"AJ Webster","year":"2003","unstructured":"Webster AJ, Payne RJH, Pagel M (2003) Molecular phylogenies link rates of evolution and speciation. Science 301:478","journal-title":"Science"},{"key":"9318_CR59","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1099\/mic.0.2007\/013672-0","volume":"154","author":"DE Whitworth","year":"2008","unstructured":"Whitworth DE, Cock PJ (2008) Two-component systems of the myxobacteria: structure, diversity and evolutionary relationships. Microbiology 154:360\u2013372","journal-title":"Microbiology"},{"key":"9318_CR60","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00726-009-0259-2","volume":"37","author":"DE Whitworth","year":"2009","unstructured":"Whitworth DE, Cock PJ (2009) Evolution of prokaryotic two-component systems: insights from comparative genomics. Amino Acids 37:459\u2013466","journal-title":"Amino Acids"},{"key":"9318_CR61","unstructured":"Williams and Wilkins (2005) In: Garrity G, Brenner DJ, Krieg NR, Staley JR (eds) Bergey\u2019s manual\u00ae of systematic bacteriology. Volume 2: The proteobacteria, part B: the gammaproteobacteria, 2nd edn. Springer, New York"},{"key":"9318_CR62","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1073\/pnas.87.12.4576","volume":"87","author":"CR Woese","year":"1990","unstructured":"Woese CR, Kandler O, Wheelis ML (1990) Towards a natural system of organisms: proposal for the domains Archaea, Bacteria, and Eucarya. Proc Natl Acad Sci USA 87:4576\u20134579","journal-title":"Proc Natl Acad Sci USA"},{"key":"9318_CR63","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0092-8674(00)00092-1","volume":"103","author":"MMSM W\u00f6sten","year":"2000","unstructured":"W\u00f6sten MMSM, Kox LFF, Chamnongpol S, Soncini FC, Groisman EA (2000) A signal transduction system that responds to extracellular iron. Cell 103:113\u2013125","journal-title":"Cell"},{"key":"9318_CR64","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1094\/MPMI-21-3-0304","volume":"21","author":"MN Yap","year":"2008","unstructured":"Yap MN, Yang CH, Charkowski AO (2008) The Response regulator HrpY of Dickeya dadantii 3937 regulates virulence genes not linked to the hrp cluster. Mol Plant Microbe Interact 21:304\u2013314","journal-title":"Mol Plant Microbe Interact"},{"key":"9318_CR65","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1099\/mic.0.27987-0","volume":"151","author":"W Zhang","year":"2005","unstructured":"Zhang W, Shi L (2005) Distribution and evolution of multiple-step phosphorelay in prokaryotes: lateral domain recruitment involved in the formation of hybrid-type histidine kinases. Microbiology 151:2159\u20132173","journal-title":"Microbiology"},{"key":"9318_CR66","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/1471-2164-10-245","volume":"10","author":"YF Zhao","year":"2009","unstructured":"Zhao YF, Wang D, Nakka S, Sundin GW, Korban S (2009) Systems level analysis of two-component signal transduction systems in Erwinia amylovora: role in virulence, regulation of amylovoran biosynthesis and swarming motility. BMC Genomics 10:245","journal-title":"BMC Genomics"},{"key":"9318_CR67","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1073\/pnas.0408238102","volume":"102","author":"I Zwir","year":"2005","unstructured":"Zwir I, Shin D, Kato A, Nishino K, Latifi T, Solomon F, Hare JM, Huang H, Groisman EA (2005) Dissecting the PhoP regulatory network of Escherichia coli and Salmonella enterica. Proc Natl Acad Sci USA 102:2862\u20132867","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Journal of Molecular Evolution"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00239-009-9318-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00239-009-9318-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00239-009-9318-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T13:53:09Z","timestamp":1558705989000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00239-009-9318-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,5]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["9318"],"URL":"https:\/\/doi.org\/10.1007\/s00239-009-9318-2","relation":{},"ISSN":["0022-2844","1432-1432"],"issn-type":[{"value":"0022-2844","type":"print"},{"value":"1432-1432","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,5]]}}}