{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:55:20Z","timestamp":1789102520633,"version":"build-2803163510"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Evol"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s00239-019-09895-3","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T05:02:38Z","timestamp":1559883758000},"page":"66-76","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Allergy in an Evolutionary Framework"],"prefix":"10.1007","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7725-981X","authenticated-orcid":false,"given":"Alvaro","family":"Daschner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Gonz\u00e1lez Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,7]]},"reference":[{"issue":"2","key":"9895_CR1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1067\/mai.2000.108434","volume":"106","author":"RC Aalberse","year":"2000","unstructured":"Aalberse RC (2000) Structural biology of allergens. J Allergy Clin Immunol 106(2):228\u2013238","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"9895_CR2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1398-9995.1978.tb01501.x","volume":"33","author":"K Aas","year":"1978","unstructured":"Aas K (1978) What makes an allergen an allergen. Allergy 33(1):3\u201314","journal-title":"Allergy"},{"issue":"5","key":"9895_CR3","doi-asserted-by":"crossref","first-page":"e1002003","DOI":"10.1371\/journal.ppat.1002003","volume":"7","author":"JE Allen","year":"2011","unstructured":"Allen JE, Wynn TA (2011) Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens. PLoS Pathog 7(5):e1002003","journal-title":"PLoS Pathog"},{"issue":"12","key":"9895_CR4","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nri2199","volume":"7","author":"RM Anthony","year":"2007","unstructured":"Anthony RM, Rutitzky LI, Urban JF, Stadecker MJ, Gause WC (2007) Protective immune mechanisms in helminth infection. Nat Rev Immunol 7(12):975\u2013987","journal-title":"Nat Rev Immunol"},{"issue":"3 Suppl","key":"9895_CR5","doi-asserted-by":"crossref","first-page":"S406","DOI":"10.1067\/mai.2001.113670","volume":"107","author":"LG Arlian","year":"2001","unstructured":"Arlian LG, Platts-Mills TA (2001) The biology of dust mites and the remediation of mite allergens in allergic disease. J Allergy Clin Immunol 107(3 Suppl):S406\u2013413","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"9895_CR6","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.jaci.2010.03.010","volume":"125","author":"R Ayuso","year":"2010","unstructured":"Ayuso R, S\u00e1nchez-Garcia S, Lin J, Fu Z, Ib\u00e1\u00f1ez MD, Carrillo T, Blanco C, Goldis M, Bardina L, Sastre J, Sampson HA (2010) Greater epitope recognition of shrimp allergens by children than by adults suggests that shrimp sensitization decreases with age. J Allergy Clin Immunol 125(6):1286\u20131293.e1283","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"9895_CR7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11882-004-0042-0","volume":"4","author":"GA Bannon","year":"2004","unstructured":"Bannon GA (2004) What makes a food protein an allergen? Curr Allergy Asthma Rep 4(1):43\u201346","journal-title":"Curr Allergy Asthma Rep"},{"issue":"5","key":"9895_CR8","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/01.all.0000182543.37724.7b","volume":"5","author":"KC Barnes","year":"2005","unstructured":"Barnes KC, Grant AV, Gao P (2005) A review of the genetic epidemiology of resistance to parasitic disease and atopic asthma: common variants for common phenotypes? Curr Opin Allergy Clin Immunol 5(5):379\u2013385","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"1 Pt 1","key":"9895_CR9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1067\/mai.2000.106929","volume":"106","author":"H Breiteneder","year":"2000","unstructured":"Breiteneder H, Ebner C (2000) Molecular and biochemical classification of plant-derived food allergens. J Allergy Clin Immunol 106(1 Pt 1):27\u201336","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"9895_CR10","first-page":"36","volume":"11","author":"G Burke","year":"2005","unstructured":"Burke G, Wikel SK, Spielman A, Telford SR, McKay K, Krause PJ, T.-b. I. S. Group (2005) Hypersensitivity to ticks and Lyme disease risk. Emerg Infect Dis 11(1):36\u201341","journal-title":"Emerg Infect Dis"},{"issue":"8","key":"9895_CR11","doi-asserted-by":"crossref","first-page":"e1002808","DOI":"10.1371\/journal.ppat.1002808","volume":"8","author":"A Casadevall","year":"2012","unstructured":"Casadevall A (2012) Fungi and the rise of mammals. PLoS Pathog 8(8):e1002808","journal-title":"PLoS Pathog"},{"issue":"1","key":"9895_CR12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/ACI.0b013e32831f44a6","volume":"9","author":"P Cooper","year":"2009","unstructured":"Cooper P (2009) Interactions between helminth parasites and allergy. Curr Opin Allergy Clin Immunol 9(1):29\u201337","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"9895_CR13","first-page":"672","volume":"7","author":"A Daschner","year":"2016","unstructured":"Daschner A (2016) An evolutionary-based framework for analyzing mold and dampness-associated symptoms in DMHS. Front Immunol 7:672","journal-title":"Front Immunol"},{"key":"9895_CR14","unstructured":"Daschner A (2018) Evolutionary plausibility of specific immunotherapy in Allergy. Medicina Evolucionista. Aportaciones pluridisciplinares. A. Daschner, J. G\u00f3mez P\u00e9rez and M. Trujillo Tiebas. Madrid, Spain, MedEvo. IV: 81\u201398 (in Spanish)"},{"issue":"6","key":"9895_CR15","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.mehy.2010.07.050","volume":"75","author":"A Daschner","year":"2010","unstructured":"Daschner A, Cu\u00e9llar C (2010) The hidden sense of symptoms: urticaria can be beneficial. Med Hypotheses 75(6):623\u2013626","journal-title":"Med Hypotheses"},{"issue":"9","key":"9895_CR16","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/j.1346-8138.2010.00869.x","volume":"37","author":"A Daschner","year":"2010","unstructured":"Daschner A, Rodero M, De Frutos C, Valls A, Cu\u00e9llar C (2010) Chronic urticaria is associated with a differential helminth-arthropod-related atopy phenotype. J Dermatol 37(9):780\u2013785","journal-title":"J Dermatol"},{"issue":"1","key":"9895_CR17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pt.2011.10.001","volume":"28","author":"A Daschner","year":"2012","unstructured":"Daschner A, Cu\u00e9llar C, Rodero M (2012) The Anisakis allergy debate: does an evolutionary approach help? Trends Parasitol 28(1):9\u201315","journal-title":"Trends Parasitol"},{"issue":"2","key":"9895_CR18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/all.13072","volume":"72","author":"SR Del Giacco","year":"2017","unstructured":"Del Giacco SR, Bakirtas A, Bel E, Custovic A, Diamant Z, Hamelmann E, Heffler E, Kalayci \u00d6, Saglani S, Sergejeva S, Seys S, Simpson A, Bjermer L (2017) Allergy in severe asthma. Allergy 72(2):207\u2013220","journal-title":"Allergy"},{"issue":"3","key":"9895_CR19","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.anai.2017.07.010","volume":"119","author":"SE Dunn","year":"2017","unstructured":"Dunn SE, Vicini JL, Glenn KC, Fleischer DM, Greenhawt MJ (2017) The allergenicity of genetically modified foods from genetically engineered crops: a narrative and systematic review. Ann Allergy Asthma Immunol 119(3):214\u2013222.e213","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"9895_CR20","first-page":"20","volume":"33","author":"AE Fisher","year":"2015","unstructured":"Fisher AE (2015) An evolutionary perspective on human cross-reactivity to tree nut and seed allergens. Aliso J Syst Evol Bot 33(2):20","journal-title":"Aliso J Syst Evol Bot"},{"issue":"6","key":"9895_CR21","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.jaci.2006.08.035","volume":"118","author":"C Flohr","year":"2006","unstructured":"Flohr C, Tuyen LN, Lewis S, Quinnell R, Minh TT, Liem HT, Campbell J, Pritchard D, Hien TT, Farrar J, Williams H, Britton J (2006) Poor sanitation and helminth infection protect against skin sensitization in Vietnamese children: a cross-sectional study. J Allergy Clin Immunol 118(6):1305\u20131311","journal-title":"J Allergy Clin Immunol"},{"key":"9895_CR22","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/978-1-4939-6925-8_18","volume":"1592","author":"Z Fu","year":"2017","unstructured":"Fu Z, Lin J (2017) An overview of bioinformatics tools and resources in allergy. Methods Mol Biol 1592:223\u2013245","journal-title":"Methods Mol Biol"},{"issue":"19","key":"9895_CR23","first-page":"731","volume":"110","author":"P Garc\u00eda-Ortega","year":"1998","unstructured":"Garc\u00eda-Ortega P, Rovira E, Bartolom\u00e9 B, Mart\u00ednez A, Mora E, Richart C (1998) Outbreak of asthma caused by soybean dust allergy. Clinical and immunologic study of the affected patients. Med Clin 110(19):731\u2013735","journal-title":"Med Clin"},{"issue":"7","key":"9895_CR24","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1046\/j.1365-3024.2000.00309.x","volume":"22","author":"RD Gillespie","year":"2000","unstructured":"Gillespie RD, Mbow ML, Titus RG (2000) The immunomodulatory factors of bloodfeeding arthropod saliva. Parasite Immunol 22(7):319\u2013331","journal-title":"Parasite Immunol"},{"key":"9895_CR25","unstructured":"Gonz\u00e1lez-Fern\u00e1ndez J (2017) Nuevos al\u00e9rgenos de Anisakis simplex: estudios in silico e in vitro. Ph.D., Universidad Complutense de Madrid"},{"issue":"10","key":"9895_CR26","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1007\/s11033-014-3534-6","volume":"41","author":"J Gonz\u00e1lez-Fern\u00e1ndez","year":"2014","unstructured":"Gonz\u00e1lez-Fern\u00e1ndez J, Rodero M, Daschner A, Cu\u00e9llar C (2014) New insights into the allergenicity of tropomyosin: a bioinformatics approach. Mol Biol Rep 41(10):6509\u20136517","journal-title":"Mol Biol Rep"},{"issue":"6","key":"9895_CR27","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ijpara.2015.01.002","volume":"45","author":"J Gonz\u00e1lez-Fern\u00e1ndez","year":"2015","unstructured":"Gonz\u00e1lez-Fern\u00e1ndez J, Daschner A, Nieuwenhuizen NE, Lopata AL, Frutos CD, Valls A, Cu\u00e9llar C (2015) Haemoglobin, a new major allergen of Anisakis simplex. Int J Parasitol 45(6):399\u2013407","journal-title":"Int J Parasitol"},{"issue":"1","key":"9895_CR28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.anai.2015.09.017","volume":"116","author":"J Gonz\u00e1lez-Fern\u00e1ndez","year":"2016","unstructured":"Gonz\u00e1lez-Fern\u00e1ndez J, Veleiro B, Daschner A, Cu\u00e9llar C (2016) Are fish tropomyosins allergens? Ann Allergy Asthma Immunol 116(1):74\u201376.e75","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"3","key":"9895_CR29","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.aller.2016.08.002","volume":"45","author":"J Gonz\u00e1lez-Fern\u00e1ndez","year":"2017","unstructured":"Gonz\u00e1lez-Fern\u00e1ndez J, Daschner A, Cu\u00e9llar C (2017a) Allergenicity of vertebrate tropomyosins: challenging an immunological dogma. Allergol Immunopathol 45(3):297\u2013304","journal-title":"Allergol Immunopathol"},{"key":"9895_CR30","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.exppara.2017.08.010","volume":"181","author":"J Gonz\u00e1lez-Fern\u00e1ndez","year":"2017","unstructured":"Gonz\u00e1lez-Fern\u00e1ndez J, Rivas L, Luque-Ortega JR, N\u00fa\u00f1ez-Ram\u00edrez R, Campioli P, G\u00e1rate T, Perteguer MJ, Daschner A, Cu\u00e9llar C (2017b) Recombinant vs native Anisakis haemoglobin (Ani s 13): its appraisal as a new gold standard for the diagnosis of allergy. Exp Parasitol 181:119\u2013129","journal-title":"Exp Parasitol"},{"issue":"4","key":"9895_CR31","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1080\/08820139.2018.1451882","volume":"47","author":"J Gonz\u00e1lez-Fern\u00e1ndez","year":"2018","unstructured":"Gonz\u00e1lez-Fern\u00e1ndez J, Alguacil-Guill\u00e9n M, Cu\u00e9llar C, Daschner A (2018) Possible allergenic role of tropomyosin in patients with adverse reactions after fish intake. Immunol Investig 47(4):416\u2013429","journal-title":"Immunol Investig"},{"issue":"5","key":"9895_CR32","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.immuni.2013.10.015","volume":"39","author":"DA Gutierrez","year":"2013","unstructured":"Gutierrez DA, Rodewald HR (2013) A sting in the tale of TH2 immunity. Immunity 39(5):803\u2013805","journal-title":"Immunity"},{"issue":"21","key":"9895_CR33","doi-asserted-by":"crossref","first-page":"8334","DOI":"10.1073\/pnas.1205624109","volume":"109","author":"I Hanski","year":"2012","unstructured":"Hanski I, von Hertzen L, Fyhrquist N, Koskinen K, Torppa K, Laatikainen T, Karisola P, Auvinen P, Paulin L, M\u00e4kel\u00e4 MJ, Vartiainen E, Kosunen TU, Alenius H, Haahtela T (2012) Environmental biodiversity, human microbiota, and allergy are interrelated. Proc Natl Acad Sci USA 109(21):8334\u20138339","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"9895_CR34","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.1073\/pnas.93.12.5675","volume":"93","author":"RC Hardison","year":"1996","unstructured":"Hardison RC (1996) A brief history of hemoglobins: plant, animal, protist, and bacteria. Proc Natl Acad Sci USA 93(12):5675\u20135679","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"9895_CR35","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/all.12562","volume":"70","author":"K Horimukai","year":"2015","unstructured":"Horimukai K, Hayashi K, Tsumura Y, Nomura I, Narita M, Ohya Y, Saito H, Matsumoto K (2015) Total serum IgE level influences oral food challenge tests for IgE-mediated food allergies. Allergy 70(3):334\u2013337","journal-title":"Allergy"},{"key":"9895_CR36","volume-title":"Immunobiology 5: the immune system in health and disease","author":"C Janeway","year":"2001","unstructured":"Janeway C (2001) Immunobiology 5: the immune system in health and disease. Garland Pub, New York"},{"issue":"13","key":"9895_CR37","doi-asserted-by":"crossref","first-page":"7550","DOI":"10.1073\/pnas.95.13.7550","volume":"95","author":"RE Jenkins","year":"1998","unstructured":"Jenkins RE, Taylor MJ, Gilvary NJ, Bianco AE (1998) Tropomyosin implicated in host protective responses to microfilariae in onchocerciasis. Proc Natl Acad Sci USA 95(13):7550\u20137555","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"9895_CR38","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.jaci.2007.08.019","volume":"120","author":"JA Jenkins","year":"2007","unstructured":"Jenkins JA, Breiteneder H, Mills EN (2007) Evolutionary distance from human homologs reflects allergenicity of animal food proteins. J Allergy Clin Immunol 120(6):1399\u20131405","journal-title":"J Allergy Clin Immunol"},{"issue":"10","key":"9895_CR39","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.pt.2018.05.011","volume":"34","author":"J Kahl","year":"2018","unstructured":"Kahl J, Brattig N, Liebau E (2018) The untapped pharmacopeic potential of helminths. Trends Parasitol 34(10):828\u2013842","journal-title":"Trends Parasitol"},{"issue":"2","key":"9895_CR40","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jaip.2018.11.011","volume":"7","author":"T Kalic","year":"2019","unstructured":"Kalic T, Morel-Codreanu F, Radauer C, Ruethers T, Taki AC, Swoboda I, Hilger C, Hoffmann-Sommergruber K, Ollert M, Hafner C, Lopata AL, Morisset M, Breiteneder H, Kuehn A (2019) Patients allergic to fish tolerate ray based on the low allergenicity of its parvalbumin. J Allergy Clin Immunol Pract 7(2):500\u2013508.e511","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"5","key":"9895_CR41","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jaci.2010.03.002","volume":"125","author":"CL Karp","year":"2010","unstructured":"Karp CL (2010) Guilt by intimate association: what makes an allergen an allergen? J Allergy Clin Immunol 125(5):955\u2013960 (quiz 961\u2013952)","journal-title":"J Allergy Clin Immunol"},{"issue":"6","key":"9895_CR42","doi-asserted-by":"crossref","first-page":"378","DOI":"10.6026\/97320630010378","volume":"10","author":"CK Kim","year":"2014","unstructured":"Kim CK, Seol YJ, Lee DJ, Jeong IS, Yoon UH, Lee JY, Lee GS, Park DS (2014) AllergenPro: an integrated database for allergenicity analysis and prediction. Bioinformation 10(6):378\u2013380","journal-title":"Bioinformation"},{"key":"9895_CR43","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13223-016-0147-8","volume":"12","author":"R Koz\u0142owska","year":"2016","unstructured":"Koz\u0142owska R, Bo\u017cek A, Jarz\u0105b J (2016) Association between cancer and allergies. Allergy Asthma Clin Immunol 12:39","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"21","key":"9895_CR44","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1093\/bioinformatics\/btp542","volume":"25","author":"D La","year":"2009","unstructured":"La D, Esquivel-Rodr\u00edguez J, Venkatraman V, Li B, Sael L, Ueng S, Ahrendt S, Kihara D (2009) 3D-SURFER: software for high-throughput protein surface comparison and analysis. Bioinformatics 25(21):2843\u20132844","journal-title":"Bioinformatics"},{"issue":"3 Suppl","key":"9895_CR45","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.yrtph.2008.10.010","volume":"54","author":"GS Ladics","year":"2009","unstructured":"Ladics GS, Selgrade MK (2009) Identifying food proteins with allergenic potential: evolution of approaches to safety assessment and research to provide additional tools. Regul Toxicol Pharmacol 54(3 Suppl):S2\u20136","journal-title":"Regul Toxicol Pharmacol"},{"key":"9895_CR46","unstructured":"Lappe M (1994) Evolution of asthma. Evolutionary medicine: rethinking the origins of disease. L. M. San Francisco, Sierra Club Books, pp 193\u2013208"},{"issue":"3","key":"9895_CR47","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/cea.12056","volume":"43","author":"R Liu","year":"2013","unstructured":"Liu R, Holck AL, Yang E, Liu C, Xue W (2013) Tropomyosin from tilapia (Oreochromis mossambicus) as an allergen. Clin Exp Allergy 43(3):365\u2013377","journal-title":"Clin Exp Allergy"},{"issue":"6","key":"9895_CR48","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cmi.2016.04.024","volume":"22","author":"RM Maizels","year":"2016","unstructured":"Maizels RM (2016) Parasitic helminth infections and the control of human allergic and autoimmune disorders. Clin Microbiol Infect 22(6):481\u2013486","journal-title":"Clin Microbiol Infect"},{"issue":"5","key":"9895_CR49","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.immuni.2013.10.005","volume":"39","author":"T Marichal","year":"2013","unstructured":"Marichal T, Starkl P, Reber LL, Kalesnikoff J, Oettgen HC, Tsai M, Metz M, Galli SJ (2013) A beneficial role for immunoglobulin E in host defense against honeybee venom. Immunity 39(5):963\u2013975","journal-title":"Immunity"},{"issue":"5566","key":"9895_CR50","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1126\/science.1071059","volume":"296","author":"P Matzinger","year":"2002","unstructured":"Matzinger P (2002) The danger model: a renewed sense of self. Science 296(5566):301\u2013305","journal-title":"Science"},{"issue":"6","key":"9895_CR51","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/(SICI)1520-6300(199911\/12)11:6<705::AID-AJHB1>3.0.CO;2-G","volume":"11","author":"TW McDade","year":"1999","unstructured":"McDade TW, Worthman CM (1999) Evolutionary process and the ecology of human immune function. Am J Hum Biol 11(6):705\u2013717","journal-title":"Am J Hum Biol"},{"issue":"1","key":"9895_CR52","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bbadis.2011.02.005","volume":"1822","author":"S Mecheri","year":"2012","unstructured":"Mecheri S (2012) Contribution of allergic inflammatory response to the pathogenesis of malaria disease. Biochim Biophys Acta 1822(1):49\u201356","journal-title":"Biochim Biophys Acta"},{"issue":"12","key":"9895_CR53","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1084\/jem.20080193","volume":"205","author":"F Meiler","year":"2008","unstructured":"Meiler F, Zumkehr J, Klunker S, R\u00fcckert B, Akdis CA, Akdis M (2008) In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J Exp Med 205(12):2887\u20132898","journal-title":"J Exp Med"},{"issue":"5","key":"9895_CR54","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/10408690490489224","volume":"44","author":"EN Mills","year":"2004","unstructured":"Mills EN, Jenkins JA, Alcocer MJ, Shewry PR (2004) Structural, biological, and evolutionary relationships of plant food allergens sensitizing via the gastrointestinal tract. Crit Rev Food Sci Nutr 44(5):379\u2013407","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"5","key":"9895_CR55","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00281-016-0565-1","volume":"38","author":"K Mukai","year":"2016","unstructured":"Mukai K, Tsai M, Starkl P, Marichal T, Galli SJ (2016) IgE and mast cells in host defense against parasites and venoms. Semin Immunopathol 38(5):581\u2013603","journal-title":"Semin Immunopathol"},{"issue":"4","key":"9895_CR56","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/01.all.0000173783.42906.95","volume":"5","author":"UR M\u00fcller","year":"2005","unstructured":"M\u00fcller UR (2005) Bee venom allergy in beekeepers and their family members. Curr Opin Allergy Clin Immunol 5(4):343\u2013347","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"1","key":"9895_CR57","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1752-4571.2007.00006.x","volume":"1","author":"RM Nesse","year":"2008","unstructured":"Nesse RM, Stearns SC (2008) The great opportunity: evolutionary applications to medicine and public health. Evol Appl 1(1):28\u201348","journal-title":"Evol Appl"},{"issue":"17","key":"9895_CR58","doi-asserted-by":"crossref","first-page":"R733","DOI":"10.1016\/j.cub.2012.07.029","volume":"22","author":"D Okin","year":"2012","unstructured":"Okin D, Medzhitov R (2012) Evolution of inflammatory diseases. Curr Biol 22(17):R733\u2013740","journal-title":"Curr Biol"},{"issue":"7395","key":"9895_CR59","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nature11047","volume":"484","author":"NW Palm","year":"2012","unstructured":"Palm NW, Rosenstein RK, Medzhitov R (2012) Allergic host defences. Nature 484(7395):465\u2013472","journal-title":"Nature"},{"key":"9895_CR60","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.3389\/fimmu.2018.01584","volume":"9","author":"M Pascal","year":"2018","unstructured":"Pascal M, Perez-Gordo M, Caballero T, Escribese MM, Lopez Longo MN, Luengo O, Manso L, Matheu V, Seoane E, Zamorano M, Labrador M, Mayorga C (2018) Microbiome and allergic diseases. Front Immunol 9:1584","journal-title":"Front Immunol"},{"issue":"1","key":"9895_CR61","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4168\/aair.2017.9.1.35","volume":"9","author":"L Perez\u00e1bad","year":"2017","unstructured":"Perez\u00e1bad L, Reche M, Valbuena T, L\u00f3pez-Fandi\u00f1o R, Molina E, L\u00f3pez-Exp\u00f3sito I (2017) Oral food desensitization in children with IgE-Mediated cow\u2019s milk allergy: immunological changes underlying desensitization. Allergy Asthma Immunol Res 9(1):35\u201342","journal-title":"Allergy Asthma Immunol Res"},{"issue":"7","key":"9895_CR62","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/alr.21340","volume":"4","author":"M Platt","year":"2014","unstructured":"Platt M, Howell S, Sachdeva R, Dumont C (2014) Allergen cross-reactivity in allergic rhinitis and oral-allergy syndrome: a bioinformatic protein sequence analysis. Int Forum Allergy Rhinol 4(7):559\u2013564","journal-title":"Int Forum Allergy Rhinol"},{"key":"9895_CR63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000331802","volume":"96","author":"TA Platts-Mills","year":"2012","unstructured":"Platts-Mills TA (2012) Allergy in evolution. Chem Immunol Allergy 96:1\u20136","journal-title":"Chem Immunol Allergy"},{"issue":"1","key":"9895_CR64","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2015.03.048","volume":"136","author":"TA Platts-Mills","year":"2015","unstructured":"Platts-Mills TA (2015) The allergy epidemics: 1870\u20132010. J Allergy Clin Immunol 136(1):3\u201313","journal-title":"J Allergy Clin Immunol"},{"key":"9895_CR65","doi-asserted-by":"crossref","first-page":"aag0479","DOI":"10.1126\/sciimmunol.aag0479","volume":"1","author":"T Pradeu","year":"2016","unstructured":"Pradeu T, Vivier E (2016) The discontinuity theory of immunity. Sci Immunol 1:aag0479","journal-title":"Sci Immunol"},{"issue":"1","key":"9895_CR66","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jaci.2012.11.019","volume":"131","author":"SL Prescott","year":"2013","unstructured":"Prescott SL (2013) Early-life environmental determinants of allergic diseases and the wider pandemic of inflammatory noncommunicable diseases. J Allergy Clin Immunol 131(1):23\u201330","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"9895_CR67","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1086\/417049","volume":"66","author":"M Profet","year":"1991","unstructured":"Profet M (1991) The function of allergy: immunological defense against toxins. Q Rev Biol 66(1):23\u201362","journal-title":"Q Rev Biol"},{"issue":"1 Pt 1","key":"9895_CR68","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1067\/mai.2000.107599","volume":"106","author":"R S\u00e1nchez-Monge","year":"2000","unstructured":"S\u00e1nchez-Monge R, Blanco C, Perales AD, Collada C, Carrillo T, Aragoncillo C, Salcedo G (2000) Class I chitinases, the panallergens responsible for the latex-fruit syndrome, are induced by ethylene treatment and inactivated by heating. J Allergy Clin Immunol 106(1 Pt 1):190\u2013195","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"9895_CR69","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/cea.12571","volume":"45","author":"S Scheurer","year":"2015","unstructured":"Scheurer S, Toda M, Vieths S (2015) What makes an allergen? Clin Exp Allergy 45(7):1150\u20131161","journal-title":"Clin Exp Allergy"},{"issue":"2","key":"9895_CR70","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2131\/jts.37.439","volume":"37","author":"M Seo","year":"2012","unstructured":"Seo M, Kobayashi R, Okamura T, Ikeda K, Satoh M, Inagaki N, Nagai H, Nagase H (2012) Enhancing effects of trichloroethylene and tetrachloroethylene on type I allergic responses in mice. J Toxicol Sci 37(2):439\u2013445","journal-title":"J Toxicol Sci"},{"key":"9895_CR71","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.fct.2018.03.032","volume":"115","author":"Y Shahali","year":"2018","unstructured":"Shahali Y, Dadar M (2018) Plant food allergy: influence of chemicals on plant allergens. Food Chem Toxicol 115:365\u2013374","journal-title":"Food Chem Toxicol"},{"issue":"4","key":"9895_CR72","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1086\/592850","volume":"83","author":"PW Sherman","year":"2008","unstructured":"Sherman PW, Holland E, Sherman JS (2008) Allergies: their role in cancer prevention. Q Rev Biol 83(4):339\u2013362","journal-title":"Q Rev Biol"},{"issue":"6","key":"9895_CR73","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ijpara.2014.02.004","volume":"44","author":"S Silas","year":"2014","unstructured":"Silas S, Fitzsimmons CM, Jones FM, Pinot de Moira A, Wawrzyniak J, Tukahebwa EM, Dunne DW (2014) Human IgE responses to different splice variants of Schistosoma mansoni tropomyosin: associations with immunity. Int J Parasitol 44(6):381\u2013390","journal-title":"Int J Parasitol"},{"issue":"6","key":"9895_CR74","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.jaci.2010.02.028","volume":"125","author":"D Soeria-Atmadja","year":"2010","unstructured":"Soeria-Atmadja D, Onell A, Borg\u00e5 A (2010) IgE sensitization to fungi mirrors fungal phylogenetic systematics. J Allergy Clin Immunol 125(6):1379\u20131386.e1371","journal-title":"J Allergy Clin Immunol"},{"issue":"1746","key":"9895_CR75","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1098\/rspb.2012.1326","volume":"279","author":"SC Stearns","year":"2012","unstructured":"Stearns SC (2012) Evolutionary medicine: its scope, interest and potential. Proc Biol Sci 279(1746):4305\u20134321","journal-title":"Proc Biol Sci"},{"issue":"2","key":"9895_CR76","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1353\/pbm.1974.0027","volume":"17","author":"JH Stebbings","year":"1974","unstructured":"Stebbings JH (1974) Immediate hypersensitivity: a defense against arthropods? Perspect Biol Med 17(2):233\u2013239","journal-title":"Perspect Biol Med"},{"issue":"6710","key":"9895_CR77","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/bmj.299.6710.1259","volume":"299","author":"DP Strachan","year":"1989","unstructured":"Strachan DP (1989) Hay fever, hygiene, and household size. BMJ 299(6710):1259\u20131260","journal-title":"BMJ"},{"issue":"5","key":"9895_CR78","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00109-012-0861-8","volume":"90","author":"RH Straub","year":"2012","unstructured":"Straub RH (2012) Evolutionary medicine and chronic inflammatory state\u2014known and new concepts in pathophysiology. J Mol Med 90(5):523\u2013534","journal-title":"J Mol Med"},{"key":"9895_CR79","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.coi.2015.07.001","volume":"36","author":"M Tsai","year":"2015","unstructured":"Tsai M, Starkl P, Marichal T, Galli SJ (2015) Testing the \u2018toxin hypothesis of allergy\u2019: mast cells, IgE, and innate and acquired immune responses to venoms. Curr Opin Immunol 36:80\u201387","journal-title":"Curr Opin Immunol"},{"key":"9895_CR80","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-065X.1992.tb01415.x","volume":"127","author":"JJ Urban","year":"1992","unstructured":"Urban JJ, Madden K, Sveti\u0107 A, Cheever A, Trotta P, Gause W, Katona I, Finkelman F (1992) The importance of Th2 cytokines in protective immunity to nematodes. Immunol Rev 127:205\u2013220","journal-title":"Immunol Rev"},{"issue":"5","key":"9895_CR81","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1086\/381767","volume":"189","author":"AH van den Biggelaar","year":"2004","unstructured":"van den Biggelaar AH, Rodrigues LC, van Ree R, van der Zee JS, Hoeksma-Kruize YC, Souverijn JH, Missinou MA, Borrmann S, Kremsner PG, Yazdanbakhsh M (2004) Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren. J Infect Dis 189(5):892\u2013900","journal-title":"J Infect Dis"},{"issue":"3","key":"9895_CR82","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nri2257","volume":"8","author":"D Vercelli","year":"2008","unstructured":"Vercelli D (2008) Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 8(3):169\u2013182","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"9895_CR83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/417048","volume":"66","author":"GC Williams","year":"1991","unstructured":"Williams GC, Nesse RM (1991) The dawn of Darwinian medicine. Q Rev Biol 66(1):1\u201322","journal-title":"Q Rev Biol"},{"issue":"2","key":"9895_CR84","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.bbrc.2014.07.124","volume":"451","author":"GW Wong","year":"2014","unstructured":"Wong GW, Zhuo L, Kimata K, Lam BK, Satoh N, Stevens RL (2014) Ancient origin of mast cells. Biochem Biophys Res Commun 451(2):314\u2013318","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"9895_CR85","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S1471-4906(01)01958-5","volume":"22","author":"M Yazdanbakhsh","year":"2001","unstructured":"Yazdanbakhsh M, van den Biggelaar A, Maizels R (2001) Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease. Trends Immunol 22(7):372\u2013377","journal-title":"Trends Immunol"},{"issue":"5567","key":"9895_CR86","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.296.5567.490","volume":"296","author":"M Yazdanbakhsh","year":"2002","unstructured":"Yazdanbakhsh M, Kremsner PG, van Ree R (2002) Allergy, parasites, and the hygiene hypothesis. Science 296(5567):490\u2013494","journal-title":"Science"}],"container-title":["Journal of Molecular Evolution"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00239-019-09895-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00239-019-09895-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00239-019-09895-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T23:27:53Z","timestamp":1591399673000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00239-019-09895-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,7]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["9895"],"URL":"https:\/\/doi.org\/10.1007\/s00239-019-09895-3","relation":{},"ISSN":["0022-2844","1432-1432"],"issn-type":[{"value":"0022-2844","type":"print"},{"value":"1432-1432","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,7]]},"assertion":[{"value":"4 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}