{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:18:13Z","timestamp":1790201893091,"version":"4.1.0"},"reference-count":123,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas","award":["Pronaii 303045"],"award-info":[{"award-number":["Pronaii 303045"]}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e1 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/25749-8"],"award-info":[{"award-number":["2018\/25749-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP190100304"],"award-info":[{"award-number":["DP190100304"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000943","name":"Commonwealth Scientific and Industrial Research Organisation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000943","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Evol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Snakes in the family Elapidae largely produce venoms rich in three-finger toxins (3FTx) that bind to the <jats:inline-formula><jats:alternatives><jats:tex-math>$$\\upalpha _1$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:msub>\n                    <mml:mi>\u03b1<\/mml:mi>\n                    <mml:mn>1<\/mml:mn>\n                  <\/mml:msub>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula> subunit of nicotinic acetylcholine receptors (nAChRs), impeding ion channel activity. These neurotoxins immobilize the prey by disrupting muscle contraction. Coral snakes of the genus <jats:italic>Micrurus<\/jats:italic> are specialist predators who produce many 3FTx, making them an interesting system for examining the coevolution of these toxins and their targets in prey animals. We used a bio-layer interferometry technique to measure the binding interaction between 15 <jats:italic>Micrurus<\/jats:italic> venoms and 12 taxon-specific mimotopes designed to resemble the orthosteric binding region of the muscular nAChR subunit. We found that <jats:italic>Micrurus<\/jats:italic> venoms vary greatly in their potency on this assay and that this variation follows phylogenetic patterns rather than previously reported patterns of venom composition. The long-tailed <jats:italic>Micrurus<\/jats:italic> tend to have greater binding to nAChR orthosteric sites than their short-tailed relatives and we conclude this is the likely ancestral state. The repeated loss of this activity may be due to the evolution of 3FTx that bind to other regions of the nAChR. We also observed variations in the potency of the venoms depending on the taxon of the target mimotope. Rather than a pattern of prey-specificity, we found that mimotopes modeled after snake nAChRs are less susceptible to <jats:italic>Micrurus<\/jats:italic> venoms and that this resistance is partly due to a characteristic tryptophan<jats:inline-formula><jats:alternatives><jats:tex-math>$$\\rightarrow$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                  <mml:mo>\u2192<\/mml:mo>\n                <\/mml:math><\/jats:alternatives><\/jats:inline-formula>serine mutation within the orthosteric site in all snake mimotopes. This resistance may be part of a Red Queen arms race between coral snakes and their prey.<\/jats:p>","DOI":"10.1007\/s00239-024-10176-x","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T11:04:02Z","timestamp":1717067042000},"page":"317-328","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Red-on-Yellow Queen: Bio-Layer Interferometry Reveals Functional Diversity Within Micrurus Venoms and Toxin Resistance in Prey Species"],"prefix":"10.1007","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4346-7252","authenticated-orcid":false,"given":"Daniel","family":"Dashevsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina N.","family":"Zdenek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melisa","family":"Benard-Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Alag\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Portes-Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita M.","family":"Tanaka-Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen F.","family":"Grego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1vio S.","family":"Sant\u2019Anna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan G.","family":"Fry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"issue":"42","key":"10176_CR1","doi-asserted-by":"publisher","first-page":"12836","DOI":"10.1021\/bi971513u","volume":"36","author":"EJ Ackermann","year":"1997","unstructured":"Ackermann EJ, Taylor P (1997) Nonidentity of the \u03b1-neurotoxin binding sites on the nicotinic acetylcholine receptor revealed by modification in \u03b1-neurotoxin and receptor structures. Biochemistry 36(42):12836\u201312844","journal-title":"Biochemistry"},{"issue":"10","key":"10176_CR2","doi-asserted-by":"publisher","first-page":"2640","DOI":"10.1093\/gbe\/evx199","volume":"9","author":"SD Aird","year":"2017","unstructured":"Aird SD, Arora J, Barua A et al (2017) Population genomic analysis of a pitviper reveals microevolutionary forces underlying venom chemistry. Genome Biol Evol 9(10):2640\u20132649. https:\/\/doi.org\/10.1093\/gbe\/evx199","journal-title":"Genome Biol Evol"},{"key":"10176_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00848","author":"LO Albulescu","year":"2019","unstructured":"Albulescu LO, Kazandjian T, Slagboom J et al (2019) A decoy-receptor approach using nicotinic acetylcholine receptor mimics reveals their potential as novel therapeutics against neurotoxic snakebite. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2019.00848","journal-title":"Front Pharmacol"},{"issue":"2","key":"10176_CR4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.2994\/057.005.0204","volume":"5","author":"RW \u00c1vila","year":"2010","unstructured":"\u00c1vila RW, Kawashita-Ribeiro RA, Ferreira VL et al (2010) Natural history of the coral snake Micrurus pyrrhocryptus cope 1862 (Elapidae) from semideciduous forests of Western Brazil. South Am J Herpetol 5(2):97\u2013101. https:\/\/doi.org\/10.2994\/057.005.0204","journal-title":"South Am J Herpetol"},{"key":"10176_CR5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.toxicon.2013.01.019","volume":"66","author":"CM Barber","year":"2013","unstructured":"Barber CM, Isbister GK, Hodgson WC (2013) Alpha neurotoxins. Toxicon 66:47\u201358. https:\/\/doi.org\/10.1016\/j.toxicon.2013.01.019","journal-title":"Toxicon"},{"issue":"16","key":"10176_CR6","doi-asserted-by":"publisher","first-page":"7717","DOI":"10.1073\/pnas.89.16.7717","volume":"89","author":"D Barchan","year":"1992","unstructured":"Barchan D, Kachalsky S, Neumann D et al (1992) How the mongoose can fight the snake: the binding site of the mongoose acetylcholine receptor. Proc Natl Acad Sci 89(16):7717\u20137721","journal-title":"Proc Natl Acad Sci"},{"issue":"28","key":"10176_CR7","doi-asserted-by":"publisher","first-page":"9172","DOI":"10.1021\/bi00028a029","volume":"34","author":"D Barchan","year":"1995","unstructured":"Barchan D, Ovadia M, Kochva E et al (1995) The binding site of the nicotinic acetylcholine receptor in animal species resistant to \u03b1-bungarotoxin. Biochemistry 34(28):9172\u20139176","journal-title":"Biochemistry"},{"issue":"1666","key":"10176_CR8","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1098\/rspb.2009.0048","volume":"276","author":"A Barlow","year":"2009","unstructured":"Barlow A, Pook CE, Harrison RA et al (2009) Coevolution of diet and prey-specific venom activity supports the role of selection in snake venom evolution. Proc Royal Soc B: Biol Sci 276(1666):2443\u20132449. https:\/\/doi.org\/10.1098\/rspb.2009.0048","journal-title":"Proc Royal Soc B: Biol Sci"},{"key":"10176_CR9","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.toxicon.2013.10.005","volume":"77","author":"M B\u00e9nard-Valle","year":"2014","unstructured":"B\u00e9nard-Valle M, Carbajal-Saucedo A, de Roodt A et al (2014) Biochemical characterization of the venom of the coral snake Micrurus tener and comparative biological activities in the mouse and a reptile model. Toxicon 77:6\u201315. https:\/\/doi.org\/10.1016\/j.toxicon.2013.10.005","journal-title":"Toxicon"},{"key":"10176_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2020.103863","volume":"225","author":"M B\u00e9nard-Valle","year":"2020","unstructured":"B\u00e9nard-Valle M, Neri-Castro E, Ya\u00f1ez-Mendoza MF et al (2020) Functional, proteomic and transcriptomic characterization of the venom from Micrurus browni: identification of the first lethal multimeric neurotoxin in coral snake venom. J Proteomics 225:103863. https:\/\/doi.org\/10.1016\/j.jprot.2020.103863","journal-title":"J Proteomics"},{"issue":"4","key":"10176_CR11","doi-asserted-by":"publisher","first-page":"249","DOI":"10.5281\/zenodo.2586853","volume":"54","author":"PS Bernarde","year":"2018","unstructured":"Bernarde PS, Turci LCB, Abegg AD et al (2018) A remarkable new species of coralsnake of the Micrurus hemprichii species group from the Brazilian Amazon. Salamandra 54(4):249\u2013258. https:\/\/doi.org\/10.5281\/zenodo.2586853","journal-title":"Salamandra"},{"issue":"7373","key":"10176_CR12","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/nature10607","volume":"479","author":"CJ Bohlen","year":"2011","unstructured":"Bohlen CJ, Chesler AT, Sharif-Naeini R et al (2011) A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature 479(7373):410\u2013414. https:\/\/doi.org\/10.1038\/nature10607","journal-title":"Nature"},{"issue":"5","key":"10176_CR13","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/0041-0101(75)90197-X","volume":"13","author":"R Bola\u00f1os","year":"1975","unstructured":"Bola\u00f1os R, Piva A, Taylor R et al (1975) Natural resistance of bovine animals to Micrurus nigrocinctus venom. Toxicon 13(5):369\u2013370","journal-title":"Toxicon"},{"key":"10176_CR14","doi-asserted-by":"publisher","first-page":"6611","DOI":"10.1021\/bi0023201","volume":"40","author":"L Bracci","year":"2001","unstructured":"Bracci L, Lozzi L, Lelli B et al (2001) Mimotopes of the nicotinic receptor binding site selected by a combinatorial peptide library. Biochemistry 40:6611\u20136619. https:\/\/doi.org\/10.1021\/bi0023201","journal-title":"Biochemistry"},{"key":"10176_CR15","doi-asserted-by":"publisher","first-page":"10194","DOI":"10.1021\/bi0256025","volume":"41","author":"L Bracci","year":"2002","unstructured":"Bracci L, Lozzi L, Pini A et al (2002) A branched peptide mimotope of the nicotinic receptor binding site is a potent synthetic antidote against the snake neurotoxin alpha-bungarotoxin. Biochemistry 41:10194\u201310199. https:\/\/doi.org\/10.1021\/bi0256025","journal-title":"Biochemistry"},{"issue":"6","key":"10176_CR16","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/0041-0101(79)90245-9","volume":"17","author":"AJ Broad","year":"1979","unstructured":"Broad AJ, Sutherland SK, Coulter AR (1979) The lethality in mice of dangerous Australian and other snake venom. Toxicon 17(6):661\u2013664","journal-title":"Toxicon"},{"key":"10176_CR17","doi-asserted-by":"publisher","unstructured":"Bucaretchi F, Capitani EMD, Vieira RJ et al (2016) Coral snake bites (Micrurus spp.) in Brazil: a review of literature reports. Clin Toxicol 54(3):222\u2013234. https:\/\/doi.org\/10.3109\/15563650.2015.1135337","DOI":"10.3109\/15563650.2015.1135337"},{"issue":"8","key":"10176_CR18","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.1073\/pnas.72.8.3245","volume":"72","author":"SJ Burden","year":"2006","unstructured":"Burden SJ, Hartzell HC, Yoshikami D (2006) Acetylcholine receptors at neuromuscular synapses: phylogenetic differences detected by snake \u03b1-neurotoxins. Proc Natl Acad Sci 72(8):3245\u20133249. https:\/\/doi.org\/10.1073\/pnas.72.8.3245","journal-title":"Proc Natl Acad Sci"},{"key":"10176_CR19","volume-title":"The venomous reptiles of the Western Hemisphere","author":"JA Campbell","year":"2004","unstructured":"Campbell JA, Lamar WW (2004) The venomous reptiles of the Western Hemisphere. Cornell University Press, Ithaca"},{"key":"10176_CR20","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.toxicon.2013.02.006","volume":"66","author":"A Carbajal-Saucedo","year":"2013","unstructured":"Carbajal-Saucedo A, L\u00f3pez-Vera E, B\u00e9nard-Valle M et al (2013) Isolation, characterization, cloning and expression of an alpha-neurotoxin from the venom of the Mexican coral snake Micrurus laticollaris (Squamata: Elapidae). Toxicon 66:64\u201374. https:\/\/doi.org\/10.1016\/j.toxicon.2013.02.006","journal-title":"Toxicon"},{"issue":"1","key":"10176_CR21","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3390\/toxins6010359","volume":"6","author":"A Carbajal-Saucedo","year":"2014","unstructured":"Carbajal-Saucedo A, Floriano RS, Belo CAD et al (2014) Neuromuscular activity of Micrurus laticollaris (Squamata: Elapidae) venom in vitro. Toxins 6(1):359\u2013370. https:\/\/doi.org\/10.3390\/toxins6010359","journal-title":"Toxins"},{"key":"10176_CR22","doi-asserted-by":"publisher","unstructured":"Cecchini AL, Marcussi S, Silveira LB et\u00a0al (2005) Biological and enzymatic activities of Micrurus sp. (Coral) snake venoms. Comp Biochem Physiol A Mol Integr Physiol 140(1):125\u2013134. https:\/\/doi.org\/10.1016\/j.cbpb.2004.11.012","DOI":"10.1016\/j.cbpb.2004.11.012"},{"issue":"11\/12","key":"10176_CR23","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1016\/S0041-0101(96)00110-9","volume":"34","author":"VA Chiappinelli","year":"1996","unstructured":"Chiappinelli VA, Weaver WR, McLane KE et al (1996) Binding of native \u03ba-neurotoxins and site-directed mutants to nicotinic acetylcholine receptors. Toxicon 34(11\/12):1243\u20131256","journal-title":"Toxicon"},{"key":"10176_CR24","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-022-00572-w","author":"A Chowdhury","year":"2022","unstructured":"Chowdhury A, Zdenek CN, Fry BG (2022) Diverse and dynamic alpha-neurotoxicity within venoms from the palearctic viperid snake clade of Daboia, Macrovipera, Montivipera, and Vipera. Neurotox Res. https:\/\/doi.org\/10.1007\/s12640-022-00572-w","journal-title":"Neurotox Res"},{"key":"10176_CR25","doi-asserted-by":"publisher","unstructured":"Corr\u00eaa-Netto C, Junqueira-de Azevedo IdLM, Silva DA et\u00a0al (2011) Snake venomics and venom gland transcriptomic analysis of Brazilian coral snakes, Micrurus altirostris and M. corallinus. J Proteomics 74(9):1795\u20131809. https:\/\/doi.org\/10.1016\/j.jprot.2011.04.003","DOI":"10.1016\/j.jprot.2011.04.003"},{"key":"10176_CR26","first-page":"335","volume":"10","author":"KR da Silva Banci","year":"2017","unstructured":"da Silva Banci KR (2017) Feeding on elongate prey: additonal data for coral snake Micrurus corallinus (Elapidae) and comments on aposematism. Herpetol Notes 10:335\u2013338","journal-title":"Herpetol Notes"},{"issue":"3","key":"10176_CR27","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S1532-0456(00)00215-5","volume":"128","author":"NJ da Silva","year":"2001","unstructured":"da Silva NJ, Aird SD (2001) Prey specificity, comparative lethality and compositional differences of coral snake venoms. Comp Biochem Physiol C: Toxicol Pharmacol 128(3):425\u2013456. https:\/\/doi.org\/10.1016\/S1532-0456(00)00215-5","journal-title":"Comp Biochem Physiol C: Toxicol Pharmacol"},{"issue":"4","key":"10176_CR28","first-page":"538","volume":"3974","author":"NJ da Silva","year":"2015","unstructured":"da Silva NJ, Pires MG, Zaher H et al (2015) A new species of monadal coral snake of the genus Micrurus (Serpentes, Elapidae) from western Amazon. Zootaxa 3974(4):538\u2013554","journal-title":"Zootaxa"},{"issue":"7","key":"10176_CR29","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.toxicon.2005.07.016","volume":"46","author":"CA Dal Belo","year":"2005","unstructured":"Dal Belo CA, Leite GB, Toyama MH et al (2005) Pharmacological and structural characterization of a novel phospholipase A2 from Micrurus dumerilii carinicauda venom. Toxicon 46(7):736\u2013750. https:\/\/doi.org\/10.1016\/j.toxicon.2005.07.016","journal-title":"Toxicon"},{"issue":"1","key":"10176_CR30","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s00239-017-9825-5","volume":"86","author":"D Dashevsky","year":"2018","unstructured":"Dashevsky D, Fry BG (2018) Ancient diversification of three-finger toxins in Micrurus coral snakes. J Mol Evol 86(1):58\u201367. https:\/\/doi.org\/10.1007\/s00239-017-9825-5","journal-title":"J Mol Evol"},{"issue":"8","key":"10176_CR31","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s00239-018-9864-6","volume":"86","author":"D Dashevsky","year":"2018","unstructured":"Dashevsky D, Debono J, Rokyta D et al (2018) Three-finger toxin diversification in the venoms of cat-eye snakes (Colubridae: Boiga). J Mol Evol 86(8):531\u2013545. https:\/\/doi.org\/10.1007\/s00239-018-9864-6","journal-title":"J Mol Evol"},{"issue":"2","key":"10176_CR32","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3390\/toxins13020124","volume":"13","author":"D Dashevsky","year":"2021","unstructured":"Dashevsky D, Rokyta D, Frank N et al (2021) Electric blue: molecular evolution of three-finger toxins in the long-glanded coral snake species Calliophis bivirgatus. Toxins 13(2):124. https:\/\/doi.org\/10.3390\/toxins13020124","journal-title":"Toxins"},{"issue":"1161","key":"10176_CR33","first-page":"489","volume":"205","author":"R Dawkins","year":"1979","unstructured":"Dawkins R, Krebs JR (1979) Arms races between and within species. Proc Royal Soc London Ser B Biol Sci 205(1161):489\u2013511","journal-title":"Proc Royal Soc London Ser B Biol Sci"},{"key":"10176_CR34","doi-asserted-by":"publisher","unstructured":"Di-Bernardo M, Borges-Martins M, Silva Da, (Jr.) NJ, (2007) A new species of coralsnake (Micrurus: Elapidae) from southern Brazil. Zootaxa. https:\/\/doi.org\/10.11646\/zootaxa.1447.1.1","DOI":"10.11646\/zootaxa.1447.1.1"},{"key":"10176_CR35","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.toxicon.2015.03.007","volume":"99","author":"DH Drabeck","year":"2015","unstructured":"Drabeck DH, Dean AM, Jansa SA (2015) Why the honey badger don\u2019t care: convergent evolution of venom-targeted nicotinic acetylcholine receptors in mammals that survive venomous snake bites. Toxicon 99:68\u201372. https:\/\/doi.org\/10.1016\/j.toxicon.2015.03.007","journal-title":"Toxicon"},{"issue":"9","key":"10176_CR36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161070","volume":"11","author":"A Figueroa","year":"2016","unstructured":"Figueroa A, McKelvy AD, Grismer LL et al (2016) A species-level phylogeny of extant snakes with description of a new colubrid subfamily and genus. PLoS ONE 11(9):e0161070. https:\/\/doi.org\/10.1371\/journal.pone.0161070","journal-title":"PLoS ONE"},{"key":"10176_CR37","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-019-02476-9","author":"RS Floriano","year":"2019","unstructured":"Floriano RS, Schezaro-Ramos R, Silva NJ et al (2019) Neurotoxicity of Micrurus lemniscatus (South American coralsnake) venom in vertebrate neuromuscular preparations in vitro and neutralization by antivenom. Archiv Toxicol. https:\/\/doi.org\/10.1007\/s00204-019-02476-9","journal-title":"Archiv Toxicol"},{"key":"10176_CR38","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14954","author":"CS Foo","year":"2019","unstructured":"Foo CS, Jobichen C, Hassan-Puttaswamy V et al (2019) Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic acetylcholine receptors. Br J Pharmacol. https:\/\/doi.org\/10.1111\/bph.14954","journal-title":"Br J Pharmacol"},{"issue":"1","key":"10176_CR39","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s00239-003-2461-2","volume":"57","author":"BG Fry","year":"2003","unstructured":"Fry BG, W\u00fcster W, Kini RM et al (2003) Molecular evolution and phylogeny of elapid snake venom three-finger toxins. J Mol Evol 57(1):110\u2013129. https:\/\/doi.org\/10.1007\/s00239-003-2461-2","journal-title":"J Mol Evol"},{"issue":"7","key":"10176_CR40","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1074\/mcp.M112.023143","volume":"12","author":"BG Fry","year":"2013","unstructured":"Fry BG, Undheim EAB, Ali SA et al (2013) Squeezers and leaf-cutters: differential diversification and degeneration of the venom system in toxicoferan reptiles. Mol Cell Proteomics 12(7):1881\u20131899. https:\/\/doi.org\/10.1074\/mcp.M112.023143","journal-title":"Mol Cell Proteomics"},{"issue":"1","key":"10176_CR41","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1146\/annurev.pa.31.040191.000345","volume":"31","author":"JL Galzi","year":"1991","unstructured":"Galzi JL, Revah F, Bessis A et al (1991) Functional architecture of the nicotinic acetylcholine receptor: from electric organ to brain. Ann Rev Pharmacol Toxicol 31(1):37\u201372. https:\/\/doi.org\/10.1146\/annurev.pa.31.040191.000345","journal-title":"Ann Rev Pharmacol Toxicol"},{"issue":"2","key":"10176_CR42","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s12080-017-0354-z","volume":"11","author":"AN Gangur","year":"2018","unstructured":"Gangur AN, Seymour JE, Liddell MJ et al (2018) When is overkill optimal? Tritrophic interactions reveal new insights into venom evolution. Theor Ecol 11(2):141\u2013149. https:\/\/doi.org\/10.1007\/s12080-017-0354-z","journal-title":"Theor Ecol"},{"issue":"2","key":"10176_CR43","first-page":"10","volume":"57","author":"JPH G\u00f3mez","year":"2021","unstructured":"G\u00f3mez JPH, Ramirez MV, G\u00f3mez FJR et al (2021) Multilocus phylogeny clarifies relationships and diversity within the Micrurus lemniscatus complex (Serpentes: Elapidae). Salamandra 57(2):10","journal-title":"Salamandra"},{"issue":"6","key":"10176_CR44","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.pneurobio.2004.09.006","volume":"74","author":"C Gotti","year":"2004","unstructured":"Gotti C, Clementi F (2004) Neuronal nicotinic receptors: from structure to pathology. Prog Neurobiol 74(6):363\u201396. https:\/\/doi.org\/10.1016\/j.pneurobio.2004.09.006","journal-title":"Prog Neurobiol"},{"key":"10176_CR45","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.biochi.2018.01.006","volume":"147","author":"JF Guerrero-Garz\u00f3n","year":"2018","unstructured":"Guerrero-Garz\u00f3n JF, B\u00e9nard-Valle M, Restano-Cassulini R et al (2018) Cloning and sequencing of three-finger toxins from the venom glands of four Micrurus species from Mexico and heterologous expression of an alpha-neurotoxin from Micrurus diastema. Biochimie 147:114\u2013121. https:\/\/doi.org\/10.1016\/j.biochi.2018.01.006","journal-title":"Biochimie"},{"key":"10176_CR46","unstructured":"Gutberlet RL Jr, Harvey MB (2004) The evolution of New World venomous snakes. The venomous reptiles of the Western Hemisphere, vol 2. Cornell University Press, Ithaca, pp 634\u2013682"},{"key":"10176_CR47","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.toxicon.2014.10.004","volume":"92","author":"AD Hargreaves","year":"2014","unstructured":"Hargreaves AD, Swain MT, Logan DW et al (2014) Testing the Toxicofera: comparative transcriptomics casts doubt on the single, early evolution of the reptile venom system. Toxicon 92:140\u2013156","journal-title":"Toxicon"},{"key":"10176_CR48","unstructured":"Harris R (2022) The co-evolutionary dynamics of \u03b1-neurotoxic snake venoms and their nicotinic acetylcholine receptor targets. PhD Thesis, The University of Queensland, School of Biological Sciences"},{"issue":"19","key":"10176_CR49","doi-asserted-by":"publisher","first-page":"7377","DOI":"10.3390\/ijms21197377","volume":"21","author":"RJ Harris","year":"2020","unstructured":"Harris RJ, Youngman NJ, Zdenek CN et al (2020a) Assessing the binding of venoms from aquatic elapids to the nicotinic acetylcholine receptor orthosteric site of different prey models. Int J Mol Sci 21(19):7377","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10176_CR50","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1007\/s12640-020-00211-2","volume":"38","author":"RJ Harris","year":"2020","unstructured":"Harris RJ, Zdenek CN, Debono J et al (2020b) Evolutionary interpretations of nicotinic acetylcholine receptor targeting venom effects by a clade of Asian Viperidae Snakes. Neurotox Res 38(2):312\u2013318. https:\/\/doi.org\/10.1007\/s12640-020-00211-2","journal-title":"Neurotox Res"},{"issue":"3","key":"10176_CR51","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3390\/toxins12030205","volume":"12","author":"RJ Harris","year":"2020","unstructured":"Harris RJ, Zdenek CN, Harrich D et al (2020c) An appetite for destruction: detecting prey-selective binding of \u03b1-neurotoxins in the venom of Afro-Asian elapids. Toxins 12(3):205","journal-title":"Toxins"},{"issue":"1","key":"10176_CR52","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/s12915-021-01195-x","volume":"19","author":"RJ Harris","year":"2021","unstructured":"Harris RJ, Nekaris KAI, Fry BG (2021) Monkeying around with venom: an increased resistance to \u03b1-neurotoxins supports an evolutionary arms race between Afro-Asian primates and sympatric cobras. BMC Biol 19(1):253. https:\/\/doi.org\/10.1186\/s12915-021-01195-x","journal-title":"BMC Biol"},{"issue":"3","key":"10176_CR53","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1111\/ele.13216","volume":"22","author":"K Healy","year":"2019","unstructured":"Healy K, Carbone C, Jackson AL (2019) Snake venom potency and yield are associated with prey-evolution, predator metabolism and habitat structure. Ecol Lett 22(3):527\u2013537. https:\/\/doi.org\/10.1111\/ele.13216","journal-title":"Ecol Lett"},{"issue":"10","key":"10176_CR54","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1016\/j.biochi.2013.06.025","volume":"95","author":"WH Heyborne","year":"2013","unstructured":"Heyborne WH, Mackessy SP (2013) Identification and characterization of a taxon-specific three-finger toxin from the venom of the Green Vinesnake (Oxybelis fulgidus; family Colubridae). Biochimie 95(10):1923\u20131932","journal-title":"Biochimie"},{"issue":"5","key":"10176_CR55","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1093\/icb\/icw082","volume":"56","author":"ML Holding","year":"2016","unstructured":"Holding ML, Drabeck DH, Jansa SA et al (2016) Venom resistance as a model for understanding the molecular basis of complex coevolutionary adaptations. Integr Comp Biol 56(5):1032\u20131043. https:\/\/doi.org\/10.1093\/icb\/icw082","journal-title":"Integr Comp Biol"},{"key":"10176_CR56","first-page":"213","volume":"1981","author":"DR Jackson","year":"1981","unstructured":"Jackson DR, Franz R (1981) Ecology of the eastern coral snake (Micrurus fulvius) in northern peninsular Florida. Herpetologica 1981:213\u2013228","journal-title":"Herpetologica"},{"issue":"3","key":"10176_CR57","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/zsc.12346","volume":"48","author":"MJ Jowers","year":"2019","unstructured":"Jowers MJ, Garcia Mudarra JL, Charles SP et al (2019) Phylogeography of West Indies Coral snakes (Micrurus): Island colonisation and banding patterns. Zool Script 48(3):263\u2013276. https:\/\/doi.org\/10.1111\/zsc.12346","journal-title":"Zool Script"},{"issue":"1","key":"10176_CR58","doi-asserted-by":"publisher","first-page":"11674","DOI":"10.1038\/s41598-023-37734-5","volume":"13","author":"MJ Jowers","year":"2023","unstructured":"Jowers MJ, Smart U, S\u00e1nchez-Ram\u00edrez S et al (2023) Unveiling underestimated species diversity within the Central American Coralsnake, a medically important complex of venomous taxa. Sci Rep 13(1):11674. https:\/\/doi.org\/10.1038\/s41598-023-37734-5","journal-title":"Sci Rep"},{"key":"10176_CR59","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ab.2017.08.002","volume":"536","author":"V Kamat","year":"2017","unstructured":"Kamat V, Rafique A (2017) Designing binding kinetic assay on the bio-layer interferometry (BLI) biosensor to characterize antibody-antigen interactions. Anal Biochem 536:16\u201331. https:\/\/doi.org\/10.1016\/j.ab.2017.08.002","journal-title":"Anal Biochem"},{"issue":"2","key":"10176_CR60","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S1074-5521(00)90063-2","volume":"8","author":"R Kasher","year":"2001","unstructured":"Kasher R, Balass M, Scherf T et al (2001) Design and synthesis of peptides that bind \u03b1-bungarotoxin with high affinity. Chem Biol 8(2):147\u2013155. https:\/\/doi.org\/10.1016\/S1074-5521(00)90063-2","journal-title":"Chem Biol"},{"key":"10176_CR61","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0301-4622(02)00287-9","volume":"100","author":"E Katchalski-Katzir","year":"2003","unstructured":"Katchalski-Katzir E, Kasher R, Balass M et al (2003) Design and synthesis of peptides that bind \u03b1-bungarotoxin with high affinity and mimic the three-dimensional structure of the binding-site of acetylcholine receptor. Biophys Chem 100:293\u2013305","journal-title":"Biophys Chem"},{"key":"10176_CR62","first-page":"205","volume":"2020","author":"MA Khan","year":"2020","unstructured":"Khan MA, Dashevsky D, Kerkkamp HM et al (2020) Widespread evolution of molecular resistance to snake venom \u03b1-neurotoxins in vertebrates. Toxins 2020:205","journal-title":"Toxins"},{"issue":"1","key":"10176_CR63","doi-asserted-by":"publisher","first-page":"4861","DOI":"10.1038\/s41467-023-40550-0","volume":"14","author":"I Koludarov","year":"2023","unstructured":"Koludarov I, Senoner T, Jackson TNW et al (2023) Domain loss enabled evolution of novel functions in the snake three-finger toxin gene superfamily. Nat Commun 14(1):4861. https:\/\/doi.org\/10.1038\/s41467-023-40550-0","journal-title":"Nat Commun"},{"issue":"1","key":"10176_CR64","doi-asserted-by":"publisher","first-page":"3861","DOI":"10.1038\/s41598-020-60768-y","volume":"10","author":"DS Kudryavtsev","year":"2020","unstructured":"Kudryavtsev DS, Tabakmakher VM, Budylin GS et al (2020) Complex approach for analysis of snake venom \u03b1-neurotoxins binding to HAP, the high-affinity peptide. Sci Rep 10(1):3861. https:\/\/doi.org\/10.1038\/s41598-020-60768-y","journal-title":"Sci Rep"},{"issue":"7","key":"10176_CR65","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1007\/s12045-015-0220-5","volume":"20","author":"P Kundu","year":"2015","unstructured":"Kundu P, Venkitachalam S, Vidya TNC (2015) Why so toxic? Resonance 20(7):617\u2013627. https:\/\/doi.org\/10.1007\/s12045-015-0220-5","journal-title":"Resonance"},{"issue":"22","key":"10176_CR66","doi-asserted-by":"publisher","first-page":"3276","DOI":"10.1093\/bioinformatics\/btu531","volume":"30","author":"A Larsson","year":"2014","unstructured":"Larsson A (2014) AliView: a fast and lightweight alignment viewer and editor for large datasets. Bioinformatics 30(22):3276\u20133278. https:\/\/doi.org\/10.1093\/bioinformatics\/btu531","journal-title":"Bioinformatics"},{"issue":"1","key":"10176_CR67","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.150277","volume":"3","author":"MSY Lee","year":"2016","unstructured":"Lee MSY, Sanders KL, King B et al (2016) Diversification rates and phenotypic evolution in venomous snakes (Elapidae). Open Sci 3(1):150277. https:\/\/doi.org\/10.1098\/rsos.150277","journal-title":"Open Sci"},{"key":"10176_CR68","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.toxicon.2016.09.008","volume":"122","author":"B Lomonte","year":"2016","unstructured":"Lomonte B, Rey-Su\u00e1rez P, Fern\u00e1ndez J et al (2016) Venoms of Micrurus coral snakes: evolutionary trends in compositional patterns emerging from proteomic analyses. Toxicon 122:7\u201325. https:\/\/doi.org\/10.1016\/j.toxicon.2016.09.008","journal-title":"Toxicon"},{"issue":"22","key":"10176_CR69","doi-asserted-by":"publisher","first-page":"13709","DOI":"10.1021\/acs.jmedchem.0c01202","volume":"63","author":"T Lynagh","year":"2020","unstructured":"Lynagh T, Kiontke S, Meyhoff-Madsen M et al (2020) Peptide inhibitors of the \u03b1-Cobratoxin-nicotinic acetylcholine receptor interaction. J Med Chem 63(22):13709\u201313718. https:\/\/doi.org\/10.1021\/acs.jmedchem.0c01202","journal-title":"J Med Chem"},{"issue":"5","key":"10176_CR70","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.toxicon.2006.01.007","volume":"47","author":"SP Mackessy","year":"2006","unstructured":"Mackessy SP, Sixberry NM, Heyborne WH et al (2006) Venom of the Brown Treesnake, Boiga irregularis: ontogenetic shifts and taxa-specific toxicity. Toxicon 47(5):537\u2013548. https:\/\/doi.org\/10.1016\/j.toxicon.2006.01.007","journal-title":"Toxicon"},{"issue":"1","key":"10176_CR71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2164-14-531","volume":"14","author":"MJ Margres","year":"2013","unstructured":"Margres MJ, Aronow K, Loyacano J et al (2013) The venom-gland transcriptome of the eastern coral snake (Micrurus fulvius) reveals high venom complexity in the intragenomic evolution of venoms. BMC Genom 14(1):1","journal-title":"BMC Genom"},{"issue":"2","key":"10176_CR72","first-page":"228","volume":"23","author":"OA Marques","year":"2002","unstructured":"Marques OA (2002) Natural history of the coral snake Micrurus decoratus (Elapidae) from the Atlantic Forest in southeast Brazil, with comments on possible mimicry. Amphibia-Reptilia 23(2):228\u2013232","journal-title":"Amphibia-Reptilia"},{"issue":"1","key":"10176_CR73","first-page":"88","volume":"5","author":"OA Marques","year":"1997","unstructured":"Marques OA, Sazima I (1997) Diet and feeding behavior of the coral snake, Micrurus corallinus, from the Atlantic forest of Brazil. Herpetol Natl Hist 5(1):88\u201393","journal-title":"Herpetol Natl Hist"},{"issue":"20","key":"10176_CR74","doi-asserted-by":"publisher","first-page":"4925","DOI":"10.1021\/bi00234a013","volume":"30","author":"KE McLane","year":"1991","unstructured":"McLane KE, Wu X, Diethelm B et al (1991) Structural determinants of \u03b1-bungarotoxin binding to the sequence segment 181\u2013200 of the muscle nicotinic acetylcholine receptor subunit: effects of cysteine\/cystine modification and species-specific amino acid substitutions. Biochemistry 30(20):4925\u20134934. https:\/\/doi.org\/10.1021\/bi00234a013","journal-title":"Biochemistry"},{"issue":"9","key":"10176_CR75","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.1021\/bi00175a029","volume":"33","author":"KE McLane","year":"1994","unstructured":"McLane KE, Wu X, Conti-Tronconi BM (1994) An \u03b1-bungarotoxin-binding sequence on the torpedo nicotinic acetylcholine receptor \u03b1-subunit: conservative amino acid substitutions reveal side-chain specific interactions. Biochemistry 33(9):2576\u20132585","journal-title":"Biochemistry"},{"key":"10176_CR76","doi-asserted-by":"publisher","unstructured":"Mebs D (2001) Toxicity in animals. Trends in evolution? Toxicon 39(1):87\u201396. https:\/\/doi.org\/10.1016\/S0041-0101(00)00155-0","DOI":"10.1016\/S0041-0101(00)00155-0"},{"issue":"1884","key":"10176_CR77","doi-asserted-by":"publisher","first-page":"20181003","DOI":"10.1098\/rspb.2018.1003","volume":"285","author":"CM Modahl","year":"2018","unstructured":"Modahl CM, Mrinalini Frietze S et al (2018) Adaptive evolution of distinct prey-specific toxin genes in rear-fanged snake venom. Proc Royal Soc B Biol Sci 285(1884):20181003. https:\/\/doi.org\/10.1098\/rspb.2018.1003","journal-title":"Proc Royal Soc B Biol Sci"},{"key":"10176_CR78","doi-asserted-by":"publisher","unstructured":"Nascimento LRS, Silva NJJ, Feitosa DT et\u00a0al (2019) Taxonomy of the Micrurus spixii species complex (Serpentes, Elapidae). Zootaxa. https:\/\/doi.org\/10.11646\/zootaxa.4668.3.4","DOI":"10.11646\/zootaxa.4668.3.4"},{"key":"10176_CR79","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114168","volume":"2020","author":"S Nirthanan","year":"2020","unstructured":"Nirthanan S (2020) Snake three-finger \u03b1-neurotoxins and nicotinic acetylcholine receptors: molecules, mechanisms and medicine. Biochem Pharmacol 2020:114168. https:\/\/doi.org\/10.1016\/j.bcp.2020.114168","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10176_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1254\/jphs.94.1","volume":"94","author":"S Nirthanan","year":"2004","unstructured":"Nirthanan S, Gwee MCE (2004) Three-finger \u03b1-neurotoxins and the nicotinic acetylcholine receptor, forty years on. J Pharmacol Sci 94(1):1\u201317. https:\/\/doi.org\/10.1254\/jphs.94.1","journal-title":"J Pharmacol Sci"},{"issue":"6","key":"10176_CR81","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.toxicon.2009.01.032","volume":"53","author":"RL Norris","year":"2009","unstructured":"Norris RL, Pfalzgraf RR, Laing G (2009) Death following coral snake bite in the United States: first documented case (with ELISA confirmation of envenomation) in over 40 years. Toxicon 53(6):693\u2013697. https:\/\/doi.org\/10.1016\/j.toxicon.2009.01.032","journal-title":"Toxicon"},{"issue":"1","key":"10176_CR82","doi-asserted-by":"publisher","first-page":"4543","DOI":"10.1038\/s41467-022-32174-7","volume":"13","author":"M Nys","year":"2022","unstructured":"Nys M, Zarkadas E, Brams M et al (2022) The molecular mechanism of snake short-chain \u03b1-neurotoxin binding to muscle-type nicotinic acetylcholine receptors. Nat Commun 13(1):4543. https:\/\/doi.org\/10.1038\/s41467-022-32174-7","journal-title":"Nat Commun"},{"issue":"5","key":"10176_CR83","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.brainresbull.2007.10.007","volume":"75","author":"DA Oliveira","year":"2008","unstructured":"Oliveira DA, Harasawa C, Seibert CS et al (2008) Phospholipases A2 isolated from Micrurus lemniscatus coral snake venom: behavioral, electroencephalographic, and neuropathological aspects. Brain Res Bull 75(5):629\u2013639. https:\/\/doi.org\/10.1016\/j.brainresbull.2007.10.007","journal-title":"Brain Res Bull"},{"key":"10176_CR84","first-page":"1","volume-title":"Clinical toxinology","author":"DR Otero-Pati\u00f1o","year":"2014","unstructured":"Otero-Pati\u00f1o DR (2014) Snake bites in Colombia. In: Gopalakrishnakone P, Faiz SMA, Gnanathasan CA et al (eds) Clinical toxinology. Springer, Netherlands, pp 1\u201342"},{"issue":"39","key":"10176_CR85","doi-asserted-by":"publisher","first-page":"29030","DOI":"10.1074\/jbc.M605850200","volume":"281","author":"J Pawlak","year":"2006","unstructured":"Pawlak J, Mackessy SP, Fry BG et al (2006) Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (Mangrove Catsnake) with bird-specific activity. J Biol Chem 281(39):29030\u201329041. https:\/\/doi.org\/10.1074\/jbc.M605850200","journal-title":"J Biol Chem"},{"issue":"2","key":"10176_CR86","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1096\/fj.08-113555","volume":"23","author":"J Pawlak","year":"2008","unstructured":"Pawlak J, Mackessy SP, Sixberry NM et al (2008) Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity. FASEB J 23(2):534\u2013545. https:\/\/doi.org\/10.1096\/fj.08-113555","journal-title":"FASEB J"},{"key":"10176_CR87","doi-asserted-by":"publisher","unstructured":"Pires MG, Jr Da Silva, NJ, Feitosa DT, et\u00a0al (2014) A new species of triadal coral snake of the genus Micrurus Wagler, 1824 (Serpentes: Elapidae) from northeastern Brazil. Zootaxa 3811(4):10. https:\/\/doi.org\/10.11646\/zootaxa.3811.4.8","DOI":"10.11646\/zootaxa.3811.4.8"},{"key":"10176_CR88","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/1471-2148-13-93","volume":"13","author":"RA Pyron","year":"2013","unstructured":"Pyron RA, Burbrink FT, Wiens JJ (2013) A phylogeny and revised classification of Squamata, including 4161 species of lizards and snakes. BMC Evol Biol 13:93. https:\/\/doi.org\/10.1186\/1471-2148-13-93","journal-title":"BMC Evol Biol"},{"key":"10176_CR89","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2015","unstructured":"R Core Team (2015) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna"},{"issue":"6","key":"10176_CR90","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.neuron.2020.03.012","volume":"106","author":"MM Rahman","year":"2020","unstructured":"Rahman MM, Teng J, Worrell BT et al (2020) Structure of the native muscle-type nicotinic receptor and inhibition by snake venom toxins. Neuron 106(6):952-962.e5. https:\/\/doi.org\/10.1016\/j.neuron.2020.03.012","journal-title":"Neuron"},{"issue":"1","key":"10176_CR91","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.toxicon.2011.10.017","volume":"59","author":"C Renjifo","year":"2012","unstructured":"Renjifo C, Smith EN, Hodgson WC et al (2012) Neuromuscular activity of the venoms of the Colombian coral snakes Micrurus dissoleucus and Micrurus mipartitus: an evolutionary perspective. Toxicon 59(1):132\u2013142. https:\/\/doi.org\/10.1016\/j.toxicon.2011.10.017","journal-title":"Toxicon"},{"key":"10176_CR92","doi-asserted-by":"publisher","DOI":"10.1016\/j.ympev.2020.106770","volume":"147","author":"J Reyes-Velasco","year":"2020","unstructured":"Reyes-Velasco J, Adams RH, Boissinot S et al (2020) Genome-wide SNPs clarify lineage diversity confused by coloration in coralsnakes of the Micrurus diastema species complex (Serpentes: Elapidae). Mol Phylogenet Evol 147:106770. https:\/\/doi.org\/10.1016\/j.ympev.2020.106770","journal-title":"Mol Phylogenet Evol"},{"issue":"2","key":"10176_CR93","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229657","volume":"15","author":"CFB Rodrigues","year":"2020","unstructured":"Rodrigues CFB, Serino-Silva C, Morais-Zani Kd et al (2020) Boa\u03b3PLI: structural and functional characterization of the gamma phospholipase A2 plasma inhibitor from the non-venomous Brazilian snake Boa constrictor. PLoS ONE 15(2):e0229657. https:\/\/doi.org\/10.1371\/journal.pone.0229657","journal-title":"PLoS ONE"},{"key":"10176_CR94","doi-asserted-by":"publisher","DOI":"10.1007\/s10886-021-01289-4","author":"CFB Rodrigues","year":"2021","unstructured":"Rodrigues CFB, Zdenek CN, Serino-Silva C et al (2021) Boa\u03b3PLI from Boa constrictor blood is a broad-spectrum inhibitor of venom PLA2 pathophysiological actions. J Chem Ecol. https:\/\/doi.org\/10.1007\/s10886-021-01289-4","journal-title":"J Chem Ecol"},{"issue":"1","key":"10176_CR95","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1186\/1471-2164-14-394","volume":"14","author":"DR Rokyta","year":"2013","unstructured":"Rokyta DR, Wray KP, Margres MJ (2013) The genesis of an exceptionally lethal venom in the timber rattlesnake (Crotalus horridus) revealed through comparative venom-gland transcriptomics. BMC Genomics 14(1):394. https:\/\/doi.org\/10.1186\/1471-2164-14-394","journal-title":"BMC Genomics"},{"key":"10176_CR96","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.toxicon.2015.02.015","volume":"98","author":"DR Rokyta","year":"2015","unstructured":"Rokyta DR, Wray KP, McGivern JJ et al (2015) The transcriptomic and proteomic basis for the evolution of a novel venom phenotype within the Timber Rattlesnake (Crotalus horridus). Toxicon 98:34\u201348. https:\/\/doi.org\/10.1016\/j.toxicon.2015.02.015","journal-title":"Toxicon"},{"key":"10176_CR97","unstructured":"Roze JA (1996) Coral snakes of the Americas: biology, identification, and venoms. Krieger Publishing Company"},{"key":"10176_CR98","volume-title":"RStudio: integrated development environment for R","author":"RStudio Team","year":"2015","unstructured":"RStudio Team (2015) RStudio: integrated development environment for R. RStudio Inc, Boston"},{"key":"10176_CR99","doi-asserted-by":"publisher","DOI":"10.1590\/1678-9199-jvatitd-2019-0041","volume":"26","author":"RTFd Santos","year":"2020","unstructured":"Santos RTFd, Silva MFP, Porto RM et al (2020) Effects of Mlx-8, a phospholipase A2 from Brazilian coralsnake Micrurus lemniscatus venom, on muscarinic acetylcholine receptors in rat hippocampus. J Venom Anim Toxins Incl Trop Dis 26:e20190041. https:\/\/doi.org\/10.1590\/1678-9199-jvatitd-2019-0041","journal-title":"J Venom Anim Toxins Incl Trop Dis"},{"key":"10176_CR100","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jprot.2019.03.014","volume":"200","author":"L Sanz","year":"2019","unstructured":"Sanz L, Quesada-Bernat S, Ramos T et al (2019) New insights into the phylogeographic distribution of the 3FTx\/PLA2 venom dichotomy across genus Micrurus in South America. J Proteomics 200:90\u2013101. https:\/\/doi.org\/10.1016\/j.jprot.2019.03.014","journal-title":"J Proteomics"},{"issue":"2","key":"10176_CR101","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0041-0101(01)00217-3","volume":"40","author":"FG Serafim","year":"2002","unstructured":"Serafim FG, Reali M, Cruz-H\u00f6fling MA et al (2002) Action of Micrurus dumerilii carinicauda coral snake venom on the mammalian neuromuscular junction. Toxicon 40(2):167\u2013174. https:\/\/doi.org\/10.1016\/S0041-0101(01)00217-3","journal-title":"Toxicon"},{"issue":"39","key":"10176_CR102","doi-asserted-by":"publisher","first-page":"24279","DOI":"10.1074\/jbc.272.39.24279","volume":"272","author":"D Servent","year":"1997","unstructured":"Servent D, Winckler-Dietrich V, Hu HY et al (1997) Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal \u03b17 nicotinic receptor. J Biol Chem 272(39):24279\u201324286","journal-title":"J Biol Chem"},{"issue":"1","key":"10176_CR103","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s42003-022-04308-6","volume":"5","author":"ZO Shenkarev","year":"2022","unstructured":"Shenkarev ZO, Chesnokov YM, Zaigraev MM et al (2022) Membrane-mediated interaction of non-conventional snake three-finger toxins with nicotinic acetylcholine receptors. Commun Biol 5(1):1\u201315. https:\/\/doi.org\/10.1038\/s42003-022-04308-6","journal-title":"Commun Biol"},{"issue":"23","key":"10176_CR104","doi-asserted-by":"publisher","first-page":"4465","DOI":"10.1007\/s00018-018-2893-x","volume":"75","author":"A Silva","year":"2018","unstructured":"Silva A, Cristofori-Armstrong B, Rash LD et al (2018) Defining the role of post-synaptic \u03b1-neurotoxins in paralysis due to snake envenoming in humans. Cell Mol Life Sci 75(23):4465\u20134478. https:\/\/doi.org\/10.1007\/s00018-018-2893-x","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"10176_CR105","doi-asserted-by":"publisher","first-page":"325","DOI":"10.2307\/1564981","volume":"29","author":"JB Slowinski","year":"1995","unstructured":"Slowinski JB (1995) A phylogenetic analysis of the new world coral snakes (Elapidae: Leptomicrurus, Micruroides, and Micrurus) based on allozymic and morphological characters. J Herpetol 29(3):325\u2013338. https:\/\/doi.org\/10.2307\/1564981","journal-title":"J Herpetol"},{"issue":"6","key":"10176_CR106","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/0041-0101(73)90009-3","volume":"11","author":"GK Snyder","year":"1973","unstructured":"Snyder GK, Ramsey HW, Taylor WJ et al (1973) Neuromuscular blockade of chick biventer cervicis nerve-muscle preparations by a fraction from coral snake venom. Toxicon 11(6):505\u2013508","journal-title":"Toxicon"},{"issue":"10","key":"10176_CR107","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3390\/toxins10100411","volume":"10","author":"LF Sousa","year":"2018","unstructured":"Sousa LF, Zdenek CN, Dobson JS (2018) Coagulotoxicity of Bothrops (Lancehead Pit-Vipers) venoms from Brazil: differential biochemistry and antivenom efficacy resulting from prey-driven venom variation. Toxins 10(10):411","journal-title":"Toxins"},{"key":"10176_CR108","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106747","volume":"191","author":"HS Tae","year":"2023","unstructured":"Tae HS, Adams DJ (2023) Nicotinic acetylcholine receptor subtype expression, function, and pharmacology: therapeutic potential of \u03b1-conotoxins. Pharmacol Res 191:106747. https:\/\/doi.org\/10.1016\/j.phrs.2023.106747","journal-title":"Pharmacol Res"},{"issue":"9","key":"10176_CR109","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1093\/oxfordjournals.molbev.a003967","volume":"18","author":"Z Takacs","year":"2001","unstructured":"Takacs Z, Wilhelmsen KC, Sorota S (2001) Snake \u03b1-neurotoxin binding site on the Egyptian Cobra (Naja haje) nicotinic acetylcholine receptor is conserved. Mol Biol Evol 18(9):1800\u20131809. https:\/\/doi.org\/10.1093\/oxfordjournals.molbev.a003967","journal-title":"Mol Biol Evol"},{"key":"10176_CR110","doi-asserted-by":"publisher","unstructured":"Takacs Z, Wilhelmsen KC, Sorota S (2004) Cobra ( Naja spp. ) nicotinic acetylcholine receptor exhibits resistance to Erabu Sea Snake (Laticauda semifasciata) short-chain a-neurotoxin. J Mol Evol 58(5):516\u2013526. https:\/\/doi.org\/10.1007\/s00239-003-2573-8","DOI":"10.1007\/s00239-003-2573-8"},{"key":"10176_CR111","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.jprot.2018.09.006","volume":"192","author":"KY Tan","year":"2019","unstructured":"Tan KY, Liew JL, Tan NH et al (2019) Unlocking the secrets of banded coral snake (Calliophis intestinalis, Malaysia): a venom with proteome novelty, low toxicity and distinct antigenicity. J Proteomics 192:246\u2013257. https:\/\/doi.org\/10.1016\/j.jprot.2018.09.006","journal-title":"J Proteomics"},{"key":"10176_CR112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.toxicon.2015.06.011","volume":"103","author":"AL Terra","year":"2015","unstructured":"Terra AL, Moreira-Dill LS, Sim\u00f5es Silva R et al (2015) Biological characterization of the Amazon coral Micrurus spixii snake venom: isolation of a new neurotoxic phospholipase A2. Toxicon 103:1\u201311. https:\/\/doi.org\/10.1016\/j.toxicon.2015.06.011","journal-title":"Toxicon"},{"issue":"11","key":"10176_CR113","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205164","volume":"13","author":"LC Terribile","year":"2018","unstructured":"Terribile LC, Feitosa DT, Pires MG et al (2018) Reducing Wallacean shortfalls for the coralsnakes of the Micrurus lemniscatus species complex: present and future distributions under a changing climate. PLoS ONE 13(11):e0205164. https:\/\/doi.org\/10.1371\/journal.pone.0205164","journal-title":"PLoS ONE"},{"issue":"D1","key":"10176_CR114","doi-asserted-by":"publisher","first-page":"D523","DOI":"10.1093\/nar\/gkac1052","volume":"51","author":"The UniProt Consortium","year":"2023","unstructured":"The UniProt Consortium (2023) UniProt: the universal protein knowledgebase in 2023. Nucleic Acids Res 51(D1):D523\u2013D531. https:\/\/doi.org\/10.1093\/nar\/gkac1052","journal-title":"Nucleic Acids Res"},{"issue":"35","key":"10176_CR115","doi-asserted-by":"publisher","first-page":"21462","DOI":"10.1016\/S0021-9258(18)45760-2","volume":"265","author":"SJ Tzartos","year":"1990","unstructured":"Tzartos SJ, Remoundos MS (1990) Fine localization of the major \u03b1-bungarotoxin binding site to residues \u03b1 189\u2013195 of the Torpedo acetylcholine receptor: residues 189, 190, and 195 are indispensable for binding. J Biol Chem 265(35):21462\u201321467","journal-title":"J Biol Chem"},{"issue":"38","key":"10176_CR116","doi-asserted-by":"publisher","first-page":"11911","DOI":"10.1073\/pnas.1511706112","volume":"112","author":"B Ujvari","year":"2015","unstructured":"Ujvari B, Casewell NR, Sunagar K et al (2015) Widespread convergence in toxin resistance by predictable molecular evolution. Proc Natl Acad Sci 112(38):11911\u201311916. https:\/\/doi.org\/10.1073\/pnas.1511706112","journal-title":"Proc Natl Acad Sci"},{"issue":"4","key":"10176_CR117","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.cca.2004.08.018","volume":"138","author":"AH Urdaneta","year":"2004","unstructured":"Urdaneta AH, Bola\u00f1os F, Guti\u00e9rrez JM (2004) Feeding behavior and venom toxicity of coral snake Micrurus nigrocinctus (Serpentes: Elapidae) on its natural prey in captivity. Comp Biochem Physiol C Toxicol Pharmacol 138(4):485\u2013492. https:\/\/doi.org\/10.1016\/j.cca.2004.08.018","journal-title":"Comp Biochem Physiol C: Toxicol Pharmacol"},{"key":"10176_CR118","first-page":"215","volume-title":"Venomous reptiles and their toxins: evolution, pathophysiology and biodiscovery","author":"Y Utkin","year":"2015","unstructured":"Utkin Y, Sunagar K, Jackson TN et al (2015) Three-finger toxins (3ftxs). In: Fry BG (ed) Venomous reptiles and their toxins: evolution, pathophysiology and biodiscovery. Oxford University Press, pp 215\u2013227"},{"key":"10176_CR119","first-page":"1","volume":"1","author":"L Van Valen","year":"1973","unstructured":"Van Valen L (1973) A new evolutionary law. Evol Theor 1:1\u201330","journal-title":"A new evolutionary law. Evol Theor"},{"issue":"3","key":"10176_CR120","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s12640-017-9771-4","volume":"32","author":"DC Yang","year":"2017","unstructured":"Yang DC, Dobson J, Cochran C et al (2017) The bold and the beautiful: a neurotoxicity comparison of new world coral snakes in the Micruroides and Micrurus genera and relative neutralization by antivenom. Neurotox Res 32(3):487\u2013495. https:\/\/doi.org\/10.1007\/s12640-017-9771-4","journal-title":"Neurotox Res"},{"issue":"5","key":"10176_CR121","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216148","volume":"14","author":"H Zaher","year":"2019","unstructured":"Zaher H, Murphy RW, Arredondo JC et al (2019) Large-scale molecular phylogeny, morphology, divergence-time estimation, and the fossil record of advanced caenophidian snakes (Squamata: Serpentes). PLoS ONE 14(5):e0216148. https:\/\/doi.org\/10.1371\/journal.pone.0216148","journal-title":"PLoS ONE"},{"issue":"10","key":"10176_CR122","doi-asserted-by":"publisher","first-page":"600","DOI":"10.3390\/toxins11100600","volume":"11","author":"CN Zdenek","year":"2019","unstructured":"Zdenek CN, Harris RJ, Kuruppu S et al (2019) A taxon-specific and high-throughput method for measuring ligand binding to nicotinic acetylcholine receptors. Toxins 11(10):600. https:\/\/doi.org\/10.3390\/toxins11100600","journal-title":"Toxins"},{"key":"10176_CR123","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.ympev.2015.10.009","volume":"94","author":"Y Zheng","year":"2016","unstructured":"Zheng Y, Wiens JJ (2016) Combining phylogenomic and supermatrix approaches, and a time-calibrated phylogeny for squamate reptiles (lizards and snakes) based on 52 genes and 4162 species. Mol Phylogenet Evol 94:537\u2013547. https:\/\/doi.org\/10.1016\/j.ympev.2015.10.009","journal-title":"Mol Phylogenet Evol"}],"container-title":["Journal of Molecular Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00239-024-10176-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00239-024-10176-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00239-024-10176-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T13:07:05Z","timestamp":1718197625000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00239-024-10176-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,30]]},"references-count":123,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10176"],"URL":"https:\/\/doi.org\/10.1007\/s00239-024-10176-x","relation":{},"ISSN":["0022-2844","1432-1432"],"issn-type":[{"value":"0022-2844","type":"print"},{"value":"1432-1432","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,30]]},"assertion":[{"value":"20 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}