{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:45:03Z","timestamp":1785732303044,"version":"3.56.0"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32270442"],"award-info":[{"award-number":["32270442"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31872219"],"award-info":[{"award-number":["31872219"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100019031","name":"Chongqing Municipal Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFF1301602"],"award-info":[{"award-number":["2022YFF1301602"]}],"id":[{"id":"10.13039\/501100019031","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mol Evol"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00239-026-10326-3","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:57:37Z","timestamp":1783324657000},"page":"615-628","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deep Dive into Evolution: How Cetaceans Adapt Their Anticoagulant Genes for Underwater Survival"],"prefix":"10.1007","volume":"94","author":[{"given":"Wenjun","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"10326_CR1","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1182\/blood.2020005382","volume":"137","author":"A Aburima","year":"2021","unstructured":"Aburima A, Berger M, Spurgeon BEJ et al (2021) Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets. Blood 137:678\u2013689. https:\/\/doi.org\/10.1182\/blood.2020005382","journal-title":"Blood"},{"key":"10326_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2022.146977","volume":"851","author":"LH Al-Jamea","year":"2023","unstructured":"Al-Jamea LH, Woodman A, Heiba NM et al (2023) TMPRSS6 gene mutations in six Saudi families with iron refractory iron deficiency anemia. Gene 851:146977. https:\/\/doi.org\/10.1016\/j.gene.2022.146977","journal-title":"Gene"},{"key":"10326_CR2","doi-asserted-by":"publisher","first-page":"48","DOI":"10.4103\/jrms.JRMS_965_18","volume":"24","author":"AM Alhabibi","year":"2019","unstructured":"Alhabibi AM, Eldewi DM, Wahab MAA et al (2019) Platelet-derived growth factor-beta as a new marker of deep venous thrombosis. J Res Med Sci 24:48. https:\/\/doi.org\/10.4103\/jrms.JRMS_965_18","journal-title":"J Res Med Sci"},{"issue":"2","key":"10326_CR4","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1182\/blood-2005-10-026294","volume":"109","author":"M Antl","year":"2007","unstructured":"Antl M, von Br\u00fchl ML, Eiglsperger C et al (2007) IRAG mediates NO\/cGMP-dependent inhibition of platelet aggregation and thrombus formation. Blood 109(2):552\u2013559. https:\/\/doi.org\/10.1182\/blood-2005-10-026294","journal-title":"Blood"},{"issue":"15","key":"10326_CR5","doi-asserted-by":"publisher","first-page":"14811","DOI":"10.1074\/jbc.M414189200","volume":"280","author":"R Bass","year":"2005","unstructured":"Bass R, Werner F, Odintsova E et al (2005) Regulation of urokinase receptor proteolytic function by the tetraspanin CD82. J Biol Chem 280(15):14811\u201314818. https:\/\/doi.org\/10.1074\/jbc.M414189200","journal-title":"J Biol Chem"},{"issue":"6","key":"10326_CR6","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1046\/j.1525-142X.2002.02033.x","volume":"4","author":"L Bejder","year":"2002","unstructured":"Bejder L, Hall BK (2002) Limbs in whales and limblessness in other vertebrates: mechanisms of evolutionary and developmental transformation and loss. Evol Dev 4(6):445\u2013458. https:\/\/doi.org\/10.1046\/j.1525-142X.2002.02033.x","journal-title":"Evol Dev"},{"issue":"6","key":"10326_CR7","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1055\/s-0031-1291382","volume":"37","author":"J Blavignac","year":"2011","unstructured":"Blavignac J, Bunimov N, Rivard GE, Hayward CP (2011) Quebec platelet disorder: update on pathogenesis, diagnosis, and treatment. Semin Thromb Hemost 37(6):713\u2013720","journal-title":"Semin Thromb Hemost"},{"issue":"2","key":"10326_CR8","doi-asserted-by":"publisher","first-page":"93","DOI":"10.2174\/1568006013337944","volume":"1","author":"L Bocksch","year":"2001","unstructured":"Bocksch L, Stephens T, Lucas A, Singh B (2001) Apolipoprotein E: possible therapeutic target for atherosclerosis. Curr Drug Targets Cardiovasc Haematol Disord 1(2):93\u2013106. https:\/\/doi.org\/10.2174\/1568006013337944","journal-title":"Curr Drug Targets Cardiovasc Haematol Disord"},{"issue":"5","key":"10326_CR9","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1249\/00005768-198810000-00003","volume":"20","author":"RE Bourey","year":"1988","unstructured":"Bourey RE, Santoro SA (1988) Interactions of exercise, coagulation, platelets, and fibrinolysis-a brief review. Med Sci Sports Exerc 20(5):439\u2013446","journal-title":"Med Sci Sports Exerc"},{"issue":"23","key":"10326_CR10","doi-asserted-by":"publisher","first-page":"e59","DOI":"10.1182\/blood-2016-05-711846","volume":"128","author":"M Bruzelius","year":"2016","unstructured":"Bruzelius M, Iglesias MJ, Hong MG et al (2016) PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study. Blood 128(23):e59\u2013e66. https:\/\/doi.org\/10.1182\/blood-2016-05-711846","journal-title":"Blood"},{"issue":"4","key":"10326_CR11","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1093\/oxfordjournals.molbev.a026334","volume":"17","author":"J Castresana","year":"2000","unstructured":"Castresana J (2000) Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. Mol Biol Evol 17(4):540\u2013552. https:\/\/doi.org\/10.1093\/oxfordjournals.molbev.a026334","journal-title":"Mol Biol Evol"},{"issue":"11","key":"10326_CR12","doi-asserted-by":"publisher","first-page":"4375","DOI":"10.1182\/blood-2005-07-2636","volume":"107","author":"G Cesarman-Maus","year":"2006","unstructured":"Cesarman-Maus G, Rios-Luna N, Deora AB et al (2006) Autoantibodies against the fibrinolytic receptor, annexin 2, in antiphospholipid syndrome. Blood 107(11):4375\u20134382. https:\/\/doi.org\/10.1182\/blood-2005-07-2636","journal-title":"Blood"},{"issue":"2","key":"10326_CR13","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1161\/STROKEAHA.110.592121","volume":"42","author":"G Cesarman-Maus","year":"2011","unstructured":"Cesarman-Maus G, Cant\u00fa-Brito C, Barinagarrementeria F et al (2011) Autoantibodies against the fibrinolytic receptor, annexin A2, in cerebral venous thrombosis. Stroke 42(2):501\u2013503. https:\/\/doi.org\/10.1161\/STROKEAHA.110.592121","journal-title":"Stroke"},{"issue":"3","key":"10326_CR14","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/j.1365-2796.2004.01444.x","volume":"257","author":"B Dahlb\u00e4ck","year":"2005","unstructured":"Dahlb\u00e4ck B (2005) Blood coagulation and its regulation by anticoagulant pathways: genetic pathogenesis of bleeding and thrombotic diseases. J Intern Med 257(3):209\u2013223. https:\/\/doi.org\/10.1111\/j.1365-2796.2004.01444.x","journal-title":"J Intern Med"},{"issue":"5","key":"10326_CR15","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1212\/wnl.35.5.667","volume":"35","author":"AP Dick","year":"1985","unstructured":"Dick AP, Massey EW (1985) Neurologic presentation of decompression sickness and air embolism in sport divers. Neurology 35(5):667\u2013671. https:\/\/doi.org\/10.1212\/wnl.35.5.667","journal-title":"Neurology"},{"issue":"6","key":"10326_CR16","doi-asserted-by":"publisher","first-page":"e198","DOI":"10.1111\/bjh.16077","volume":"186","author":"G Egan","year":"2019","unstructured":"Egan G, Pluthero FG, Bouskill V et al (2019) Abnormal fibrinolysis recognized by thromboelastography in a case of severe bleeding with normal coagulation and platelet function, leads to detection of a novel SERPINF2 variant causing severe alpha-2-antiplasmin deficiency. Br J Haematol 186(6):e198\u2013e201. https:\/\/doi.org\/10.1111\/bjh.16077","journal-title":"Br J Haematol"},{"issue":"1","key":"10326_CR17","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1600-0838.2005.00440.x","volume":"15","author":"GE Foster","year":"2005","unstructured":"Foster GE, Sheel AW (2005) The human diving response, its function, and its control. Scand J Med Sci Sports 15(1):3\u201312. https:\/\/doi.org\/10.1111\/j.1600-0838.2005.00440.x","journal-title":"Scand J Med Sci Sports"},{"issue":"2","key":"10326_CR18","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.ympev.10.012","volume":"66","author":"J Gatesy","year":"2012","unstructured":"Gatesy J, Geisler JH, Chang J, Buell C, Berta A, Meredith RW, Springer MS, McGowen MR (2012) A phylogenetic blueprint for a modern whale. Mol Phylogenet Evol 66(2):479\u2013506. https:\/\/doi.org\/10.1016\/j.ympev.10.012","journal-title":"Mol Phylogenet Evol"},{"issue":"4595","key":"10326_CR19","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1126\/science.220.4595.403","volume":"220","author":"PD Gingerich","year":"1983","unstructured":"Gingerich PD, Wells NA, Russell DE, Shah SM (1983) Origin of whales in epicontinental remnant seas: new evidence from the early Eocene of Pakistan. Science 220(4595):403\u2013406. https:\/\/doi.org\/10.1126\/science.220.4595.403","journal-title":"Science"},{"key":"10326_CR20","volume-title":"StatPearls","author":"D Godek","year":"2023","unstructured":"Godek D, Freeman AM (2023) Physiology, diving reflex. StatPearls. StatPearls Publishing, Treasure Island"},{"issue":"Pt 11","key":"10326_CR21","doi-asserted-by":"publisher","first-page":"jeb166033","DOI":"10.1242\/jeb.166033","volume":"221","author":"JA Goldbogen","year":"2018","unstructured":"Goldbogen JA, Madsen PT (2018) The evolution of foraging capacity and gigantism in cetaceans. J Exp Biol 221(Pt 11):jeb166033. https:\/\/doi.org\/10.1242\/jeb.166033","journal-title":"J Exp Biol"},{"key":"10326_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1074\/jbc.R400035200","volume":"280","author":"F Hofmann","year":"2005","unstructured":"Hofmann F (2005) The biology of cyclic GMP-dependent protein kinases. J Biol Chem 280:1\u20134","journal-title":"J Biol Chem"},{"key":"10326_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1152\/physrev.00015.2005","volume":"86","author":"F Hofmann","year":"2006","unstructured":"Hofmann F, Feil R, Kleppisch T, Schlossmann J (2006) Function of cGMP-dependent protein kinases as revealed by gene deletion. Physiol Rev 86:1\u201323","journal-title":"Physiol Rev"},{"issue":"9","key":"10326_CR24","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw6671","volume":"5","author":"M Huelsmann","year":"2019","unstructured":"Huelsmann M, Hecker N, Springer MS et al (2019) Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations. Sci Adv 5(9):eaaw6671. https:\/\/doi.org\/10.1126\/sciadv.aaw6671","journal-title":"Sci Adv"},{"issue":"1","key":"10326_CR25","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1152\/jappl.1996.80.1.298","volume":"80","author":"WE Hurford","year":"1996","unstructured":"Hurford WE, Hochachka PW, Schneider RC et al (1996) Splenic contraction, catecholamine release, and blood volume redistribution during diving in the Weddell seal. J Appl Physiol 80(1):298\u2013306. https:\/\/doi.org\/10.1152\/jappl.1996.80.1.298","journal-title":"J Appl Physiol"},{"key":"10326_CR26","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/425575a","volume":"425","author":"PD Jepson","year":"2003","unstructured":"Jepson PD, Arbelo M, Deaville R et al (2003) Gas-bubble lesions in stranded cetaceans. Nature 425:575\u2013576. https:\/\/doi.org\/10.1038\/425575a","journal-title":"Nature"},{"issue":"1","key":"10326_CR27","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s11239-013-1026-5","volume":"37","author":"J Kalz","year":"2014","unstructured":"Kalz J, ten Cate H, Spronk HM (2014) Thrombin generation and atherosclerosis. J Thromb Thrombolysis 37(1):45\u201355. https:\/\/doi.org\/10.1007\/s11239-013-1026-5","journal-title":"J Thromb Thrombolysis"},{"key":"10326_CR28","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/B978-0-12-800100-4.00002-7","volume":"121","author":"AP Kaplan","year":"2014","unstructured":"Kaplan AP, Joseph K (2014) Pathogenic mechanisms of bradykinin mediated diseases: Dysregulation of an innate inflammatory pathway. Adv Immunol 121:41\u201389. https:\/\/doi.org\/10.1016\/B978-0-12-800100-4.00002-7","journal-title":"Adv Immunol"},{"issue":"4","key":"10326_CR29","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1159\/000445106","volume":"201","author":"S Kreft","year":"2016","unstructured":"Kreft S, Klatt AR, Stra\u00dfburger J et al (2016) Skin wound repair is not altered in the absence of endogenous AnxA1 or AnxA5, but pharmacological concentrations of AnxA4 and AnxA5 inhibit wound hemostasis. Cells Tissues Organs 201(4):287\u2013298. https:\/\/doi.org\/10.1159\/000445106","journal-title":"Cells Tissues Organs"},{"issue":"7","key":"10326_CR30","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1093\/molbev\/msx116","volume":"34","author":"S Kumar","year":"2017","unstructured":"Kumar S, Stecher G, Suleski M, Hedges SB (2017) TimeTree: a resource for timelines, timetrees, and divergence times. Mol Biol Evol 34(7):1812\u20131819. https:\/\/doi.org\/10.1093\/molbev\/msx116","journal-title":"Mol Biol Evol"},{"issue":"2","key":"10326_CR31","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/j.1538-7933.2004.00593.x","volume":"2","author":"HC Kwaan","year":"2004","unstructured":"Kwaan HC, Wang J, Weiss I (2004) Expression of receptors for plasminogen activators on endothelial cell surface depends on their origin. J Thromb Haemost 2(2):306\u2013312. https:\/\/doi.org\/10.1111\/j.1538-7933.2004.00593.x","journal-title":"J Thromb Haemost"},{"issue":"2","key":"10326_CR32","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/BF00691600","volume":"59","author":"J Lehtosalo","year":"1983","unstructured":"Lehtosalo J, Tervo T, Laitinen LA (1983) Bubbles and hematologic alterations in intracranial veins during experimental decompression sickness. Acta Neuropathol 59(2):139\u2013144. https:\/\/doi.org\/10.1007\/BF00691600","journal-title":"Acta Neuropathol"},{"issue":"14","key":"10326_CR33","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1080\/02640410903121351","volume":"27","author":"F Lemaitre","year":"2009","unstructured":"Lemaitre F, Fahlman A, Gardette B, Kohshi K (2009) Decompression sickness in breath-hold divers: A review. J Sports Sci 27(14):1519\u20131534. https:\/\/doi.org\/10.1080\/02640410903121351","journal-title":"J Sports Sci"},{"key":"10326_CR73","doi-asserted-by":"publisher","unstructured":"L\u00f6ytynoja A. Phylogeny-aware alignment with PRANK. Methods Mol Biol. 2014;1079:155\u201370. https:\/\/doi.org\/10.1007\/978-1-62703-646-7_10","DOI":"10.1007\/978-1-62703-646-7_10"},{"issue":"4","key":"10326_CR35","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3892\/etm.2021.9791","volume":"21","author":"J Ma","year":"2021","unstructured":"Ma J, Chen Z, Li G et al (2021) A novel mutation in GP1BA gene in a family with autosomal dominant Bernard Soulier syndrome variant: a case report. Exp Ther Med 21(4):360. https:\/\/doi.org\/10.3892\/etm.2021.9791","journal-title":"Exp Ther Med"},{"key":"10326_CR36","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.thromres.2022.06.002","volume":"216","author":"H Ma","year":"2022","unstructured":"Ma H, Yan X, Liu J et al (2022) Secondary ferroptosis promotes thrombogenesis after venous injury in rats. Thromb Res 216:59\u201373. https:\/\/doi.org\/10.1016\/j.thromres.2022.06.002","journal-title":"Thromb Res"},{"key":"10326_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103041","volume":"70","author":"H Ma","year":"2024","unstructured":"Ma H, Huang Y, Tian W et al (2024) Endothelial transferrin receptor 1 contributes to thrombogenesis through cascade ferroptosis. Redox Biol 70:103041. https:\/\/doi.org\/10.1016\/j.redox.2024.103041","journal-title":"Redox Biol"},{"key":"10326_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2020.592383","author":"JPV Mariz","year":"2020","unstructured":"Mariz JPV, Nery MF (2020) Unraveling the molecular evolution of blood coagulation genes in fishes and cetaceans. Front Mar Sci. https:\/\/doi.org\/10.3389\/fmars.2020.592383","journal-title":"Front Mar Sci"},{"issue":"12","key":"10326_CR39","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1111\/j.1398-9995.2011.02686.x","volume":"66","author":"M Maurer","year":"2011","unstructured":"Maurer M, Bader M, Bas M et al (2011) New topics in bradykinin research. Allergy 66(12):1397\u20131406. https:\/\/doi.org\/10.1111\/j.1398-9995.2011.02686.x","journal-title":"Allergy"},{"issue":"6","key":"10326_CR40","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1182\/bloodadvances.2023012186","volume":"8","author":"S Mohsenian","year":"2024","unstructured":"Mohsenian S, Palla R, Menegatti M et al (2024) Congenital fibrinogen disorders: a retrospective clinical and genetic analysis of the prospective rare bleeding disorders database. Blood Adv 8(6):1392\u20131404. https:\/\/doi.org\/10.1182\/bloodadvances.2023012186","journal-title":"Blood Adv"},{"issue":"5","key":"10326_CR41","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/0049-3848(84)90013-6","volume":"33","author":"M Murayama","year":"1984","unstructured":"Murayama M (1984) Ex vivo human platelet aggregation induced by decompression during reduced barometric pressure, hydrostatic, and hydrodynamic (Bernoulli) effect. Thromb Res 33(5):477\u2013485. https:\/\/doi.org\/10.1016\/0049-3848(84)90013-6","journal-title":"Thromb Res"},{"issue":"6","key":"10326_CR42","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/0049-3848(87)90083-1","volume":"45","author":"M Murayama","year":"1987","unstructured":"Murayama M (1987) Compression inhibits aggregation of human platelets under high hydraulic pressure. Thromb Res 45(6):729\u2013738. https:\/\/doi.org\/10.1016\/0049-3848(87)90083-1","journal-title":"Thromb Res"},{"key":"10326_CR43","first-page":"65","volume":"2019","author":"VK Nambiar","year":"2019","unstructured":"Nambiar VK, Chalappurath DR (2019) Thrombotic tendencies in excess catecholamine states. Biogenic Amines Neurotrans Human Dis 2019:65","journal-title":"Biogenic Amines Neurotrans Human Dis"},{"issue":"6","key":"10326_CR44","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3357\/ASEM.2626.2010","volume":"81","author":"R Olsza\u0144ski","year":"2010","unstructured":"Olsza\u0144ski R, Radziwon P, Piszcz J et al (2010) Activation of platelets and fibrinolysis induced by saturated air dives. Aviat Space Environ Med 81(6):585\u2013588. https:\/\/doi.org\/10.3357\/ASEM.2626.2010","journal-title":"Aviat Space Environ Med"},{"key":"10326_CR45","first-page":"1","volume":"5","author":"D Orme","year":"2013","unstructured":"Orme D, Freckleton R, Thomas G et al (2013) The caper package: comparative analysis of phylogenetics and evolution in R. R Package Version 5:1\u201336","journal-title":"R Package Version"},{"issue":"3","key":"10326_CR46","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/0049-3848(93)90129-C","volume":"70","author":"WR Patterson","year":"1993","unstructured":"Patterson WR, Dalton LM, McGlasson DL, Cissik JH (1993) Aggregation of killer whale platelets. Thromb Res 70(3):225\u2013231. https:\/\/doi.org\/10.1016\/0049-3848(93)90129-C","journal-title":"Thromb Res"},{"key":"10326_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nature02527a","volume":"428","author":"C Piantadosi","year":"2004","unstructured":"Piantadosi C, Thalmann E (2004) Whales, sonar and decompression sickness. Nature 428:1\u20132. https:\/\/doi.org\/10.1038\/nature02527a","journal-title":"Nature"},{"issue":"9","key":"10326_CR48","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1161\/01.CIR.92.9.2585","volume":"92","author":"VA Ploplis","year":"1995","unstructured":"Ploplis VA, Carmeliet P, Vazirzadeh S et al (1995) Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice. Circulation 92(9):2585\u20132593","journal-title":"Circulation"},{"issue":"10","key":"10326_CR49","doi-asserted-by":"publisher","first-page":"2582","DOI":"10.1093\/molbev\/msy159","volume":"35","author":"V Ranwez","year":"2018","unstructured":"Ranwez V, Douzery EJP, Cambon C et al (2018) MACSE v2: toolkit for the alignment of coding sequences accounting for frameshifts and stop codons. Mol Biol Evol 35(10):2582\u20132584. https:\/\/doi.org\/10.1093\/molbev\/msy159","journal-title":"Mol Biol Evol"},{"key":"10326_CR50","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1586\/14779072.5.4.733","volume":"5","author":"T Renn\u00e9","year":"2007","unstructured":"Renn\u00e9 T, Gailani D (2007) Role of factor XII in hemostasis and thrombosis: clinical implications. Expert Rev Cardiovasc Ther 5:733\u2013741. https:\/\/doi.org\/10.1586\/14779072.5.4.733","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"10326_CR51","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.16505","volume":"12","author":"LJ Revell","year":"2024","unstructured":"Revell LJ (2024) Phytools 2.0: an updated R ecosystem for phylogenetic comparative methods (and other things). PeerJ 12:e16505. https:\/\/doi.org\/10.7717\/peerj.16505","journal-title":"PeerJ"},{"key":"10326_CR52","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1038\/nm1102-1227","volume":"8","author":"ZM Ruggeri","year":"2002","unstructured":"Ruggeri ZM (2002) Platelets in atherothrombosis. Nat Med 8:1227\u20131234","journal-title":"Nat Med"},{"issue":"8","key":"10326_CR53","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1111\/jth.14160","volume":"16","author":"J Saes","year":"2018","unstructured":"Saes J, Schols S, Van Heerde W, Nijziel M (2018) Hemorrhagic disorders of fibrinolysis: a clinical review. J Thromb Haemost 16(8):1498\u20131509","journal-title":"J Thromb Haemost"},{"issue":"9","key":"10326_CR54","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.3390\/jcm10092023","volume":"10","author":"R Santacroce","year":"2021","unstructured":"Santacroce R, D\u2019Andrea G, Maffione AB, Margaglione M, d\u2019Apolito M (2021) The genetics of hereditary angioedema: a review. J Clin Med 10(9):2023. https:\/\/doi.org\/10.3390\/jcm10092023","journal-title":"J Clin Med"},{"issue":"4","key":"10326_CR55","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/ng1533","volume":"37","author":"P Sebastiani","year":"2005","unstructured":"Sebastiani P, Ramoni MF, Nolan V, Baldwin CT, Steinberg MH (2005) Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia. Nat Genet 37(4):435\u2013440. https:\/\/doi.org\/10.1038\/ng1533","journal-title":"Nat Genet"},{"key":"10326_CR71","doi-asserted-by":"publisher","unstructured":"Shearer JM, Quick NJ, Cioffi WR et al (2019) Diving behaviour of Cuvier's beaked whales (Ziphius cavirostris) off Cape Hatteras, North Carolina. R Soc Open Sci 6(2):181728 https:\/\/doi.org\/10.1098\/rsos.181728","DOI":"10.1098\/rsos.181728"},{"issue":"3","key":"10326_CR56","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1007\/s12325-022-02401-0","volume":"40","author":"ES Sinnathamby","year":"2023","unstructured":"Sinnathamby ES, Issa PP, Roberts L et al (2023) Hereditary angioedema: diagnosis, clinical implications, and pathophysiology. Adv Ther 40(3):814\u2013827. https:\/\/doi.org\/10.1007\/s12325-022-02401-0","journal-title":"Adv Ther"},{"issue":"4","key":"10326_CR57","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.cbpc.2004.05.004","volume":"138","author":"G Soslau","year":"2004","unstructured":"Soslau G, Wallace B, Vicente C et al (2004) Comparison of functional aspects of the coagulation cascade in human and sea turtle plasmas. Comp Biochem Physiol B Biochem Mol Biol 138(4):399\u2013406. https:\/\/doi.org\/10.1016\/j.cbpc.2004.05.004","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"issue":"5","key":"10326_CR58","doi-asserted-by":"publisher","first-page":"537","DOI":"10.3390\/ani12050537","volume":"12","author":"CY Su","year":"2022","unstructured":"Su CY, Hughes MW, Liu TY et al (2022) Defining wound healing progression in cetacean skin: characteristics of full-thickness wound healing in Fraser\u2019s dolphins (Lagenodelphis hosei). Animals (Basel) 12(5):537. https:\/\/doi.org\/10.3390\/ani12050537","journal-title":"Animals (Basel)"},{"key":"10326_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ygcen.2017.04.004","volume":"248","author":"M Suzuki","year":"2017","unstructured":"Suzuki M, Tomoshige M, Ito M et al (2017) Increase in serum noradrenaline concentration by short dives with bradycardia in Indo-Pacific bottlenose dolphin Tursiops aduncus. Gen Comp Endocrinol 248:1\u20134. https:\/\/doi.org\/10.1016\/j.ygcen.2017.04.004","journal-title":"Gen Comp Endocrinol"},{"issue":"Pt 1","key":"10326_CR60","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1042\/BJ20050299","volume":"390","author":"R Szabo","year":"2005","unstructured":"Szabo R, Netzel-Arnett S, Hobson JP, Antalis TM, Bugge TH (2005) Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity. Biochem J 390(Pt 1):231\u2013242. https:\/\/doi.org\/10.1042\/BJ20050299","journal-title":"Biochem J"},{"key":"10326_CR61","doi-asserted-by":"publisher","first-page":"D447","DOI":"10.1093\/nar\/gku1003","volume":"43","author":"D Szklarczyk","year":"2015","unstructured":"Szklarczyk D, Franceschini A, Wyder S et al (2015) STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res 43:D447\u2013D452. https:\/\/doi.org\/10.1093\/nar\/gku1003","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"10326_CR62","first-page":"101","volume":"20","author":"T Thorsen","year":"1993","unstructured":"Thorsen T, Klausen H, Lie RT, Holmsen H (1993) Bubble-induced aggregation of platelets: effects of gas species, proteins, and decompression. Undersea Hyperb Med 20(2):101\u201319","journal-title":"Undersea Hyperb Med"},{"key":"10326_CR63","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.676499","volume":"8","author":"A Vel\u00e1zquez-Wallraf","year":"2021","unstructured":"Vel\u00e1zquez-Wallraf A, Fern\u00e1ndez A, Caballero MJ et al (2021) Decompressive pathology in cetaceans based on an experimental pathological model. Front Vet Sci 8:676499. https:\/\/doi.org\/10.3389\/fvets.2021.676499","journal-title":"Front Vet Sci"},{"key":"10326_CR64","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1182\/blood-2004-06-2389","volume":"104","author":"U Walter","year":"2004","unstructured":"Walter U, Gambaryan S (2004) Roles of cGMP\/cGMP dependent protein kinase in platelet activation. Blood 104:2609","journal-title":"Blood"},{"key":"10326_CR65","doi-asserted-by":"publisher","first-page":"e91","DOI":"10.1161\/CIRCRESAHA.116.308955","volume":"119","author":"W Wang","year":"2016","unstructured":"Wang W, Tang Y, Wang Y et al (2016) LNK\/SH2B3 loss of function promotes atherosclerosis and thrombosis. Circ Res 119:e91\u2013e103","journal-title":"Circ Res"},{"issue":"2","key":"10326_CR66","first-page":"163","volume":"54","author":"BA Warren","year":"1973","unstructured":"Warren BA, Philp RB, Inwood MJ (1973) The ultrastructural morphology of air embolism: platelet adhesion to the interface and endothelial damage. Br J Exp Pathol 54(2):163\u2013172","journal-title":"Br J Exp Pathol"},{"key":"10326_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2024.105286","volume":"308","author":"Q Wei","year":"2024","unstructured":"Wei Q, Li K, Su L et al (2024) Plasma proteomics implicate glutamic oxaloacetic transaminases as potential markers for acute myocardial infarction. J Proteomics 308:105286. https:\/\/doi.org\/10.1016\/j.jprot.2024.105286","journal-title":"J Proteomics"},{"issue":"8","key":"10326_CR68","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1093\/molbev\/msm088","volume":"24","author":"Z Yang","year":"2007","unstructured":"Yang Z (2007) PAML 4: phylogenetic analysis by maximum likelihood. Mol Biol Evol 24(8):1586\u20131591. https:\/\/doi.org\/10.1093\/molbev\/msm088","journal-title":"Mol Biol Evol"},{"issue":"1","key":"10326_CR69","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nmeth.3213","volume":"12","author":"J Yang","year":"2015","unstructured":"Yang J, Yan R, Roy A et al (2015) The I-TASSER Suite: protein structure and function prediction. Nat Methods 12(1):7\u20138. https:\/\/doi.org\/10.1038\/nmeth.3213","journal-title":"Nat Methods"},{"issue":"3","key":"10326_CR70","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1182\/blood-2018-04-844480","volume":"133","author":"Z Zhao","year":"2019","unstructured":"Zhao Z, Wu Y, Zhou J et al (2019) The transmembrane protein disulfide isomerase TMX1 negatively regulates platelet responses. Blood 133(3):246\u2013251. https:\/\/doi.org\/10.1182\/blood-2018-04-844480","journal-title":"Blood"},{"key":"10326_CR72","unstructured":"Zhou KY, Pilleri G, Li YM (1980) Observations on Baiji (Lipotes vexillifer) and finless porpoise (Neophocaena asiaeorientalis) in the lower reaches of the Chang Jiang. Sci Sin 23(6):785-794"}],"container-title":["Journal of Molecular Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00239-026-10326-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00239-026-10326-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00239-026-10326-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T03:57:35Z","timestamp":1785729455000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00239-026-10326-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10326"],"URL":"https:\/\/doi.org\/10.1007\/s00239-026-10326-3","relation":{},"ISSN":["0022-2844","1432-1432"],"issn-type":[{"value":"0022-2844","type":"print"},{"value":"1432-1432","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]},"assertion":[{"value":"18 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The funding and acknowledgment section has been updated.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have not disclosed any competing interests.","order":1,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}