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Although consent was not obtained from patients for data extraction, all data extracted was anonymised and modelled with low risk of identification. Studies analysing data using The Health Improvement Network (THIN) database have ethical approval from the NHS South-East Multicentre Research Ethics Committee, subject to prior independent scientific review. The Scientific Review Committee (IMS Health) approved the study protocol before we performed our analysis (SRC Reference Number: 17THIN007).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Full dataset available from the corresponding author at k.nirantharan@bham.ac.uk.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data sharing and accessibility"}}]}}