{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:15:39Z","timestamp":1787163339195,"version":"build-2736575974"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100022025","name":"South Valley University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100022025","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Urolithiasis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To assess the effect of co-trimoxazole and N-acetylcysteine (NAC), alone and in combination, on bacterial adherence to biofilm formed on ureteral stent surfaces. This prospective randomized study was conducted on 636 patients who underwent double J ureteral stent insertion after variable urological procedures. Patients were randomized into four groups: A (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009165), no antibiotics or mucolytics during stent indwelling; B (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009153), oral NAC (200 mg\/day for children aged\u2009&lt;\u200912 years old and 600 mg\/day for adults) during stent indwelling; C (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009162), oral co-trimoxazole (2 mg TMP\/kg\/day) during stent indwelling; and D (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009156), both oral NAC and co-trimoxazole during stent indwelling. Two weeks following double J stent (JJ stent) insertion, urinalysis was performed on all patients and urine culture was done for all the patients at the day of double J stent removal. The stent was removed 2 weeks postoperatively, and a stent segment sized 3\u20135 cm from the bladder segment of the stent was sent for culture. Positive stent cultures were found in 63.6% (105\/165), 43.1% (66\/153), 37% (60\/162), and 19.2% (30\/156) patients of groups A, B, C, and D, respectively.\n                    <jats:italic>E. coli<\/jats:italic>\n                    was the organism most commonly isolated from the stent culture in all groups. The combination of co-trimoxazole and NAC was more effective in reducing bacterial adherence on ureteral stent surfaces than either alone.\n                  <\/jats:p>","DOI":"10.1007\/s00240-023-01508-5","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T07:03:57Z","timestamp":1702278237000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of co-trimoxazole and N-acetylcysteine alone and in combination on bacterial adherence on ureteral stent surface"],"prefix":"10.1007","volume":"52","author":[{"given":"Mostafa","family":"AbdelRazek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reham","family":"Ashour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Alemam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El-Gelany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"Abdel-Kader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"issue":"5","key":"1508_CR1","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1089\/end.1999.13.377","volume":"13","author":"K Mohan-Pillai","year":"1999","unstructured":"Mohan-Pillai K, Keeley FX, Moussa SA Jr, Smith G, Tolley DA (1999) Endourological management of severely encrusted ureteral stents. 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The Registration No. of the study (Registration number UR0011-2 180). That is not Animal Studies.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all patients in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"11"}}