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Effectiveness of different classes of photonic nanoparticles in fragmenting human stones is assessed.\u00a0De-identified human stones were collected after institutional approval. Stones of a size range between 2\u20134\u00a0mm were rehydrated in simulated urine for 24\u00a0h. Stones were then coated with a solution of nanoparticles prior to activation with either a 785\u00a0nm or 1320\u00a0nm near-infrared energy source.\u00a0Photonic lithotripsy achieved greater than 70% success rate in fragmentating calcium oxalate monohydrate stones using carbon-based nanoparticles for both near-infrared wavelengths. For gold-based nanoparticles, there was a similar success rate with the 785\u00a0nm wavelength but a significant decrease when using the 1320\u00a0nm wavelength energy source. All stones fragmented with the energy source at a distance\u2009\u2265\u200920\u00a0mm from the stone\u2019s surface. Limitations include the use of mixed-composition stones, a lack of complete stone immersion in liquid during treatment, and smaller stone size.\u00a0Different classes of nanoparticles when excited with a near-infrared energy source can fragment common stone types in vitro. 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