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A novel approach that employs a magnetic suspension and a magnetic probe for the passive collection and removal of small residual fragments was developed. This study assessed the feasibility of this system in porcine models. Five female domestic pigs underwent retrograde intrarenal surgery under general anaesthesia to assess the new magnetic system. Pre-analysed human calculi were endoscopically inserted and comminuted using lithotripsy. The magnetic suspension was applied, and the magnetic-stone fragment complex was extracted. After nephrectomy, independent blinded pathologists evaluated all the kidneys. Safety and tolerance assessments revealed no adverse events (i.e. no complications on the Clavien-Dindo scale\u2009&gt;\u20091) or complications associated with treatment. This study revealed superficial urothelial damage in all animals, characterized by desquamation and inflammation, caused primarily by the insertion of access sheaths and laser lithotripsy. Residual magnetic particles were observed in the renal pelvis but did not show signs of toxicity even though this study is limited to the acute treatment. No pathological indicators were observed in the hemogram and urinalysis. Overall, the treatment did not cause any significant pathological changes. Preclinical in vivo evaluation of magnetic extraction of small rest fragments in porcine kidneys presents a promising, atraumatic approach for fragments removal. It demonstrated safety, tolerance, and feasibility that warrants clinical investigation. This method has the potential to increase stone-clearance rates with shorter extraction times, offering a possibility for addressing the challenge of urolithiasis in clinical practice.<\/jats:p>","DOI":"10.1007\/s00240-024-01684-y","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T22:23:58Z","timestamp":1734992638000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Harnessing magnetism: evaluation of safety, tolerance and feasibility of magnetic kidney stone retrieval in vivo in porcine models"],"prefix":"10.1007","volume":"53","author":[{"given":"Thomas","family":"Amiel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Turrina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Ebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Straub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian P.","family":"Schwaminger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"1684_CR1","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1089\/end.2016.0101","volume":"30","author":"S Hein","year":"2016","unstructured":"Hein S, Miernik A, Wilhelm K et al (2016) Endoscopically determined stone clearance predicts disease recurrence within 5 years after retrograde intrarenal surgery. 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Schwaminger: founded the company Dymium GmbH. In addition, Shyam Srinivasan and Sebastian Schwaminger hold the patents AU2021229560A1, CA3168407A1, CN115243671A, EP3875075B1, EP3875075A1, KR20220143098A, JP2023516703A, US2023149450A1, and WO2021175660A1 all issued by the Technical University of Munich. Shyam Srinivasan also holds the patents EP4144308A1 and WO2023036817A1 filed by the Dymium GmbH. None of the other authors has any other conflict of interest or financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Animal studies were approved by the local governmental review board for animal studies and performed in accordance with current EU regulations and were performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Stone models were anonymized to prevent traceability. Ethical approval was obtained from the Landesamt f\u00fcr Arbeitsschutz, Verbraucherschutz und Gesundheit of the Land Brandenburg (2347-06-2022-25-G) and Ethics Committee of the Technical University of Munich (2023-227-S-KH).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"12"}}