{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T23:07:30Z","timestamp":1766531250265,"version":"3.48.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Urolithiasis"],"DOI":"10.1007\/s00240-025-01739-8","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T13:05:41Z","timestamp":1743685541000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brown adipose tissue detection using positron emission tomography could help reduce urolithiasis risk"],"prefix":"10.1007","volume":"53","author":[{"given":"Teruaki","family":"Sugino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3092-5114","authenticated-orcid":false,"given":"Kazumi","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Yanase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rei","family":"Unno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Ando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Yasui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"1739_CR1","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1053\/j.ajkd.2011.03.021","volume":"58","author":"IG Jeong","year":"2011","unstructured":"Jeong IG, Kang T, Bang JK, Park J, Kim W, Hwang SS, Kim HK, Park HK (2011) Association between metabolic syndrome and the presence of kidney stones in a screened population. Am J Kidney Dis 58:383\u2013388. https:\/\/doi.org\/10.1053\/j.ajkd.2011.03.021","journal-title":"Am J Kidney Dis"},{"key":"1739_CR2","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1007\/s00345-017-2008-6","volume":"35","author":"I Sorokin","year":"2017","unstructured":"Sorokin I, Mamoulakis C, Miyazawa K, Rodgers A, Talati J, Lotan Y (2017) Epidemiology of stone disease across the world. World J Urol 35:1301\u20131320. https:\/\/doi.org\/10.1007\/s00345-017-2008-6","journal-title":"World J Urol"},{"key":"1739_CR3","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1016\/j.juro.2012.11.045","volume":"189","author":"R Ando","year":"2013","unstructured":"Ando R, Nagaya T, Suzuki S, Takahashi H, Kawai M, Okada A, Yasui T, Kubota Y, Umemoto Y, Tozawa K, Kohri K (2013) Kidney stone formation is positively associated with conventional risk factors for coronary heart disease in Japanese men. J Urol 189:1340\u20131346. https:\/\/doi.org\/10.1016\/j.juro.2012.11.045","journal-title":"J Urol"},{"key":"1739_CR4","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s40620-014-0085-9","volume":"27","author":"D Rendina","year":"2014","unstructured":"Rendina D, De Filippo G, D\u2019Elia L, Strazzullo P (2014) Metabolic syndrome and nephrolithiasis: A systematic review and meta-analysis of the scientific evidence. J Nephrol 27:371\u2013376. https:\/\/doi.org\/10.1007\/s40620-014-0085-9","journal-title":"J Nephrol"},{"key":"1739_CR5","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s00345-014-1391-5","volume":"33","author":"JP Haymann","year":"2015","unstructured":"Haymann JP (2015) Metabolic disorders: stones as first clinical manifestation of significant diseases. World J Urol 33:187\u2013192. https:\/\/doi.org\/10.1007\/s00345-014-1391-5","journal-title":"World J Urol"},{"key":"1739_CR6","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/nrendo.2010.20","volume":"6","author":"TT Tran","year":"2010","unstructured":"Tran TT, Kahn CR (2010) Transplantation of adipose tissue and stem cells: role in metabolism and disease. Nat Rev Endocrinol 6:195\u2013213. https:\/\/doi.org\/10.1038\/nrendo.2010.20","journal-title":"Nat Rev Endocrinol"},{"key":"1739_CR7","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1172\/jci62308","volume":"123","author":"KI Stanford","year":"2013","unstructured":"Stanford KI, Middelbeek RJ, Townsend KL, An D, Nygaard EB, Hitchcox KM, Markan KR, Nakano K, Hirshman MF, Tseng YH, Goodyear LJ (2013) Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest 123:215\u2013223. https:\/\/doi.org\/10.1172\/jci62308","journal-title":"J Clin Invest"},{"key":"1739_CR8","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.2337\/db09-0530","volume":"58","author":"M Saito","year":"2009","unstructured":"Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, Iwanaga T, Miyagawa M, Kameya T, Nakada K, Kawai Y, Tsujisaki M (2009) High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58:1526\u20131531. https:\/\/doi.org\/10.2337\/db09-0530","journal-title":"Diabetes"},{"key":"1739_CR9","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1056\/nejmoa0810780","volume":"360","author":"AM Cypess","year":"2009","unstructured":"Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR (2009) Identification and importance of brown adipose tissue in adult humans. N Engl J Med 360:1509\u20131517. https:\/\/doi.org\/10.1056\/nejmoa0810780","journal-title":"N Engl J Med"},{"key":"1739_CR10","doi-asserted-by":"publisher","first-page":"3404","DOI":"10.1172\/jci67803","volume":"123","author":"T Yoneshiro","year":"2013","unstructured":"Yoneshiro T, Aita S, Matsushita M, Kayahara T, Kameya T, Kawai Y, Iwanaga T, Saito M (2013) Recruited brown adipose tissue as an antiobesity agent in humans. J Clin Invest 123:3404\u20133408. https:\/\/doi.org\/10.1172\/jci67803","journal-title":"J Clin Invest"},{"key":"1739_CR11","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cmet.2014.12.009","volume":"21","author":"AM Cypess","year":"2015","unstructured":"Cypess AM, Weiner LS, Roberts-Toler C, Franquet El\u00eda E, Kessler SH, Kahn PA, English J, Chatman K, Trauger SA, Doria A, Kolodny GM (2015) Activation of human brown adipose tissue by a \u03b23-adrenergic receptor agonist. Cell Metab 21:33\u201338. https:\/\/doi.org\/10.1016\/j.cmet.2014.12.009","journal-title":"Cell Metab"},{"key":"1739_CR12","doi-asserted-by":"publisher","first-page":"10937","DOI":"10.1073\/pnas.1901655116","volume":"116","author":"W Sui","year":"2019","unstructured":"Sui W, Li H, Yang Y, Jing X, Xue F, Cheng J, Dong M, Zhang M, Pan H, Chen Y, Zhang Y, Zhou Q, Shi W, Wang X, Zhang H, Zhang C, Zhang Y, Cao Y (2019) Bladder drug, Mirabegron, exacerbates atherosclerosis through activation of brown fat-mediated lipolysis. Proc Natl Acad Sci U S A 116:10937\u201310942. https:\/\/doi.org\/10.1073\/pnas.1901655116","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1739_CR13","doi-asserted-by":"publisher","first-page":"F1282","DOI":"10.1152\/ajprenal.00523.2018","volume":"316","author":"T Sugino","year":"2019","unstructured":"Sugino T, Okada A, Taguchi K, Unno R, Hamamoto S, Ando R, Mogami T, Kohri K, Yamashita H, Yasui T (2019) Brown adipocytes and \u03b23-stimulant-induced brown-like adipocytes contribute to the prevention of renal crystal formation. Am J Physiol Ren Physiol 316:F1282\u2013F1292. https:\/\/doi.org\/10.1152\/ajprenal.00523.2018","journal-title":"Am J Physiol Ren Physiol"},{"key":"1739_CR14","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1126\/science.1190816","volume":"328","author":"J Ishibashi","year":"2010","unstructured":"Ishibashi J, Seale P (2010) Beige can be slimming. Science 328:1113\u20131114. https:\/\/doi.org\/10.1126\/science.1190816","journal-title":"Science"},{"key":"1739_CR15","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1007\/s12020-018-1698-x","volume":"62","author":"P Santhanam","year":"2018","unstructured":"Santhanam P, Ahima RS, Mammen JS, Giovanella L, Treglia G (2018) Brown adipose tissue (BAT) detection by 18F-FDG PET and thyroid hormone level(s): A systematic review. Endocrine 62:496\u2013500. https:\/\/doi.org\/10.1007\/s12020-018-1698-x","journal-title":"Endocrine"},{"key":"1739_CR16","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1442-2042.2009.02410.x","volume":"17","author":"M Hirose","year":"2010","unstructured":"Hirose M, Yasui T, Okada A, Hamamoto S, Shimizu H, Itoh Y, Tozawa K, Kohri K (2010) Renal tubular epithelial cell injury and oxidative stress induce calcium oxalate crystal formation in mouse kidney. Int J Urol 17:83\u201392. https:\/\/doi.org\/10.1111\/j.1442-2042.2009.02410.x","journal-title":"Int J Urol"},{"key":"1739_CR17","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.3390\/cells9112449","volume":"9","author":"M Nishio","year":"2020","unstructured":"Nishio M, Saeki K (2020) The remaining mysteries about brown adipose tissues. Cells 9:2449. https:\/\/doi.org\/10.3390\/cells9112449","journal-title":"Cells"},{"key":"1739_CR18","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","volume":"1813","author":"J Scheller","year":"2011","unstructured":"Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S (2011) The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta 1813:878\u2013888. https:\/\/doi.org\/10.1016\/j.bbamcr.2011.01.034","journal-title":"Biochim Biophys Acta"},{"key":"1739_CR19","doi-asserted-by":"publisher","first-page":"e61343","DOI":"10.1371\/journal.pone.0061343","volume":"8","author":"Y Fujii","year":"2013","unstructured":"Fujii Y, Okada A, Yasui T, Niimi K, Hamamoto S, Hirose M, Kubota Y, Tozawa K, Hayashi Y, Kohri K (2013) Effect of adiponectin on kidney crystal formation in metabolic syndrome model mice via Inhibition of inflammation and apoptosis. PLoS ONE 8:e61343. https:\/\/doi.org\/10.1371\/journal.pone.0061343","journal-title":"PLoS ONE"},{"key":"1739_CR20","doi-asserted-by":"publisher","first-page":"218142","DOI":"10.4061\/2010\/218142","volume":"2010","author":"YR Yun","year":"2010","unstructured":"Yun YR, Won JE, Jeon E, Lee S, Kang W, Jo H, Jang JH, Shin US, Kim HW (2010) Fibroblast growth factors: biology, function, and application for tissue regeneration. J Tissue Eng 2010:218142. https:\/\/doi.org\/10.4061\/2010\/218142","journal-title":"J Tissue Eng"},{"key":"1739_CR21","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1038\/ncomms3019","volume":"4","author":"A Planavila","year":"2013","unstructured":"Planavila A, Redondo I, Hondares E, Vinciguerra M, Munts C, Iglesias R, Gabrielli LA, Sitges M, Giralt M, van Bilsen M, Villarroya F (2013) Fibroblast growth factor 21 protects against cardiac hypertrophy in mice. Nat Commun 4:2019. https:\/\/doi.org\/10.1038\/ncomms3019","journal-title":"Nat Commun"},{"key":"1739_CR22","doi-asserted-by":"publisher","first-page":"3366","DOI":"10.1210\/en.2012-2276","volume":"154","author":"HW Kim","year":"2013","unstructured":"Kim HW, Lee JE, Cha JJ, Hyun YY, Kim JE, Lee MH, Song HK, Nam DH, Han JY, Han SY, Han KH, Kang YS, Cha DR (2013) Fibroblast growth factor 21 improves insulin resistance and ameliorates renal injury in Db\/db mice. Endocrinology 154:3366\u20133376. https:\/\/doi.org\/10.1210\/en.2012-2276","journal-title":"Endocrinology"},{"key":"1739_CR23","doi-asserted-by":"publisher","first-page":"e82275","DOI":"10.1371\/journal.pone.0082275","volume":"8","author":"C Zhang","year":"2013","unstructured":"Zhang C, Shao M, Yang H, Chen L, Yu L, Cong W, Tian H, Zhang F, Cheng P, Jin L, Tan Y, Li X, Cai L, Lu X (2013) Attenuation of hyperlipidemia- and diabetes-induced early-stage apoptosis and late-stage renal dysfunction via administration of fibroblast growth factor-21 is associated with suppression of renal inflammation. PLoS ONE 8:e82275. https:\/\/doi.org\/10.1371\/journal.pone.0082275","journal-title":"PLoS ONE"},{"key":"1739_CR24","doi-asserted-by":"publisher","first-page":"15167","DOI":"10.1038\/s41598-021-94441-9","volume":"11","author":"S Kashima","year":"2021","unstructured":"Kashima S, Inoue K, Matsumoto M (2021) Low creatinine levels in diabetes mellitus among older individuals: the Yuport medical checkup center study. Sci Rep 11:15167. https:\/\/doi.org\/10.1038\/s41598-021-94441-9","journal-title":"Sci Rep"},{"key":"1739_CR25","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1161\/circresaha.115.306647","volume":"118","author":"G Hoeke","year":"2016","unstructured":"Hoeke G, Kooijman S, Boon MR, Rensen PC, Berb\u00e9e JF (2016) Role of brown fat in lipoprotein metabolism and atherosclerosis. Circ Res 118:173\u2013182. https:\/\/doi.org\/10.1161\/circresaha.115.306647","journal-title":"Circ Res"},{"key":"1739_CR26","doi-asserted-by":"publisher","first-page":"6356","DOI":"10.1038\/ncomms7356","volume":"6","author":"JF Berb\u00e9e","year":"2015","unstructured":"Berb\u00e9e JF, Boon MR, Khedoe PP, Bartelt A, Schlein C, Worthmann A, Kooijman S, Hoeke G, Mol IM, John C, Jung C, Vazirpanah N, Brouwers LP, Gordts PL, Esko JD, Hiemstra PS, Havekes LM, Scheja L, Heeren J, Rensen PC (2015) Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun 6:6356. https:\/\/doi.org\/10.1038\/ncomms7356","journal-title":"Nat Commun"},{"key":"1739_CR27","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/nrendo.2016.136","volume":"13","author":"F Villarroya","year":"2017","unstructured":"Villarroya F, Cereijo R, Villarroya J, Giralt M (2017) Brown adipose tissue as a secretory organ. Nat Rev Endocrinol 13:26\u201335. https:\/\/doi.org\/10.1038\/nrendo.2016.136","journal-title":"Nat Rev Endocrinol"},{"key":"1739_CR28","doi-asserted-by":"publisher","first-page":"1026240","DOI":"10.1155\/2020\/1026240","volume":"2020","author":"W Luo","year":"2020","unstructured":"Luo W, Zhou Y, Gao C, Yan P, Xu L (2020) Urolithiasis, independent of uric acid, increased risk of coronary artery and carotid atherosclerosis: A meta-analysis of observational studies. BioMed Res Int 2020:1026240. https:\/\/doi.org\/10.1155\/2020\/1026240","journal-title":"BioMed Res Int"},{"key":"1739_CR29","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.urology.2007.09.034","volume":"71","author":"T Yasui","year":"2008","unstructured":"Yasui T, Iguchi M, Suzuki S, Kohri K (2008) Prevalence and epidemiological characteristics of urolithiasis in Japan: National trends between 1965 and 2005. Urology 71:209\u2013213. https:\/\/doi.org\/10.1016\/j.urology.2007.09.034","journal-title":"Urology"}],"container-title":["Urolithiasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00240-025-01739-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00240-025-01739-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00240-025-01739-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T23:02:52Z","timestamp":1766530972000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00240-025-01739-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1739"],"URL":"https:\/\/doi.org\/10.1007\/s00240-025-01739-8","relation":{},"ISSN":["2194-7236"],"issn-type":[{"type":"electronic","value":"2194-7236"}],"subject":[],"published":{"date-parts":[[2025,4,1]]},"assertion":[{"value":"1 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Review Board of Anjo Kosei Hospital, Anjo, Japan (R20-033) and was conducted in accordance with the principles stated in the Declaration of Helsinki (2013).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained in the form of opt-out on the hospital website.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publish"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}},{"value":"The authors declare no competing interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"64"}}