{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:52:34Z","timestamp":1788897154740,"version":"build-2803163510"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Urolithiasis"],"DOI":"10.1007\/s00240-025-01794-1","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T08:29:06Z","timestamp":1751272146000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reno-protection by Didymocarpus pedicellata against oxalate-induced damage: mechanistic insights into mitigation of oxidative stress induced signaling pathways in renal cell line and rat model"],"prefix":"10.1007","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2744-7502","authenticated-orcid":false,"given":"Anubha","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0630-4838","authenticated-orcid":false,"given":"Kshama","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6937-0216","authenticated-orcid":false,"given":"Simran","family":"Tandon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2935-7575","authenticated-orcid":false,"given":"Tanzeer","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3720-0455","authenticated-orcid":false,"given":"Chanderdeep","family":"Tandon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"1794_CR1","unstructured":"Ahmed S, Hasan MM, Mahmood ZA et al (2016) Antiurolithiatic plants: multidimensional Pharmacology. J Pharmacognosy Phytochemistry 5(2):4-24"},{"issue":"2","key":"1794_CR2","doi-asserted-by":"publisher","first-page":"100029","DOI":"10.1016\/j.phyplu.2021.100029","volume":"1","author":"M Prasathkumar","year":"2021","unstructured":"Prasathkumar M, Anisha S et al (2021) Therapeutic and Pharmacological efficacy of selective Indian medicinal plants\u2013 A review. Phytomedicine Plus 1(2):100029","journal-title":"Phytomedicine Plus"},{"key":"1794_CR3","doi-asserted-by":"publisher","first-page":"3068365","DOI":"10.1155\/2018\/3068365","volume":"2018","author":"T Alelign","year":"2018","unstructured":"Alelign T, Petros B (2018) Kidney stone disease: an update on current concepts. Adv Urol 2018:3068365","journal-title":"Adv Urol"},{"key":"1794_CR4","doi-asserted-by":"crossref","unstructured":"Demoulin N, Aydin S, Gillion V et al (2022) Pathophysiology and management of hyperoxaluria and oxalate nephropathy: A review. Am J Kidney Dis 79(5):717-727","DOI":"10.1053\/j.ajkd.2021.07.018"},{"key":"1794_CR5","first-page":"256","volume":"3","author":"SR Khan","year":"2014","unstructured":"Khan SR (2014) Reactive oxygen species, inflammation and calcium oxalate nephrolithiasis. Translational Androl Urol 3:256\u2013276","journal-title":"Translational Androl Urol"},{"issue":"1","key":"1794_CR6","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cbi.2006.10.012","volume":"165","author":"G Kaur","year":"2007","unstructured":"Kaur G, Lone IA, Athar M, Alam MS (2007) Protective effect of Didymocarpus pedicellata on ferric nitrilotriacetate (Fe-NTA) induced renal oxidative stress and hyperproliferative response. Chemico-Biol Interact 165(1):33\u201344","journal-title":"Chemico-Biol Interact"},{"issue":"3","key":"1794_CR7","first-page":"36","volume":"5","author":"IA Lone","year":"2016","unstructured":"Lone IA, Ali M, Alam MS, Lone SA (2016) Isolation, characterization and antioxidant activities of steroidal constituents from the aerial parts of Didymocarpus pedicellata R. Br. J Pharmacognosy Phytochemistry 5(3):36\u201342","journal-title":"J Pharmacognosy Phytochemistry"},{"issue":"6","key":"1794_CR8","first-page":"7342","volume":"12","author":"A Singh","year":"2022","unstructured":"Singh A, Tandon S, Kaur T, Tandon C (2022) In vitro studies on calcium oxalate induced apoptosis attenuated by Didymocarpus pedicellata. Biointerface Res Appl Chem 12(6):7342\u20137355","journal-title":"Biointerface Res Appl Chem"},{"key":"1794_CR9","first-page":"1","volume-title":"Indian materia medica","author":"AK Nadkarni","year":"1976","unstructured":"Nadkarni AK (1976) Indian materia medica. Popular Prakashan, Bombay, pp 1\u20132"},{"key":"1794_CR10","first-page":"113","volume":"2","author":"BM Sharma","year":"1983","unstructured":"Sharma BM, Panagariya A, Jain K (1983) Clinical trial of cystone in various renal disorders. Probe 2:113\u2013114","journal-title":"Probe"},{"key":"1794_CR11","first-page":"484","volume":"9","author":"SC Rai","year":"1960","unstructured":"Rai SC (1960) Clinical trials with cystone in urolithiasis. Curr Med Pract 9:484\u2013487","journal-title":"Curr Med Pract"},{"key":"1794_CR12","first-page":"26","volume":"5","author":"MS Misgar","year":"1982","unstructured":"Misgar MS (1982) Controlled trial in 100 cases with nephrourethrolithiasis with cystone, an Indigenous drug and other advanced methods. Curr Med Pract 5:26\u201329","journal-title":"Curr Med Pract"},{"key":"1794_CR13","first-page":"519","volume":"16","author":"SJ Warsi","year":"1939","unstructured":"Warsi SJ (1939) The constituents of Didymocarpus pedicellata. Part IV. Isolation of two new colouring matters and their relationship to pedicin. Indian Chem Soc 16:519\u2013524","journal-title":"Indian Chem Soc"},{"key":"1794_CR14","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/S0031-9422(00)89387-5","volume":"17","author":"CP Bose","year":"1978","unstructured":"Bose CP, Chaudhury N (1978) Didymocarpin, a new Flavanone from Didymocarpus pedicellata. Phytochemistry 17:587\u2013588","journal-title":"Phytochemistry"},{"issue":"12","key":"1794_CR15","first-page":"2577","volume":"5","author":"S Mehrotra","year":"2011","unstructured":"Mehrotra S, Jamwal R, Shyam R et al (2011) Anti-Helicobacter pylori and antioxidant properties of Emblica officinalis pulp extract: A potential source for therapeutic use against gastric ulcer. J Med Plants Res 5(12):2577\u20132583","journal-title":"J Med Plants Res"},{"key":"1794_CR16","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/BF00393304","volume":"23","author":"B Hess","year":"1995","unstructured":"Hess B, Meinhardt U, Zipperle L et al (1995) Simultaneous measurements of calcium oxalate crystal nucleation and aggregation: impact of various modifiers. Urol Res 23:231\u2013238","journal-title":"Urol Res"},{"issue":"6","key":"1794_CR17","doi-asserted-by":"publisher","first-page":"S77","DOI":"10.5530\/pj.2018.6s.15","volume":"10","author":"I Hanafi","year":"2018","unstructured":"Hanafi I, Irawan C, Rochaeni H et al (2018) Phytochemical screening, LC-MS studies and antidiabetic potential of methanol extracts of seed shells of Archidendron Bubalinum (Jack) I.C. Nielson (Julang Jaling) from lampung, Indonesia. Pharmacognosy J 10(6):S77\u2013S82","journal-title":"Pharmacognosy J"},{"key":"1794_CR18","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/s12906-019-2679-1","volume":"19","author":"R Zafar","year":"2019","unstructured":"Zafar R, Ullah H, Zahoor M et al (2019) Isolation of bioactive compounds from Bergenia ciliata (Haw) sternb rhizome and their antioxidant and anticholinesterase activities. BMC Complement Altern Med 19:296","journal-title":"BMC Complement Altern Med"},{"key":"1794_CR19","doi-asserted-by":"publisher","first-page":"114104","DOI":"10.1016\/j.jep.2021.114104","volume":"275","author":"A Singh","year":"2021","unstructured":"Singh A, Tandon S, Nandi SP, Kaur T, Tandon C (2021) Downregulation of inflammatory mediators by ethanolic extract of Bergenia ligulata (Wall) in oxalate-injured renal epithelial cells. J Ethnopharmacol 275:114104","journal-title":"J Ethnopharmacol"},{"key":"1794_CR20","doi-asserted-by":"publisher","first-page":"e0182361","DOI":"10.1371\/journal.pone.0183218","volume":"12","author":"J Kaushik","year":"2017","unstructured":"Kaushik J, Tandon S, Gupta V et al (2017) Response surface methodology-based extraction of Tribulus terrestris leads to an upsurge of antilithiatic potential by Inhibition of calcium oxalate crystallization processes. PLoS ONE 12:e0182361","journal-title":"PLoS ONE"},{"issue":"5","key":"1794_CR21","first-page":"466","volume":"11","author":"K Bodakhe","year":"2013","unstructured":"Bodakhe K et al (2013) A polyherbal formulation attenuates hyperoxaluria-induced oxidative stress and prevents subsequent deposition of calcium oxalate crystals and renal cell injury in rat kidneys. Chin J Nat Med 11(5):466\u2013471","journal-title":"Chin J Nat Med"},{"issue":"3","key":"1794_CR22","first-page":"361","volume":"71","author":"T Reynolds","year":"2005","unstructured":"Reynolds T (2005) Calcium oxalate in plants. Bot Rev 71(3):361\u2013425","journal-title":"Bot Rev"},{"key":"1794_CR23","doi-asserted-by":"publisher","unstructured":"Prasad K, Chandra D (2017) Antioxidant activity, phytochemical and nutrients of Didymocarpus pedicellata R. Br from pithoragarh, Uttarakhand Himalayas. Indian J Pharmacol Clin Res 4. https:\/\/doi.org\/10.19080\/JPCR.2017.04.555640.","DOI":"10.19080\/JPCR.2017.04.555640"},{"key":"1794_CR24","doi-asserted-by":"publisher","first-page":"704197","DOI":"10.3389\/fphar.2021.704197","volume":"12","author":"ML Del Prado-Audelo","year":"2021","unstructured":"Del Prado-Audelo ML, Cort\u00e9s H et al (2021) Therapeutic applications of terpenes on inflammatory diseases. Front Pharmacol 12:704197","journal-title":"Front Pharmacol"},{"issue":"3","key":"1794_CR25","first-page":"36","volume":"5","author":"IA Lone","year":"2016","unstructured":"Lone IA, Ali M et al (2016) Isolation, characterization and antioxidant activities of steroidal constituents from the aerial parts of Didymocarpus pedicellata R. Br. J Pharmacognosy Phytochemistry 5(3):36\u201342","journal-title":"J Pharmacognosy Phytochemistry"},{"issue":"3","key":"1794_CR26","first-page":"341","volume":"29","author":"Y Murakami","year":"2015","unstructured":"Murakami Y, Kawata A, Ito S, Katayama T, Fujisawa S (2015) The radical scavenging activity and cytotoxicity of resveratrol, orcinol and 4-allylphenol and their inhibitory effects on COX-2 gene expression and NF-\u03baB activation in RAW264.7 cells stimulated with Porphyromonas gingivalis-fimbriae. Vivo 29(3):341\u2013349","journal-title":"Vivo"},{"key":"1794_CR27","first-page":"30","volume":"3","author":"D Kalpana","year":"2012","unstructured":"Kalpana D, Shanmugasundaram R, Mohan V (2012) GC\u2013MS analysis of ethanol extract of Entada pursaetha DC seed. Bioscience Discovery 3:30\u201333","journal-title":"Bioscience Discovery"},{"issue":"9","key":"1794_CR28","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.3390\/cells8091076","volume":"8","author":"V Thongboonkerd","year":"2019","unstructured":"Thongboonkerd V (2019) Proteomics of crystal-cell interactions: A model for kidney stone research. Cells 8(9):1076","journal-title":"Cells"},{"key":"1794_CR29","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1096\/fj.201600543r","volume":"31","author":"K Fong-ngern","year":"2017","unstructured":"Fong-ngern K, Vinaiphat A, Thongboonkerd V (2017) Microvillar injury in renal tubular epithelial cells induced by calcium oxalate crystal and the protective role of epigallocatechin-3-gallate. FASEB J 31:120\u2013131","journal-title":"FASEB J"},{"issue":"2","key":"1794_CR30","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1046\/j.1523-1755.2001.059002637.x","volume":"59","author":"JH Iessner","year":"2001","unstructured":"Iessner JH, Hasegawa AT, Hung LY et al (2001) Mechanisms of calcium oxalate crystal attachment to injured renal collecting duct cells. Kidney Int 59(2):637\u2013644","journal-title":"Kidney Int"},{"issue":"7","key":"1794_CR31","doi-asserted-by":"publisher","first-page":"2346","DOI":"10.3390\/ijms21072346","volume":"21","author":"J Yue","year":"2020","unstructured":"Yue J, L\u00f3pez JM (2020) Understanding MAPK signaling pathways in apoptosis. Int J Mol Sci 21(7):2346","journal-title":"Int J Mol Sci"},{"key":"1794_CR32","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s12079-009-0068-0","volume":"3","author":"SA Lund","year":"2009","unstructured":"Lund SA, Giachelli CM, Scatena M (2009) The role of osteopontin in inflammatory processes. J Cell Communication Signal 3:311\u2013322","journal-title":"J Cell Communication Signal"},{"key":"1794_CR33","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.cca.2012.10.040","volume":"415","author":"KP Aggarwal","year":"2013","unstructured":"Aggarwal KP, Tandon S, Naik PK, Singh SK, Tandon C (2013) Novel antilithiatic cationic proteins from human calcium oxalate renal stone matrix identified by MALDI-TOF-MS endowed with cytoprotective potential: an insight into the molecular mechanism of urolithiasis. Clin Chim Acta 415:181\u2013190","journal-title":"Clin Chim Acta"},{"key":"1794_CR34","doi-asserted-by":"publisher","first-page":"153562","DOI":"10.1016\/j.phymed.2021.153562","volume":"86","author":"T Ding","year":"2021","unstructured":"Ding T, Zhao T, Li Y et al (2021) Vitexin exerts protective effects against calcium oxalate crystal-induced kidney pyroptosis in vivo and in vitro. Phytomedicine 86:153562","journal-title":"Phytomedicine"},{"key":"1794_CR35","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1002\/jcp.27023","volume":"234","author":"XF Wang","year":"2019","unstructured":"Wang XF et al (2019) Gastrin-releasing peptide receptor gene Silencing inhibits the development of the epithelial-mesenchymal transition and formation of a calcium oxalate crystal in renal tubular epithelial cells in mice with kidney stones via the PI3K\/Akt signaling pathway. J Cell Physiol 234:1567\u20131577","journal-title":"J Cell Physiol"},{"key":"1794_CR36","first-page":"642309","volume":"8","author":"X Zhang","year":"2021","unstructured":"Zhang X, Yang J, Chen C et al (2021) High-oxalate diet-induced kidney injury involves osteopontin-mediated activation of the PI3K\/Akt signaling pathway. Front Med 8:642309","journal-title":"Front Med"}],"container-title":["Urolithiasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00240-025-01794-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00240-025-01794-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00240-025-01794-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T23:02:52Z","timestamp":1766530972000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00240-025-01794-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1794"],"URL":"https:\/\/doi.org\/10.1007\/s00240-025-01794-1","relation":{},"ISSN":["2194-7236"],"issn-type":[{"value":"2194-7236","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]},"assertion":[{"value":"15 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Experiments were performed as instructed by the guidelines for care and use of animals in scientific research which has been authorized by the Institutional Animal Ethical Committee, Amity University, Noida, Uttar Pradesh (\n                      1327\/PO\/ReBi\/S\/10\/CPCSEA)\n                      .","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"131"}}