{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T17:03:57Z","timestamp":1766595837810,"version":"3.48.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82370768"],"award-info":[{"award-number":["82370768"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Research Project of Anhui Educational Committee","award":["2023AH040372"],"award-info":[{"award-number":["2023AH040372"]}]},{"name":"Clinical Research Initiation Plan of First Affiliated Hospital of Anhui Medical University","award":["LCYJ2021ZD001"],"award-info":[{"award-number":["LCYJ2021ZD001"]}]},{"name":"Excellent innovation team in scientific research of Anhui provincial colleges","award":["2022AH010071"],"award-info":[{"award-number":["2022AH010071"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Urolithiasis"],"DOI":"10.1007\/s00240-025-01923-w","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T15:26:30Z","timestamp":1766589990000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["GGT1 protects against calcium oxalate crystal-induced renal tubular epithelial cell injury by targeting GCLC"],"prefix":"10.1007","volume":"54","author":[{"given":"Junfeng","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuexian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xudong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongyao","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"issue":"5","key":"1923_CR1","first-page":"1570","volume":"193","author":"DG Assimos","year":"2015","unstructured":"Assimos DG (2015) Re: dietary and pharmacologic management to prevent recurrent nephrolithiasis in adults: a clinical practice guideline from the American college of physicians. J Urol 193(5):1570\u20131571","journal-title":"J Urol"},{"issue":"1","key":"1923_CR2","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/bju.13828","volume":"120","author":"G Zeng","year":"2017","unstructured":"Zeng G, Mai Z, Xia S et al (2017) Prevalence of kidney stones in China: an ultrasonography based cross-sectional study. BJU Int 120(1):109\u2013116","journal-title":"BJU Int"},{"issue":"9","key":"1923_CR3","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1007\/s00345-017-2008-6","volume":"35","author":"I Sorokin","year":"2017","unstructured":"Sorokin I, Mamoulakis C, Miyazawa K, Rodgers A, Talati J, Lotan Y (2017) Epidemiology of stone disease across the world. World J Urol 35(9):1301\u20131320","journal-title":"World J Urol"},{"issue":"12","key":"1923_CR4","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1681\/ASN.2014060631","volume":"25","author":"BH Eisner","year":"2014","unstructured":"Eisner BH, Goldfarb DS (2014) A nomogram for the prediction of kidney stone recurrence. J Am Soc Nephrol 25(12):2685\u20132687","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"1923_CR5","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3892\/ijmm.2021.4982","volume":"48","author":"Z Wang","year":"2021","unstructured":"Wang Z, Zhang Y, Zhang J, Deng Q, Liang H (2021) Recent advances on the mechanisms of kidney stone formation (Review). Int J Mol Med 48(2):149 [pii]","journal-title":"Int J Mol Med"},{"key":"1923_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-017-0587-8","author":"A Abhishek","year":"2017","unstructured":"Abhishek A, Benita S, Kumari M et al (2017) Molecular analysis of oxalate-induced endoplasmic reticulum stress mediated apoptosis in the pathogenesis of kidney stone disease. J Physiol Biochem. 73(4): https:\/\/doi.org\/10.1007\/s13105-017-0587-8","journal-title":"J Physiol Biochem"},{"issue":"10","key":"1923_CR7","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.2215\/CJN.11201016","volume":"12","author":"AL Zisman","year":"2017","unstructured":"Zisman AL (2017) Effectiveness of treatment modalities on kidney stone recurrence. Clin J Am Soc Nephrol 12(10):1699\u20131708","journal-title":"Clin J Am Soc Nephrol"},{"issue":"3","key":"1923_CR8","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1681\/ASN.2016040486","volume":"28","author":"SR Mulay","year":"2017","unstructured":"Mulay SR, Eberhard JN, Desai J et al (2017) Hyperoxaluria requires TNF receptors to initiate crystal adhesion and kidney stone disease. J Am Soc Nephrol 28(3):761\u2013768","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"1923_CR9","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1007\/s11033-024-09259-1","volume":"51","author":"J Yang","year":"2024","unstructured":"Yang J, Wu W, Amier Y et al (2024) Ferroptosis and its emerging role in kidney stone formation. Mol Biol Rep 51(1):314","journal-title":"Mol Biol Rep"},{"issue":"7","key":"1923_CR10","first-page":"5987","volume":"16","author":"C Hou","year":"2024","unstructured":"Hou C, Zhong B, Gu S, Wang Y, Ji L (2024) Identification and validation of the biomarkers related to ferroptosis in calcium oxalate nephrolithiasis. Aging 16(7):5987\u20136007","journal-title":"Aging"},{"key":"1923_CR11","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/978-1-60761-756-3_18","volume":"648","author":"JB Owen","year":"2010","unstructured":"Owen JB, Butterfield DA (2010) Measurement of oxidized\/reduced glutathione ratio. Methods Mol Biol 648:269\u2013277","journal-title":"Methods Mol Biol"},{"key":"1923_CR12","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.freeradbiomed.2023.09.020","volume":"208","author":"A Mitri\u0107","year":"2023","unstructured":"Mitri\u0107 A, Castellano I (2023) Targeting gamma-glutamyl transpeptidase: a pleiotropic enzyme involved in glutathione metabolism and in the control of redox homeostasis. Free Radic Biol Med 208:672\u2013683","journal-title":"Free Radic Biol Med"},{"key":"1923_CR13","doi-asserted-by":"publisher","first-page":"121110","DOI":"10.1016\/j.biomaterials.2021.121110","volume":"277","author":"B Niu","year":"2021","unstructured":"Niu B, Liao K, Zhou Y et al (2021) Application of glutathione depletion in cancer therapy: enhanced ROS-based therapy, ferroptosis, and chemotherapy. Biomaterials 277:121110","journal-title":"Biomaterials"},{"issue":"1","key":"1923_CR14","doi-asserted-by":"publisher","first-page":"4193","DOI":"10.1038\/s41467-023-39901-8","volume":"14","author":"Z Yang","year":"2023","unstructured":"Yang Z, Zou S, Zhang Y et al (2023) ACTL6A protects gastric cancer cells against ferroptosis through induction of glutathione synthesis. Nat Commun 14(1):4193","journal-title":"Nat Commun"},{"key":"1923_CR15","doi-asserted-by":"publisher","first-page":"1041117","DOI":"10.3389\/fphar.2022.1041117","volume":"13","author":"B Hou","year":"2022","unstructured":"Hou B, Liu M, Chen Y et al (2022) Cpd-42 protects against calcium oxalate nephrocalcinosis-induced renal injury and inflammation by targeting RIPK3-mediated necroptosis. Front Pharmacol 13:1041117","journal-title":"Front Pharmacol"},{"issue":"1","key":"1923_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01232-3","volume":"8","author":"H Liu","year":"2023","unstructured":"Liu H, Duan C, Yang X et al (2023) Metformin suppresses calcium oxalate crystal-induced kidney injury by promoting Sirt1 and M2 macrophage-mediated anti-inflammatory activation. Signal Transduct Target Ther 8(1):38","journal-title":"Signal Transduct Target Ther"},{"issue":"16","key":"1923_CR17","doi-asserted-by":"publisher","first-page":"7319","DOI":"10.7150\/thno.44054","volume":"10","author":"H Liu","year":"2020","unstructured":"Liu H, Yang X, Tang K et al (2020) Sulforaphane elicts dual therapeutic effects on renal inflammatory injury and crystal deposition in calcium oxalate nephrocalcinosis. Theranostics 10(16):7319\u20137334","journal-title":"Theranostics"},{"issue":"3","key":"1923_CR18","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/bjc.2013.323","volume":"109","author":"C Grimm","year":"2013","unstructured":"Grimm C, Hofstetter G, Aust S et al (2013) Association of gamma-glutamyltransferase with severity of disease at diagnosis and prognosis of ovarian cancer. Br J Cancer 109(3):610\u2013614","journal-title":"Br J Cancer"},{"issue":"4","key":"1923_CR19","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.coph.2007.04.004","volume":"7","author":"A Pompella","year":"2007","unstructured":"Pompella A, Corti A, Paolicchi A, Giommarelli C, Zunino F (2007) Gamma-glutamyltransferase, redox regulation and cancer drug resistance. Curr Opin Pharmacol 7(4):360\u2013366","journal-title":"Curr Opin Pharmacol"},{"issue":"4","key":"1923_CR20","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s00439-008-0487-7","volume":"123","author":"N Heisterkamp","year":"2008","unstructured":"Heisterkamp N, Groffen J, Warburton D, Sneddon TP (2008) The human gamma-glutamyltransferase gene family. Hum Genet 123(4):321\u2013332","journal-title":"Hum Genet"},{"issue":"14","key":"1923_CR21","doi-asserted-by":"publisher","first-page":"6303","DOI":"10.1073\/pnas.88.14.6303","volume":"88","author":"N Heisterkamp","year":"1991","unstructured":"Heisterkamp N, Rajpert-De Meyts E, Uribe L, Forman HJ, Groffen J (1991) Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase. Proc Natl Acad Sci U S A 88(14):6303\u20136307","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1923_CR22","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/B978-0-12-420117-0.00003-7","volume":"122","author":"MH Hanigan","year":"2014","unstructured":"Hanigan MH (2014) Gamma-glutamyl transpeptidase: redox regulation and drug resistance. Adv Cancer Res 122:103\u2013141","journal-title":"Adv Cancer Res"},{"issue":"9","key":"1923_CR23","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1158\/1541-7786.MCR-18-1204","volume":"17","author":"A Bansal","year":"2019","unstructured":"Bansal A, Sanchez DJ, Nimgaonkar V et al (2019) Gamma-Glutamyltransferase 1 promotes clear cell renal cell carcinoma initiation and progression. Mol Cancer Res 17(9):1881\u20131892","journal-title":"Mol Cancer Res"},{"issue":"5","key":"1923_CR24","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149(5):1060\u20131072","journal-title":"Cell"},{"issue":"10","key":"1923_CR25","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1038\/s41418-021-00859-z","volume":"28","author":"X Chen","year":"2021","unstructured":"Chen X, Kang R, Kroemer G, Tang D (2021) Organelle-specific regulation of ferroptosis. Cell Death Differ 28(10):2843\u20132856","journal-title":"Cell Death Differ"},{"issue":"2","key":"1923_CR26","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","volume":"171","author":"BR Stockwell","year":"2017","unstructured":"Stockwell BR, Friedmann Angeli JP, Bayir H et al (2017) Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell 171(2):273\u2013285","journal-title":"Cell"},{"issue":"6","key":"1923_CR27","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.ccell.2019.04.002","volume":"35","author":"B Hassannia","year":"2019","unstructured":"Hassannia B, Vandenabeele P, Vanden Berghe T (2019) Targeting ferroptosis to iron out cancer. Cancer Cell 35(6):830\u2013849","journal-title":"Cancer Cell"},{"issue":"4","key":"1923_CR28","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22(4):266\u2013282","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"1923_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2023.119452","volume":"1870","author":"J Zhao","year":"2023","unstructured":"Zhao J, Wu Y, Zhou K et al (2023) Ferroptosis in calcium oxalate kidney stone formation and the possible regulatory mechanism of ANKRD1. Biochimica et Biophysica Acta (BBA) 1870(5):119452","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"issue":"35","key":"1923_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202300379","volume":"62","author":"F Zeng","year":"2023","unstructured":"Zeng F, Nijiati S, Tang L, Ye J, Zhou Z, Chen X (2023) Ferroptosis detection: from approaches to applications. Angew Chem Int Ed Engl 62(35):e202300379","journal-title":"Angew Chem Int Ed Engl"},{"key":"1923_CR31","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.917537","volume":"12","author":"M Lu","year":"2022","unstructured":"Lu M, Zhou Y, Sun L et al (2022) The molecular mechanisms of ferroptosis and its role in glioma progression and treatment. Front Oncol 12:917537","journal-title":"Front Oncol"},{"key":"1923_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.966007","volume":"9","author":"Z Tan","year":"2022","unstructured":"Tan Z, Huang H, Sun W, Li Y, Jia Y (2022) Current progress of ferroptosis study in ovarian cancer. Front Mol Biosci 9:966007","journal-title":"Front Mol Biosci"},{"issue":"17","key":"1923_CR33","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.3390\/cells11172726","volume":"11","author":"LH Xie","year":"2022","unstructured":"Xie LH, Fefelova N, Pamarthi SH, Gwathmey JK (2022) Molecular mechanisms of ferroptosis and relevance to cardiovascular disease. Cells 11(17):2726","journal-title":"Cells"},{"key":"1923_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113611","volume":"154","author":"K Yang","year":"2022","unstructured":"Yang K, Zeng L, Yuan X et al (2022) The mechanism of ferroptosis regulating oxidative stress in ischemic stroke and the regulation mechanism of natural pharmacological active components. Biomed Pharmacother 154:113611","journal-title":"Biomed Pharmacother"},{"key":"1923_CR35","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.965064","volume":"9","author":"H Ma","year":"2022","unstructured":"Ma H, Dong Y, Chu Y, Guo Y, Li L (2022) The mechanisms of ferroptosis and its role in Alzheimer\u2019s disease. Front Mol Biosci 9:965064","journal-title":"Front Mol Biosci"},{"key":"1923_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110107","volume":"365","author":"Y Lin","year":"2022","unstructured":"Lin Y, Xu W, Hou Y et al (2022) The multifaceted role of ferroptosis in kidney diseases. Chem Biol Interact 365:110107","journal-title":"Chem Biol Interact"},{"issue":"2","key":"1923_CR37","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2022.12772","volume":"26","author":"J Xie","year":"2022","unstructured":"Xie J, Ye Z, Li L et al (2022) Ferrostatin\u20111 alleviates oxalate\u2011induced renal tubular epithelial cell injury, fibrosis and calcium oxalate stone formation by inhibiting ferroptosis. Mol Med Rep 26(2):256","journal-title":"Mol Med Rep"},{"key":"1923_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114925","volume":"164","author":"Z Ye","year":"2023","unstructured":"Ye Z, Xia Y, Li L et al (2023) p53 deacetylation alleviates calcium oxalate deposition-induced renal fibrosis by inhibiting ferroptosis. Biomed Pharmacother 164:114925","journal-title":"Biomed Pharmacother"},{"issue":"17","key":"1923_CR39","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309234","volume":"11","author":"Z He","year":"2024","unstructured":"He Z, Song C, Li S et al (2024) Development and application of the CRISPR-dcas13d-eIF4G translational regulatory system to inhibit ferroptosis in calcium oxalate crystal-induced kidney injury. Adv Sci 11(17):e2309234","journal-title":"Adv Sci"},{"issue":"7","key":"1923_CR40","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1002\/iub.1756","volume":"70","author":"AK Bachhawat","year":"2018","unstructured":"Bachhawat AK, Yadav S (2018) The glutathione cycle: glutathione metabolism beyond the \u03b3-glutamyl cycle. IUBMB Life 70(7):585\u2013592","journal-title":"IUBMB Life"},{"issue":"1\u20132","key":"1923_CR41","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.mam.2008.08.004","volume":"30","author":"N Ballatori","year":"2009","unstructured":"Ballatori N, Krance SM, Marchan R, Hammond CL (2009) Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology. Mol Aspects Med 30(1\u20132):13\u201328","journal-title":"Mol Aspects Med"},{"issue":"1","key":"1923_CR42","doi-asserted-by":"publisher","first-page":"7616","DOI":"10.1038\/s41598-020-64400-x","volume":"10","author":"R Nasr","year":"2020","unstructured":"Nasr R, Lorendeau D, Khonkarn R et al (2020) Molecular analysis of the massive GSH transport mechanism mediated by the human multidrug resistant protein 1\/ABCC1. Sci Rep 10(1):7616","journal-title":"Sci Rep"},{"key":"1923_CR43","doi-asserted-by":"publisher","first-page":"1269451","DOI":"10.3389\/fimmu.2023.1269451","volume":"14","author":"XD Zhang","year":"2023","unstructured":"Zhang XD, Liu ZY, Wang MS et al (2023) Mechanisms and regulations of ferroptosis. Front Immunol 14:1269451","journal-title":"Front Immunol"},{"issue":"1","key":"1923_CR44","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/gerona\/glac135","volume":"78","author":"P Kumar","year":"2023","unstructured":"Kumar P, Liu C, Suliburk J et al (2023) Supplementing glycine and N-acetylcysteine (GlyNAC) in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, physical function, and aging hallmarks: a randomized clinical trial. J Gerontol A Biol Sci Med Sci 78(1):75\u201389","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"12","key":"1923_CR45","doi-asserted-by":"publisher","first-page":"L1274","DOI":"10.1152\/ajplung.00220.2014","volume":"308","author":"ME Fletcher","year":"2015","unstructured":"Fletcher ME, Boshier PR, Wakabayashi K et al (2015) Influence of glutathione-S-transferase (GST) Inhibition on lung epithelial cell injury: role of oxidative stress and metabolism. Am J Physiol Lung Cell Mol Physiol 308(12):L1274\u2013L1285","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"1923_CR46","doi-asserted-by":"publisher","first-page":"628651","DOI":"10.3389\/fphar.2021.628651","volume":"12","author":"YR Liu","year":"2021","unstructured":"Liu YR, Yang NJ, Zhao ML et al (2021) Hypericum perforatum L. regulates glutathione redox stress and normalizes Ggt1\/Anpep signaling to alleviate OVX-induced kidney dysfunction. Front Pharmacol 12:628651","journal-title":"Front Pharmacol"},{"issue":"1","key":"1923_CR47","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.cmet.2020.12.007","volume":"33","author":"YP Kang","year":"2021","unstructured":"Kang YP, Mockabee-Macias A, Jiang C et al (2021) Non-canonical glutamate-cysteine ligase activity protects against ferroptosis. Cell Metab 33(1):174-189.e7","journal-title":"Cell Metab"},{"issue":"21","key":"1923_CR48","doi-asserted-by":"publisher","first-page":"3371","DOI":"10.3390\/cells11213371","volume":"11","author":"L Luo","year":"2022","unstructured":"Luo L, Zhang Z, Weng Y, Zeng J (2022) Ferroptosis-related gene GCLC is a novel prognostic molecular and correlates with immune infiltrates in lung adenocarcinoma. Cells 11(21):3371","journal-title":"Cells"},{"issue":"1\u20132","key":"1923_CR49","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.mam.2008.08.009","volume":"30","author":"CC Franklin","year":"2009","unstructured":"Franklin CC, Backos DS, Mohar I, White CC, Forman HJ, Kavanagh TJ (2009) Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase. Mol Aspects Med 30(1\u20132):86\u201398","journal-title":"Mol Aspects Med"}],"container-title":["Urolithiasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00240-025-01923-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00240-025-01923-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00240-025-01923-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T17:01:49Z","timestamp":1766595709000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00240-025-01923-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1923"],"URL":"https:\/\/doi.org\/10.1007\/s00240-025-01923-w","relation":{},"ISSN":["2194-7236"],"issn-type":[{"type":"electronic","value":"2194-7236"}],"subject":[],"published":{"date-parts":[[2025,12,24]]},"assertion":[{"value":"19 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors declare that they have no competing financial or non-financial interests relevant to this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All animal procedures were conducted in accordance with The ARRIVE Guidelines 2.0 for preclinical studies and adhered to the Institutional Animal Care and Use Committee standards of Anhui Medical University (Approval No. LLSC20242201).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"20"}}