{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T15:16:56Z","timestamp":1788103016710,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Urolithiasis"],"DOI":"10.1007\/s00240-026-02048-4","type":"journal-article","created":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T14:56:19Z","timestamp":1788101779000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two decades of kidney stone interventional trials on clinicaltrials.gov: a registry-based landscape analysis of design, endpoints, and dissemination"],"prefix":"10.1007","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-9834","authenticated-orcid":false,"given":"Yadong","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donovan","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9174-5654","authenticated-orcid":false,"given":"Jathin","family":"Bandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2546-5264","authenticated-orcid":false,"given":"Scott O","family":"Quarrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,30]]},"reference":[{"issue":"2","key":"2048_CR1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1097\/MOU.0000000000001138","volume":"34","author":"AK Vo","year":"2024","unstructured":"Vo AK, Somani BK, Ulvik O, Beisland C, Seitz C, Juliebo-Jones P (2024) Measuring quality of life in patients with kidney stone disease: is it the future in endourology? Curr Opin Urol 34(2):91\u201397. https:\/\/doi.org\/10.1097\/MOU.0000000000001138","journal-title":"Curr Opin Urol"},{"issue":"9","key":"2048_CR2","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1007\/s00345-017-2008-6","volume":"35","author":"I Sorokin","year":"2017","unstructured":"Sorokin I, Mamoulakis C, Miyazawa K, Rodgers A, Talati J, Lotan Y (2017) Epidemiology of stone disease across the world. World J Urol 35(9):1301\u20131320. https:\/\/doi.org\/10.1007\/s00345-017-2008-6","journal-title":"World J Urol"},{"key":"2048_CR3","doi-asserted-by":"publisher","first-page":"449","DOI":"10.2147\/RRU.S517758","volume":"17","author":"M Akram","year":"2025","unstructured":"Akram M, Somani B (2025) Epidemiology and Management of Kidney Stone Disease - Current Insights. Res Rep Urol 17:449\u2013459. https:\/\/doi.org\/10.2147\/RRU.S517758","journal-title":"Res Rep Urol"},{"key":"2048_CR4","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.urology.2023.03.040","volume":"176","author":"M Monga","year":"2023","unstructured":"Monga M, Murphy M, Paranjpe R, Cutone B, Eisner B (2023) Prevalence of Stone Disease and Procedure Trends in the United States. Urology 176:63\u201368. https:\/\/doi.org\/10.1016\/j.urology.2023.03.040","journal-title":"Urology"},{"issue":"4","key":"2048_CR5","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/j.juro.2016.05.090","volume":"196","author":"D Assimos","year":"2016","unstructured":"Assimos D, Krambeck A, Miller NL, Monga M, Murad MH, Nelson CP, Pace KT, Pais VM Jr., Pearle MS, Preminger GM, Razvi H, Shah O, Matlaga BR (2016) Surgical Management of Stones: American Urological Association\/Endourological Society Guideline, PART I. J Urol 196(4):1153\u20131160. https:\/\/doi.org\/10.1016\/j.juro.2016.05.090","journal-title":"J Urol"},{"key":"2048_CR6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.urology.2023.08.042","volume":"183","author":"P Dangle","year":"2024","unstructured":"Dangle P, Tasian GE, Chu DI, Shannon R, Spiardi R, Xiang AH, Jadcherla A, Arenas J, Ellison JS (2024) A Systematic Scoping Review of Comparative Effectiveness Studies in Kidney Stone Disease. Urology 183:3\u201310. https:\/\/doi.org\/10.1016\/j.urology.2023.08.042","journal-title":"Urology"},{"issue":"6","key":"2048_CR7","doi-asserted-by":"publisher","first-page":"102436","DOI":"10.1016\/j.clgc.2025.102436","volume":"23","author":"M Steidle","year":"2025","unstructured":"Steidle M, Malshy K, Hunt TC, Cheng Z, Li A, Doersch K, Bandari J (2025) Study Endpoint Fulfillment and FDA Approval Success in Phase III Clinical Trials of Genitourinary Malignancies. Clin Genitourin Cancer 23(6):102436. https:\/\/doi.org\/10.1016\/j.clgc.2025.102436","journal-title":"Clin Genitourin Cancer"},{"issue":"1","key":"2048_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.7326\/0003-4819-155-1-201107050-00006","volume":"155","author":"A Dechartres","year":"2011","unstructured":"Dechartres A, Boutron I, Trinquart L, Charles P, Ravaud P (2011) Single-center trials show larger treatment effects than multicenter trials: evidence from a meta-epidemiologic study. Ann Intern Med 155(1):39\u201351. https:\/\/doi.org\/10.7326\/0003-4819-155-1-201107050-00006","journal-title":"Ann Intern Med"},{"issue":"9","key":"2048_CR9","doi-asserted-by":"publisher","first-page":"e1000144","DOI":"10.1371\/journal.pmed.1000144","volume":"6","author":"JS Ross","year":"2009","unstructured":"Ross JS, Mulvey GK, Hines EM, Nissen SE, Krumholz HM (2009) Trial publication after registration in ClinicalTrials.Gov: a cross-sectional analysis. PLoS Med 6(9):e1000144. https:\/\/doi.org\/10.1371\/journal.pmed.1000144","journal-title":"PLoS Med"},{"issue":"3","key":"2048_CR10","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.juro.2012.08.247","volume":"189","author":"KL Penniston","year":"2013","unstructured":"Penniston KL, Nakada SY (2013) Development of an instrument to assess the health related quality of life of kidney stone formers. J Urol 189(3):921\u2013930. https:\/\/doi.org\/10.1016\/j.juro.2012.08.247","journal-title":"J Urol"},{"issue":"5","key":"2048_CR11","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1016\/j.juro.2016.11.097","volume":"197","author":"KL Penniston","year":"2017","unstructured":"Penniston KL, Antonelli JA, Viprakasit DP, Averch TD, Sivalingam S, Sur RL, Pais VM Jr., Chew BH, Bird VG, Nakada SY (2017) Validation and Reliability of the Wisconsin Stone Quality of Life Questionnaire. J Urol 197(5):1280\u20131288. https:\/\/doi.org\/10.1016\/j.juro.2016.11.097","journal-title":"J Urol"},{"issue":"2","key":"2048_CR12","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1097\/MOU.0000000000000716","volume":"30","author":"J Serna","year":"2020","unstructured":"Serna J, Talwar R, Ziemba JB (2020) Health-related quality of life in renal stone formers: are we improving? Curr Opin Urol 30(2):190\u2013195. https:\/\/doi.org\/10.1097\/MOU.0000000000000716","journal-title":"Curr Opin Urol"},{"issue":"1","key":"2048_CR13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1089\/end.2017.0241","volume":"32","author":"JS Ellison","year":"2018","unstructured":"Ellison JS, Williams M, Keeley FX Jr (2018) Patient-Reported Outcomes in Nephrolithiasis: Can We Do Better? J Endourol 32(1):10\u201320. https:\/\/doi.org\/10.1089\/end.2017.0241","journal-title":"J Endourol"},{"key":"2048_CR14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.urology.2020.09.058","volume":"148","author":"NM Streeper","year":"2021","unstructured":"Streeper NM, Galida M, Boltz S, Li S, Nakada SY, Raffin EP, Brown DR, Pais VM, Chan JYH, Scotland KB, Chew BH, Penniston KL (2021) Is Stone-free Status After Surgical Intervention for Kidney Stones Associated With Better Health-related Quality of Life? - A Multicenter Study From the North American Stone Quality of Life Consortium. Urology 148:77\u201382. https:\/\/doi.org\/10.1016\/j.urology.2020.09.058","journal-title":"Urology"},{"issue":"1","key":"2048_CR15","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1007\/s00345-025-05572-x","volume":"43","author":"OF Cavdar","year":"2025","unstructured":"Cavdar OF, Aydin A, Tokas T, Tozsin A, Gadzhiev N, Sonmez MG, Tekeli R, Ortner G, Kallidonis P, Akgul B, Knoll T, Bianchi G, Rassweiler J, Ahmed K, Guven S (2025) Residual stone fragments: systematic review of definitions, diagnostic standards. World J Urol 43(1):194. https:\/\/doi.org\/10.1007\/s00345-025-05572-x","journal-title":"World J Urol"},{"issue":"1","key":"2048_CR16","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s00345-024-04774-z","volume":"42","author":"RA Kingma","year":"2024","unstructured":"Kingma RA, Doppen C, Bus MTJ, Altobelli E, de Jong IJ, Roemeling S (2024) The significance of clinically insignificant residual fragments after percutaneous nephrolithotomy: an analysis into the relevance of complete stone clearance. World J Urol 42(1):78. https:\/\/doi.org\/10.1007\/s00345-024-04774-z","journal-title":"World J Urol"},{"issue":"7593","key":"2048_CR17","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1136\/bmj.39119.595081.55","volume":"334","author":"G Nabi","year":"2007","unstructured":"Nabi G, Cook J, N\u2019Dow J, McClinton S (2007) Outcomes of stenting after uncomplicated ureteroscopy: systematic review and meta-analysis. BMJ 334(7593):572. https:\/\/doi.org\/10.1136\/bmj.39119.595081.55","journal-title":"BMJ"},{"key":"2048_CR18","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.urology.2020.09.042","volume":"147","author":"R Talwar","year":"2021","unstructured":"Talwar R, Dobbs RW, Stambakio H, Lin G, Tasian GE, Ziemba JB (2021) A Longitudinal Cohort Study of Pain Intensity and Interference After Ureteroscopy for Nephrolithiasis Without Postoperative Opioids. Urology 147:81\u201386. https:\/\/doi.org\/10.1016\/j.urology.2020.09.042","journal-title":"Urology"},{"issue":"12","key":"2048_CR19","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1089\/end.2018.0177","volume":"32","author":"K Du","year":"2018","unstructured":"Du K, Wang RS, Vetter J, Paradis AG, Figenshau RS, Venkatesh R, Desai AC (2018) Unplanned 30-Day Encounters After Ureterorenoscopy for Urolithiasis. J Endourol 32(12):1100\u20131107. https:\/\/doi.org\/10.1089\/end.2018.0177","journal-title":"J Endourol"},{"issue":"6","key":"2048_CR20","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1097\/JU.0000000000001653","volume":"205","author":"SC Hiller","year":"2021","unstructured":"Hiller SC, Daignault-Newton S, Pimentel H, Ambani SN, Ludlow J, Hollingsworth JM, Ghani KR, Dauw CA (2021) Ureteral Stent Placement following Ureteroscopy Increases Emergency Department Visits in a Statewide Surgical Collaborative. J Urol 205(6):1710\u20131717. https:\/\/doi.org\/10.1097\/JU.0000000000001653","journal-title":"J Urol"},{"issue":"11","key":"2048_CR21","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.jclinepi.2013.05.016","volume":"66","author":"S Unverzagt","year":"2013","unstructured":"Unverzagt S, Prondzinsky R, Peinemann F (2013) Single-center trials tend to provide larger treatment effects than multicenter trials: a systematic review. J Clin Epidemiol 66(11):1271\u20131280. https:\/\/doi.org\/10.1016\/j.jclinepi.2013.05.016","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"2048_CR22","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1089\/end.2013.0436","volume":"28","author":"J de la Rosette","year":"2014","unstructured":"de la Rosette J, Denstedt J, Geavlete P, Keeley F, Matsuda T, Pearle M, Preminger G, Traxer O, Group CUS (2014) The clinical research office of the endourological society ureteroscopy global study: indications, complications, and outcomes in 11,885 patients. J Endourol 28(2):131\u2013139. https:\/\/doi.org\/10.1089\/end.2013.0436","journal-title":"J Endourol"},{"key":"2048_CR23","doi-asserted-by":"publisher","unstructured":"Zwarenstein M, Treweek S, Gagnier JJ, Altman DG, Tunis S, Haynes B, Oxman AD, Moher D, Pragmatic Trials in Healthcare g (2008) group C, Improving the reporting of pragmatic trials: an extension of the CONSORT statement. BMJ 337:a2390. https:\/\/doi.org\/10.1136\/bmj.a2390","DOI":"10.1136\/bmj.a2390"},{"issue":"4","key":"2048_CR24","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1097\/JU.0000000000001432","volume":"205","author":"CJ Magnani","year":"2021","unstructured":"Magnani CJ, Steinberg JR, Harmange CI, Zhang X, Driscoll C, Bell A, Larson J, You JG, Weeks BT, Hernandez-Boussard T, Turner BE, Brooks JD (2021) Clinical Trial Outcomes in Urology: Assessing Early Discontinuation, Results Reporting and Publication in ClinicalTrials.Gov Registrations 2007\u20132019. J Urol 205(4):1159\u20131168. https:\/\/doi.org\/10.1097\/JU.0000000000001432","journal-title":"J Urol"},{"issue":"6","key":"2048_CR25","doi-asserted-by":"publisher","first-page":"102210","DOI":"10.1016\/j.clgc.2024.102210","volume":"22","author":"B Wong","year":"2024","unstructured":"Wong B, Peng J, Jiang DM, Fizazi K, Powles T, James N, Sridhar SS (2024) Comparison of Industry-Sponsored Trials (IST) and Investigator-Initiated Trials (IIT) in Advanced Genitourinary Cancers in the United States, Canada, United Kingdom and France. Clin Genitourin Cancer 22(6):102210. https:\/\/doi.org\/10.1016\/j.clgc.2024.102210","journal-title":"Clin Genitourin Cancer"},{"issue":"3","key":"2048_CR26","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.urolonc.2020.10.070","volume":"39","author":"KD Stensland","year":"2021","unstructured":"Stensland KD, DePorto K, Ryan J, Kaffenberger S, Reinstatler LS, Galsky M, Canes D, Skolarus TA, Moinzadeh A (2021) Estimating the rate and reasons of clinical trial failure in urologic oncology. Urol Oncol 39(3):154\u2013160. https:\/\/doi.org\/10.1016\/j.urolonc.2020.10.070","journal-title":"Urol Oncol"},{"issue":"12","key":"2048_CR27","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1056\/NEJMe048225","volume":"351","author":"C De Angelis","year":"2004","unstructured":"De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J, Horton R, Kotzin S, Laine C, Marusic A, Overbeke AJ, Schroeder TV, Sox HC, Van Der Weyden MB, International Committee of Medical Journal E (2004) Clinical trial registration: a statement from the International Committee of Medical Journal Editors. N Engl J Med 351(12):1250\u20131251. https:\/\/doi.org\/10.1056\/NEJMe048225","journal-title":"N Engl J Med"},{"issue":"20","key":"2048_CR28","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1056\/NEJMsr1611785","volume":"375","author":"DA Zarin","year":"2016","unstructured":"Zarin DA, Tse T, Williams RJ, Carr S (2016) Trial Reporting in ClinicalTrials.gov - The Final Rule. N Engl J Med 375(20):1998\u20132004. https:\/\/doi.org\/10.1056\/NEJMsr1611785","journal-title":"N Engl J Med"},{"key":"2048_CR29","doi-asserted-by":"publisher","first-page":"e2300349","DOI":"10.1200\/GO.23.00349","volume":"10","author":"A Alhajahjeh","year":"2024","unstructured":"Alhajahjeh A, Hmeidan M, Elatrsh M, Al-Abbadi F, Kakish D, Sukerji R, Salah M, Al Awamlh BAH, Lee DI, Shahait M (2024) Understanding the Termination of Urologic Cancer Clinical Trials: Insights and Challenges. JCO Glob Oncol 10:e2300349. https:\/\/doi.org\/10.1200\/GO.23.00349","journal-title":"JCO Glob Oncol"},{"key":"2048_CR30","doi-asserted-by":"publisher","first-page":"102413","DOI":"10.1016\/j.eclinm.2023.102413","volume":"68","author":"M Paravathaneni","year":"2024","unstructured":"Paravathaneni M, Safa H, Joshi V, Tamil MK, Adashek JJ, Ionescu F, Shah S, Chadha JS, Gilbert S, Manley B, Semaan A, Jim HSL, Kalos D, Kim Y, Spiess PE, Chahoud J (2024) 15 years of patient-reported outcomes in clinical trials leading to GU cancer drug approvals: a systematic review on the quality of data reporting and analysis. EClinicalMedicine 68:102413. https:\/\/doi.org\/10.1016\/j.eclinm.2023.102413","journal-title":"EClinicalMedicine"}],"container-title":["Urolithiasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00240-026-02048-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00240-026-02048-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00240-026-02048-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T14:56:19Z","timestamp":1788101779000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00240-026-02048-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,30]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2048"],"URL":"https:\/\/doi.org\/10.1007\/s00240-026-02048-4","relation":{},"ISSN":["2194-7236"],"issn-type":[{"value":"2194-7236","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,30]]},"assertion":[{"value":"15 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"140"}}