{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T02:02:00Z","timestamp":1780970520429,"version":"3.54.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T00:00:00Z","timestamp":1390953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arch Environ Contam Toxicol"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1007\/s00244-013-9991-4","type":"journal-article","created":{"date-parts":[[2014,1,28]],"date-time":"2014-01-28T00:30:25Z","timestamp":1390869025000},"page":"390-399","source":"Crossref","is-referenced-by-count":16,"title":["Changes to Cuticle Surface Ultrastructure and Some Biological Functions in the Nematode Caenorhabditis Elegans Exposed to Excessive Copper"],"prefix":"10.1007","volume":"66","author":[{"given":"Shaojuan","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enbo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"issue":"4","key":"9991_CR1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/etc.5620200419","volume":"20","author":"GL Anderson","year":"2001","unstructured":"Anderson GL, Boyd WA, Williams PL (2001) Assessment of sublethal endpoints for toxicity testing with the nematode Caenorhabditis elegans. Environ Toxicol Chem 20(4):833\u2013838","journal-title":"Environ Toxicol Chem"},{"key":"9991_CR2","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1897\/03-264","volume":"23","author":"GL Anderson","year":"2004","unstructured":"Anderson GL, Cole RD, Williams PL (2004) Assessing behavioral toxicity with Caenorhabditis elegans. Environ Toxicol Chem 23:1235\u20131240","journal-title":"Environ Toxicol Chem"},{"issue":"2","key":"9991_CR3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s00244-013-9905-5","volume":"65","author":"MC Arnold","year":"2013","unstructured":"Arnold MC, Badireddy AR, Wiesner MR, Di Giulio RT, Meyer JN (2013) Cerium oxide nanoparticles are more toxic than equimolar bulk cerium oxide in Caenorhabditis elegans. Arch Environ Contam Toxicol 65(2):224\u2013233","journal-title":"Arch Environ Contam Toxicol"},{"issue":"2","key":"9991_CR4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/path.2098","volume":"211","author":"L Baumann","year":"2007","unstructured":"Baumann L (2007) Skin ageing and its treatment. J Pathol 211(2):241\u2013251","journal-title":"J Pathol"},{"issue":"11","key":"9991_CR5","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1897\/02-573","volume":"22","author":"WA Boyd","year":"2003","unstructured":"Boyd WA, Willams PL (2003) Comparison of the sensitivity of three nematode species to copper and their utility in aquatic and soil toxicity tests. Environ Toxicol Chem 22(11):2768\u20132774","journal-title":"Environ Toxicol Chem"},{"issue":"12","key":"9991_CR6","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1897\/02-565","volume":"22","author":"WA Boyd","year":"2003","unstructured":"Boyd WA, Cole RD, Anderson GL, Williams PL (2003) The effects of metals and food availability on the behavior of Caenorhabditis elegans. Environ Toxicol Chem 22(12):3049\u20133055","journal-title":"Environ Toxicol Chem"},{"key":"9991_CR7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","volume":"77","author":"S Brenner","year":"1974","unstructured":"Brenner S (1974) The genetics of Caenorhabidits elegans. Genetics 77:71\u201394","journal-title":"Genetics"},{"issue":"2","key":"9991_CR8","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00244-012-9835-7","volume":"64","author":"QL Chen","year":"2013","unstructured":"Chen QL, Luo Z, Liu X, Song YF, Liu CX, Zheng JL et al (2013) Effects of waterborne chronic copper exposure on hepatic lipid metabolism and metal-element composition in Synechogobius hasta. Arch Environ Contam Toxicol 64(2):301\u2013315","journal-title":"Arch Environ Contam Toxicol"},{"issue":"6","key":"9991_CR9","first-page":"879","volume":"1","author":"AD Chisholm","year":"2012","unstructured":"Chisholm AD, Xu S (2012) The Caenorhabditis elegans epidermis as a model skin. II: differentiation and physiological roles. Wiley interdisciplinary reviews. Dev Biol 1(6):879\u2013902","journal-title":"Dev Biol"},{"issue":"4","key":"9991_CR10","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.aquatox.2005.06.006","volume":"74","author":"KW Chu","year":"2005","unstructured":"Chu KW, Chan SK, Chow KL (2005) Improvement of heavy metal stress and toxicity assays by coupling a transgenic reporter in a mutant nematode strain. Aquat Toxicol 74(4):320\u2013332","journal-title":"Aquat Toxicol"},{"issue":"1","key":"9991_CR11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1083\/jcb.90.1.7","volume":"90","author":"GN Cox","year":"1981","unstructured":"Cox GN, Kusch M, Edgar RS (1981) Cuticle of Caenorhabditis elegans: its isolation and partial characterization. J Cell Biol 90(1):7\u201317","journal-title":"J Cell Biol"},{"issue":"9","key":"9991_CR12","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1177\/0748233711422735","volume":"28","author":"JVD Olivera De","year":"2012","unstructured":"De Olivera JVD, Boufleur LA, Santos CEID, Dias JF, Squeff CH, Silva GRG et al (2012) Occupational genotoxicity among copper smelters. Toxicol Ind Health 28(9):789\u2013795","journal-title":"Toxicol Ind Health"},{"issue":"2","key":"9991_CR13","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF00212125","volume":"25","author":"SG Donkin","year":"1993","unstructured":"Donkin SG, Dusenbery DB (1993) A soil toxicity test using the nematode Caenorhabditis elegans and an effective method of recovery. Arch Environ Contam Toxicol 25(2):145\u2013151","journal-title":"Arch Environ Contam Toxicol"},{"issue":"12","key":"9991_CR14","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1002\/etc.5620141218","volume":"14","author":"SG Donkin","year":"1995","unstructured":"Donkin SG, Williams PL (1995) Influence of developmental stage, salts and food presence on various end points using Caenorhabditis elegans for aquatic toxicity testing. Environ Toxicol Chem 14(12):2139\u20132147","journal-title":"Environ Toxicol Chem"},{"key":"9991_CR15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0092-8674(00)80399-2","volume":"91","author":"RT Emily","year":"1997","unstructured":"Emily RT, Bruce EK, Bargmann CI (1997) Reprogramming chemotaxis responses: sensory neurons define olfactory preferences in C. elegans. Cell 91:161\u2013169","journal-title":"Cell"},{"issue":"6","key":"9991_CR16","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1021\/cr040410w","volume":"106","author":"E Gaggelli","year":"2006","unstructured":"Gaggelli E, Kozlowski H, Valensin D, Valensin G (2006) Copper homeostasis and neurodegenerative disorders (Alzheimer\u2019s, prion, and Parkinson\u2019s diseases and amyotrophic lateral sclerosis). Chem Rev 106(6):1995\u20132044","journal-title":"Chem Rev"},{"issue":"2","key":"9991_CR17","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/0012-1606(84)90201-X","volume":"102","author":"JW Golden","year":"1984","unstructured":"Golden JW, Riddle DL (1984) The Caenorhabditis elegans dauer larva: developmental effects of pheromone, food, and temperature. Dev Biol 102(2):368\u2013378","journal-title":"Dev Biol"},{"issue":"4","key":"9991_CR18","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s00244-004-0031-2","volume":"48","author":"A Graves","year":"2005","unstructured":"Graves A, Boyd W, Williams P (2005) Using transgenic Caenorhabditis elegans in soil toxicity testing. Arch Environ Contam Toxicol 48(4):490\u2013494","journal-title":"Arch Environ Contam Toxicol"},{"key":"9991_CR19","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ecoenv.2006.02.017","volume":"66","author":"H Harada","year":"2007","unstructured":"Harada H, Kurauchi M, Hayashi R, Eki T (2007) Shortened lifespan of nematode Caenorhabditis elegans after prolonged exposure to heavy metals and detergents. Ecotoxicol Environ Safe 66:378\u2013383","journal-title":"Ecotoxicol Environ Safe"},{"issue":"2","key":"9991_CR20","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s00244-007-9017-1","volume":"54","author":"S Hashemi","year":"2008","unstructured":"Hashemi S, Blust R, De Boeck G (2008) Combined effects of different food rations and sublethal copper exposure on growth and energy metabolism in common carp. Arch Environ Contam Toxicol 54(2):318\u2013324","journal-title":"Arch Environ Contam Toxicol"},{"key":"9991_CR21","unstructured":"Hedges KA (2010) Copper exposure damages neurons and induces paralysis in the nematode, Caenorhabditis elegans, far below lethal concentrations. Master\u2019s thesis, Humboldt State University, Arcata, CA"},{"key":"9991_CR22","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1081\/CLT-120037433","volume":"42","author":"WH Huang","year":"2004","unstructured":"Huang WH, Lin JL (2004) Acute renal failure following ingestion of manganses containing fertilizer. J Toxicol Clin Toxicol 42:305\u2013307","journal-title":"J Toxicol Clin Toxicol"},{"issue":"15","key":"9991_CR23","doi-asserted-by":"crossref","first-page":"5620","DOI":"10.1021\/es050154k","volume":"39","author":"BP Jackson","year":"2005","unstructured":"Jackson BP, Williams PL, Lanzirotti A, Bertsch PM (2005) Evidence for biogenic pyromorphite formation by the nematode Caenorhabditis elegans. Environ Sci Technol 39(15):5620\u20135625","journal-title":"Environ Sci Technol"},{"issue":"2\u20133","key":"9991_CR24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tox.2011.03.001","volume":"283","author":"K Jomova","year":"2011","unstructured":"Jomova K, Valko M (2011) Advances in metal-induced oxidative stress and human disease. Toxicology 283(2\u20133):65\u201387","journal-title":"Toxicology"},{"issue":"1","key":"9991_CR25","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s002449900162","volume":"32","author":"N Khanna","year":"1996","unstructured":"Khanna N, Cressman CP III, Tatara CP, Williams PL (1996) Tolerance of the nematode Caenorhabditis elegans to pH, salinity, and hardness in aquatic media. Arch Environ Contam Toxicol 32(1):110\u2013114","journal-title":"Arch Environ Contam Toxicol"},{"key":"9991_CR26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/toxsci\/kfn121","volume":"106","author":"MCK Leung","year":"2008","unstructured":"Leung MCK, Williams PL, Benedetto A, Au C, Helmke KJ, Aschner M et al (2008) Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. Toxicol Sci 106:5\u201328","journal-title":"Toxicol Sci"},{"issue":"2","key":"9991_CR27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s12264-011-1152-z","volume":"27","author":"YX Li","year":"2011","unstructured":"Li YX, Wang Y, Hu YO, Zhong JX, Wang DY (2011) Modulation of the assay system for the sensory integration of 2 sensory stimuli that inhibit each other in nematode Caenorhabditis elegans. Neurosci Bull 27(2):69\u201382","journal-title":"Neurosci Bull"},{"issue":"6","key":"9991_CR28","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1897\/08-496.1","volume":"28","author":"H Ma","year":"2009","unstructured":"Ma H, Glenn TC, Jagoe CH, Jones KL, Williams PL (2009) A transgenic strain of the nematode Caenorhabditis elegans as a biomonitor for heavy metal contamination. Environ Toxicol Chem 28(6):1311\u20131318","journal-title":"Environ Toxicol Chem"},{"issue":"2","key":"9991_CR29","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jdermsci.2010.03.003","volume":"58","author":"H Masaki","year":"2010","unstructured":"Masaki H (2010) Role of antioxidants in the skin: anti-aging effects. J Dermatol Sci 58(2):85\u201390","journal-title":"J Dermatol Sci"},{"issue":"22","key":"9991_CR30","doi-asserted-by":"crossref","first-page":"8189","DOI":"10.1128\/AEM.06357-11","volume":"77","author":"T Mosser","year":"2011","unstructured":"Mosser T, Matic I, Leroy M (2011) Bacterium-induced internal egg hatching frequency is predictive of life span in Caenorhabditis elegans populations. Appl Environ Microbiol 77(22):8189\u20138192","journal-title":"Appl Environ Microbiol"},{"issue":"1","key":"9991_CR31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s002440010086","volume":"39","author":"CL Peredney","year":"2000","unstructured":"Peredney CL, Williams PL (2000) Utility of Caenorhabditis elegans for assessing heavy metal contamination in artificial soil. Arch Environ Contam Toxicol 39(1):113\u2013118","journal-title":"Arch Environ Contam Toxicol"},{"issue":"3","key":"9991_CR32","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s00244-008-9231-5","volume":"56","author":"E Rogevich","year":"2009","unstructured":"Rogevich E, Hoang T, Rand G (2009) Effects of sublethal chronic copper exposure on the growth and reproductive success of the Florida apple snail (Pomacea\u00a0paludosa). Arch Environ Contam Toxicol 56(3):450\u2013458","journal-title":"Arch Environ Contam Toxicol"},{"key":"9991_CR33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/375073a0","volume":"375","author":"WR Schafer","year":"1995","unstructured":"Schafer WR, Kenyon CJ (1995) A calcium-channel homologue required for adaptation to dopamine and serotonin in Caenorhabditis elegans. Nature 375:73\u201378","journal-title":"Nature"},{"issue":"5","key":"9991_CR34","first-page":"832","volume":"27","author":"S Song","year":"2008","unstructured":"Song S, Guo Y, Yin K, Wu H, Zhang X, Yang M et al (2008) Copper on long-term role of nematode physiological characteristics. Sichuan J Zool 27(5):832\u2013834","journal-title":"Sichuan J Zool"},{"issue":"2","key":"9991_CR35","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s00244-007-9028-y","volume":"54","author":"S Subathra","year":"2008","unstructured":"Subathra S, Karuppasamy R (2008) Bioaccumulation and depuration pattern of copper in different tissues of mystus vittatus related to various size groups. Arch Environ Contam Toxicol 54(2):236\u2013244","journal-title":"Arch Environ Contam Toxicol"},{"issue":"4","key":"9991_CR36","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/genetics\/104.4.619","volume":"104","author":"C Trent","year":"1983","unstructured":"Trent C, Tsung N, Horvitz HR (1983) Egg-laying defective mutant of the nematode Caenorhabditis elegans. Genetics 104(4):619\u2013647","journal-title":"Genetics"},{"issue":"2","key":"9991_CR37","first-page":"10","volume":"7","author":"Y Wang","year":"2007","unstructured":"Wang Y, Wang DY (2007) Copper exposure causes transferable defects of phenotypes and behaviors in C. elegans. J Saf Environ 7(2):10\u201314","journal-title":"J Saf Environ"},{"issue":"3","key":"9991_CR38","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00244-007-9050-0","volume":"54","author":"DY Wang","year":"2008","unstructured":"Wang DY, Wang Y (2008) Phenotypic and behavioral defects caused by barium exposure in nematode Caenorhabditis elegans. Arch Environ Contam Toxicol 54(3):447\u2013453","journal-title":"Arch Environ Contam Toxicol"},{"issue":"2","key":"9991_CR39","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cbi.2009.03.012","volume":"180","author":"S Wang","year":"2009","unstructured":"Wang S, Wu L, Wang Y, Luo X, Lu Y (2009) Copper-induced germline apoptosis in Caenorhabditis elegans: the independent roles of DNA damage response signaling and the dependent roles of MAPK cascades. Chem Biol Interact 180(2):151\u2013157","journal-title":"Chem Biol Interact"},{"issue":"10","key":"9991_CR40","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1897\/1552-8618(1990)9[1285:ATTUTN]2.0.CO;2","volume":"9","author":"PL Williams","year":"1990","unstructured":"Williams PL, Dusenbery DB (1990a) Aquatic toxicity testing using the nematode, Caenorhabditis elegans. Environ Toxicol Chem 9(10):129\u20131285","journal-title":"Environ Toxicol Chem"},{"key":"9991_CR41","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1177\/074823379000600306","volume":"6","author":"PL Williams","year":"1990","unstructured":"Williams PL, Dusenbery DB (1990b) A promising indicator of neurobehavioural toxicology using the nematode Caenorhabditis elegans and computer tracking. Toxicol Ind Health 6:425\u2013440","journal-title":"Toxicol Ind Health"},{"key":"9991_CR42","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/S1001-0742(08)62474-2","volume":"21","author":"XJ Xing","year":"2009","unstructured":"Xing XJ, Du M, Zhang YF, Wang DY (2009) Adverse effects of metal exposure on chemotaxis towards water-soluble attractants regulated mainly by ASE sensory neuron in nematode Caenorhabditis elegans. J Environ Sci 21:1684\u20131694","journal-title":"J Environ Sci"},{"issue":"11","key":"9991_CR43","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.resconrec.2010.02.005","volume":"54","author":"X Xiong","year":"2010","unstructured":"Xiong X, Yanxia L, Wei L, Chunye L, Wei H, Ming Y (2010) Copper content in animal manures and potential risk of soil copper pollution with animal manure use in agriculture. Resour Conserv Recycl 54(11):985\u2013990","journal-title":"Resour Conserv Recycl"},{"issue":"2","key":"9991_CR44","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s10933-010-9413-9","volume":"44","author":"H Yan","year":"2010","unstructured":"Yan H, Sun L, Wang Y, Liu X, Qiu S, Cheng W (2010) A 2000-year record of copper pollution in South China Sea derived from seabird excrements: a potential indicator for copper production and civilization of China. J Paleolimnol 44(2):431\u2013442","journal-title":"J Paleolimnol"},{"issue":"11","key":"9991_CR45","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.chemosphere.2012.02.029","volume":"87","author":"ZY Yu","year":"2012","unstructured":"Yu ZY, Zhang J, Yin DQ (2012) Toxic and recovery effects of copper on Caenorhabditis elegans by various food-borne and water-borne pathways. Chemosphere 87(11):1361\u20131367","journal-title":"Chemosphere"},{"issue":"1","key":"9991_CR46","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00244-009-9456-y","volume":"59","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Ye B, Wang D (2010) Effects of metal exposure on associative learning behavior in nematode Caenorhabditis elegans. Arch Environ Contam Toxicol 59(1):129\u2013136","journal-title":"Arch Environ Contam Toxicol"},{"key":"9991_CR47","doi-asserted-by":"crossref","first-page":"5741","DOI":"10.1039\/c2ra22798c","volume":"3","author":"YL Zhao","year":"2013","unstructured":"Zhao YL, Wu QL, Li YP, Wang DY (2013) Translocation, transfer, and in vivo safety evaluation of engineered nanomaterials in the non-mammalian alternative toxicity assay model of nematode Caenorhabditis elegans. RSC Adv 3:5741\u20135757","journal-title":"RSC Adv"}],"container-title":["Archives of Environmental Contamination and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00244-013-9991-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00244-013-9991-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00244-013-9991-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T15:01:43Z","timestamp":1648134103000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00244-013-9991-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,29]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["9991"],"URL":"https:\/\/doi.org\/10.1007\/s00244-013-9991-4","relation":{},"ISSN":["0090-4341","1432-0703"],"issn-type":[{"value":"0090-4341","type":"print"},{"value":"1432-0703","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,29]]}}}