{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T19:06:52Z","timestamp":1782587212899,"version":"3.54.5"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Environ Contam Toxicol"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s00244-022-00955-2","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T13:02:51Z","timestamp":1662555771000},"page":"201-213","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Endocrine-Disrupting Chemicals Exposure Alter Neuroendocrine Factors, Disrupt Cardiac Functions and Provokes Hypoxia Conditions in Zebrafish Model"],"prefix":"10.1007","volume":"83","author":[{"given":"Sweta","family":"Thakkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barathi","family":"Seetharaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamsini","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7730-0728","authenticated-orcid":false,"given":"Ramasamy","family":"Vasantharekha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"955_CR1","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1242\/jcs.035022","volume":"122","author":"MC Brahimi-Horn","year":"2009","unstructured":"Brahimi-Horn MC, Pouyss\u00e9gur J (2009) HIF at a glance. J Cell Sci 122:1055\u20131057. https:\/\/doi.org\/10.1242\/jcs.035022","journal-title":"J Cell Sci"},{"key":"955_CR2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cbpc.2015.06.006","volume":"174\u2013175","author":"AD Cypher","year":"2015","unstructured":"Cypher AD, Ickes JR, Bagatto B (2015) Bisphenol A alters the cardiovascular response to hypoxia in danio rerio embryos. Comp Biochem Physiol Part - C Toxicol Pharmacol 174\u2013175:39\u201345. https:\/\/doi.org\/10.1016\/j.cbpc.2015.06.006","journal-title":"Comp Biochem Physiol Part - C Toxicol Pharmacol"},{"key":"955_CR3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ecoenv.2017.02.048","volume":"141","author":"VY Dambal","year":"2017","unstructured":"Dambal VY, Selvan KP, Lite C et al (2017) Developmental toxicity and induction of vitellogenin in embryo-larval stages of zebrafish (danio rerio) exposed to methyl Paraben. Ecotoxicol Environ Saf 141:113\u2013118. https:\/\/doi.org\/10.1016\/j.ecoenv.2017.02.048","journal-title":"Ecotoxicol Environ Saf"},{"key":"955_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1002\/jat.958","volume":"24","author":"PD Darbre","year":"2004","unstructured":"Darbre PD, Aljarrah A, Miller WR et al (2004) Concentrations of parabens in human breast tumours. J Appl Toxicol 24:5\u201313. https:\/\/doi.org\/10.1002\/jat.958","journal-title":"J Appl Toxicol"},{"key":"955_CR5","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1111\/j.1600-0625.2007.00625.x","volume":"16","author":"S El Hussein","year":"2007","unstructured":"El Hussein S, Muret P, Berard M et al (2007) Assessment of principal parabens used in cosmetics after their passage through human epidermis? Dermis layers (ex-vivo study). Exp Dermatol 16:830\u2013836. https:\/\/doi.org\/10.1111\/j.1600-0625.2007.00625.x","journal-title":"Exp Dermatol"},{"key":"955_CR6","unstructured":"FAO\/WHO WHO | Toxicological and health aspects of bisphenol A"},{"key":"955_CR7","doi-asserted-by":"publisher","first-page":"29341","DOI":"10.1007\/s11356-020-09318-7","volume":"27","author":"L Fenske","year":"2020","unstructured":"Fenske L, Concato AC, Vanin AP et al (2020) 17-\u03b1-Ethinylestradiol modulates endocrine and behavioral responses to stress in zebrafish. Environ Sci Pollut Res 27:29341\u201329351. https:\/\/doi.org\/10.1007\/s11356-020-09318-7","journal-title":"Environ Sci Pollut Res"},{"key":"955_CR8","doi-asserted-by":"publisher","first-page":"8399","DOI":"10.3390\/ijerph110808399","volume":"11","author":"X Gao","year":"2014","unstructured":"Gao X, Wang H-S (2014) Impact of bisphenol A on the cardiovascular system \u2014 epidemiological and experimental evidence and molecular mechanisms. Int J Environ Res Public Health 11:8399\u20138413. https:\/\/doi.org\/10.3390\/ijerph110808399","journal-title":"Int J Environ Res Public Health"},{"key":"955_CR9","doi-asserted-by":"publisher","first-page":"17329","DOI":"10.1007\/s11356-020-08232-2","volume":"27","author":"E Gyimah","year":"2020","unstructured":"Gyimah E, Dong X, Qiu W et al (2020) Sublethal concentrations of triclosan elicited oxidative stress, DNA damage, and histological alterations in the liver and brain of adult zebrafish. Environ Sci Pollut Res 27:17329\u201317338. https:\/\/doi.org\/10.1007\/s11356-020-08232-2","journal-title":"Environ Sci Pollut Res"},{"key":"955_CR10","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jprot.2018.07.006","volume":"186","author":"KA Horzmann","year":"2018","unstructured":"Horzmann KA, Reidenbach LS, Thanki DH et al (2018) Embryonic atrazine exposure elicits proteomic, behavioral, and brain abnormalities with developmental time specific gene expression signatures. J Proteomics 186:71\u201382. https:\/\/doi.org\/10.1016\/j.jprot.2018.07.006","journal-title":"J Proteomics"},{"key":"955_CR11","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1812","author":"J Hu","year":"2020","unstructured":"Hu J, Xia M, Wang Y et al (2020) Paternal exposure to di-n-butyl-phthalate induced developmental toxicity in zebrafish (danio rerio). Birth Defects Res. https:\/\/doi.org\/10.1002\/bdr2.1812","journal-title":"Birth Defects Res"},{"key":"955_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.124751","author":"SKSS Kim","year":"2020","unstructured":"Kim SKSS, Hwang KS, Yang JY et al (2020) Neurochemical and behavioral analysis by acute exposure to bisphenol A in zebrafish larvae model. Chemosphere. https:\/\/doi.org\/10.1016\/j.chemosphere.2019.124751","journal-title":"Chemosphere"},{"key":"955_CR13","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.bbrc.2004.04.125","volume":"318","author":"T Kubo","year":"2004","unstructured":"Kubo T, Maezawa N, Osada M et al (2004) Bisphenol A, an environmental endocrine-disrupting chemical, inhibits hypoxic response via degradation of hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1): Structural requirement of bisphenol A for degradation of HIF-1\u03b1. Biochem Biophys Res Commun 318:1006\u20131011. https:\/\/doi.org\/10.1016\/j.bbrc.2004.04.125","journal-title":"Biochem Biophys Res Commun"},{"key":"955_CR14","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.ygcen.2018.11.001","volume":"279","author":"G Luzeena Raja","year":"2019","unstructured":"Luzeena Raja G, Divya Subhashree K, Lite C et al (2019) Transient exposure of methylparaben to zebrafish (danio rerio) embryos altered cortisol level, acetylcholinesterase activity and induced anxiety-like behaviour. Comp EndocrinoGenerallogy 279:53\u201359. https:\/\/doi.org\/10.1016\/j.ygcen.2018.11.001","journal-title":"Comp EndocrinoGenerallogy"},{"key":"955_CR15","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1097\/JOM.0000000000000183","volume":"56","author":"JK MacIsaac","year":"2014","unstructured":"MacIsaac JK, Gerona RR, Blanc PD et al (2014) Health care worker exposures to the antibacterial agent triclosan. J Occup Environ Med 56:834\u2013839. https:\/\/doi.org\/10.1097\/JOM.0000000000000183","journal-title":"J Occup Environ Med"},{"key":"955_CR16","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1289\/ehp.6961","volume":"112","author":"T Negishi","year":"2004","unstructured":"Negishi T, Kawasaki K, Suzaki S et al (2004) Behavioral alterations in response to fear-provoking stimuli and tranylcypromine induced by perinatal exposure to bisphenol A and nonylphenol in male rats. Environ Health Perspect 112:1159\u20131164. https:\/\/doi.org\/10.1289\/ehp.6961","journal-title":"Environ Health Perspect"},{"key":"955_CR17","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.yhbeh.2017.12.001","volume":"101","author":"D Nesan","year":"2018","unstructured":"Nesan D, Sewell LC, Kurrasch DM (2018) Opening the black box of endocrine disruption of brain development: Lessons from the characterization of bisphenol A. Horm Behav 101:50\u201358","journal-title":"Horm Behav"},{"key":"955_CR18","unstructured":"NTP (2008) NTP-CERHR monograph on the potential human reproductive and developmental effects of bisphenol A"},{"key":"955_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-3287-x","author":"LWB Olaniyan","year":"2016","unstructured":"Olaniyan LWB, Mkwetshana N, Okoh AI (2016) Triclosan in water, implications for human and environmental health. Springerplus. https:\/\/doi.org\/10.1186\/s40064-016-3287-x","journal-title":"Springerplus"},{"key":"955_CR20","unstructured":"Efsa Draft Scientific Opinion on the risks to public health related to the presence of bisphenol A in foodstuffs-part exposure assessment"},{"key":"955_CR21","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.envres.2008.07.023","volume":"108","author":"P Palanza","year":"2008","unstructured":"Palanza P, Gioiosa L, vom Saal FS, Parmigiani S (2008) Effects of developmental exposure to bisphenol A on brain and behavior in mice. Environ Res 108:150\u2013157","journal-title":"Environ Res"},{"key":"955_CR22","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1002\/jat.1647","volume":"31","author":"J Pant","year":"2011","unstructured":"Pant J, Ranjan P, Deshpande SB (2011) Bisphenol A decreases atrial contractility involving NO-dependent G-cyclase signaling pathway. J Appl Toxicol 31:698\u2013702. https:\/\/doi.org\/10.1002\/jat.1647","journal-title":"J Appl Toxicol"},{"key":"955_CR23","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.cmet.2006.01.012","volume":"3","author":"I Papandreou","year":"2006","unstructured":"Papandreou I, Cairns RA, Fontana L et al (2006) HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 3:187\u2013197. https:\/\/doi.org\/10.1016\/j.cmet.2006.01.012","journal-title":"Cell Metab"},{"key":"955_CR24","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1016\/j.scitotenv.2018.09.283","volume":"650","author":"CC Parenti","year":"2019","unstructured":"Parenti CC, Ghilardi A, Della Torre C et al (2019) Environmental concentrations of triclosan activate cellular defence mechanism and generate cytotoxicity on zebrafish (Danio rerio) embryos. Sci Total Environ 650:1752\u20131758. https:\/\/doi.org\/10.1016\/j.scitotenv.2018.09.283","journal-title":"Sci Total Environ"},{"key":"955_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2019.06.006","author":"K Pelch","year":"2019","unstructured":"Pelch K, Wignall JA, Goldstone AE et al (2019) A scoping review of the health and toxicological activity of bisphenol A (BPA) structural analogues and functional alternatives. Toxicology. https:\/\/doi.org\/10.1016\/j.tox.2019.06.006","journal-title":"Toxicology"},{"key":"955_CR26","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8416763","author":"G Pizzino","year":"2017","unstructured":"Pizzino G, Irrera N, Cucinotta M et al (2017) Oxidative Stress: harms and benefits for human health. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2017\/8416763","journal-title":"Oxid Med Cell Longev"},{"key":"955_CR27","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.tox.2011.11.001","volume":"291","author":"KS Saili","year":"2012","unstructured":"Saili KS, Corvi MM, Weber DN et al (2012) Neurodevelopmental low-dose bisphenol A exposure leads to early life-stage hyperactivity and learning deficits in adult zebrafish. Toxicology 291:83\u201392. https:\/\/doi.org\/10.1016\/j.tox.2011.11.001","journal-title":"Toxicology"},{"key":"955_CR28","doi-asserted-by":"publisher","first-page":"141633","DOI":"10.1016\/j.scitotenv.2020.141633","volume":"750","author":"A Salahinejad","year":"2021","unstructured":"Salahinejad A, Attaran A, Naderi M et al (2021) Chronic exposure to bisphenol S induces oxidative stress, abnormal anxiety, and fear responses in adult zebrafish (danio rerio). Sci Total Environ 750:141633. https:\/\/doi.org\/10.1016\/j.scitotenv.2020.141633","journal-title":"Sci Total Environ"},{"key":"955_CR29","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1016\/j.chemosphere.2011.07.048","volume":"85","author":"MP S\u00e1rria","year":"2011","unstructured":"S\u00e1rria MP, Soares J, Vieira MN et al (2011) Rapid-behaviour responses as a reliable indicator of estrogenic chemical toxicity in zebrafish juveniles. Chemosphere 85:1543\u20131547. https:\/\/doi.org\/10.1016\/j.chemosphere.2011.07.048","journal-title":"Chemosphere"},{"key":"955_CR30","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.envint.2014.03.018","volume":"68","author":"Q Song","year":"2014","unstructured":"Song Q, Li J (2014) A systematic review of the human body burden of e-waste exposure in China. Environ Int 68:82\u201393","journal-title":"Environ Int"},{"key":"955_CR31","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-06878-w","author":"S Thakkar","year":"2021","unstructured":"Thakkar S, Seetharaman B, Ramasamy V (2021) Impact of chronic sub-lethal methylparaben exposure on cardiac hypoxia and alterations in neuroendocrine factors in zebrafish model. Mol Biol Rep. https:\/\/doi.org\/10.1007\/s11033-021-06878-w","journal-title":"Mol Biol Rep"},{"key":"955_CR32","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.fct.2016.03.027","volume":"98","author":"SE Wirbisky","year":"2016","unstructured":"Wirbisky SE, Weber GJ, Schlotman KE et al (2016) Embryonic atrazine exposure alters zebrafish and human miRNAs associated with angiogenesis, cancer, and neurodevelopment. Food Chem Toxicol 98:25\u201333. https:\/\/doi.org\/10.1016\/j.fct.2016.03.027","journal-title":"Food Chem Toxicol"},{"key":"955_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2020.105469","author":"S Xu","year":"2020","unstructured":"Xu S, Zhang H, Pao PC et al (2020) Exposure to phthalates impaired neurodevelopment through estrogenic effects and induced DNA damage in neurons. Aquat Toxicol. https:\/\/doi.org\/10.1016\/j.aquatox.2020.105469","journal-title":"Aquat Toxicol"},{"key":"955_CR34","doi-asserted-by":"publisher","first-page":"113627","DOI":"10.1016\/j.envpol.2019.113627","volume":"257","author":"J Zhao","year":"2020","unstructured":"Zhao J, Zhang Q, Zhang B et al (2020) Developmental exposure to lead at environmentally relevant concentrations impaired neurobehavior and NMDAR-dependent BDNF signaling in zebrafish larvae. Environ Pollut 257:113627. https:\/\/doi.org\/10.1016\/j.envpol.2019.113627","journal-title":"Environ Pollut"},{"key":"955_CR35","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/j.scitotenv.2017.11.317","volume":"622\u2013623","author":"L Zhu","year":"2018","unstructured":"Zhu L, Shao Y, Xiao H et al (2018) Electrochemical simulation of triclosan metabolism and toxicological evaluation. Sci Total Environ 622\u2013623:1193\u20131201. https:\/\/doi.org\/10.1016\/j.scitotenv.2017.11.317","journal-title":"Sci Total Environ"}],"container-title":["Archives of Environmental Contamination and Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00244-022-00955-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00244-022-00955-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00244-022-00955-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T08:11:16Z","timestamp":1665562276000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00244-022-00955-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,7]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["955"],"URL":"https:\/\/doi.org\/10.1007\/s00244-022-00955-2","relation":{},"ISSN":["0090-4341","1432-0703"],"issn-type":[{"value":"0090-4341","type":"print"},{"value":"1432-0703","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,7]]},"assertion":[{"value":"14 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no potential conflict of interest concerning the research, authorship, and\/or publication of this article. All authors read and approved the final manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This article does not contain any studies involving human participants and\/or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human or Animal Rights"}},{"value":"Informed consent was obtained from all authors included in the manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}