{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:39:06Z","timestamp":1791142746062,"version":"4.1.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T00:00:00Z","timestamp":1423612800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1007\/s00246-015-1101-0","type":"journal-article","created":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T13:55:09Z","timestamp":1423576509000},"page":"887-895","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Aortic Involvement in Pediatric Marfan syndrome: A Review"],"prefix":"10.1007","volume":"36","author":[{"given":"Omonigho","family":"Ekhomu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra J.","family":"Naheed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,2,11]]},"reference":[{"key":"1101_CR1","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1016\/S0140-6736(05)79822-6","volume":"352","author":"JN Adams","year":"1998","unstructured":"Adams JN, Trent RJ (1998) Aortic complications of Marfan\u2019s syndrome. Lancet 352:1722\u20131723","journal-title":"Lancet"},{"key":"1101_CR2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1042\/0264-6021:3400171","volume":"340","author":"JL Ashworth","year":"1999","unstructured":"Ashworth JL, Murphy G, Rock MJ, Sherratt MJ (1999) Fibrillin degradation by matrix metalloproteinases: implication for connective tissue remodelling. Biochem J 340:171\u2013181","journal-title":"Biochem J"},{"key":"1101_CR3","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.jtcvs.2004.07.019","volume":"129","author":"D Baumgartner","year":"2005","unstructured":"Baumgartner D, Baumgartner C, Matayas G, Steinmann B et al (2005) Diagnostic power of aortic elastic properties in young patients with Marfan syndrome. J Thorac Cardiovasc Surg 129:730\u2013739","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1101_CR4","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00059-006-2836-4","volume":"31","author":"JFM Bechtel","year":"2006","unstructured":"Bechtel JFM, Erasmi AW, Misfeld M, Sievers H (2006) Reconstructive surgery of the aortic valve: the Ross, David, and Yacoub procedures. Herz 31:413\u2013422","journal-title":"Herz"},{"key":"1101_CR5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1651-2227.1999.tb01277.x","volume":"88","author":"D Bresters","year":"1999","unstructured":"Bresters D, Nikkels PGJ, Meijboom EJM, Hoorntje TM et al (1999) Clinical, pathological and molecular genetic findings in a case of neonatal Marfan syndrome. Acta Paediatr 88:98\u2013101","journal-title":"Acta Paediatr"},{"key":"1101_CR6","doi-asserted-by":"crossref","unstructured":"Brooke BS, Habashi JP, Judge DP et al (2008) Angiotensin II blockade and aortic-root dilation in Marfan\u2019s syndrome. N Engl J Med 358(26):2787\u20132795","DOI":"10.1056\/NEJMoa0706585"},{"key":"1101_CR7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1010-7940(03)00302-6","volume":"24","author":"T Carrel","year":"2003","unstructured":"Carrel T, Berdat P, Pavlovic M, Sukhanov S et al (2003) Surgery of the dilated aortic root and ascending aorta in pediatric patients: techniques and results. Eur J Cardiothorac Surg 24:249\u2013254","journal-title":"Eur J Cardiothorac Surg"},{"key":"1101_CR8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.mayocp.2012.11.005","volume":"88","author":"H Chiu","year":"2013","unstructured":"Chiu H, Wu M, Wang J, Lu C (2013) Losartan Added to \u00df-blockade therapy for aortic root dilation in Marfan syndrome: a randomized, open-label pilot study. Mayo Clin Proc 88:271\u2013276","journal-title":"Mayo Clin Proc"},{"key":"1101_CR9","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1242\/jcs.107.3.727","volume":"107","author":"EC Davis","year":"1994","unstructured":"Davis EC (1994) Immunolocalization of microfibril and microfibril-associated proteins in the subendothelial matrix of the developing mouse aorta. J Cell Sci 107:727\u2013736","journal-title":"J Cell Sci"},{"key":"1101_CR10","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.ijcard.2005.11.043","volume":"113","author":"A Della Corte","year":"2006","unstructured":"Della Corte A, Romano G, Tizzano F, Amarelli C et al (2006) Echocardiographic anatomy of ascending aorta dilatation: correlations with aortic valve morphology and function. Int J Cardiol 113:320\u2013326","journal-title":"Int J Cardiol"},{"key":"1101_CR11","unstructured":"Dietz HC (2011) Marfan syndrome. In: Pagon RA, Bird TD, Dolan CR, et al (eds) GeneReviews [Internet]. University of Washington, Seattle, WA, pp 1993\u20132011. Available from: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1335\/ . Accessed 9 Sept 2012"},{"key":"1101_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-0185(20000101)258:1<1::AID-AR1>3.0.CO;2-7","volume":"258","author":"KP Dingemans","year":"2000","unstructured":"Dingemans KP, Teeling P, Lagendijk JH, Becker AE (2000) Extracellular matrix of the human aortic media: an ultrastructural histochemical and immunohistochemical study of the adult aortic media. Anat Rec 258:1\u201314","journal-title":"Anat Rec"},{"issue":"3","key":"1101_CR13","first-page":"1","volume":"12","author":"H Elshershari","year":"2014","unstructured":"Elshershari H, Esseid M, Sueblinvong V, Harris C (2014) Angiotensin II receptor blocker slows the rate of progression of aortic root dilatation in Marfan syndrome: two case reports and review of the literature. Congenit Cardiol Today 12(3):1\u20133","journal-title":"Congenit Cardiol Today"},{"issue":"1","key":"1101_CR14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/hrt.2004.055111","volume":"92","author":"R Erbel","year":"2006","unstructured":"Erbel R, Eggebrecht H (2006) Aortic dimensions and the risk of dissection. Heart 92(1):137\u2013142","journal-title":"Heart"},{"key":"1101_CR15","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1542\/peds.2008-0703","volume":"123","author":"L Faivre","year":"2009","unstructured":"Faivre L, Masurel-Paulet A, Collod-B\u00e9roud G, Callewaert BL (2009) Clinical and molecular study of 320 children with Marfan syndrome and related type 1 fibrillinopathies in a series of 1009 probands with pathogenic FBN1 mutations. Pediatrics 123:391\u2013398","journal-title":"Pediatrics"},{"issue":"3","key":"1101_CR16","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0022-5223(03)00613-5","volume":"126","author":"PWM Fedak","year":"2003","unstructured":"Fedak PWM, de Sa MPL, Verma S, Nili N et al (2003) Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation. J Thorac Cardiovasc Surg 126(3):805\u2013806","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1101_CR17","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1111\/j.1651-2227.2011.02293.x","volume":"100","author":"L Gao","year":"2011","unstructured":"Gao L, Mao Q, Wen D, Zhang L et al (2011) The effect of beta-blocker therapy on progressive aortic dilatation in children and adolescents with Marfan\u2019s syndrome: a meta-analysis. Acta Paediatr 100:e101\u2013e105","journal-title":"Acta Paediatr"},{"key":"1101_CR18","doi-asserted-by":"crossref","unstructured":"Gersony DR, McClaughlin M, Zhezhen J, Gersony WM (2007) The effect of beta-blocker therapy on clinical outcome in patients with Marfan\u2019s syndrome: a meta-analysis. Int J Cardiol 303\u2013308","DOI":"10.1016\/j.ijcard.2005.11.116"},{"issue":"5770","key":"1101_CR19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1126\/science.1124287","volume":"312","author":"JP Habashi","year":"2006","unstructured":"Habashi JP, Judge DP, Holm TM, Cohn RD et al (2006) Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 312(5770):117\u2013121","journal-title":"Science"},{"issue":"5","key":"1101_CR20","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1517\/14656566.2012.665446","volume":"13","author":"AW Hartog","year":"2012","unstructured":"Hartog AW, Franken R, Zwinderman AH, Groenink M et al (2012) Current and future pharmacological treatment strategies with regard to aortic disease in Marfan syndrome. Expert Opin Pharmacother 13(5):647\u2013662","journal-title":"Expert Opin Pharmacother"},{"issue":"Suppl. 1","key":"1101_CR21","first-page":"I-365","volume":"114","author":"JS Ikonomidis","year":"2006","unstructured":"Ikonomidis JS, Jones JA, Barbour JR, Stroud RE et al (2006) Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Circulation. 114(Suppl. 1):I-365\u2013I-370","journal-title":"Circulation."},{"key":"1101_CR22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11886-010-0083-z","volume":"12","author":"JA Jones","year":"2010","unstructured":"Jones JA, Ikonomidis JS (2010) The pathogenesis of Aortopathy in Marfan syndrome and related diseases. Curr Cardiol Rep 12:99\u2013107","journal-title":"Curr Cardiol Rep"},{"key":"1101_CR23","doi-asserted-by":"crossref","unstructured":"Keane MG, Pyeritz RE (2008) Medical management of Marfan syndrome. Circulation\u00a0117:2802\u20132813","DOI":"10.1161\/CIRCULATIONAHA.107.693523"},{"key":"1101_CR24","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.echo.2009.06.002","volume":"22","author":"MS Kemna","year":"2009","unstructured":"Kemna MS, Murphy DJ, Silverman NH (2009) Screening for aortic root dilation in Marfan syndrome using the ratio of the aortic root to descending aortic diameters in children. J Am Soc Echocardiogr 22:1109\u20131113","journal-title":"J Am Soc Echocardiogr"},{"issue":"Suppl. 2","key":"1101_CR25","doi-asserted-by":"crossref","first-page":"S146","DOI":"10.1055\/s-2004-830455","volume":"53","author":"T Kraseman","year":"2005","unstructured":"Kraseman T, Kotthoff S, Kehl HG et al (2005) Cardiac transplantation in neonatal Marfan syndrome\u2014a life-saving approach. Thorac Cardiov Surg 53(Suppl. 2):S146\u2013S148","journal-title":"Thorac Cardiov Surg"},{"key":"1101_CR26","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.ahj.2013.02.019","volume":"165","author":"RV Lacro","year":"2013","unstructured":"Lacro RV, Guey LT, Dietz HC, Pearson GD (2013) Characteristics of children and young adults with Marfan syndrome and aortic root dilatation in a randomized trial comparing atenolol and losartan therapy. Am Heart J 165:828\u2013835","journal-title":"Am Heart J"},{"key":"1101_CR27","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.amjcard.2006.08.048","volume":"99","author":"M Ladouceur","year":"2007","unstructured":"Ladouceur M, Fermanian C, Lupoglazoff J, Edouard T et al (2007) Effect of beta-blockade on ascending aortic dilatation in children with the Marfan syndrome. Am J Cardiol 99:406\u2013409","journal-title":"Am J Cardiol"},{"key":"1101_CR28","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijcard.2005.01.040","volume":"106","author":"AM Lazarevic","year":"2006","unstructured":"Lazarevic AM, Nakatani S, Okita Y, Marinkovic J et al (2006) Determinants of rapid progression of aortic root dilatation and complications in Marfan syndrome. Int J Cardiol 106:177\u2013182","journal-title":"Int J Cardiol"},{"key":"1101_CR29","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/hrt.75.4.389","volume":"75","author":"ME Legget","year":"1996","unstructured":"Legget ME, Unger TA, O\u2019Sullivan CK, Zwink TR (1996) Aortic root complications in Marfan\u2019s syndrome: identification of a lower risk group. Heart 75:389\u2013395","journal-title":"Heart"},{"issue":"10","key":"1101_CR30","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1586\/erc.11.130","volume":"9","author":"RS Loomba","year":"2011","unstructured":"Loomba RS, Arora RR (2011) Role of angiotensin receptor blockers for management of aortic dilation associated with Marfan syndrome. Expert Rev Cardiovasc Ther 9(10):1257\u20131259","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"1101_CR31","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/0735-1097(89)90197-6","volume":"14","author":"DL Marsalese","year":"1989","unstructured":"Marsalese DL, Moodie DS, Vacante M, Lytle BW, Gill CC et al (1989) Marfan\u2019s syndrome: natural history and long-term follow-up of cardiovascular involvement. J Am Coll Cardiol 14:422\u2013428","journal-title":"J Am Coll Cardiol"},{"key":"1101_CR32","first-page":"888","volume":"86","author":"RP Morse","year":"1990","unstructured":"Morse RP, Rockenmacher S, Pyeritz RE, Sanders SP (1990) Diagnosis and management of infantile Marfan syndrome. Pediatrics 86:888\u2013895","journal-title":"Pediatrics"},{"key":"1101_CR33","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1136\/heartjnl-2013-304946","volume":"100","author":"GC Mueller","year":"2014","unstructured":"Mueller GC, Stierle L, Stark V, Steiner K et al (2014) Retrospective analysis of the effect of angiotensin II receptor blocker versus \u03b2-blocker on aortic root growth in paediatric patients with Marfan syndrome. Heart 100:214\u2013218","journal-title":"Heart"},{"key":"1101_CR34","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1186\/1745-6215-14-408","volume":"14","author":"MJ Mullen","year":"2013","unstructured":"Mullen MJ, Flather MD, Jin XY, Newman WG et al (2013) A prospective, randomized, placebo-controlled, double-blind, multicenter study of the effects of irbesartan on aortic dilatation in Marfan syndrome (AIMS trial): study protocol. Trials 14:408","journal-title":"Trials"},{"key":"1101_CR35","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1161\/01.CIR.103.3.393","volume":"103","author":"K Niwa","year":"2001","unstructured":"Niwa K, Perloff JK, Bhuta SM, Laks H et al (2001) Structural abnormalities of great arterial walls in congenital heart disease. Circulation 103:393\u2013400","journal-title":"Circulation"},{"key":"1101_CR36","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/j.athoracsur.2008.01.032","volume":"85","author":"ND Patel","year":"2008","unstructured":"Patel ND, Weiss ES, Alejo DE, Nwakanma LU et al (2008) Aortic root operations for Marfan syndrome: a comparison of the Bentall and valve-sparing procedures. Ann Thorac Surg 85:2003\u20132011","journal-title":"Ann Thorac Surg"},{"key":"1101_CR37","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1510\/icvts.2010.255596","volume":"12","author":"ND Patel","year":"2011","unstructured":"Patel ND, Arnaoutakis GJ, George TJ, Allen JG et al (2011) Valve-sparing aortic root replacement in children: intermediate-term results. Interact CardioVasc Thorac Surg 12:415\u2013419","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"1101_CR38","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.amjcard.2013.06.019","volume":"112","author":"C Pees","year":"2013","unstructured":"Pees C, Laccone F, Hagl M, DeBrauwer V (2013) Usefulness of Losartan on the size of the ascending aorta in an unselected cohort of children, adolescents, and young adults with Marfan syndrome. Am J Cardiol 112:1477\u20131483","journal-title":"Am J Cardiol"},{"key":"1101_CR39","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/ng1097-218","volume":"17","author":"L Pereira","year":"1997","unstructured":"Pereira L, Andrikopoulos K, Tian J, Lee SY et al (1997) Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome. Nat Genet 17(2):218\u2013222","journal-title":"Nat Genet"},{"issue":"8","key":"1101_CR40","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.echo.2008.02.006","volume":"21","author":"MD Pettersen","year":"2008","unstructured":"Pettersen MD, Wei D, Skeens M, Humes RA (2008) Regression equations for calculation of z-scores of cardiac structures in a large cohort of healthy infants, children, and adolescents: an echocardiographic study. J Am Soc Echocardiogr 21(8):922\u2013934","journal-title":"J Am Soc Echocardiogr"},{"key":"1101_CR41","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1136\/hrt.2008.160515","volume":"95","author":"RE Pyeritz","year":"2009","unstructured":"Pyeritz RE (2009) Marfan syndrome: 30\u00a0years of research equals 30\u00a0years of additional life expectancy. Heart 95:173\u2013175","journal-title":"Heart"},{"key":"1101_CR42","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.jtcvs.2012.05.038","volume":"144","author":"SS Rakhra","year":"2012","unstructured":"Rakhra SS, Brizard CP, d\u2019Udekem Y, Konstantinov IE (2012) Valve-sparing aortic root replacement in children. J Thorac Cardiovasc Surg 144:980\u2013981","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1101_CR43","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/S0003-4975(99)00437-3","volume":"67","author":"F Ramirez","year":"1999","unstructured":"Ramirez F, Pereira L (1999) Mutations of extracellular matrix components in vascular disease. Ann Thorac Surg 67:1857\u20131858","journal-title":"Ann Thorac Surg"},{"key":"1101_CR44","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00246-006-1378-0","volume":"27","author":"P Ramswamy","year":"2006","unstructured":"Ramswamy P, Lytrivi ID, Nguyen K, Gelb BD (2006) Neonatal Marfan syndrome. Pediatr Cardiol 27:763\u2013765","journal-title":"Pediatr Cardiol"},{"key":"1101_CR45","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/0735-1097(93)90559-J","volume":"22","author":"MJ Roman","year":"1993","unstructured":"Roman MJ, Rosen SE, Kramer-Fox R, Devereux RD (1993) Prognostic significance of the pattern of aortic root dilatation in the Marfan syndrome. J Am Coll Cardiol 22:1470\u20131476","journal-title":"J Am Coll Cardiol"},{"key":"1101_CR46","doi-asserted-by":"crossref","unstructured":"Rozendaal L, Blom NA, Hilhorst-Hofstee Y, Ten Harkel ADJ (2011) Dilatation of the great arteries in an infant with Marfan syndrome and ventricular septal defect. Case Rep Med 1\u20135","DOI":"10.1155\/2011\/172109"},{"key":"1101_CR47","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ijcard.2005.11.011","volume":"113","author":"M Ruzmetov","year":"2006","unstructured":"Ruzmetov M, Vijay P, Rodefeld MD, Turrentine MW et al (2006) Evolution of aortic valve replacement in children : a single experience. Int J Cardiol 113:194\u2013200","journal-title":"Int J Cardiol"},{"issue":"Suppl. 19","key":"1101_CR48","first-page":"II331","volume":"98","author":"AM Segura","year":"1998","unstructured":"Segura AM, Luna RE, Horiba K, Stetler-Stevenson WG et al (1998) Immunohistochemistry of matrix metalloproteinases and their inhibitors in thoracic aortic aneurysms and aortic valves of patients with Marfan\u2019s syndrome. Circulation 98(Suppl. 19):II331\u2013337","journal-title":"Circulation"},{"key":"1101_CR49","doi-asserted-by":"crossref","first-page":"330","DOI":"10.5761\/atcs.ra.11.01675","volume":"17","author":"H Shimizu","year":"2011","unstructured":"Shimizu H, Yozu R (2011) Valve-sparing aortic root replacement. Ann Thorac Cardiovasc Surg 17:330\u2013336","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"1101_CR50","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00246-006-0066-4","volume":"28","author":"S Strigl","year":"2007","unstructured":"Strigl S, Quagebeur JM, Gersony WM (2007) Quadrivalvar replacement in infantile Marfan syndrome. Pediatr Cardiol 28:403\u2013405","journal-title":"Pediatr Cardiol"},{"key":"1101_CR51","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s00059-010-3325-3","volume":"35","author":"S Subramanian","year":"2010","unstructured":"Subramanian S, Borger MA (2010) Aortic valve reconstruction: current status. Herz 35:88\u201393","journal-title":"Herz"},{"key":"1101_CR52","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jpeds.2006.09.003","volume":"150","author":"ESS Tierney","year":"2007","unstructured":"Tierney ESS, Feingold B, Printz BF, Park SC et al (2007) Beta-blocker therapy does not alter the rate of aortic root dilation in pediatric patients with Marfan syndrome. J Pediatr 150:77\u201382","journal-title":"J Pediatr"},{"key":"1101_CR53","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.athoracsur.2011.12.097","volume":"94","author":"JS Tweddell","year":"2012","unstructured":"Tweddell JS, Earing MG, Bartz PJ, Dunham-Ingles JL et al (2012) Valve-sparing aortic root reconstruction in children, teenagers and young adults. Ann Thorac Surg 94:587\u2013591","journal-title":"Ann Thorac Surg"},{"key":"1101_CR54","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1136\/adc.84.2.129","volume":"84","author":"CDM Karnebeek van","year":"2001","unstructured":"van Karnebeek CDM, Naeff MSJ, Mulder BJM, Hennekam RCM et al (2001) Natural history of cardiovascular manifestations in Marfan syndrome. Arch Dis Child 84:129\u2013137","journal-title":"Arch Dis Child"},{"key":"1101_CR55","first-page":"641","volume":"137","author":"IV Volguina","year":"2009","unstructured":"Volguina IV, Miller DC, LeMaire SA, Palmero LC et al (2009) Valve-sparing and valve-replacing techniques for aortic root replacement in patients with Marfan syndrome: analysis of early outcome. Int J Cardiol 137:641\u2013649","journal-title":"Int J Cardiol"},{"issue":"8","key":"1101_CR56","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1365-2362.2012.02668.x","volume":"42","author":"A Williams","year":"2012","unstructured":"Williams A, Kenny D, Wilson D, Fagenello G et al (2012) Effects of atenolol, perindopril and verapamil on haemodynamic and vascular formation in Marfan syndrome\u2014a randomised, double-blind, crossover trial. Eur J Clin Invest 42(8):891\u2013899","journal-title":"Eur J Clin Invest"},{"key":"1101_CR57","unstructured":"Wright MJ, Connolly HM, Otto CM, Yeon SB (2012) Genetics, clinical features, and diagnosis of Marfan syndrome and related disorders. (Uptodate)"},{"key":"1101_CR58","unstructured":"Wright MJ, Connolly HM, Otto CM, Yeon SB (2012) Management of Marfan syndrome and related disorders. (Uptodate)"},{"key":"1101_CR59","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jacc.2008.10.035","volume":"53","author":"AT Yetman","year":"2009","unstructured":"Yetman AT, Graham T (2009) The dilated aorta in patients with congenital cardiac defects. J Am Coll Cardiol 53:461\u2013467","journal-title":"J Am Coll Cardiol"},{"key":"1101_CR60","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0002-9149(02)03012-6","volume":"91","author":"AT Yetman","year":"2003","unstructured":"Yetman AT, Huang P, Bornemeier RA, McCrindle BW (2003) Comparison of Outcome of the Marfan syndrome in patients diagnosed at age \u22646\u00a0years versus those diagnosed at >6\u00a0years of age. Am J Cardiol 91:102\u2013103","journal-title":"Am J Cardiol"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-015-1101-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00246-015-1101-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-015-1101-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:27:51Z","timestamp":1651210071000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00246-015-1101-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,11]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["1101"],"URL":"https:\/\/doi.org\/10.1007\/s00246-015-1101-0","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,11]]}}}