{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:45:31Z","timestamp":1758123931223},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2015,5,30]],"date-time":"2015-05-30T00:00:00Z","timestamp":1432944000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1007\/s00246-015-1189-2","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T01:33:46Z","timestamp":1432863226000},"page":"1476-1482","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of TGFBR2 rs6785358 Polymorphism with Increased Risk of Congenital Ventricular Septal Defect in a Chinese Population"],"prefix":"10.1007","volume":"36","author":[{"given":"Xiang-Ting","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Qing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Kui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zong-Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ru","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,5,30]]},"reference":[{"issue":"3","key":"1189_CR1","doi-asserted-by":"crossref","first-page":"e647","DOI":"10.1542\/peds.2010-1399","volume":"127","author":"CJ Alverson","year":"2011","unstructured":"Alverson CJ, Strickland MJ, Gilboa SM, Correa A (2011) Maternal smoking and congenital heart defects in the Baltimore-Washington Infant Study. Pediatrics 127(3):e647\u2013e653","journal-title":"Pediatrics"},{"issue":"2","key":"1189_CR2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/dvdy.21854","volume":"238","author":"M Azhar","year":"2009","unstructured":"Azhar M, Runyan RB, Gard C, Sanford LP, Miller ML, Andringa A et al (2009) Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development. Dev Dyn 238(2):431\u2013442","journal-title":"Dev Dyn"},{"issue":"9","key":"1189_CR3","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1002\/dvdy.22702","volume":"240","author":"M Azhar","year":"2011","unstructured":"Azhar M, Brown K, Gard C, Chen H, Rajan S, Elliott DA et al (2011) Transforming growth factor Beta2 is required for valve remodeling during heart development. Dev Dyn 240(9):2127\u20132141","journal-title":"Dev Dyn"},{"issue":"1","key":"1189_CR4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/bdrc.10006","volume":"69","author":"JV Barnett","year":"2003","unstructured":"Barnett JV, Desgrosellier JS (2003) Early events in valvulogenesis: a signaling perspective. Birth Defects Res C Embryo Today 69(1):58\u201372","journal-title":"Birth Defects Res C Embryo Today"},{"issue":"12","key":"1189_CR5","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1002\/ajmg.a.36182","volume":"161A","author":"AL Bettinelli","year":"2013","unstructured":"Bettinelli AL, Mulder TJ, Funke BH, Lafferty KA, Longo SA, Niyazov DM (2013) Familial ebstein anomaly, left ventricular hypertrabeculation, and ventricular septal defect associated with a MYH7 mutation. Am J Med Genet A 161A(12):3187\u20133190","journal-title":"Am J Med Genet A"},{"issue":"5659","key":"1189_CR6","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.1090922","volume":"303","author":"NA Bhowmick","year":"2004","unstructured":"Bhowmick NA, Chytil A, Plieth D, Gorska AE, Dumont N, Shappell S et al (2004) TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303(5659):848\u2013851","journal-title":"Science"},{"issue":"4","key":"1189_CR7","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/dvdy.1154","volume":"221","author":"AS Boyer","year":"2001","unstructured":"Boyer AS, Runyan RB (2001) TGFbeta Type III and TGFbeta Type II receptors have distinct activities during epithelial-mesenchymal cell transformation in the embryonic heart. Dev Dyn 221(4):454\u2013459","journal-title":"Dev Dyn"},{"issue":"2","key":"1189_CR8","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1006\/dbio.1999.9211","volume":"208","author":"AS Boyer","year":"1999","unstructured":"Boyer AS, Ayerinskas II, Vincent EB, McKinney LA, Weeks DL, Runyan RB (1999) TGFbeta2 and TGFbeta3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart. Dev Biol 208(2):530\u2013545","journal-title":"Dev Biol"},{"issue":"8","key":"1189_CR9","doi-asserted-by":"crossref","first-page":"e42527","DOI":"10.1371\/journal.pone.0042527","volume":"7","author":"PR Buskohl","year":"2012","unstructured":"Buskohl PR, Sun MJ, Thompson RP, Butcher JT (2012) Serotonin potentiates transforming growth factor-beta3 induced biomechanical remodeling in avian embryonic atrioventricular valves. PLoS One 7(8):e42527","journal-title":"PLoS One"},{"issue":"1484","key":"1189_CR10","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1098\/rstb.2007.2130","volume":"362","author":"JT Butcher","year":"2007","unstructured":"Butcher JT, Markwald RR (2007) Valvulogenesis: the moving target. Philos Trans R Soc Lond B Biol Sci 362(1484):1489\u20131503","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"32","key":"1189_CR11","doi-asserted-by":"crossref","first-page":"16984","DOI":"10.1016\/S0021-9258(18)37487-8","volume":"263","author":"S Cheifetz","year":"1988","unstructured":"Cheifetz S, Andres JL, Massague J (1988) The transforming growth factor-beta receptor type III is a membrane proteoglycan. Domain structure of the receptor. J Biol Chem 263(32):16984\u201316991","journal-title":"J Biol Chem"},{"issue":"11","key":"1189_CR12","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1089\/ten.tea.2010.0027","volume":"16","author":"YN Chiu","year":"2010","unstructured":"Chiu YN, Norris RA, Mahler G, Recknagel A, Butcher JT (2010) Transforming growth factor beta, bone morphogenetic protein, and vascular endothelial growth factor mediate phenotype maturation and tissue remodeling by embryonic valve progenitor cells: relevance for heart valve tissue engineering. Tissue Eng Part A 16(11):3375\u20133383","journal-title":"Tissue Eng Part A"},{"issue":"8","key":"1189_CR13","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.addr.2011.02.003","volume":"63","author":"KN Chua","year":"2011","unstructured":"Chua KN, Poon KL, Lim J, Sim WJ, Huang RY, Thiery JP (2011) Target cell movement in tumor and cardiovascular diseases based on the epithelial-mesenchymal transition concept. Adv Drug Deliv Rev 63(8):558\u2013567","journal-title":"Adv Drug Deliv Rev"},{"issue":"Suppl 1","key":"1189_CR14","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1111\/nure.12058","volume":"71","author":"A Correa","year":"2013","unstructured":"Correa A, Marcinkevage J (2013) Prepregnancy obesity and the risk of birth defects: an update. Nutr Rev 71(Suppl 1):S68\u2013S77","journal-title":"Nutr Rev"},{"issue":"1","key":"1189_CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2003.10.004","volume":"15","author":"M Caestecker de","year":"2004","unstructured":"de Caestecker M (2004) The transforming growth factor-beta superfamily of receptors. Cytokine Growth Factor Rev 15(1):1\u201311","journal-title":"Cytokine Growth Factor Rev"},{"issue":"8","key":"1189_CR16","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/CIRCULATIONAHA.110.958405","volume":"123","author":"H Dolk","year":"2011","unstructured":"Dolk H, Loane M, Garne E, European Surveillance of Congenital Anomalies Working G (2011) Congenital heart defects in Europe: prevalence and perinatal mortality, 2000 to 2005. Circulation 123(8):841\u2013849","journal-title":"Circulation"},{"issue":"4","key":"1189_CR17","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1161\/CIRCRESAHA.112.300853","volume":"112","author":"AC Fahed","year":"2013","unstructured":"Fahed AC, Gelb BD, Seidman JG, Seidman CE (2013) Genetics of congenital heart disease: the glass half empty. Circ Res 112(4):707\u2013720","journal-title":"Circ Res"},{"issue":"5","key":"1189_CR18","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1016\/j.athoracsur.2010.12.060","volume":"91","author":"E Girdauskas","year":"2011","unstructured":"Girdauskas E, Schulz S, Borger MA, Mierzwa M, Kuntze T (2011) Transforming growth factor-beta receptor type II mutation in a patient with bicuspid aortic valve disease and intraoperative aortic dissection. Ann Thorac Surg 91(5):e70\u2013e71","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"1189_CR19","doi-asserted-by":"crossref","first-page":"e54338","DOI":"10.1371\/journal.pone.0054338","volume":"8","author":"J Glas","year":"2013","unstructured":"Glas J, Seiderer J, Bues S, Stallhofer J, Fries C, Olszak T et al (2013) IRGM variants and susceptibility to inflammatory bowel disease in the German population. PLoS One 8(1):e54338","journal-title":"PLoS One"},{"issue":"2","key":"1189_CR20","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2217\/fca.12.6","volume":"8","author":"M Greutmann","year":"2012","unstructured":"Greutmann M, Tobler D (2012) Changing epidemiology and mortality in adult congenital heart disease: looking into the future. Future Cardiol 8(2):171\u2013177","journal-title":"Future Cardiol"},{"issue":"3","key":"1189_CR21","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.immuni.2011.03.005","volume":"34","author":"I Gutcher","year":"2011","unstructured":"Gutcher I, Donkor MK, Ma Q, Rudensky AY, Flavell RA, Li MO (2011) Autocrine transforming growth factor-beta1 promotes in vivo Th17 cell differentiation. Immunity 34(3):396\u2013408","journal-title":"Immunity"},{"issue":"6659","key":"1189_CR22","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/37284","volume":"390","author":"CH Heldin","year":"1997","unstructured":"Heldin CH, Miyazono K, ten Dijke P (1997) TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390(6659):465\u2013471","journal-title":"Nature"},{"issue":"4","key":"1189_CR23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.5830\/CVJA-2013-028","volume":"24","author":"J Hoffman","year":"2013","unstructured":"Hoffman J (2013) The global burden of congenital heart disease. Cardiovasc J Afr 24(4):141\u2013145","journal-title":"Cardiovasc J Afr"},{"issue":"7","key":"1189_CR24","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/ng.2636","volume":"45","author":"Z Hu","year":"2013","unstructured":"Hu Z, Shi Y, Mo X, Xu J, Zhao B, Lin Y et al (2013) A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations. Nat Genet 45(7):818\u2013821","journal-title":"Nat Genet"},{"issue":"1","key":"1189_CR25","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/ATVBAHA.111.238410","volume":"32","author":"M Jaffe","year":"2012","unstructured":"Jaffe M, Sesti C, Washington IM, Du L, Dronadula N, Chin MT et al (2012) Transforming growth factor-beta signaling in myogenic cells regulates vascular morphogenesis, differentiation, and matrix synthesis. Arterioscler Thromb Vasc Biol 32(1):e1\u2013e11","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"22","key":"1189_CR26","doi-asserted-by":"crossref","first-page":"4585","DOI":"10.1242\/dev.02597","volume":"133","author":"K Jiao","year":"2006","unstructured":"Jiao K, Langworthy M, Batts L, Brown CB, Moses HL, Baldwin HS (2006) Tgfbeta signaling is required for atrioventricular cushion mesenchyme remodeling during in vivo cardiac development. Development 133(22):4585\u20134593","journal-title":"Development"},{"issue":"4","key":"1189_CR27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.5603\/FHC.a2014.0033","volume":"52","author":"K Knapczyk-Stwora","year":"2014","unstructured":"Knapczyk-Stwora K, Grzesiak M, Duda M, Koziorowski M, Galas J, Slomczynska M (2014) TGFbeta (transforming growth factor beta) superfamily members and their receptors in the fetal porcine ovaries: effect of prenatal flutamide treatment. Folia Histochem Cytobiol\u00a052(4):317\u2013325","journal-title":"Folia Histochem Cytobiol"},{"issue":"1","key":"1189_CR28","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.diff.2012.04.003","volume":"84","author":"BP Kruithof","year":"2012","unstructured":"Kruithof BP, Duim SN, Moerkamp AT, Goumans MJ (2012) TGFbeta and BMP signaling in cardiac cushion formation: lessons from mice and chicken. Differentiation 84(1):89\u2013102","journal-title":"Differentiation"},{"issue":"35","key":"1189_CR29","doi-asserted-by":"crossref","first-page":"14035","DOI":"10.1073\/pnas.1210730109","volume":"109","author":"K Lage","year":"2012","unstructured":"Lage K, Greenway SC, Rosenfeld JA, Wakimoto H, Gorham JM, Segre AV et al (2012) Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development. Proc Natl Acad Sci USA 109(35):14035\u201314040","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"1189_CR30","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s11248-010-9379-4","volume":"19","author":"D Langlois","year":"2010","unstructured":"Langlois D, Hneino M, Bouazza L, Parlakian A, Sasaki T, Bricca G et al (2010) Conditional inactivation of TGF-beta type II receptor in smooth muscle cells and epicardium causes lethal aortic and cardiac defects. Transgenic Res 19(6):1069\u20131082","journal-title":"Transgenic Res"},{"issue":"5","key":"1189_CR31","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1055\/s-0030-1254155","volume":"222","author":"A Lindinger","year":"2010","unstructured":"Lindinger A, Schwedler G, Hense HW (2010) Prevalence of congenital heart defects in newborns in Germany: results of the first registration year of the PAN Study (July 2006\u2013June 2007). Klin Padiatr 222(5):321\u2013326","journal-title":"Klin Padiatr"},{"issue":"9859","key":"1189_CR32","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","volume":"380","author":"R Lozano","year":"2012","unstructured":"Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V et al (2012) Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859):2095\u20132128","journal-title":"Lancet"},{"key":"1189_CR33","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/978-1-60761-869-0_21","volume":"677","author":"PY Mantel","year":"2011","unstructured":"Mantel PY, Schmidt-Weber CB (2011) Transforming growth factor-beta: recent advances on its role in immune tolerance. Methods Mol Biol 677:303\u2013338","journal-title":"Methods Mol Biol"},{"issue":"9","key":"1189_CR34","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1161\/CIRCULATIONAHA.113.008396","volume":"130","author":"AJ Marelli","year":"2014","unstructured":"Marelli AJ, Ionescu-Ittu R, Mackie AS, Guo L, Dendukuri N, Kaouache M (2014) Lifetime prevalence of congenital heart disease in the general population from 2000 to 2010. Circulation 130(9):749\u2013756","journal-title":"Circulation"},{"issue":"4","key":"1189_CR35","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.jacc.2010.07.052","volume":"57","author":"M Martin","year":"2011","unstructured":"Martin M, Rodriguez I, Palacin M, Rios-Gomez E, Coto E (2011) TGFBR2 gene mutational spectrum in aortic pathology. J Am Coll Cardiol 57(4):518\u2013519 author reply 519","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"1189_CR36","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm3434","volume":"13","author":"J Massague","year":"2012","unstructured":"Massague J (2012) TGFbeta signalling in context. Nat Rev Mol Cell Biol 13(10):616\u2013630","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"1189_CR37","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0092-8674(00)00121-5","volume":"103","author":"J Massague","year":"2000","unstructured":"Massague J, Blain SW, Lo RS (2000) TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 103(2):295\u2013309","journal-title":"Cell"},{"issue":"8","key":"1189_CR38","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/humu.20353","volume":"27","author":"G Matyas","year":"2006","unstructured":"Matyas G, Arnold E, Carrel T, Baumgartner D, Boileau C, Berger W et al (2006) Identification and in silico analyses of novel TGFBR1 and TGFBR2 mutations in Marfan syndrome-related disorders. Hum Mutat 27(8):760\u2013769","journal-title":"Hum Mutat"},{"issue":"1\u20133","key":"1189_CR39","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1159\/000101315","volume":"185","author":"ME Mercado-Pimentel","year":"2007","unstructured":"Mercado-Pimentel ME, Runyan RB (2007) Multiple transforming growth factor-beta isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart. Cells Tissues Organs 185(1\u20133):146\u2013156","journal-title":"Cells Tissues Organs"},{"issue":"8","key":"1189_CR40","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/ng1392","volume":"36","author":"T Mizuguchi","year":"2004","unstructured":"Mizuguchi T, Collod-Beroud G, Akiyama T, Abifadel M, Harada N, Morisaki T et al (2004) Heterozygous TGFBR2 mutations in Marfan syndrome. Nat Genet 36(8):855\u2013860","journal-title":"Nat Genet"},{"issue":"2","key":"1189_CR41","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/(SICI)1097-0185(20000201)258:2<119::AID-AR1>3.0.CO;2-U","volume":"258","author":"Y Nakajima","year":"2000","unstructured":"Nakajima Y, Yamagishi T, Hokari S, Nakamura H (2000) Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: roles of transforming growth factor (TGF)-beta and bone morphogenetic protein (BMP). Anat Rec 258(2):119\u2013127","journal-title":"Anat Rec"},{"issue":"10","key":"1189_CR42","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1002\/ajmg.a.35555","volume":"158A","author":"SS Patel","year":"2012","unstructured":"Patel SS, Burns TL, Botto LD, Riehle-Colarusso TJ, Lin AE, Shaw GM et al (2012) Analysis of selected maternal exposures and non-syndromic atrioventricular septal defects in the National Birth Defects Prevention Study, 1997\u20132005. Am J Med Genet A 158A(10):2447\u20132455","journal-title":"Am J Med Genet A"},{"issue":"9771","key":"1189_CR43","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S0140-6736(10)61339-6","volume":"377","author":"DJ Penny","year":"2011","unstructured":"Penny DJ, Vick GW 3rd (2011) Ventricular septal defect. Lancet 377(9771):1103\u20131112","journal-title":"Lancet"},{"key":"1189_CR44","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0074-7696(05)43005-3","volume":"243","author":"AD Person","year":"2005","unstructured":"Person AD, Klewer SE, Runyan RB (2005) Cell biology of cardiac cushion development. Int Rev Cytol 243:287\u2013335","journal-title":"Int Rev Cytol"},{"issue":"9","key":"1189_CR45","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1002\/dvdy.22376","volume":"239","author":"A Robson","year":"2010","unstructured":"Robson A, Allinson KR, Anderson RH, Henderson DJ, Arthur HM (2010) The TGFbeta type II receptor plays a critical role in the endothelial cells during cardiac development. Dev Dyn 239(9):2435\u20132442","journal-title":"Dev Dyn"},{"issue":"2","key":"1189_CR46","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.amjcard.2011.03.036","volume":"108","author":"FH Rodriguez 3rd","year":"2011","unstructured":"Rodriguez FH 3rd, Moodie DS, Parekh DR, Franklin WJ, Morales DL, Zafar F et al (2011) Outcomes of hospitalization in adults in the United States with atrial septal defect, ventricular septal defect, and atrioventricular septal defect. Am J Cardiol 108(2):290\u2013293","journal-title":"Am J Cardiol"},{"issue":"6","key":"1189_CR47","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1042\/CS20110086","volume":"121","author":"JF Santibanez","year":"2011","unstructured":"Santibanez JF, Quintanilla M, Bernabeu C (2011) TGF-beta\/TGF-beta receptor system and its role in physiological and pathological conditions. Clin Sci 121(6):233\u2013251","journal-title":"Clin Sci"},{"issue":"Suppl 7","key":"1189_CR48","doi-asserted-by":"crossref","first-page":"vii89","DOI":"10.1093\/annonc\/mdq292","volume":"21","author":"P Savagner","year":"2010","unstructured":"Savagner P (2010) The epithelial-mesenchymal transition (EMT) phenomenon. Ann Oncol 21(Suppl 7):vii89\u2013vii92","journal-title":"Ann Oncol"},{"issue":"6","key":"1189_CR49","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","volume":"113","author":"Y Shi","year":"2003","unstructured":"Shi Y, Massague J (2003) Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113(6):685\u2013700","journal-title":"Cell"},{"issue":"12","key":"1189_CR50","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1161\/CIRCRESAHA.108.180752","volume":"103","author":"MV Stevens","year":"2008","unstructured":"Stevens MV, Broka DM, Parker P, Rogowitz E, Vaillancourt RR, Camenisch TD (2008) MEKK3 initiates transforming growth factor beta 2-dependent epithelial-to-mesenchymal transition during endocardial cushion morphogenesis. Circ Res 103(12):1430\u20131440","journal-title":"Circ Res"},{"issue":"2","key":"1189_CR51","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1006\/geno.1996.0471","volume":"36","author":"S Takenoshita","year":"1996","unstructured":"Takenoshita S, Hagiwara K, Nagashima M, Gemma A, Bennett WP, Harris CC (1996) The genomic structure of the gene encoding the human transforming growth factor beta type II receptor (TGF-beta RII). Genomics 36(2):341\u2013344","journal-title":"Genomics"},{"issue":"5","key":"1189_CR52","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","volume":"139","author":"JP Thiery","year":"2009","unstructured":"Thiery JP, Acloque H, Huang RY, Nieto MA (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139(5):871\u2013890","journal-title":"Cell"},{"issue":"1","key":"1189_CR53","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cellsig.2011.09.006","volume":"24","author":"TA Townsend","year":"2012","unstructured":"Townsend TA, Robinson JY, How T, DeLaughter DM, Blobe GC, Barnett JV (2012) Endocardial cell epithelial-mesenchymal transformation requires Type III TGFbeta receptor interaction with GIPC. Cell Signal 24(1):247\u2013256","journal-title":"Cell Signal"},{"issue":"1","key":"1189_CR54","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nrcardio.2010.166","volume":"8","author":"T Bom van der","year":"2011","unstructured":"van der Bom T, Zomer AC, Zwinderman AH, Meijboom FJ, Bouma BJ, Mulder BJ (2011) The changing epidemiology of congenital heart disease. Nat Rev Cardiol 8(1):50\u201360","journal-title":"Nat Rev Cardiol"},{"issue":"21","key":"1189_CR55","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1016\/j.jacc.2011.08.025","volume":"58","author":"D Linde van der","year":"2011","unstructured":"van der Linde D, Konings EE, Slager MA, Witsenburg M, Helbing WA, Takkenberg JJ et al (2011) Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J Am Coll Cardiol 58(21):2241\u20132247","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"1189_CR56","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1089\/dna.2012.1814","volume":"31","author":"J Wang","year":"2012","unstructured":"Wang J, Luo XJ, Xin YF, Liu Y, Liu ZM, Wang Q et al (2012) Novel GATA6 mutations associated with congenital ventricular septal defect or tetralogy of fallot. DNA Cell Biol 31(11):1610\u20131617","journal-title":"DNA Cell Biol"},{"issue":"5","key":"1189_CR57","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1158\/1078-0432.CCR-12-3039","volume":"19","author":"E Wik","year":"2013","unstructured":"Wik E, Raeder MB, Krakstad C, Trovik J, Birkeland E, Hoivik EA et al (2013) Lack of estrogen receptor-alpha is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma. Clin Cancer Res 19(5):1094\u20131105","journal-title":"Clin Cancer Res"},{"issue":"2","key":"1189_CR58","first-page":"210","volume":"29","author":"J Xie","year":"2012","unstructured":"Xie J, Chen Y, Li H, Zhou B, Rao L (2012) Association between rs6658835 polymorphism of transforming growth factor beta 2 gene and congenital heart diseases in Chinese Han population. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29(2):210\u2013213","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"issue":"3","key":"1189_CR59","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s12565-009-0027-0","volume":"84","author":"T Yamagishi","year":"2009","unstructured":"Yamagishi T, Ando K, Nakamura H (2009) Roles of TGFbeta and BMP during valvulo-septal endocardial cushion formation. Anat Sci Int 84(3):77\u201387","journal-title":"Anat Sci Int"},{"issue":"3","key":"1189_CR60","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1210\/me.2009-0432","volume":"24","author":"G Yao","year":"2010","unstructured":"Yao G, Yin M, Lian J, Tian H, Liu L, Li X et al (2010) MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4. Mol Endocrinol 24(3):540\u2013551","journal-title":"Mol Endocrinol"},{"issue":"2","key":"1189_CR61","doi-asserted-by":"crossref","first-page":"e87437","DOI":"10.1371\/journal.pone.0087437","volume":"9","author":"X Zhu","year":"2014","unstructured":"Zhu X, Deng X, Huang G, Wang J, Yang J, Chen S et al (2014) A novel mutation of Hyaluronan synthase 2 gene in Chinese children with ventricular septal defect. PLoS One 9(2):e87437","journal-title":"PLoS One"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-015-1189-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00246-015-1189-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-015-1189-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T23:00:47Z","timestamp":1652137247000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00246-015-1189-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,30]]},"references-count":61,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["1189"],"URL":"https:\/\/doi.org\/10.1007\/s00246-015-1189-2","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,30]]}}}