{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:00:28Z","timestamp":1789768828329,"version":"4.0.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T00:00:00Z","timestamp":1471910400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"JSPS KAKENHI","award":["#26350944"],"award-info":[{"award-number":["#26350944"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s00246-016-1457-9","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T23:40:16Z","timestamp":1471909216000},"page":"1458-1464","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Variability of Myocardial Repolarization in Pediatric Patients with a Ventricular Septal Defect"],"prefix":"10.1007","volume":"37","author":[{"given":"Hidetoshi","family":"Uchida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Nishio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Omeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Oikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arisa","family":"Nagatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Eryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadayoshi","family":"Hata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsushi","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,23]]},"reference":[{"issue":"21","key":"1457_CR1","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1016\/j.jacc.2011.08.025","volume":"58","author":"D Linde Van der","year":"2011","unstructured":"Van der Linde D, Konings EE, Slager MA, Witsenburg M, Helbing WA, Takkenberg JJ, Roos-Hesselink JW (2011) Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J Am Coll Cardiol 58(21):2241\u20132247. doi: 10.1016\/j.jacc.2011.08.025","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"1457_CR2","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.jtcvs.2012.11.032","volume":"145","author":"BR Anderson","year":"2013","unstructured":"Anderson BR, Anderson BR, Stevens KN, Nicolson SC, Gruber SB, Spray TL, Wernovsky G, Gruber PJ (2013) Contemporary outcomes of surgical ventricular septal defect closure. J Thorac Cardiovasc Surg 145(3):641\u2013647. doi: 10.1016\/j.jtcvs.2012.11.032","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1457_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/2015-310154","volume":"18","author":"J Jortveit","year":"2016","unstructured":"Jortveit J, Leirgul E, Eskedal L, Greve G, Fomina T, D\u00f8hlen G, Tell GS, Birkeland S, \u00d8yen N, Holmstr\u00f8m H (2016) Mortality and complications in 3495 children with isolated ventricular septal defects. Arch Dis Child 18:1\u20136. doi: 10.1136\/2015-310154","journal-title":"Arch Dis Child"},{"issue":"9771","key":"1457_CR4","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/S0140-6736(10)61339-6","volume":"377","author":"DJ Penny","year":"2011","unstructured":"Penny DJ, Vick GW 3rd (2011) Ventricular septal defect. Lancet 377(9771):1103\u20131112. doi: 10.1016\/S0140-6736(10)61339-6","journal-title":"Lancet"},{"issue":"20","key":"1457_CR5","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1161\/CIRCULATIONAHA.106.618124","volume":"114","author":"MS Minette","year":"2006","unstructured":"Minette MS, Sahn DJ (2006) Ventricular septal defects. Circulation 114(20):2190\u20132197. doi: 10.1161\/CIRCULATIONAHA.106.618124","journal-title":"Circulation"},{"key":"1457_CR6","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.lfs.2014.12.024","volume":"123","author":"VP Long 3rd","year":"2015","unstructured":"Long VP 3rd, Bonilla IM, Vargas-Pinto P, Nishijima Y, Sridhar A, Li C, Mowrey K, Wright P, Velayutham M, Kumar S, Lee NY, Zweier JL, Mohler PJ, Gy\u00f6rke S, Carnes CA (2015) Heart failure duration progressively modulates the arrhythmia substrate through structural and electrical remodeling. Life Sci 123:61\u201371. doi: 10.1016\/j.lfs.2014.12.024","journal-title":"Life Sci"},{"issue":"4","key":"1457_CR7","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1161\/01.CIR.57.4.793","volume":"57","author":"RJ Levy","year":"1978","unstructured":"Levy RJ, Rosenthal A, Miettinen OS, Nadas AS (1978) Determinants of growth in patients with ventricular septal defect. Circulation 57(4):793\u2013797","journal-title":"Circulation"},{"issue":"5","key":"1457_CR8","first-page":"178","volume":"26","author":"J Rozenblit","year":"1971","unstructured":"Rozenblit J (1971) Katz and Wachtel type of electrocardiogram. Evolution and changes during a 4-year follow-up. Pol Tyg Lek 26(5):178\u2013180","journal-title":"Pol Tyg Lek"},{"issue":"6","key":"1457_CR9","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/BF00798059","volume":"16","author":"MA Fogel","year":"1995","unstructured":"Fogel MA, Lieb DR, Seliem MA (1995) Validity of electrocardiographic criteria for left ventricular hypertrophy in children with pressure- or volume-loaded ventricles: comparison with echocardiographic left ventricular muscle mass. Pediatr Cardiol 16(6):261\u2013269. doi: 10.1007\/BF00798059","journal-title":"Pediatr Cardiol"},{"issue":"Suppl","key":"1457_CR10","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0022-0736(99)90074-2","volume":"32","author":"C Antzelevitch","year":"1999","unstructured":"Antzelevitch C, Yan GX, Shimizu W (1999) Transmural dispersion of repolarization and arrhythmogenicity: the Brugada syndrome versus the long QT syndrome. J Electrocardiol 32(Suppl):158\u2013165","journal-title":"J Electrocardiol"},{"issue":"4","key":"1457_CR11","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1161\/CIRCEP.110.960658","volume":"4","author":"R Panikkath","year":"2011","unstructured":"Panikkath R, Reinier K, Uy-Evanado A, Teodorescu C, Hattenhauer J, Mariani R, Gunson K, Jui J, Chugh SS (2011) Prolonged Tpeak-to-Tend interval on the resting ECG is associated with increased risk of sudden cardiac death. Circ Arrhythm Electrophysiol 4(4):441\u2013447. doi: 10.1161\/CIRCEP.110.960658","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"6","key":"1457_CR12","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1136\/hrt.63.6.342","volume":"63","author":"CP Day","year":"1990","unstructured":"Day CP, McComb JM, Campbell RW (1990) QT dispersion: an indication of arrhythmia risk in patients with long QT intervals. Br Heart J 63(6):342\u2013344","journal-title":"Br Heart J"},{"issue":"5","key":"1457_CR13","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1161\/01.CIR.96.5.1557","volume":"96","author":"RD Berger","year":"1997","unstructured":"Berger RD, Kasper EK, Baughman KL, Marban E, Calkins H, Tomaselli GF (1997) Beat-to-beat QT interval variability: novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy. Circulation 96(5):1557\u20131565","journal-title":"Circulation"},{"issue":"9","key":"1457_CR14","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/j.1540-8167.1998.tb00130.x","volume":"9","author":"WL Atiga","year":"1998","unstructured":"Atiga WL, Calkins H, Lawrence JH, Tomaselli GF, Smith JM, Berger RD (1998) Beat-to-beat repolarization lability identifies patients at risk for sudden cardiac death. J Cardiovasc Electrophysiol 9(9):899\u2013908","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"2","key":"1457_CR15","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.pcad.2013.07.004","volume":"56","author":"CP Dobson","year":"2013","unstructured":"Dobson CP, Kim A, Haigney M (2013) QT variability index. Prog Cardiovasc Dis 56(2):186\u2013194. doi: 10.1016\/j.pcad.2013.07.004","journal-title":"Prog Cardiovasc Dis"},{"issue":"4","key":"1457_CR16","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s00246-011-9908-9","volume":"32","author":"M Kuriki","year":"2011","unstructured":"Kuriki M, Fujino M, Tanaka K, Horio K, Kusuki H, Hosoi M, Eryu Y, Kato T, Yamazaki T, Hata T (2011) Ventricular repolarization lability in children with Kawasaki disease. Pediatr Cardiol 32(4):487\u2013491. doi: 10.1007\/s00246-011-9908-9","journal-title":"Pediatr Cardiol"},{"issue":"3","key":"1457_CR17","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.jelectrocard.2010.07.016","volume":"44","author":"H Kusuki","year":"2011","unstructured":"Kusuki H, Kuriki M, Horio K, Hosoi M, Matsuura H, Fujino M, Eryu Y, Miyata M, Yasuda T, Yamazaki T, Nagaoka S, Hata T (2011) Beat-to-beat QT interval variability in children: normal and physiologic data. J Electrocardiol 44(3):326\u2013332. doi: 10.1016\/j.jelectrocard.2010.07.016","journal-title":"J Electrocardiol"},{"issue":"5","key":"1457_CR18","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.ahj.2014.07.010","volume":"168","author":"J Vicente","year":"2014","unstructured":"Vicente J, Johannesen L, Galeotti L, Strauss DG (2014) Mechanisms of sex and age differences in ventricular repolarization in humans. Am Heart J 168(5):749\u2013756. doi: 10.1016\/j.ahj.2014.07.010","journal-title":"Am Heart J"},{"issue":"3","key":"1457_CR19","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.jelectrocard.2011.03.004","volume":"44","author":"P Smetana","year":"2011","unstructured":"Smetana P, Schmidt A, Zabel M, Hnatkova K, Franz M, Huber K, Malik M (2011) Assessment of repolarization heterogeneity for prediction of mortality in cardiovascular disease: peak to the end of the T wave interval and nondipolar repolarization components. J Electrocardiol 44(3):301\u2013308. doi: 10.1016\/j.jelectrocard.2011.03.004","journal-title":"J Electrocardiol"},{"issue":"8","key":"1457_CR20","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1093\/europace\/eur426","volume":"14","author":"DP Morin","year":"2012","unstructured":"Morin DP, Saad MN, Shams OF, Owen JS, Xue JQ, Abi-Samra FM, Khatib S, Nelson-Twakor OS, Milani RV (2012) Relationships between the T-peak to T-end interval, ventricular tachyarrhythmia, and death in left ventricular systolic dysfunction. Europace 14(8):1172\u20131179. doi: 10.1093\/europace\/eur426","journal-title":"Europace"},{"issue":"2","key":"1457_CR21","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1093\/europace\/eup357","volume":"12","author":"KP Letsas","year":"2010","unstructured":"Letsas KP, Weber R, Astheimer K, Kalusche D, Arentz T (2010) Tpeak-Tend interval and Tpeak-Tend\/QT ratio as markers of ventricular tachycardia inducibility in subjects with Brugada ECG phenotype. Europace 12(2):271\u2013274. doi: 10.1093\/europace\/eup357","journal-title":"Europace"},{"issue":"12","key":"1457_CR22","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/0002-9149(94)90558-4","volume":"74","author":"CI Berul","year":"1994","unstructured":"Berul CI, Sweeten TL, Dubin AM, Shah MJ, Vetter VL (1994) Use of the rate-corrected JT interval for prediction of repolarization abnormalities in children. Am J Cardiol 74(12):1254\u20131257","journal-title":"Am J Cardiol"},{"issue":"Suppl","key":"1457_CR23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0022-0736(92)90079-F","volume":"25","author":"SH Zhou","year":"1992","unstructured":"Zhou SH, Wong S, Rautaharju PM, Karnik N, Calhoun HP (1992) Should the JT rather than the QT interval be used to detect prolongation of ventricular repolarization? An assessment in normal conduction and in ventricular conduction defects. J Electrocardiol 25(Suppl):131\u2013136","journal-title":"J Electrocardiol"},{"issue":"1","key":"1457_CR24","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1161\/01.CIR.81.1.281","volume":"81","author":"CW Haws","year":"1990","unstructured":"Haws CW, Lux RL (1990) Correlation between in vivo transmembrane action potential durations and activation-recovery intervals from electrograms. Effects of interventions that alter repolarization time. Circulation 81(1):281\u2013288","journal-title":"Circulation"},{"issue":"6","key":"1457_CR25","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1161\/01.CIR.72.6.1372","volume":"72","author":"CK Millar","year":"1985","unstructured":"Millar CK, Kralios FA, Lux RL (1985) Correlation between refractory periods and activation-recovery intervals from electrograms: effects of rate and adrenergic interventions. Circulation 72(6):1372\u20131379","journal-title":"Circulation"},{"issue":"Suppl 1","key":"1457_CR26","first-page":"205","volume":"27","author":"MJ Burgess","year":"1986","unstructured":"Burgess MJ, Baruffi S, Spaggiari S, Macchi E, Lux R, Taccardi B (1986) Determination of activation and recovery sequences and local repolarization durations from distant electrocardiographic leads. Jpn Heart J 27(Suppl 1):205\u2013216","journal-title":"Jpn Heart J"},{"issue":"4","key":"1457_CR27","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s002469900178","volume":"18","author":"M Massin","year":"1997","unstructured":"Massin M, von Bernuth G (1997) Normal ranges of heart rate variability during infancy and childhood. Pediatr Cardiol 18(4):297\u2013302","journal-title":"Pediatr Cardiol"},{"issue":"12","key":"1457_CR28","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s004310050979","volume":"157","author":"M Massin","year":"1998","unstructured":"Massin M, von Bernuth G (1998) Clinical and haemodynamic correlates of heart rate variability in children with congenital heart disease. Eur J Pediatr 157(12):967\u2013971","journal-title":"Eur J Pediatr"},{"issue":"6","key":"1457_CR29","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.jchf.2015.02.006","volume":"3","author":"WT Abraham","year":"2015","unstructured":"Abraham WT, Zile MR, Weaver FA, Butter C, Ducharme A, Halbach M, Klug D, Lovett EG, M\u00fcller-Ehmsen J, Schafer JE, Senni M, Swarup V, Wachter R, Little WC (2015) Baroreflex activation therapy for the treatment of heart failure with a reduced ejection fraction. JACC Heart Fail 3(6):487\u2013496. doi: 10.1016\/j.jchf.2015.02.006","journal-title":"JACC Heart Fail"},{"issue":"19","key":"1457_CR30","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1016\/j.jacc.2009.05.015","volume":"54","author":"F Triposkiadis","year":"2009","unstructured":"Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J (2009) The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications. J Am Coll Cardiol 54(19):1747\u20131762. doi: 10.1016\/j.jacc.2009.05.015","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"1457_CR31","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1152\/ajpheart.01184.2010","volume":"300","author":"M Baumert","year":"2011","unstructured":"Baumert M, Schlaich MP, Nalivaiko E, Lambert E, Sari CI, Kaye DM, Elser MD, Sanders P, Lambert G (2011) Relation between QT interval variability and cardiac sympathetic activity in hypertension. Am J Physiol Heart Circ Physiol 300(4):1412\u20131417. doi: 10.1152\/ajpheart.01184.2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"10","key":"1457_CR32","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1152\/ajpregu.00652.2011","volume":"302","author":"S Mak","year":"2012","unstructured":"Mak S, Witte KK, Al-Hesayen A, Granton JJ, Parker JD (2012) Cardiac sympathetic activation in patients with pulmonary arterial hypertension. Am J Physiol Regul Integr Comp Physiol 302(10):1153\u20131157. doi: 10.1152\/ajpregu.00652.2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"10","key":"1457_CR33","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1016\/j.amjcard.2004.07.123","volume":"94","author":"K Bilchick","year":"2004","unstructured":"Bilchick K, Viitasalo M, Oikarinen L, Fetics B, Tomaselli G, Swan H, Laitinen PJ, V\u00e4\u00e4n\u00e4nen H, Kontula K, Berger RD (2004) Temporal repolarization lability differences among genotyped patients with the long QT syndrome. Am J Cardiol 94(10):1312\u20131316. doi: 10.1016\/j.amjcard.2004.07.123","journal-title":"Am J Cardiol"},{"key":"1457_CR34","unstructured":"U.S. Food and Drug Administration (2012) E14 clinical evaluation of QT\/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs\u2014Questions and Answers"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-016-1457-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00246-016-1457-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-016-1457-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T17:09:49Z","timestamp":1498324189000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00246-016-1457-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,23]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["1457"],"URL":"https:\/\/doi.org\/10.1007\/s00246-016-1457-9","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,23]]}}}