{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:55:06Z","timestamp":1774580106654,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T00:00:00Z","timestamp":1491955200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s00246-017-1597-6","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T01:50:45Z","timestamp":1491961845000},"page":"915-921","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of Ventricular Septal Defect with Special Reference to the Spontaneous Closure Rate, Subaortic Ridge, and Aortic Valve Prolapse II"],"prefix":"10.1007","volume":"38","author":[{"given":"Ayse Guler","family":"Eroglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sezen Ugan","family":"Atik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esma","family":"Sengenc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulnaz","family":"Cig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irfan Levent","family":"Saltik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Funda","family":"Oztunc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,4,12]]},"reference":[{"key":"1597_CR1","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","volume":"39","author":"JI Hoffman","year":"2002","unstructured":"Hoffman JI, Kaplan S (2002) The incidence of congenital heart disease. J Am Coll Cardiol 39:1890\u20131900","journal-title":"J Am Coll Cardiol"},{"key":"1597_CR2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1161\/01.CIR.49.2.375","volume":"49","author":"RM Freedom","year":"1974","unstructured":"Freedom RM, White RD, Pieroni DR et al (1974) The natural history of the so-called aneurysm of the membranous septum in childhood. Circulation 49:375\u2013384","journal-title":"Circulation"},{"issue":"1","key":"1597_CR3","doi-asserted-by":"crossref","first-page":"I82","DOI":"10.1161\/01.CIR.56.1.82","volume":"56","author":"EW Nugent","year":"1977","unstructured":"Nugent EW, Freedom RM, Rowe RD, Wagner HR, Rees JK (1977) Aneurysm of the membranous septum in ventricular septal defect. Circulation 56(1):I82\u2013I84","journal-title":"Circulation"},{"key":"1597_CR4","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/0002-9149(86)90903-3","volume":"57","author":"C Ramaciotti","year":"1986","unstructured":"Ramaciotti C, Keren A, Silverman NH (1986) Importance of (perimembranous) ventricular septal aneurysm in the natural history of isolated perimembranous ventricular septal defect. Am J Cardiol 57:268\u2013272","journal-title":"Am J Cardiol"},{"key":"1597_CR5","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/0002-9149(93)90358-J","volume":"72","author":"MH Wu","year":"1993","unstructured":"Wu MH, Wu JM, Chang C et al (1993) Implication of aneurysmal transformation in isolated perimembranous ventricular septal defect. Am J Cardiol 72:596\u2013601","journal-title":"Am J Cardiol"},{"key":"1597_CR6","doi-asserted-by":"crossref","first-page":"e262","DOI":"10.1542\/peds.2005-1255","volume":"117","author":"MH Wu","year":"2006","unstructured":"Wu MH, Wang JK, Lin MT et al (2006) Ventricular septal defect with secondary left ventricular-to-right atrial shunt is associated with a higher risk for infective endocarditis and a lower late chance of closure. Pediatrics 117:e262\u2013e267","journal-title":"Pediatrics"},{"key":"1597_CR7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0002-9149(83)90135-2","volume":"52","author":"RH Anderson","year":"1983","unstructured":"Anderson RH, Lenox CC, Zuberbuhler JR (1983) Mechanisms of closure of perimembranous ventricular septal defect. Am J Cardiol 52:341\u2013345","journal-title":"Am J Cardiol"},{"key":"1597_CR8","first-page":"516","volume":"28","author":"J Zhang","year":"2015","unstructured":"Zhang J, Ko JM, Guileyardo JM, Roberts WC (2015) A review of spontaneous closure of ventricular septal defect. Proceedings 28:516\u2013520","journal-title":"Proceedings"},{"key":"1597_CR9","first-page":"342","volume":"19","author":"U Kazmi","year":"2009","unstructured":"Kazmi U, Sadiq M, Hyder SN (2009) Pattern of ventricular septal defects and associated complications. J Coll Physicians Surg Pak 19:342\u2013345","journal-title":"J Coll Physicians Surg Pak"},{"key":"1597_CR10","first-page":"1001","volume":"61","author":"TA Chaudhry","year":"2011","unstructured":"Chaudhry TA, Younas M, Baig A (2011) Ventricular septal defect and associated complications. J Pak Med Assoc 61:1001\u20131004","journal-title":"J Pak Med Assoc"},{"key":"1597_CR11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5543\/tkda.2012.01679","volume":"40","author":"S Erdem","year":"2012","unstructured":"Erdem S, Ozbarlas N, K\u00fc\u00e7\u00fckosmano\u011flu O, Poyrazo\u011flu H, Salih OK (2012) Long term follow-up of 799 children with isolated ventricular septal defects. Turk Kardiyol Dern Ars 40:22\u201325","journal-title":"Turk Kardiyol Dern Ars"},{"key":"1597_CR12","doi-asserted-by":"crossref","first-page":"e113822","DOI":"10.1371\/journal.pone.0113822","volume":"9","author":"J Sun","year":"2014","unstructured":"Sun J, Sun K, Chen S, Yao L, Zhang Y (2014) A new scoring system for spontaneous closure prediction of perimembranous ventricular septal defects in children. PLoS ONE 9:e113822","journal-title":"PLoS ONE"},{"key":"1597_CR13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00246-002-1345-3","volume":"24","author":"AG Ero\u011flu","year":"2003","unstructured":"Ero\u011flu AG, Oztun\u00e7 F, Saltik L, Bakari S, Dedeo\u011flu S, Ahunbay G (2003) Evolution of ventricular septal defect with special reference to spontaneous closure rate, subaortic ridge and aortic valve prolapse. Pediatr Cardiol 24:31\u201335","journal-title":"Pediatr Cardiol"},{"key":"1597_CR14","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/0002-9149(87)90380-8","volume":"60","author":"DG Moe","year":"1987","unstructured":"Moe DG, Guntheroth WG (1987) Spontaneous closure of uncomplicated ventricular septal defect. Am J Cardiol 60:674\u2013678","journal-title":"Am J Cardiol"},{"key":"1597_CR15","first-page":"384","volume-title":"Echocardiography","author":"H Feigenbaum","year":"1994","unstructured":"Feigenbaum H (1994) Echocardiography, 5th edn. Lea&Febiger, Philadelphia, p\u00a0384\u2013392","edition":"5"},{"key":"1597_CR16","first-page":"724","volume-title":"Heart disease in infants, children and adolescents: including the fetus and young adult","author":"TP Graham","year":"1995","unstructured":"Graham TP, Gutgesell HP (1995) Ventricular septal defects. In: Emmanouilides GC, Riemenschneider TA, Allien HD, Gutgesell HP (eds) Heart disease in infants, children and adolescents: including the fetus and young adult. Williams & Wilkins, Baltimore, p\u00a0724\u2013746"},{"key":"1597_CR17","first-page":"675","volume-title":"Echocardiography","author":"H Feigenbaum","year":"1994","unstructured":"Feigenbaum H (1994) Echocardiography, 5th edn. Lea&Febiger, Philadelphia, p\u00a0675","edition":"5"},{"key":"1597_CR18","doi-asserted-by":"crossref","first-page":"I38","DOI":"10.1161\/01.CIR.87.1.38","volume":"87","author":"L Kidd","year":"1993","unstructured":"Kidd L, Driscoll DJ, Gersony WM, et al (1993) Second natural history of congenital heart defects. Results of treatment of patients with ventricular septal defects. Circulation 87:I38\u2013I51","journal-title":"Circulation"},{"key":"1597_CR19","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/hrt.47.4.316","volume":"47","author":"GR Sutherland","year":"1982","unstructured":"Sutherland GR, Godman MJ, Smallhorn JF et al (1982) Ventricular septal defects: two-dimensional echocardiographic and morphological correlations. Br Heart J 47:316\u2013328","journal-title":"Br Heart J"},{"key":"1597_CR20","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/BF01957273","volume":"149","author":"E Trowitzsch","year":"1990","unstructured":"Trowitzsch E, Braun W, Stute M, Pielemeier W (1990) Diagnosis, therapy and outcome of ventricular septal defects in the 1st year of life: a two-dimensional color-Doppler echocardiography study. Eur J Pediatr 149:758\u2013761","journal-title":"Eur J Pediatr"},{"key":"1597_CR21","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0002-9149(92)90620-E","volume":"70","author":"AV Mehta","year":"1992","unstructured":"Mehta AV, Chidambaram B (1992) Ventricular septal defect in the first year of life. Am J Cardiol 70:364\u2013366","journal-title":"Am J Cardiol"},{"key":"1597_CR22","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0003-4975(10)62804-4","volume":"43","author":"K Hisatomi","year":"1987","unstructured":"Hisatomi K, Kosuga K, Isomura T et al (1987) Ventricular septal defect associated with aortic regurgitation. Ann Thorac Surg 43:363\u2013367","journal-title":"Ann Thorac Surg"},{"key":"1597_CR23","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1111\/j.1651-2227.2011.02333.x","volume":"100","author":"T Miyake","year":"2011","unstructured":"Miyake T, Shinohara T, Inoue T, Marutani S, Takemura T (2011) Spontaneous closure of muscular trabecular ventricular septal defect: comparison of defect positions. Acta Paediatr 100:e158\u2013e162","journal-title":"Acta Paediatr"},{"key":"1597_CR24","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s002469900480","volume":"20","author":"G Ahunbay","year":"1999","unstructured":"Ahunbay G, Onat T, C\u00b8 elebi A, Batmaz G (1999) Regression of right ventricular pressure in ventricular septal defect in infancy: a longitudinal color-flow Doppler echocardiographic study. Pediatr Cardiol 20:336\u2013342","journal-title":"Pediatr Cardiol"},{"key":"1597_CR25","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1542\/peds.63.2.204","volume":"65","author":"BS Alpert","year":"1979","unstructured":"Alpert BS, Cook DH, Varghese PJ, Rowe RD (1979) Spontaneous closure of small ventricular septal defects: ten-year follow-up. Pediatrics 65:204\u2013206","journal-title":"Pediatrics"},{"key":"1597_CR26","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1001\/archpedi.1973.04160020028005","volume":"125","author":"BS Alpert","year":"1973","unstructured":"Alpert BS, Mellits ED, Rowe RD (1973) Spontaneous closure of small ventricular septal defects. Probability rates in the first five years of life. Am J Dis Child 125:194\u2013196","journal-title":"Am J Dis Child"},{"key":"1597_CR27","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0002-8703(72)90186-X","volume":"84","author":"G Collins","year":"1972","unstructured":"Collins G, Calder L, Rose V, Kidd L, Keith J (1972) Ventricular septal defect: clinical and hemodynamic changes in the first five years of life. Am Heart J 84:695\u2013705","journal-title":"Am Heart J"},{"key":"1597_CR28","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1161\/01.CIR.55.6.908","volume":"55","author":"P Corone","year":"1977","unstructured":"Corone P, Doyon F, Gaudeau S et al (1977) Natural history of ventricular septal defect. A study involving 790 cases. Circulation 55:908\u2013915","journal-title":"Circulation"},{"key":"1597_CR29","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s002469900291","volume":"79","author":"T Onat","year":"1998","unstructured":"Onat T, Ahunbay G, Batmaz G, Celebi A (1998) The natural course of isolated ventricular septal defect during adolescence. Pediatr Cardiol 79:230\u2013234","journal-title":"Pediatr Cardiol"},{"key":"1597_CR30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0002-8703(70)90005-0","volume":"80","author":"M Yokoyama","year":"1970","unstructured":"Yokoyama M, Takao A, Sakakibara S (1970) Natural history and surgical indications of ventricular septal defect. Am Heart J 80:597\u2013605","journal-title":"Am Heart J"},{"key":"1597_CR31","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1080\/080352500300002552","volume":"89","author":"A Meberg","year":"2000","unstructured":"Meberg A, Otterstad JE, Fr\u00f8land G, Lindberg H, S\u00f8rland SJ (2000) Outcome of congenital heart defects\u2014a population-based study. Acta Paediatr 89:1344\u20131351","journal-title":"Acta Paediatr"},{"key":"1597_CR32","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/adc.81.5.413","volume":"81","author":"SW Turner","year":"1999","unstructured":"Turner SW, Hunter S, Wyllie JP (1999) The natural history of ventricular septal defects. Arch Dis Child 81:413\u2013416","journal-title":"Arch Dis Child"},{"key":"1597_CR33","doi-asserted-by":"crossref","first-page":"96","DOI":"10.5152\/jtgga.2014.0012","volume":"15","author":"O Erol","year":"2014","unstructured":"Erol O, Sevket O, Keskin S, Yaz\u0131c\u0131o\u011flu HF, G\u00fcl A (2014) Natural history of prenatal isolated muscular ventricular septal defects. J Turk Ger Gynecol Assoc 15:96\u201399","journal-title":"J Turk Ger Gynecol Assoc"},{"key":"1597_CR34","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1442-200X.2008.02642.x","volume":"50","author":"T Miyake","year":"2008","unstructured":"Miyake T, Shinohara T, Fukuda T, Ikeoka M, Takemura T (2008) Spontaneous closure of perimembranous ventricular septal defect after school age. Pediatr Int 50:632\u2013635","journal-title":"Pediatr Int"},{"key":"1597_CR35","first-page":"38","volume":"88","author":"MH Wu","year":"1989","unstructured":"Wu MH, Lue HC, Wang JK, Hung CR (1989) Color flow mapping in perimembranous ventricular septal defect with left ventricular-to-right atrial shunts. Taiwan Yi Xue Hui Za Zhi 88:38\u201342","journal-title":"Taiwan Yi Xue Hui Za Zhi"},{"key":"1597_CR36","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1253\/circj.CJ-08-0113","volume":"72","author":"KP Weng","year":"2008","unstructured":"Weng KP, Huang SH, Lin CC, Huang SM, Chien KJ, Ger LP, Hsieh KS (2008) Reappraisal of left ventricular to right atrial (LV-RA) shunt in pediatric patients with isolated perimembranous ventricular septal defect. Circ J 72:1487\u20131491","journal-title":"Circ J"},{"key":"1597_CR37","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S0002-9149(97)00105-7","volume":"79","author":"K Tohyama","year":"1997","unstructured":"Tohyama K, Satomi G, Momma K (1997) Aortic valve prolapse and aortic regurgitation associated with subpulmonic ventricular septal defect. Am J Cardiol 79:1285\u20131289","journal-title":"Am J Cardiol"},{"key":"1597_CR38","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/0003-4975(94)90222-4","volume":"57","author":"S Ishikawa","year":"1994","unstructured":"Ishikawa S, Morishita Y, Sato Y et al (1994) Frequency and operative correction of aortic insufficiency associated with ventricular septal defect. Ann Thorac Surg 57:996\u2013998","journal-title":"Ann Thorac Surg"},{"key":"1597_CR39","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0022-5223(19)39352-3","volume":"82","author":"PP Karpawich","year":"1981","unstructured":"Karpawich PP, Duff DF, Mullins CE, Cooley DA, McNamara DG (1981) Ventricular septal defect with associated aortic valve insufficiency. J Thorac Cardiovasc Surg 82:182\u2013189","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00246-017-1597-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-017-1597-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-017-1597-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T11:52:57Z","timestamp":1658922777000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00246-017-1597-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,12]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["1597"],"URL":"https:\/\/doi.org\/10.1007\/s00246-017-1597-6","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,12]]}}}