{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:12:12Z","timestamp":1774926732781,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s00246-018-1854-3","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T08:14:43Z","timestamp":1520583283000},"page":"1023-1030","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["A Novel Mechanism for Improved Exercise Performance in Pediatric Fontan Patients After Cardiac Rehabilitation"],"prefix":"10.1007","volume":"39","author":[{"given":"Samuel","family":"Wittekind","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne","family":"Mays","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvette","family":"Gerdes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Knecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Hambrook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Border","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Lynn","family":"Jefferies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,3,9]]},"reference":[{"issue":"2","key":"1854_CR1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jacc.2008.02.081","volume":"52","author":"SM Paridon","year":"2008","unstructured":"Paridon SM, Mitchell PD, Colan SD, Williams RV, Blaufox A, Li JS, Margossian R, Mital S, Russell J, Rhodes J (2008) A cross-sectional study of exercise performance during the first 2 decades of life after the Fontan operation. J Am Coll Cardiol 52(2):99\u2013107. https:\/\/doi.org\/10.1016\/j.jacc.2008.02.081","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"1854_CR2","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1016\/S0735-1097(10)80034-8","volume":"15","author":"MH Gewillig","year":"1990","unstructured":"Gewillig MH, Lundstr\u00f6m UR, Bull C, Wyse RK, Deanfield JE (1990) Exercise responses in patients with congenital heart disease after Fontan repair: patterns and determinants of performance. J Am Coll Cardiol 15(6):1424\u20131432","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"1854_CR3","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jacc.2007.12.063","volume":"52","author":"J Meadows","year":"2008","unstructured":"Meadows J, Lang P, Marx G, Rhodes J (2008) Fontan fenestration closure has no acute effect on exercise capacity but improves ventilatory response to exercise. J Am Coll Cardiol 52(2):108\u2013113","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"1854_CR4","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1542\/peds.2004-2697","volume":"116","author":"J Rhodes","year":"2005","unstructured":"Rhodes J, Curran TJ, Camil L, Rabideau N, Fulton DR, Gauthier NS, Gauvreau K, Jenkins KJ (2005) Impact of cardiac rehabilitation on the exercise function of children with serious congenital heart disease. Pediatrics 116(6):1339\u20131345. https:\/\/doi.org\/10.1542\/peds.2004-2697","journal-title":"Pediatrics"},{"issue":"6","key":"1854_CR5","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/S0002-9149(01)01822-7","volume":"88","author":"S Minamisawa","year":"2001","unstructured":"Minamisawa S, Nakazawa M, Momma K, Imai Y, Satomi G (2001) Effect of aerobic training on exercise performance in patients after the Fontan operation. Am J Cardiol 88(6):695\u2013698","journal-title":"Am J Cardiol"},{"issue":"1","key":"1854_CR6","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.amjcard.2004.08.085","volume":"95","author":"F Opocher","year":"2005","unstructured":"Opocher F, Varnier M, Sanders SP, Tosoni A, Zaccaria M, Stellin G, Milanesi O (2005) Effects of aerobic exercise training in children after the Fontan operation. Am J Cardiol 95(1):150\u2013152","journal-title":"Am J Cardiol"},{"key":"1854_CR7","volume-title":"Principles of exercise testing and interpretation: including pathophysiology and clinical applications","author":"K Wasserman","year":"2005","unstructured":"Wasserman K (2005) Principles of exercise testing and interpretation: including pathophysiology and clinical applications. Lippincott Williams & Wilkins, Philadelphia"},{"issue":"24","key":"1854_CR8","doi-asserted-by":"publisher","first-page":"2796","DOI":"10.1161\/CIRCULATIONAHA.105.594218","volume":"113","author":"K Dimopoulos","year":"2006","unstructured":"Dimopoulos K, Okonko DO, Diller G-P, Broberg CS, Salukhe TV, Babu-Narayan SV, Li W, Uebing A, Bayne S, Wensel R (2006) Abnormal ventilatory response to exercise in adults with congenital heart disease relates to cyanosis and predicts survival. Circulation 113(24):2796\u20132802","journal-title":"Circulation"},{"issue":"5","key":"1854_CR9","doi-asserted-by":"publisher","first-page":"S30","DOI":"10.1097\/00005768-200105001-00168","volume":"33","author":"SJ Kopser","year":"2001","unstructured":"Kopser SJ, Mays WA, Lockwood SK, Knilans TK, Claytor RP, Shore S (2001) Modified maximal cycle ergometry test protocol for patients with univentricular heart after Fontan Palliation. Med Sci Sports Exerc 33(5):S30","journal-title":"Med Sci Sports Exerc"},{"issue":"3","key":"1854_CR10","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1161\/01.CIR.76.3.539","volume":"76","author":"J Christie","year":"1987","unstructured":"Christie J, Sheldahl LM, Tristani FE, Sagar KB, Ptacin MJ, Wann S (1987) Determination of stroke volume and cardiac output during exercise: comparison of two-dimensional and Doppler echocardiography, Fick oximetry, and thermodilution. Circulation 76(3):539\u2013547","journal-title":"Circulation"},{"issue":"9","key":"1854_CR11","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1161\/01.CIR.102.9.1069","volume":"102","author":"GJ Balady","year":"2000","unstructured":"Balady GJ, Ades PA, Comoss P, Limacher M, Pina IL, Southard D, Williams MA, Bazzarre T (2000) Core components of cardiac rehabilitation\/secondary prevention programs: a statement for healthcare professionals from the American Heart Association and the American Association of Cardiovascular and Pulmonary Rehabilitation Writing Group. Circulation 102(9):1069\u20131073","journal-title":"Circulation"},{"key":"1854_CR12","volume-title":"Guidelines for cardia rehabilitation and secondary prevention programs(with web resource)","author":"Cardiovascular AAo & Pulmonary Rehabilitation","year":"2013","unstructured":"Cardiovascular AAo & Pulmonary Rehabilitation (2013) Guidelines for cardia rehabilitation and secondary prevention programs(with web resource). Human Kinetics, Champaign"},{"issue":"12","key":"1854_CR13","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/0002-9149(85)91155-5","volume":"56","author":"LM Bradley","year":"1985","unstructured":"Bradley LM, Galioto FM, Vaccaro P, Hansen DA, Vaccaro J (1985) Effect of intense aerobic training on exercise performance in children after surgical repair of tetralogy of Fallot or complete transposition of the great arteries. Am J Cardiol 56(12):816\u2013818","journal-title":"Am J Cardiol"},{"issue":"6","key":"1854_CR14","first-page":"627","volume":"145","author":"IC Balfour","year":"1991","unstructured":"Balfour IC, Drimmer AM, Nouri S, Pennington DG, Hemkens CL, Harvey LL (1991) Pediatric cardiac rehabilitation. Am J Dis Child 145(6):627\u2013630","journal-title":"Am J Dis Child"},{"issue":"2","key":"1854_CR15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1017\/S1047951100006557","volume":"10","author":"PM Fredriksen","year":"2000","unstructured":"Fredriksen PM, Kahrs N, Blaasvaer S, Sigurdsen E, Gundersen O, Roeksund O, Norgaand G, Vik J, Soerbye O, Ingjer F (2000) Effect of physical training in children and adolescents with congenital heart disease. Cardiol Young 10(2):107\u2013114","journal-title":"Cardiol Young"},{"issue":"15","key":"1854_CR16","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.2165\/00007256-200333150-00004","volume":"33","author":"G Baquet","year":"2003","unstructured":"Baquet G, van Praagh E, Berthoin S (2003) Endurance training and aerobic fitness in young people. Sports Med 33(15):1127\u20131143 (Auckland NZ)","journal-title":"Sports Med"},{"issue":"6","key":"1854_CR17","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1152\/jappl.1996.81.6.2674","volume":"81","author":"BJ Whipp","year":"1996","unstructured":"Whipp BJ, Higgenbotham MB, Cobb FC (1996) Estimating exercise stroke volume from asymptotic oxygen pulse in humans. J Appl Physiol 81(6):2674\u20132679","journal-title":"J Appl Physiol"},{"issue":"9","key":"1854_CR18","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1016\/j.jacc.2005.08.005","volume":"46","author":"P Agostoni","year":"2005","unstructured":"Agostoni P, Cattadori G, Apostolo A, Contini M, Palermo P, Marenzi G, Wasserman K (2005) Noninvasive measurement of cardiac output during exercise by inert gas rebreathing technique: a new tool for heart failure evaluation. J Am Coll Cardiol 46(9):1779\u20131781","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"1854_CR19","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1053\/j.jvca.2011.05.002","volume":"25","author":"K Taylor","year":"2011","unstructured":"Taylor K, La Rotta G, McCrindle BW, Manlhiot C, Redington A, Holtby H (2011) A comparison of cardiac output by thoracic impedance and direct fick in children with congenital heart disease undergoing diagnostic cardiac catheterization. J Cardiothorac Vasc Anesthesia 25(5):776\u2013779","journal-title":"J Cardiothorac Vasc Anesthesia"},{"issue":"6\u20137","key":"1854_CR20","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.ejheart.2007.01.007","volume":"9","author":"C Laethem Van","year":"2007","unstructured":"Van Laethem C, Van De Veire N, De Backer G, Bihija S, Seghers T, Cambier D, Vanderheyden M, De Sutter J (2007) Response of the oxygen uptake efficiency slope to exercise training in patients with chronic heart failure. Eur J Heart Fail 9(6\u20137):625\u2013629","journal-title":"Eur J Heart Fail"},{"issue":"5","key":"1854_CR21","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1152\/japplphysiol.00365.2004","volume":"97","author":"M Guazzi","year":"2004","unstructured":"Guazzi M, Reina G, Tumminello G, Guazzi MD (2004) Improvement of alveolar-capillary membrane diffusing capacity with exercise training in chronic heart failure. J Appl Physiol 97(5):1866\u20131873","journal-title":"J Appl Physiol"},{"issue":"1","key":"1854_CR22","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1161\/hc0102.101509","volume":"105","author":"X-G Sun","year":"2002","unstructured":"Sun X-G, Hansen JE, Oudiz RJ, Wasserman K (2002) Gas exchange detection of exercise-induced right-to-left shunt in patients with primary pulmonary hypertension. Circulation 105(1):54\u201360","journal-title":"Circulation"},{"issue":"11","key":"1854_CR23","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1161\/CIRCULATIONAHA.110.981746","volume":"123","author":"DJ Goldberg","year":"2011","unstructured":"Goldberg DJ, French B, McBride MG, Marino BS, Mirarchi N, Hanna BD, Wernovsky G, Paridon SM, Rychik J (2011) Impact of oral sildenafil on exercise performance in children and young adults after the Fontan operation. Circulation 123(11):1185\u20131193","journal-title":"Circulation"},{"issue":"3","key":"1854_CR24","doi-asserted-by":"publisher","first-page":"e586e593","DOI":"10.1542\/peds.2006-0264","volume":"118","author":"J Rhodes","year":"2006","unstructured":"Rhodes J, Curran TJ, Camil L, Rabideau N, Fulton DR, Gauthier NS, Gauvreau K, Jenkins KJ (2006) Sustained effects of cardiac rehabilitation in children with serious congenital heart disease. Pediatrics 118(3):e586\u2013e593. https:\/\/doi.org\/10.1542\/peds.2006-0264","journal-title":"Pediatrics"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00246-018-1854-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-018-1854-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-018-1854-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T15:12:26Z","timestamp":1570893146000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00246-018-1854-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,9]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["1854"],"URL":"https:\/\/doi.org\/10.1007\/s00246-018-1854-3","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,9]]},"assertion":[{"value":"2 August 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Samuel Wittekind, Wayne Mays, Yvette Gerdes, Sandra Knecht, John Hambrook, William Border, and John Lynn Jefferies declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}