{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:17:25Z","timestamp":1786979845517,"version":"build-2736575974"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100009840","name":"Le Bonheur Children's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009840","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s00246-019-02114-2","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T16:47:18Z","timestamp":1557247638000},"page":"1046-1056","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Concurrent Use of Calcium Chloride and Arginine Vasopressin Infusions in Pediatric Patients with Acute Cardiocirculatory Failure"],"prefix":"10.1007","volume":"40","author":[{"given":"Karan B.","family":"Karki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Towbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camden","family":"Harrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Tansey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Krebs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Bigelow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Saini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4983-2065","authenticated-orcid":false,"given":"Sachin D.","family":"Tadphale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,7]]},"reference":[{"issue":"3","key":"2114_CR1","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s00246-017-1787-2","volume":"39","author":"RE Shaddy","year":"2018","unstructured":"Shaddy RE, George AT, Jaecklin T et al (2018) Systematic literature review on the incidence and prevalence of heart failure in children and adolescents. Pediatr Cardiol 39(3):415\u2013436","journal-title":"Pediatr Cardiol"},{"issue":"6","key":"2114_CR2","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1161\/CIRCRESAHA.116.308996","volume":"120","author":"RB Hinton","year":"2017","unstructured":"Hinton RB, Ware SM (2017) Heart failure in pediatric patients with congenital heart disease. Circ Res 120(6):978\u2013994","journal-title":"Circ Res"},{"issue":"6","key":"2114_CR3","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.cardfail.2012.03.001","volume":"18","author":"JW Rossano","year":"2012","unstructured":"Rossano JW, Kim JJ, Decker JA et al (2012) Prevalence, morbidity, and mortality of heart failure-related hospitalizations in children in the United States: a population-based study. J Card Fail 18(6):459\u2013470","journal-title":"J Card Fail"},{"issue":"7","key":"2114_CR4","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1111\/j.1476-5381.2011.01588.x","volume":"165","author":"MN Bangash","year":"2012","unstructured":"Bangash MN, Kong ML, Pearse RM (2012) Use of inotropes and vasopressor agents in critically ill patients. Br J Pharmacol 165(7):2015\u20132033","journal-title":"Br J Pharmacol"},{"issue":"2 Suppl 1","key":"2114_CR5","first-page":"1","volume":"6","author":"WS Colucci","year":"2000","unstructured":"Colucci WS, Sawyer DB, Singh K, Communal C (2000) Adrenergic overload and apoptosis in heart failure: implications for therapy. J Card Fail 6(2 Suppl 1):1\u20137","journal-title":"J Card Fail"},{"issue":"3","key":"2114_CR6","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/S0008-6363(99)00370-3","volume":"45","author":"K Singh","year":"2000","unstructured":"Singh K, Communal C, Sawyer DB, Colucci WS (2000) Adrenergic regulation of myocardial apoptosis. Cardiovasc Res 45(3):713\u2013719","journal-title":"Cardiovasc Res"},{"issue":"3","key":"2114_CR7","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1007\/s00246-015-1322-2","volume":"37","author":"K Averin","year":"2016","unstructured":"Averin K, Villa C, Krawczeski CD et al (2016) Initial observations of the effects of calcium chloride infusions in pediatric patients with low cardiac output. Pediatr Cardiol 37(3):610\u2013617","journal-title":"Pediatr Cardiol"},{"issue":"12","key":"2114_CR8","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1007\/s00431-006-0400-0","volume":"166","author":"E Lechner","year":"2007","unstructured":"Lechner E, Hofer A, Mair R, Moosbauer W, Sames-Dolzer E, Tulzer G (2007) Arginine-vasopressin in neonates with vasodilatory shock after cardiopulmonary bypass. Eur J Pediatr 166(12):1221\u20131227","journal-title":"Eur J Pediatr"},{"issue":"8","key":"2114_CR9","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1161\/01.CIR.92.8.2226","volume":"92","author":"G Wernovsky","year":"1995","unstructured":"Wernovsky G, Wypij D, Jonas RA et al (1995) Postoperative course and hemodynamic profile after the arterial switch operation in neonates and infants. Circulation 92(8):2226\u20132235","journal-title":"Circulation"},{"issue":"2","key":"2114_CR10","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1097\/PCC.0b013e3181b806fc","volume":"11","author":"MG Gaies","year":"2010","unstructured":"Gaies MG, Gurney JG, Yen AH et al (2010) Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass. Pediatr Crit Care Med. 11(2):234\u2013238","journal-title":"Pediatr Crit Care Med."},{"key":"2114_CR11","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1177\/0272989X9901900408","volume":"19","author":"S Leteurtre","year":"1999","unstructured":"Leteurtre S, Martinot A, Duhamel A et al (1999) Development of a pediatric multiple organ dysfunction score : use of two strategies. Med Decis Mak 19:399\u2013410","journal-title":"Med Decis Mak"},{"key":"2114_CR12","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/S0140-6736(03)13908-6","volume":"362","author":"S Leteurtre","year":"2003","unstructured":"Leteurtre S, Martinot A, Duhamel A et al (2003) Validation of the paediatric logistic organ dysfunction (PELOD) score : prospective, observational, multicentre study. Lancet 362:192\u2013197","journal-title":"Lancet"},{"issue":"7","key":"2114_CR13","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1097\/CCM.0b013e31828a2bbd","volume":"41","author":"S Leteurtre","year":"2013","unstructured":"Leteurtre S, Duhamel A, Salleron J, Grandbastien B, Lacroix J, Leclerc F (2013) PELOD-2: an update of the PEdiatric logistic organ dysfunction score. Crit Care Med 41(7):1761\u20131773","journal-title":"Crit Care Med"},{"issue":"6","key":"2114_CR14","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1007\/s00134-002-1265-y","volume":"28","author":"M D\u00fcnser","year":"2002","unstructured":"D\u00fcnser M, Mayr A, Stallinger A et al (2002) Cardiac performance during vasopressin infusion in postcardiotomy shock. Intens Care Med 28(6):746\u2013751","journal-title":"Intens Care Med"},{"issue":"3","key":"2114_CR15","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1378\/chest.11-2604","volume":"142","author":"AC Gordon","year":"2012","unstructured":"Gordon AC, Wang N, Walley KR, Ashby D, Russell JA (2012) The cardiopulmonary effects of vasopressin compared with norepinephrine in septic shock. Chest 142(3):593\u2013605. https:\/\/doi.org\/10.1378\/chest.11-2604","journal-title":"Chest"},{"issue":"7","key":"2114_CR16","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1007\/s00134-004-2283-8","volume":"30","author":"GM Mutlu","year":"2004","unstructured":"Mutlu GM, Factor P (2004) Role of vasopressin in the management of septic shock. Intens Care Med 30(7):1276\u20131291","journal-title":"Intens Care Med"},{"issue":"3","key":"2114_CR17","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/S0003-4975(02)04408-9","volume":"75","author":"DLS Morales","year":"2003","unstructured":"Morales DLS, Garrido MJ, Madigan JD et al (2003) A double-blind randomized trial: prophylactic vasopressin reduces hypotension after cardiopulmonary bypass. Ann Thorac Surg 75(3):926\u2013930","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"2114_CR18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF00794837","volume":"14","author":"A Lewis","year":"1993","unstructured":"Lewis A, Chabot M (1993) The effect of treatment of angiotensin-converting enzyme inhibitors on survival of pediatric patients with dilated cardiomyopathy. Pediatr Cardiol 14(1):9\u201312","journal-title":"Pediatr Cardiol"},{"issue":"3","key":"2114_CR19","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1007\/s00246-012-0527-x","volume":"34","author":"M Huang","year":"2013","unstructured":"Huang M, Zhang X, Chen S et al (2013) The effect of carvedilol treatment on chronic heart failure in pediatric patients with dilated cardiomyopathy: a prospective, randomized-controlled study. Pediatr Cardiol 34(3):680\u2013685","journal-title":"Pediatr Cardiol"},{"issue":"10 Suppl","key":"2114_CR20","doi-asserted-by":"publisher","first-page":"S214","DOI":"10.1097\/00003246-200110001-00003","volume":"29","author":"SM Schwartz","year":"2001","unstructured":"Schwartz SM, Duffy JY, Pearl JM, Nelson DP (2001) Cellular and molecular aspects of myocardial dysfunction. Crit Care Med 29(10 Suppl):S214\u2013S219","journal-title":"Crit Care Med"},{"key":"2114_CR21","first-page":"H22","volume":"252","author":"W Pegg","year":"1987","unstructured":"Pegg W, Michalak M (1987) Differentiation of sarcoplasmic reticulum during cardiac myogenesis. Am J Physiol 252:H22\u2013H31","journal-title":"Am J Physiol"},{"issue":"3","key":"2114_CR22","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1161\/01.RES.61.3.465","volume":"61","author":"R Nassar","year":"1987","unstructured":"Nassar R, Reedy M, Anderson P (1987) Developmental-changes in the ultrastructure and sarcomere shortening of the isolated rabbit ventricular myocyte. Circ Res 61(3):465\u2013483","journal-title":"Circ Res"},{"issue":"2","key":"2114_CR23","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0022-2828(86)80471-0","volume":"18","author":"M Seguchi","year":"1986","unstructured":"Seguchi M, Harding JA, Jarmakani JM (1986) Developmental change in the function of sarcoplasmic reticulum. J Mol Cell Cardiol 18(2):189\u2013195","journal-title":"J Mol Cell Cardiol"},{"issue":"6","key":"2114_CR24","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1186\/cc2337","volume":"7","author":"CL Holmes","year":"2003","unstructured":"Holmes CL, Landry DW, Granton JT (2003) Science review: vasopressin and the cardiovascular system part 1\u2014receptor physiology. Crit Care 7(6):427\u2013434","journal-title":"Crit Care"},{"key":"2114_CR25","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1161\/01.RES.69.1.239","volume":"69","author":"YJ Xu","year":"1991","unstructured":"Xu YJ, Gopalakrishnan V (1991) Vasopressin increases cytosolic free [Ca2+] in the neonatal rat cardiomyocyte. Evidence for V1 subtype receptors. Circ Res 69:239\u2013245","journal-title":"Circ Res"},{"issue":"5","key":"2114_CR26","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1097\/00004872-199917050-00011","volume":"17","author":"T Okamura","year":"1999","unstructured":"Okamura T, Ayajiki K, Fujioka H, Toda N (1999) Mechanisms underlying arginine vasopressin-induced relaxation in monkey isolated coronary arteries. J Hypertens 17(5):673\u2013678","journal-title":"J Hypertens"},{"issue":"2","key":"2114_CR27","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.resuscitation.2004.07.013","volume":"64","author":"V Wenzel","year":"2005","unstructured":"Wenzel V, Kern KB, Hilwig RW et al (2005) Effects of intravenous arginine vasopressin on epicardial coronary artery cross sectional area in a swine resuscitation model. Resuscitation 64(2):219\u2013226","journal-title":"Resuscitation"},{"issue":"2","key":"2114_CR28","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.resuscitation.2006.07.030","volume":"74","author":"VD Mayr","year":"2007","unstructured":"Mayr VD, Wenzel V, Wagner-Berger HG et al (2007) Arginine vasopressin during sinus rhythm: effects on haemodynamic variables, left anterior descending coronary artery cross sectional area and cardiac index, before and after inhibition of NO-synthase, in pigs. Resuscitation 74(2):366\u2013371","journal-title":"Resuscitation"},{"issue":"2","key":"2114_CR29","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1159\/000159082","volume":"32","author":"V Rudichenko","year":"1995","unstructured":"Rudichenko V, Beierwaltes W (1995) Arginine vasopressin- induced renal vasodilatation mediated by nitric oxide. J Vasc Res 32(2):100\u2013105","journal-title":"J Vasc Res"},{"issue":"2","key":"2114_CR30","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1046\/j.1365-2796.1999.00556.x","volume":"246","author":"A Eisenman","year":"1999","unstructured":"Eisenman A, Armali Z, Enat R, Bankir L, Baruch Y (1999) Low-dose vasopressin restores diuresis both in patients with hepatorenal syndrome and in anuric patients with end-stage heart failure. J Intern Med 246(2):183\u2013190","journal-title":"J Intern Med"},{"issue":"2","key":"2114_CR31","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1097\/PCC.0b013e31829f5fce","volume":"15","author":"A Mohamed","year":"2014","unstructured":"Mohamed A, Nasef N, Shah V, McNamara PJ (2014) Vasopressin as a rescue therapy for refractory pulmonary hypertension in neonates: case series. Pediatr Crit Care Med 15(2):148\u2013154","journal-title":"Pediatr Crit Care Med"},{"issue":"4","key":"2114_CR32","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1378\/chest.103.4.1241","volume":"103","author":"PR Evora","year":"1993","unstructured":"Evora PR, Pearson PJ, Schaff HV (1993) ARginine vasopressin induces endothelium-dependent vasodilatation of the pulmonary artery. v1-receptor-mediated production of nitric oxide. Chest 103(4):1241\u20131245. https:\/\/doi.org\/10.1378\/chest.103.4.1241","journal-title":"Chest"},{"issue":"6","key":"2114_CR33","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1510\/icvts.2007.159624","volume":"6","author":"E Tayama","year":"2007","unstructured":"Tayama E, Ueda T, Shojima T et al (2007) Arginine vasopressin is an ideal drug after cardiac surgery for the management of low systemic vascular resistant hypotension concomitant with pulmonary hypertension. Interact Cardiovasc Thorac Surg. 6(6):715\u2013719","journal-title":"Interact Cardiovasc Thorac Surg."},{"issue":"7","key":"2114_CR34","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1161\/01.STR.24.7.1049","volume":"24","author":"Y Suzuki","year":"1993","unstructured":"Suzuki Y, Satoh SI, Oyama H, Takayasu M, Shibuya M (1993) Regional differences in the vasodilator response to vasopressin in canine cerebral arteries in vivo. Stroke 24(7):1049\u20131053","journal-title":"Stroke"},{"issue":"3","key":"2114_CR35","first-page":"S421","volume":"2","author":"PM Vanhoutte","year":"1984","unstructured":"Vanhoutte PM, Katusi\u0107 ZS, Shepherd JT (1984) Vasopressin induces endothelium-dependent relaxations of cerebral and coronary, but not of systemic arteries. J Hypertens Suppl. 2(3):S421\u2013S422","journal-title":"J Hypertens Suppl."},{"issue":"2","key":"2114_CR36","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/01.PCC.0000059421.13161.88","volume":"4","author":"JA Tantale\u00e1n","year":"2003","unstructured":"Tantale\u00e1n JA, Le\u00f3n RJ, Santos AA, S\u00e1nchez E (2003) Multiple organ dysfunction syndrome in children. Pediatr Crit Care Med 4(2):181\u2013185","journal-title":"Pediatr Crit Care Med"},{"issue":"3","key":"2114_CR37","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1097\/PCC.0b013e3182720473","volume":"14","author":"MC Davalos","year":"2013","unstructured":"Davalos MC, Barrett R, Seshadri S et al (2013) Hyponatremia during arginine vasopressin therapy in children following cardiac surgery. Pediatr Crit Care Med 14(3):290\u2013297","journal-title":"Pediatr Crit Care Med"},{"issue":"7","key":"2114_CR38","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1007\/s00134-008-1055-2","volume":"34","author":"N Jerath","year":"2008","unstructured":"Jerath N, Frndova H, McCrindle BW, Gurofsky R, Humpl T (2008) Clinical impact of vasopressin infusion on hemodynamics, liver and renal function in pediatric patients. Intens Care Med 34(7):1274\u20131280","journal-title":"Intens Care Med"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-019-02114-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00246-019-02114-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-019-02114-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T10:17:32Z","timestamp":1663409852000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00246-019-02114-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,7]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["2114"],"URL":"https:\/\/doi.org\/10.1007\/s00246-019-02114-2","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,7]]},"assertion":[{"value":"7 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors do not have any conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}