{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:56:13Z","timestamp":1761562573386},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s00246-019-02254-5","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T19:02:46Z","timestamp":1574276566000},"page":"290-296","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Profile and Long-Term Follow-Up of Children with Brugada Syndrome"],"prefix":"10.1007","volume":"41","author":[{"given":"Ibrahim","family":"El-Battrawy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gretje","family":"Roterberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Schlentrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Liebe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Rudic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erol","family":"T\u00fcl\u00fcmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Borggrefe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"2254_CR1","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/j.1365-201X.2005.01496.x","volume":"185","author":"AS Amin","year":"2005","unstructured":"Amin AS, Verkerk AO, Bhuiyan ZA, Wilde AA, Tan HL (2005) Novel Brugada syndrome-causing mutation in ion-conducting pore of cardiac Na+ channel does not affect ion selectivity properties. Acta Physiol Scand 185:291\u2013301","journal-title":"Acta Physiol Scand"},{"key":"2254_CR2","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.jacc.2016.05.073","volume":"68","author":"R Casado-Arroyo","year":"2016","unstructured":"Casado-Arroyo R, Berne P, Rao JY, Rodriguez-Manero M, Levinstein M, Conte G, Sieira J, Namdar M, Ricciardi D, Chierchia GB, de Asmundis C, Pappaert G, La Meir M, Wellens F, Brugada J, Brugada P (2016) Long-term trends in newly diagnosed brugada syndrome: implications for risk stratification. J Am Coll Cardiol 68:614\u2013623","journal-title":"J Am Coll Cardiol"},{"key":"2254_CR3","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1093\/eurheartj\/ehv316","volume":"36","author":"SG Priori","year":"2015","unstructured":"Priori SG, Blomstrom-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, Elliott PM, Fitzsimons D, Hatala R, Hindricks G, Kirchhof P, Kjeldsen K, Kuck KH, Hernandez-Madrid A, Nikolaou N, Norekval TM, Spaulding C, Van Veldhuisen DJ (2015) 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the european society of cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J 36:2793\u20132867","journal-title":"Eur Heart J"},{"key":"2254_CR4","doi-asserted-by":"publisher","first-page":"e005053","DOI":"10.1161\/CIRCEP.117.005053","volume":"10","author":"C Pappone","year":"2017","unstructured":"Pappone C, Brugada J, Vicedomini G, Ciconte G, Manguso F, Saviano M, Vitale R, Cuko A, Giannelli L, Calovic Z, Conti M, Pozzi P, Natalizia A, Crisa S, Borrelli V, Brugada R, Sarquella-Brugada G, Guazzi M, Frigiola A, Menicanti L, Santinelli V (2017) Electrical substrate elimination in 135 consecutive patients with Brugada syndrome. Circ Arrhythm Electrophysiol 10:e005053","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2254_CR5","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1016\/j.hrthm.2016.02.013","volume":"13","author":"A Andorin","year":"2016","unstructured":"Andorin A, Behr ER, Denjoy I, Crotti L, Dagradi F, Jesel L, Sacher F, Petit B, Mabo P, Maltret A, Wong LC, Degand B, Bertaux G, Maury P, Dulac Y, Delasalle B, Gourraud JB, Babuty D, Blom NA, Schwartz PJ, Wilde AA, Probst V (2016) Impact of clinical and genetic findings on the management of young patients with Brugada syndrome. Heart Rhythm 13:1274\u20131282","journal-title":"Heart Rhythm"},{"key":"2254_CR6","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1111\/j.1540-8159.2011.03033.x","volume":"34","author":"A Sorgente","year":"2011","unstructured":"Sorgente A, Sarkozy A, De Asmundis C, Chierchia GB, Capulzini L, Paparella G, Henkens S, Brugada P (2011) Ajmaline challenge in young individuals with suspected Brugada syndrome. Pacing Clin Electrophysiol 34:736\u2013741","journal-title":"Pacing Clin Electrophysiol"},{"key":"2254_CR7","first-page":"1864","volume":"19","author":"MC Gonzalez Corcia","year":"2017","unstructured":"Gonzalez Corcia MC, Sieira J, Sarkozy A, de Asmundis C, Chierchia GB, Hernandez Ojeda J, Pappaert G, Brugada P (2017) Brugada syndrome in the young: an assessment of risk factors predicting future events. Europace 19:1864\u20131873","journal-title":"Europace"},{"key":"2254_CR8","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jacc.2017.10.082","volume":"71","author":"MC Gonzalez Corcia","year":"2018","unstructured":"Gonzalez Corcia MC, Sieira J, Pappaert G, de Asmundis C, Chierchia GB, La Meir M, Sarkozy A, Brugada P (2018) Implantable cardioverter-defibrillators in children and adolescents With Brugada Syndrome. J Am Coll Cardiol 71:148\u2013157","journal-title":"J Am Coll Cardiol"},{"key":"2254_CR9","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1161\/01.CIR.0000152479.54298.51","volume":"111","author":"C Antzelevitch","year":"2005","unstructured":"Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, Gussak I, LeMarec H, Nademanee K, Perez Riera AR, Shimizu W, Schulze-Bahr E, Tan H, Wilde A (2005) Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation 111:659\u2013670","journal-title":"Circulation"},{"key":"2254_CR10","first-page":"665","volume":"19","author":"C Antzelevitch","year":"2017","unstructured":"Antzelevitch C, Yan GX, Ackerman MJ, Borggrefe M, Corrado D, Guo J, Gussak I, Hasdemir C, Horie M, Huikuri H, Ma C, Morita H, Nam GB, Sacher F, Shimizu W, Viskin S, Wilde AAM (2017) J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge. Europace 19:665\u2013694","journal-title":"Europace"},{"key":"2254_CR11","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1093\/eurheartj\/ehv316","volume":"36","author":"Priori SG, Blomstrom-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, Elliott PM, Fitzsimons D, Hatala R, Hindricks G, Kirchhof P, Kjeldsen K, Kuck KH, Hernandez-Madrid A, Nikolaou N, Norekval TM, Spaulding C, Van Veldhuisen DJ, Group ESCSD","year":"2015","unstructured":"Priori SG, Blomstrom-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, Elliott PM, Fitzsimons D, Hatala R, Hindricks G, Kirchhof P, Kjeldsen K, Kuck KH, Hernandez-Madrid A, Nikolaou N, Norekval TM, Spaulding C, Van Veldhuisen DJ, Group ESCSD (2015) 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the european society of cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J 36:2793\u20132867","journal-title":"Eur Heart J"},{"key":"2254_CR12","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1590\/S0104-11692007000300023","volume":"15","author":"CM da Costa Santos","year":"2007","unstructured":"da Costa Santos CM, de Mattos Pimenta CA, Nobre MR (2007) The PICO strategy for the research question construction and evidence search. Rev Lat Am Enfermagem 15:508\u2013511","journal-title":"Rev Lat Am Enfermagem"},{"key":"2254_CR13","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.jacc.2018.01.031","volume":"71","author":"M Papadakis","year":"2018","unstructured":"Papadakis M, Papatheodorou E, Mellor G, Raju H, Bastiaenen R, Wijeyeratne Y, Wasim S, Ensam B, Finocchiaro G, Gray B, Malhotra A, D'Silva A, Edwards N, Cole D, Attard V, Batchvarov VN, Tome-Esteban M, Homfray T, Sheppard MN, Sharma S, Behr ER (2018) The diagnostic yield of brugada syndrome after sudden death with normal autopsy. J Am Coll Cardiol 71:1204\u20131214","journal-title":"J Am Coll Cardiol"},{"key":"2254_CR14","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1002\/humu.9144","volume":"21","author":"E Schulze-Bahr","year":"2003","unstructured":"Schulze-Bahr E, Eckardt L, Breithardt G, Seidl K, Wichter T, Wolpert C, Borggrefe M, Haverkamp W (2003) Sodium channel gene (SCN5A) mutations in 44 index patients with Brugada syndrome: different incidences in familial and sporadic disease. Hum Mutat 21:651\u2013652","journal-title":"Hum Mutat"},{"key":"2254_CR15","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.hrthm.2006.10.028","volume":"4","author":"N Makita","year":"2007","unstructured":"Makita N, Sumitomo N, Watanabe I, Tsutsui H (2007) Novel SCN5A mutation (Q55X) associated with age-dependent expression of Brugada syndrome presenting as neurally mediated syncope. Heart Rhythm 4:516\u2013519","journal-title":"Heart Rhythm"},{"key":"2254_CR16","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.jacc.2005.03.066","volume":"46","author":"GC Beaufort-Krol","year":"2005","unstructured":"Beaufort-Krol GC, van den Berg MP, Wilde AA, van Tintelen JP, Viersma JW, Bezzina CR, Bink-Boelkens MT (2005) Developmental aspects of long QT syndrome type 3 and Brugada syndrome on the basis of a single SCN5A mutation in childhood. J Am Coll Cardiol 46:331\u2013337","journal-title":"J Am Coll Cardiol"},{"key":"2254_CR17","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1046\/j.1460-9592.2003.t01-1-00227.x","volume":"26","author":"K Matsuo","year":"2003","unstructured":"Matsuo K, Akahoshi M, Seto S, Yano K (2003) Disappearance of the Brugada-type electrocardiogram after surgical castration: a role for testosterone and an explanation for the male preponderance. Pacing Clin Electrophysiol 26:1551\u20131553","journal-title":"Pacing Clin Electrophysiol"},{"key":"2254_CR18","doi-asserted-by":"crossref","first-page":"e007394","DOI":"10.1161\/JAHA.117.007394","volume":"7","author":"I El-Battrawy","year":"2018","unstructured":"Battrawy I, Lan H, Cyganek L, Zhao Z, Li X, Buljubasic F, Lang S, Yucel G, Sattler K, Zimmermann WH, Utikal J, Wieland T, Ravens U, Borggrefe M, Zhou XB, Akin I (2018) Modeling short QT syndrome using human-induced pluripotent stem cell-derived cardiomyocytes. J Am Heart Assoc 7:e007394","journal-title":"J Am Heart Assoc"},{"key":"2254_CR19","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1093\/europace\/euz122","volume":"21","author":"I El-Battrawy","year":"2019","unstructured":"El-Battrawy I, Albers S, Cyganek L, Zhao Z, Lan H, Li X, Xu Q, Kleinsorge M, Huang M, Liao Z, Zhong R, Rudic B, Muller J, Dinkel H, Lang S, Diecke S, Zimmermann WH, Utikal J, Wieland T, Borggrefe M, Zhou X, Akin I (2019) A cellular model of Brugada syndrome with SCN10A variants using human-induced pluripotent stem cell-derived cardiomyocytes. Europace 21:1410\u20131421","journal-title":"Europace"},{"key":"2254_CR20","doi-asserted-by":"publisher","first-page":"e0166143","DOI":"10.1371\/journal.pone.0166143","volume":"11","author":"I El-Battrawy","year":"2016","unstructured":"El-Battrawy I, Lang S, Zhao Z, Akin I, Yucel G, Meister S, Patocskai B, Behnes M, Rudic B, Tulumen E, Liebe V, Tiburcy M, Dworacek J, Zimmermann WH, Utikal J, Wieland T, Borggrefe M, Zhou XB (2016) Hyperthermia influences the effects of sodium channel blocking drugs in human-induced pluripotent stem cell-derived cardiomyocytes. PLoS ONE 11:e0166143","journal-title":"PLoS ONE"},{"key":"2254_CR21","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1253\/circj.69.946","volume":"69","author":"M Sumiyoshi","year":"2005","unstructured":"Sumiyoshi M, Nakazato Y, Tokano T, Yasuda M, Mineda Y, Nakata Y, Daida H (2005) Sinus node dysfunction concomitant with Brugada syndrome. Circ J 69:946\u2013950","journal-title":"Circ J"},{"key":"2254_CR22","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.hrthm.2004.11.025","volume":"2","author":"C Wolpert","year":"2005","unstructured":"Wolpert C, Echternach C, Veltmann C, Antzelevitch C, Thomas GP, Spehl S, Streitner F, Kuschyk J, Schimpf R, Haase KK, Borggrefe M (2005) Intravenous drug challenge using flecainide and ajmaline in patients with Brugada syndrome. Heart Rhythm 2:254\u2013260","journal-title":"Heart Rhythm"},{"key":"2254_CR23","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1093\/europace\/eup189","volume":"11","author":"C Veltmann","year":"2009","unstructured":"Veltmann C, Wolpert C, Sacher F, Mabo P, Schimpf R, Streitner F, Brade J, Kyndt F, Kuschyk J, Le Marec H, Borggrefe M, Probst V (2009) Response to intravenous ajmaline: a retrospective analysis of 677 ajmaline challenges. Europace 11:1345\u20131352","journal-title":"Europace"},{"key":"2254_CR24","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1016\/j.jacc.2014.02.574","volume":"63","author":"G Conte","year":"2014","unstructured":"Conte G, Dewals W, Sieira J, de Asmundis C, Ciconte G, Chierchia GB, Di Giovanni G, Baltogiannis G, Saitoh Y, Levinstein M, La Meir M, Wellens F, Pappaert G, Brugada P (2014) Drug-induced brugada syndrome in children: clinical features, device-based management, and long-term follow-up. J Am Coll Cardiol 63:2272\u20132279","journal-title":"J Am Coll Cardiol"},{"key":"2254_CR25","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1111\/j.1540-8167.2008.01223.x","volume":"19","author":"F Sacher","year":"2008","unstructured":"Sacher F, Meregalli P, Veltmann C, Field ME, Solnon A, Bru P, Abbey S, Jais P, Tan HL, Wolpert C, Lande G, Bertault V, Derval N, Babuty D, Lacroix D, Boveda S, Maury P, Hocini M, Clementy J, Mabo P, Lemarec H, Mansourati J, Borggrefe M, Wilde A, Haissaguerre M, Probst V (2008) Are women with severely symptomatic brugada syndrome different from men? J Cardiovasc Electrophysiol 19:1181\u20131185","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2254_CR26","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1161\/CIRCULATIONAHA.113.001941","volume":"128","author":"F Sacher","year":"2013","unstructured":"Sacher F, Probst V, Maury P, Babuty D, Mansourati J, Komatsu Y, Marquie C, Rosa A, Diallo A, Cassagneau R, Loizeau C, Martins R, Field ME, Derval N, Miyazaki S, Denis A, Nogami A, Ritter P, Gourraud JB, Ploux S, Rollin A, Zemmoura A, Lamaison D, Bordachar P, Pierre B, Jais P, Pasquie JL, Hocini M, Legal F, Defaye P, Boveda S, Iesaka Y, Mabo P, Haissaguerre M (2013) Outcome after implantation of a cardioverter-defibrillator in patients with Brugada syndrome: a multicenter study-part 2. Circulation 128:1739\u20131747","journal-title":"Circulation"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-019-02254-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00246-019-02254-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-019-02254-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T13:34:50Z","timestamp":1665063290000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00246-019-02254-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,20]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["2254"],"URL":"https:\/\/doi.org\/10.1007\/s00246-019-02254-5","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,20]]},"assertion":[{"value":"18 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research Involving Human and Animal Participants"}},{"value":"Informed consent is not required regarding the pooled analysis of data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}