{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:37:08Z","timestamp":1789425428288,"version":"build-2803163510"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Cardiol"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s00246-019-02264-3","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T15:02:58Z","timestamp":1576767778000},"page":"350-360","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Eccentric Enlargement of the Aortic Sinuses in Pediatric and Adult Patients with Bicuspid Aortic Valves: A Cardiac MRI Study"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0991-9836","authenticated-orcid":false,"given":"Heather A.","family":"Stefek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin H.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia K.","family":"Rigsby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector I.","family":"Michelena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Aouad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex J.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,19]]},"reference":[{"key":"2264_CR1","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.amjcard.2003.11.031","volume":"93","author":"C Basso","year":"2004","unstructured":"Basso C, Boschello M, Perrone C et al (2004) An echocardiographic survey of primary school children for bicuspid aortic valve. Am J Cardiol 93:661\u2013663","journal-title":"Am J Cardiol"},{"key":"2264_CR2","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/0002-9149(70)90761-7","volume":"26","author":"WC Roberts","year":"1970","unstructured":"Roberts WC (1970) The congenitally bicuspid aortic valve. A study of 85 autopsy cases. Am J Cardiol 26:72\u201383","journal-title":"Am J Cardiol"},{"key":"2264_CR3","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1001\/jama.2011.1286","volume":"306","author":"HI Michelena","year":"2011","unstructured":"Michelena HI, Khanna AD, Mahoney D et al (2011) Incidence of aortic complications in patients with bicuspid aortic valves. JAMA 306:1104\u20131112","journal-title":"JAMA"},{"key":"2264_CR4","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.jcmg.2012.11.007","volume":"6","author":"JW Kang","year":"2013","unstructured":"Kang JW, Song HG, Yang DH et al (2013) Association between bicuspid aortic valve phenotype and patterns of valvular dysfunction and bicuspid aortopathy: comprehensive evaluation using MDCT and echocardiography. JACC Cardiovasc Imaging 6:150\u2013161","journal-title":"JACC Cardiovasc Imaging"},{"key":"2264_CR5","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1001\/jamacardio.2016.5228","volume":"2","author":"WK Kong","year":"2017","unstructured":"Kong WK, Delgado V, Poh KK et al (2017) Prognostic implications of raphe in bicuspid aortic valve anatomy. JAMA Cardiol 2:285\u2013292","journal-title":"JAMA Cardiol"},{"key":"2264_CR6","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1161\/CIRCIMAGING.112.973370","volume":"5","author":"AJ Barker","year":"2012","unstructured":"Barker AJ, Markl M, Burk J et al (2012) Bicuspid aortic valve is associated with altered wall shear stress in the ascending aorta. Circ Cardiovasc Imaging 5:457\u2013466","journal-title":"Circ Cardiovasc Imaging"},{"key":"2264_CR7","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1161\/CIRCULATIONAHA.113.003026","volume":"129","author":"R Mahadevia","year":"2014","unstructured":"Mahadevia R, Barker AJ, Schnell S et al (2014) Bicuspid aortic cusp fusion morphology alters aortic three-dimensional outflow patterns, wall shear stress, and expression of aortopathy. Circulation 129:673\u2013682","journal-title":"Circulation"},{"key":"2264_CR8","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.echo.2017.12.008","volume":"31","author":"R Capoulade","year":"2018","unstructured":"Capoulade R, Teoh JG, Bartko PE et al (2018) Relationship between proximal aorta morphology and progression rate of aortic stenosis. J Am Soc Echocardiogr 31:561\u2013569.e561","journal-title":"J Am Soc Echocardiogr"},{"key":"2264_CR9","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.ijcard.2015.08.106","volume":"201","author":"HI Michelena","year":"2015","unstructured":"Michelena HI, Della Corte A, Prakash SK et al (2015) Bicuspid aortic valve aortopathy in adults: incidence, etiology, and clinical significance. Int J Cardiol 201:400\u2013407","journal-title":"Int J Cardiol"},{"key":"2264_CR10","first-page":"126","volume":"100","author":"D Detaint","year":"2014","unstructured":"Detaint D, Michelena HI, Nkomo VT et al (2014) Aortic dilatation patterns and rates in adults with bicuspid aortic valves: a comparative study with Marfan syndrome and degenerative aortopathy. Heart (British Cardiac Society) 100:126\u2013134","journal-title":"Heart (British Cardiac Society)"},{"key":"2264_CR11","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1007\/s10554-013-0268-9","volume":"29","author":"FS Torres","year":"2013","unstructured":"Torres FS, Windram JD, Bradley TJ et al (2013) Impact of asymmetry on measurements of the aortic root using cardiovascular magnetic resonance imaging in patients with a bicuspid aortic valve. Int J Cardiovasc Imaging 29:1769\u20131777","journal-title":"Int J Cardiovasc Imaging"},{"key":"2264_CR12","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.echo.2018.08.004","volume":"32","author":"JC Vis","year":"2019","unstructured":"Vis JC, Rodriguez-Palomares JF, Teixido-Tura G et al (2019) Implications of asymmetry and valvular morphotype on echocardiographic measurements of the aortic root in bicuspid aortic valve. J Am Soc Echocardiogr 32:105\u2013112","journal-title":"J Am Soc Echocardiogr"},{"key":"2264_CR13","doi-asserted-by":"publisher","first-page":"179","DOI":"10.4103\/0974-2069.99622","volume":"5","author":"H Chubb","year":"2012","unstructured":"Chubb H, Simpson JM (2012) The use of Z-scores in paediatric cardiology. Ann Pediatr Cardiol 5:179\u2013184","journal-title":"Ann Pediatr Cardiol"},{"key":"2264_CR14","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.amjcard.2014.06.024","volume":"114","author":"L Campens","year":"2014","unstructured":"Campens L, Demulier L, De Groote K et al (2014) Reference values for echocardiographic assessment of the diameter of the aortic root and ascending aorta spanning all age categories. Am J Cardiol 114:914\u2013920","journal-title":"Am J Cardiol"},{"key":"2264_CR15","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1161\/CIRCULATIONAHA.113.007851","volume":"129","author":"HI Michelena","year":"2014","unstructured":"Michelena HI, Prakash SK, Della Corte A et al (2014) Bicuspid aortic valve: identifying knowledge gaps and rising to the challenge from the International Bicuspid Aortic Valve Consortium (BAVCon). Circulation 129:2691\u20132704","journal-title":"Circulation"},{"key":"2264_CR16","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1002\/jmri.24498","volume":"40","author":"P Entezari","year":"2014","unstructured":"Entezari P, Schnell S, Mahadevia R et al (2014) From unicuspid to quadricuspid: influence of aortic valve morphology on aortic three-dimensional hemodynamics. J Magn Reson Imaging 40:1342\u20131346","journal-title":"J Magn Reson Imaging"},{"key":"2264_CR17","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.echo.2018.08.004","volume":"32","author":"JC Vis","year":"2018","unstructured":"Vis JC, Rodriguez-Palomares JF, Teixido-Tura G et al (2018) Implications of asymmetry and valvular morphotype on echocardiographic measurements of the aortic root in bicuspid aortic valve. J Am Soc Echocardiogr 32:105\u2013112","journal-title":"J Am Soc Echocardiogr"},{"key":"2264_CR18","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1016\/j.jacc.2009.07.044","volume":"54","author":"B Fernandez","year":"2009","unstructured":"Fernandez B, Duran AC, Fernandez-Gallego T et al (2009) Bicuspid aortic valves with different spatial orientations of the leaflets are distinct etiological entities. J Am Coll Cardiol 54:2312\u20132318","journal-title":"J Am Coll Cardiol"},{"key":"2264_CR19","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1093\/cvr\/cvt132","volume":"99","author":"HM Phillips","year":"2013","unstructured":"Phillips HM, Mahendran P, Singh E et al (2013) Neural crest cells are required for correct positioning of the developing outflow cushions and pattern the arterial valve leaflets. Cardiovasc Res 99:452\u2013460","journal-title":"Cardiovasc Res"},{"key":"2264_CR20","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.amjcard.2006.04.022","volume":"98","author":"RS Beroukhim","year":"2006","unstructured":"Beroukhim RS, Kruzick TL, Taylor AL et al (2006) Progression of aortic dilation in children with a functionally normal bicuspid aortic valve. Am J Cardiol 98:828\u2013830","journal-title":"Am J Cardiol"},{"key":"2264_CR21","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00246-013-0856-4","volume":"35","author":"G Spaziani","year":"2014","unstructured":"Spaziani G, Ballo P, Favilli S et al (2014) Clinical outcome, valve dysfunction, and progressive aortic dilation in a pediatric population with isolated bicuspid aortic valve. Pediatr Cardiol 35:803\u2013809","journal-title":"Pediatr Cardiol"},{"key":"2264_CR22","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.amjcard.2017.03.245","volume":"120","author":"R Merkx","year":"2017","unstructured":"Merkx R, Duijnhouwer AL, Vink E et al (2017) Aortic diameter growth in children with a bicuspid aortic valve. Am J Cardiol 120:131\u2013136","journal-title":"Am J Cardiol"},{"key":"2264_CR23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1148\/radiol.09091437","volume":"255","author":"MD Hope","year":"2010","unstructured":"Hope MD, Hope TA, Meadows AK et al (2010) Bicuspid aortic valve: four-dimensional MR evaluation of ascending aortic systolic flow patterns. Radiology 255:53\u201361","journal-title":"Radiology"},{"key":"2264_CR24","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s12968-018-0451-1","volume":"20","author":"JF Rodriguez-Palomares","year":"2018","unstructured":"Rodriguez-Palomares JF, Dux-Santoy L, Guala A et al (2018) Aortic flow patterns and wall shear stress maps by 4D-flow cardiovascular magnetic resonance in the assessment of aortic dilatation in bicuspid aortic valve disease. J Cardiovasc Magn Reson 20:28","journal-title":"J Cardiovasc Magn Reson"},{"key":"2264_CR25","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1161\/CIRCULATIONAHA.109.934679","volume":"123","author":"D Aicher","year":"2011","unstructured":"Aicher D, Kunihara T, Abou Issa O et al (2011) Valve configuration determines long-term results after repair of the bicuspid aortic valve. Circulation 123:178\u2013185","journal-title":"Circulation"},{"key":"2264_CR26","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1016\/j.athoracsur.2013.12.022","volume":"97","author":"M Ugur","year":"2014","unstructured":"Ugur M, Schaff HV, Suri RM et al (2014) Late outcome of noncoronary sinus replacement in patients with bicuspid aortic valves and aortopathy. Ann Thorac Surg 97:1242\u20131246","journal-title":"Ann Thorac Surg"}],"container-title":["Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-019-02264-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00246-019-02264-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00246-019-02264-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T01:05:07Z","timestamp":1608253507000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00246-019-02264-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,19]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["2264"],"URL":"https:\/\/doi.org\/10.1007\/s00246-019-02264-3","relation":{},"ISSN":["0172-0643","1432-1971"],"issn-type":[{"value":"0172-0643","type":"print"},{"value":"1432-1971","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,19]]},"assertion":[{"value":"9 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors of this manuscript declare no relevant conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}